Abstract Background Polymyxin E (colistin) is a last-resort antibiotic to treat infections caused by carbapenemase-producing Enterobacteriaceae (CPE). However, reports of CPEs resistant to colistin have been increasing, and the mcr genes are emerging as resistance mechanisms. Among them, plasmid-mediate mcr-9 is known to be associated with colistin resistance, whereas reports on chromosomal mcr-9 and its association with colistin resistance in humans are few. Case presentation We identified Enterobacter asburiae harboring mcr-9 and blaIMP-60 in the...

Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma. Methods: We included nine databases contributing data from January to June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients (‘diagnosed’ and ‘hospitalized’) based on COVID-19 disease codes. We followed patients from COVID-19 index...

Drug molecules cannot suitably permeate the cornea, but nano eye-drops may be used to improve intraocular drug permeation. We synthesized a homodimeric prodrug of dexamethasone in an anti-inflammatory drug with carbon chain linkers of varying lengths to establish a new prodrug and fabricated the corresponding dexamethasone nanoparticles. A longer carbon chain linker reduces the size of the nanoparticles and increases their hydrolysis resistance. The fabricated nanoparticles permeate into rat eye and then hydrolyze to release...

Supplemental information

Supplemental information

Additional file 1: Fig. S1. Pectoral fin skeletons of Paracanthopterygii (A–F) and Acanthopterygii excluding Eupercaria (G–R). (A–C) Pectoral fin skeleton of Gadus chalcogrammus (32 cm TL) observed from the lateral view (A, C) and medial view (B). (D–F) Pectoral fin skeleton of Physiculus japonicus (24 cm TL) observed from the lateral view (D, F) and medial view (F). (G–I) Pectoral fin skeleton of Pterogobius zonoleucus (5.2 cm TL) observed from the lateral view (G, I)...

Supplemental material, sj-tif-1-jet-10.1177_15266028221134886 for Characteristics, Antithrombotic Patterns, and Prognostic Outcomes in Claudication and Critical Limb-Threatening Ischemia Undergoing Endovascular Therapy by Osami Kawarada, Kan Zen, Koji Hozawa, Hideaki Obara, Kentaro Matsubara, Yoshito Yamamoto, Tatsuki Doijiri, Nozomu Tamai, Shigenori Ito, Akihiro Higashimori, Daizo Kawasaki, Hideki Doi, Kensuke Matsushita, Kengo Tsukahara, Katsuo Noda, Masahisa Shimpo, Yuki Tsuda, Shinjo Sonoda, Takuya Taniguchi, Katsuhisa Waseda, Masato Munehisa, Eiji Taguchi, Tatsuya Kinjo, Yohei Sasaki, Kenichiro Yuba, Shinichiro Yamaguchi, Takuo Nakagami, Shinobu...

Additional file 2: Figure S2. SEM images of surface topology of conductive materials on CSNF substrate. (a) The boundary between CNT networks and CSNF substrate where CNT networks partially detached. (b) Wrinkles on the surface of PEDOT:PSS micropatterns on the CSNF substrate. (c) The surface of CNT/PEDOT:PSS composite micropattern on the CSNF substrate. Scale bars: (a) 5µm, (b) 2µm, (c) 2µm.

Abstract An increasing demand for bioelectronics that interface with living systems has driven the development of materials to resolve mismatches between electronic devices and biological tissues. So far, a variety of different polymers have been used as substrates for bioelectronics. Especially, biopolymers have been investigated as next-generation materials for bioelectronics because they possess interesting characteristics such as high biocompatibility, biodegradability, and sustainability. However, their range of applications has been restricted due to the limited compatibility...

Radiomics is a method for extracting a large amount of information from images and used to predict treatment outcomes, side effects and diagnosis. In this study, we developed and validated a radiomic model of [18F]FDG-PET/CT for predicting progression-free survival (PFS) of definitive chemoradiotherapy (dCRT) for patients with esophageal cancer. Patients with stage II – III esophageal cancer who underwent [18F]FDG-PET/CT within 45 days before dCRT between 2005 and 2017 were included. Patients were randomly assigned...

Additional file 1: Table S1. Studies not included (n=125) in the review after full text reading and reason for exclusion.

Additional file 1: Supplementary Materials. Receiver operating characteristic curve for social participation and social engagement used to detect the cut point for social inactivity. The Youden index resulted in two “No” cut points for social participation and one “No” cut point for social engagement. AUC, Area Under Curve; 95%CI, 95% confidence interval. Social participation (a), Social engagement (b).

Additional file 2: Figure S2. Representative data and example of the Raman microscopic analysis for CO2 fluid inclusion. (a) Raman spectrum of a CO2 fluid inclusion in MPSX-PX5 pyroxenite. The peaks of volatile species except for CO2 were lower than the detection limit of Raman spectroscopy. (b) An image of CO2 fluid inclusions in the same sample.

Additional file 1: Fig. S1. Illustration of street network. Fig. S2. Distributions of street network centralities in the study area. Fig. S3. Pearson correlation coefficients between all streetscape indicators. Table S1. Relationship between sample points on the street and proximity to surrounding facilities.

Supplementary Material 1

The emergence of HIV drug resistance seriously affects the quality of life of patients. However, there has been no extensive study of CSF resistance. The aim of this study is to evaluate common HIV-1 resistance in CSF and compare it with resistance in matched plasma, and analyse the influencing factors of cerebrospinal fluid drug resistance. The matched CSF and plasma samples of 62 HIV-1 patients were tested at one study site in China (Chongqing; 2019–2022)....

Multi-parametric MRI (mpMRI) is a critical tool in prostate cancer (PCa) diagnosis and management. To further advance the use of mpMRI in patient care, computer aided diagnostic methods are under continuous development for supporting/supplanting standard radiological interpretation. While voxel-wise PCa classification models are the gold standard, few if any approaches have incorporated the inherent structure of the mpMRI data, such as spatial heterogeneity and between-voxel correlation, into PCa classification. We propose a machine learning-based method...

Supplemental material, sj-rtf-1-spp-10.1177_19485506231153012 for Transmission of Basic Psychological Need Satisfaction Between Parents and Adolescents by Vanessa Kurdi, Noriaki Fukuzumi, Ryo Ishii, Ayame Tamura, Naoki Nakazato, Kazuhiro Ohtani, Shin-ichi Ishikawa, Takashi Suzuki, Michiko Sakaki, Kou Murayama and Ayumi Tanaka in Social Psychological and Personality Science

Although studies have documented the importance of basic psychological need satisfaction in parent–child relationships, a gap remains in understanding how parent and adolescent need satisfaction are associated. Using two longitudinal intergenerational data sets (200 parent–adolescent dyads and 408 mother–adolescent dyads; two waves), we examined whether (a) parents’ need satisfaction predicts adolescents’ need satisfaction (parental needs effect), (b) adolescents’ need satisfaction predicts parents’ need satisfaction (child’s needs effect), and (c) parental perception of adolescent’s need satisfaction...

Additional file 1: Table S1. Limacina dissolution index and carbon and oxygen isotope data for pteropods (Heliconoides inflatus) from IODP Site U1461. Table S2. Limacina dissolution index and carbon and oxygen isotope data for pteropods (Heliconoides inflatus) and benthic foraminifera (Uvigerina spp.) from IODP Site U1463. Table S3. Calculated water temperatures and carbonate ion concentrations based on the δ13C and δ18O values of pteropods (Heliconoides inflatus) from IODP Site U1461. Water temperatures were calculated based...

Abstract Background KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucidated because of its wide variety of mutational subtypes. Here, we focused on two distinct base substitution types: transversion mutations and transition mutations, as well as their association with environmental factors and clinical...

Abstract Background KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucidated because of its wide variety of mutational subtypes. Here, we focused on two distinct base substitution types: transversion mutations and transition mutations, as well as their association with environmental factors and clinical...

Additional file 1 Table S1. Elution program used in the UPLC system. Table S2. Primers used in qPCR analysis. Table S3. Characteristic chemicals identified from LC-MS/MS analysis. figure S1. ZSP showed no severe toxic effects on mice. a Food intake and water intake of mice (n=7). b Body length of mice (n=7). c Assessment of liver function of mice (n=7). Normal group: wt/wt mice treated with distilled water. Model group: db/db mice treated with distilled...

Neonicotinoid insecticides target insect nicotinic acetylcholine receptors (nAChRs) and their adverse effects on non-target insects are of serious concern. We recently found that cofactor TMX3 enables robust functional expression of insect nAChRs in Xenopus laevis oocytes and showed that neonicotinoids (imidacloprid, thiacloprid, and clothianidin) exhibited agonist actions on some nAChRs of the fruit fly (Drosophila melanogaster), honeybee (Apis mellifera) and bumblebee (Bombus terrestris) nAChRs with more potent actions on the pollinator nAChRs. However, other subunits...

Additional file 2. Table S1. No. of cases in each TCGA tumor type.