371 Works

Additional file 4 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin

Tian Du, Lu Pan, Chengyou Zheng, Keming Chen, Yuanzhong Yang, Jiewei Chen, Xue Chao, Mei Li, Jiabin Lu, Rongzhen Luo, Jinhui Zhang, Yu Wu, Jiehua He, Dongping Jiang & Peng Sun
Additional file 4. Table S3. Correlation between protein and mRNA levels of 9 candidate genes.

Additional file 1 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin

Tian Du, Lu Pan, Chengyou Zheng, Keming Chen, Yuanzhong Yang, Jiewei Chen, Xue Chao, Mei Li, Jiabin Lu, Rongzhen Luo, Jinhui Zhang, Yu Wu, Jiehua He, Dongping Jiang & Peng Sun
Additional file 1: Fig. S1. The mRNA levels of candidate genes in different molecular subtypes of breast cancer. ER/PR+ (ER/PR+ and HER−, n = 685), HER2+ (n = 168), and TNBC (n = 177). TCGA BRCA ER, PR, and HER2 status were retrieved from Thennavan et al. [21].

10x barcode fastq of Anolis sagrei used for Supernova de novo assembly

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
10x barcode fastq of Anolis sagrei used for Supernova de novo assembly. Paired-end short read data for Supernova de novo assembly were deposited in the DDBJ Short Read Archive database under BioProject accession number PRJDB13431.

Anolis homolechis gene annotation

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
The result of gene annotation for Anolis homolechis genome using BRAKER2.

Anolis allogus CDS

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Anolis allogus CDS predicted using BRAKER2.

Anolis sagrei CDS

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Anolis sagrei CDS predicted using BRAKER2.

Anolis sagrei peptide sequences

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Anolis sagrei peptide sequences predicted using BRAKER2.

10x barcode fastq of Anolis isolepis used for Supernova de novo assembly

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi & Masakado Kawata
10x barcode fastq of Anolis isolepis used for Supernova de novo assembly. Paired-end short read data for Supernova de novo assembly were deposited in the DDBJ Short Read Archive database under BioProject accession number PRJDB13431.

Anolis homolechis CDS

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Anolis homolechis CDS predicted using BRAKER2.

Anolis homolechis gene annotation

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
The result of gene annotation for Anolis homolechis genome using BRAKER2.

Anolis porcatus peptide sequences

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Anolis porcatus peptide sequences predicted using BRAKER2.

Anolis isolepis draft genome (repeat-softmasked)

Shunsuke Kanamori, Luis M. Díaz, Antonio Cádiz, Katsushi Yamaguchi, Shuji Shigenobu & Masakado Kawata
Repeatitive elements annotated by RepeatMasker were softmasked.

Additional file 2 of Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura … & Kei Takase
Additional file 2: Supplementary Table 1. Standardized protocol for non-contrast T1-weighted imaging to assess coronary plaques: recommended protocol for CMR coronary plaque imaging.

Association between the number of remaining teeth and disability-free life expectancy, and the impact of oral self-care in older Japanese adults: a prospective cohort study

Maya Yamato, Sanae Matsuyama, Yoshitaka Murakami, Jun Aida, Yukai Lu, Yumi Sugawara & Ichiro Tsuji
Abstract Background Tooth loss has been reportedly associated with shorter disability-free life expectancy (DFLE). However, no study has explored whether oral self-care offsets reduction in DFLE. The present study aimed to assess the association between oral self-care and DFLE in older individuals with tooth loss. Methods Data on the 13-year follow-up from a cohort study of 14,206 older Japanese adults aged ≥ 65 years in 2006 were analyzed. Information on the number of remaining teeth...

Additional file 1 of Association between the number of remaining teeth and disability-free life expectancy, and the impact of oral self-care in older Japanese adults: a prospective cohort study

Maya Yamato, Sanae Matsuyama, Yoshitaka Murakami, Jun Aida, Yukai Lu, Yumi Sugawara & Ichiro Tsuji
Additional file 1: Supplementary Table 1. Baseline characteristics according to whether or not agreed to a review of their LTCI information. Supplementary Table 2. DFLE, DLE, and TLE at 65 years by the number of remaining teeth with brushing (once vs. twice or more per day). Supplementary Table 3. DFLE, DLE, and TLE at 65 years according to the number of remaining teeth stratified by smoking status. Supplementary Table 4. DFLE, DLE, and TLE at...

Metabolic syndrome and the immunogenicity of Pfizer–BioNTech vaccine: a cross-sectional study in Japanese healthcare workers

Dong Van Hoang, Shohei Yamamoto, Ami Fukunaga, Yosuke Inoue, Tetsuya Mizoue & Norio Ohmagari
Abstract Background The clustering of metabolic abnormalities may weaken vaccine-induced immunity, but epidemiological data regarding SARS-CoV-2 vaccines are scarce. The present study aimed to examine the cross-sectional association between metabolic syndrome (MetS) and humoral immune response to Pfizer–BioNTech vaccine among the staff of a research center for medical care in Japan. Methods Participants were the staff (aged 21–75 years) of the National Center of Global Health and Medicine who had completed the second dose of...

Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Abstract Background Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in other malignant neoplasms. We aimed to determine the function of NOTCH1 expression and the effects of GSI on adult T-cell leukemia/lymphoma (ATL) caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Methods We analyzed the expression of...

Additional file 1 of Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Additional file 1.

Additional file 3 of Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Additional file 3.

Data from: Recovery of macrobenthic communities in tidal flats following the Great East Japan Earthquake

Jotaro Urabe, Takeshi Yuhara, Takao Suzuki, Tatsuki Nishita, Junichi Murakami, Wataru Makino, , Kyoko Kinoshita, Natsuru Yasuno & Takashi Uchino
Extreme geo-climatic events can occur everywhere in the world. The Great East Japan Earthquake, with a moment magnitude scale of 9.0 M on March 11, 2011, was one of these events and caused huge tsunamis that changed largely tidal communities on the Pacific coast of eastern Japan. However, subsequent long-term changes in the communities after such an extreme geo-climatic event have rarely been examined. Therefore, we performed the biological monitoring over a ten-year span, before...

Additional file 1 of Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure & Shinichi Kuriyama
Additional file 1.

Additional file 2 of Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano

Kazuto Mikuni, Naoto Hirano, Norikatsu Akizawa, Junji Yamamoto, Shiki Machida, Akihiro Tamura, Yuuki Hagiwara & Tomoaki Morishita
Additional file 2: Figure S2. Representative data and example of the Raman microscopic analysis for CO2 fluid inclusion. (a) Raman spectrum of a CO2 fluid inclusion in MPSX-PX5 pyroxenite. The peaks of volatile species except for CO2 were lower than the detection limit of Raman spectroscopy. (b) An image of CO2 fluid inclusions in the same sample.

Additional file 3 of Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano

Kazuto Mikuni, Naoto Hirano, Norikatsu Akizawa, Junji Yamamoto, Shiki Machida, Akihiro Tamura, Yuuki Hagiwara & Tomoaki Morishita
Additional file 3. Supplementary information about the numerical process. The method of error calculation for the two pyroxene thermometry of Brey and Köhler (1990), the two pyroxene thermobarometry using the equation (36) and (38) of Putirka (2008), and the geobarometry of CO2 inclusion in pyroxene by Raman spectroscopy are described. The process of depth-pressure conversion is also attached.

Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano

Kazuto Mikuni, Naoto Hirano, Norikatsu Akizawa, Junji Yamamoto, Shiki Machida, Akihiro Tamura, Yuuki Hagiwara & Tomoaki Morishita
Abstract The lithospheric mantle, formed at the mid-ocean ridge as a residue of crustal production, comprises theoretically depleted peridotite, but more fertile components (e.g., lherzolite and pyroxenite) have been reported, creating an enigmatic picture of the lithosphere. The oceanic lithosphere has also been found to be locally modified by intraplate magmatism as proposed from geochemistry of mantle xenolith. Petit-spot xenoliths are particularly notable as direct evidence of old lithospheric mantle and expected to retain essential...

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis

Hajime Kato, Hiroyasu Sato, Michiaki Okuda, Jun Wu, Shingo Koyama, Yasuhiko Izumi, Tomonori Waku, Mitsuyoshi Iino, Masashi Aoki, Shigeki Arawaka, Yasuyuki Ohta, Kenichi Ishizawa, Kanan Kawasaki, Yasuomi Urano, Tomohiro Miyasaka, Noriko Noguchi, Toshiaki Kume, Akinori Akaike, Hachiro Sugimoto & Takeo Kato
The present study investigated the therapeutic effects of the curcumin derivative 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole (GT863) in amyotrophic lateral sclerosis (ALS). The inhibitory effect of GT863 on superoxide dismutase 1 (SOD1) aggregation was evaluated in cell-free assays. GT863 interfered with the conformational changes of the SOD1 protein and later, oligomeric aggregation. Furthermore, its antioxidant, anti-inflammatory, and neuroprotective effects were evaluated in cell-free and cultured cell assays. GT863 inhibited H2O2− and glutamate-induced cytotoxicity and activated an antioxidant responsive element...

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