Additional file 2. Table S1. No. of cases in each TCGA tumor type.

Abstract Background Metastatic breast carcinoma is commonly considered during differential diagnosis when metastatic disease is detected in females. In addition to the tumor morphology and documented clinical history, sensitive and specific immunohistochemical (IHC) markers such as GCDFP-15, mammaglobin, and GATA3 are helpful for determining breast origin. However, these markers are reported to show lower sensitivity in certain subtypes, such as triple-negative breast cancer (TNBC). Materials and methods Using bioinformatics analyses, we identified a potential diagnostic...

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Geographic differences in floral traits may reflect geographic differences in effective pollinator assemblages. Independent local adaptation to pollinator assemblages in multiple regions would be expected to cause parallel floral trait evolution, although sufficient evidence for this is still lacking. In this study, we investigated the relationship between flower spur length and pollinator size in 16 populations of Aquilegia buergeriana var. buergeriana distributed in four mountain regions in the Japanese Alps. We also examined the genetic...

All raw data used in this study are available. Each npy file contains the position data for each agent (predator and prey). The differences of file names represent the condition, participant, and set number. Participants A through J are the human participant and K is the artificial agent.

Cognitive impairment caused by systemic chemotherapy is a critical question that perplexes the effective implementation of clinical treatment, but related molecular events are poorly understood. Herein, we show that bortezomib exposure leads to microglia activation and cognitive impairment, this occurs along with decreased nuclear translocation of TFEB (transcription factor EB), which is linked to macroautophagy/autophagy disorder, STAT3 (signal transducer and activator of transcription 3) phosphorylation and IL23A (interleukin 23 subunit alpha) expression. Pharmacological enhancement of...

In this study, cold atmospheric pressure plasma jet was adopted to glass fibers surface modification with tetraethyl orthosilicate as a precursor. To enhance the interfacial bonding forces of glass fiber reinforced polypropylene (GFRP) composites, SiOx nanoparticles were polymerized on the fiber surfaces. The effect of two factors (the distance between nozzle and fiber (D) and the treatment time (T)) on the interfacial bonding behavior of GFRP composites was studied. The modified fibers and composites properties,...

Tensile strained GeSn alloys are being extensively explored as a potential gain medium for lasers compatible with complementary metal-oxide-semiconductor (CMOS) technology. Despite having achieved drastically improved lasing characteristics by harnessing tensile strain, the current methods of introducing a sizeable tensile strain into GeSn lasers require complex fabrication processes, thus reducing the viability of the lasers for practical applications. The geometric strain amplification is a simple technique that can concentrate residual and small tensile strain into...

Multi-parametric MRI (mpMRI) is a critical tool in prostate cancer (PCa) diagnosis and management. To further advance the use of mpMRI in patient care, computer aided diagnostic methods are under continuous development for supporting/supplanting standard radiological interpretation. While voxel-wise PCa classification models are the gold standard, few if any approaches have incorporated the inherent structure of the mpMRI data, such as spatial heterogeneity and between-voxel correlation, into PCa classification. We propose a machine learning-based method...

The emergence of HIV drug resistance seriously affects the quality of life of patients. However, there has been no extensive study of CSF resistance. The aim of this study is to evaluate common HIV-1 resistance in CSF and compare it with resistance in matched plasma, and analyse the influencing factors of cerebrospinal fluid drug resistance. The matched CSF and plasma samples of 62 HIV-1 patients were tested at one study site in China (Chongqing; 2019–2022)....

Although studies have documented the importance of basic psychological need satisfaction in parent–child relationships, a gap remains in understanding how parent and adolescent need satisfaction are associated. Using two longitudinal intergenerational data sets (200 parent–adolescent dyads and 408 mother–adolescent dyads; two waves), we examined whether (a) parents’ need satisfaction predicts adolescents’ need satisfaction (parental needs effect), (b) adolescents’ need satisfaction predicts parents’ need satisfaction (child’s needs effect), and (c) parental perception of adolescent’s need satisfaction...

Supplemental material, sj-rtf-1-spp-10.1177_19485506231153012 for Transmission of Basic Psychological Need Satisfaction Between Parents and Adolescents by Vanessa Kurdi, Noriaki Fukuzumi, Ryo Ishii, Ayame Tamura, Naoki Nakazato, Kazuhiro Ohtani, Shin-ichi Ishikawa, Takashi Suzuki, Michiko Sakaki, Kou Murayama and Ayumi Tanaka in Social Psychological and Personality Science

Sex chromosomes rapidly turn over in several taxonomic groups. Sex chromosome turnover is generally thought to start with the appearance of a new sex-determining gene on an autosome while an old sex-determining gene still exists, followed by the fixation of the new one. However, we do not know how prevalent the transient state is, where multiple sex-determining loci co-exist within natural populations. Here, we removed a Y chromosome with a master male-determining gene DMY from...

Additional file 4: Fig. S3. ROC curve analysis for predicting poor outcome in patients with severe COVID-19 receiving mechanical ventilation. (A) ROC curve for age, (B) for body mass index, (C) for the number of ventilator days, and (D) for the number of mechanical ventilations experienced at an institution for patients with severe COVID-19. ROC, receiver operating characteristic curve; COVID-19, coronavirus disease 2019

Additional file 1: Fig. S1. Pectoral fin skeletons of Paracanthopterygii (A–F) and Acanthopterygii excluding Eupercaria (G–R). (A–C) Pectoral fin skeleton of Gadus chalcogrammus (32 cm TL) observed from the lateral view (A, C) and medial view (B). (D–F) Pectoral fin skeleton of Physiculus japonicus (24 cm TL) observed from the lateral view (D, F) and medial view (F). (G–I) Pectoral fin skeleton of Pterogobius zonoleucus (5.2 cm TL) observed from the lateral view (G, I)...

Additional file 2: Fig. S2. Pectoral fin skeletons in Eupercaria, a major group of Acanthopterygii. (A–C) Pectoral fin skeleton of Takifugu pardalis (18 cm TL) observed from the lateral view (A, C) and medial view (B). (D–F) Pectoral fin skeleton of Epinephelus akaara (6.5 cm TL) observed from the lateral view (D, F) and medial view (E). (G–I) Pectoral fin skeleton of Sebastes cheni (22 cm TL) observed from the lateral view (G, I) and...

Abstract Background Detecting genomic variants and their accumulation processes during species diversification and adaptive radiation is important for understanding the molecular and genetic basis of evolution. Anolis lizards in the West Indies are good models for studying evolutionary mechanisms because of the repeated evolution of their morphology and the ecology. We performed de novo genome assembly of six Cuban Anolis lizards with different ecomorphs and thermal habitats (Anolis isolepis, Anolis allisoni, Anolis porcatus, Anolis allogus,...

Abstract A fundamental parameter-based quantification scheme for confocal XRF was applied to sub-micron synchrotron radiation X-ray fluorescence (SR-XRF) data obtained at the beamline P06 of the Deutsches Elektronen-Synchrotron (DESY, Hamburg, Germany) from two sections C0033-01 and C0033-04 that were wet cut from rock fragment C0033 collected from Cb-type asteroid (162173) Ryugu by JAXA’s Hayabusa2 mission. Trace-element quantifications show that C0033 bulk matrix is CI-like, whereas individual mineral grains (i.e., magnetite, pyrrhotite, dolomite, apatite and breunnerite)...

Additional file 1: Supplemental Figure 1. Lifestyle factors assessed in a dose-dependent manner using the least-squares method.

The present study investigated the therapeutic effects of the curcumin derivative 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole (GT863) in amyotrophic lateral sclerosis (ALS). The inhibitory effect of GT863 on superoxide dismutase 1 (SOD1) aggregation was evaluated in cell-free assays. GT863 interfered with the conformational changes of the SOD1 protein and later, oligomeric aggregation. Furthermore, its antioxidant, anti-inflammatory, and neuroprotective effects were evaluated in cell-free and cultured cell assays. GT863 inhibited H2O2− and glutamate-induced cytotoxicity and activated an antioxidant responsive element...

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Additional file 4: Fig. S3. ROC curve analysis for predicting poor outcome in patients with severe COVID-19 receiving mechanical ventilation. (A) ROC curve for age, (B) for body mass index, (C) for the number of ventilator days, and (D) for the number of mechanical ventilations experienced at an institution for patients with severe COVID-19. ROC, receiver operating characteristic curve; COVID-19, coronavirus disease 2019

Abstract An increasing demand for bioelectronics that interface with living systems has driven the development of materials to resolve mismatches between electronic devices and biological tissues. So far, a variety of different polymers have been used as substrates for bioelectronics. Especially, biopolymers have been investigated as next-generation materials for bioelectronics because they possess interesting characteristics such as high biocompatibility, biodegradability, and sustainability. However, their range of applications has been restricted due to the limited compatibility...