371 Works

Dataset for: Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

Kenji Ohgane, Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Mikiko Sodeoka & Yuichi Hashimoto
Niemann-Pick disease type C is a rare, fatal neurodegenerative disorder characterized by massive intracellular accumulation of cholesterol. In most cases, loss-of-function mutations in NPC1 gene that encodes for a lysosomal cholesterol transporter NPC1 are responsible for the disease, and more than half of the mutations are considered to interfere with biogenesis or folding of the protein. Previously we have identified a series of oxysterol derivatives and phenanthridine-6-one derivatives as pharmacological chaperones, small molecules that rescue...

Seasonal change in male reproductive investment of a fish

Shingo Fujimoto, Mitsuharu Yagi, Kazunori Yamahira & Satoshi Takeda
Many animals are sexually dimorphic, whereby males may display brighter body coloration and more distinctive ornamentation than females. Fishes in temperate regions markedly change their energy allocation toward reproduction in response to the seasonal environment. Seasonal change in reproductive investment affects the expression of sexually dimorphic traits in males through gonadal weight change. Here, we report seasonal changes in body size, testis weight and sexual dimorphism of the fins (anal fin length and dorsal fin...

Non-biodegradable objects may boost microbial growth in water bodies by harnessing bubbles

Atul Srivastava, Kenji Kikuchi & Takuji Ishikawa
Given the ubiquity of bubbles and non-biodegradable wastes in aqueous environments, their transport through bubbles should be widely extant in water bodies. In this study, we investigate the effect of bubble-induced waste transport on microbial growth by using yeasts as model microbes and a silicone rubber object as a model waste. Noteworthily, this object repeatedly rises and sinks in fluid through fluctuations in bubble acquired buoyant forces produced by cyclic nucleation, growth and release of...

Datasets for phylogenetic analyses of Pavlomulina ranunculiformis

Ryoma Kamikawa, Masanobu Kawachi, Takuro Nakayama, Motoki Kayama, Mami Nomura, Hideaki Miyashita, Othman Bojo, Lesley Rhodes, Stuart Sym, Richard Pienaar, Ian Probert & Isao Inouye
Rapidly accumulating genetic data from environmental sequencing approaches have revealed an extraordinary level of unsuspected diversity within marine phytoplankton, which is responsible for around 50% of global net primary production. However, the phenotypic identity of many of the organisms distinguished by environmental DNA sequences remains unclear. The rappemonads are a plastid-bearing protistan lineage that to date has only been identified by environmental plastid 16S rRNA sequences. The phenotypic identity of this group, which does not...

Stable persistence of relict populations involved evolutionary shifts of reproductive characters in the genus Tanakaea (Saxifragaceae)

Daiki Takahashi
Tertiary relicts often show evolutionary stasis in morphology and ecology and have been hypothesised to retain stable population sizes in refugia. However, recent studies have reported that some relicts evolutionarily shifted their physiology, ecology, and morphology and experienced various patterns of demography. To understand the historical survival of relict plants, a multidimensional study investigating the evolution of ecological and morphological traits as well as population demographic history is needed. The genus Tanakaea (Saxifragaceae) comprises two...

The pteropod species Heliconoides inflatus as an archive of late Pleistocene to Holocene environmental conditions on the Northwest Shelf of Australia

Maximilian Hallenberger, Lars Reuning, Hideko Takayanagi, Yasufumi Iryu, Nina Keul, Takeshige Ishiwa & Yusuke Yokoyama
Abstract There is growing interest in the use of pteropods as potential archives of past changes in ocean chemistry. However, pteropods have rarely been used in studies of millennial-scale sedimentary records, especially in shallow-marine environments. This study obtained core data for the last 16 kyr from the Northwest Shelf of Australia (NWS). Changes in the carbonate saturation state were assessed based on the carbon isotope ratios (δ13C) of shells and the Limacina dissolution index (LDX)...

Additional file 2 of Chromosomal coharboring of blaIMP-60 and mcr-9 in Enterobacter asburiae isolated from a Japanese woman with empyema: a case report

Yusuke Miyazato, Noriko Iwamoto, Masaru Usui, Toyotaka Sato, Tohru Miyoshi-Akiyama, Maki Nagashima, Kazuhisa Mezaki, Kayoko Hayakawa & Norio Ohmagari
Additional file 2: Supplementary Figure 2. Magnified image of E test's micro-colonies. Red arrows indicate resistant colonies.

Additional file 3 of Chromosomal coharboring of blaIMP-60 and mcr-9 in Enterobacter asburiae isolated from a Japanese woman with empyema: a case report

Yusuke Miyazato, Noriko Iwamoto, Masaru Usui, Toyotaka Sato, Tohru Miyoshi-Akiyama, Maki Nagashima, Kazuhisa Mezaki, Kayoko Hayakawa & Norio Ohmagari
Additional file 3: Supplementary Table 1. Case Reports of Enterobacteriaceae carrying chromosomally located mcr-9 isolated from humans.

Additional file 1 of Metabolic syndrome and the immunogenicity of Pfizer–BioNTech vaccine: a cross-sectional study in Japanese healthcare workers

Dong Van Hoang, Shohei Yamamoto, Ami Fukunaga, Yosuke Inoue, Tetsuya Mizoue & Norio Ohmagari
Additional file 1: Table S1. Characteristics of included versus excluded participants. Table S2. Association between MetS and SARS-Cov-2 spike IgG titers. Table S3. Association between MetS and SARS-Cov-2 IgG titers after excluding those with SARS-Cov-2 infection, or comorbid cancer, heart or lung diseases (N = 912). Figure S1. Distribution of SARS-CoV-2 spike IgG titer across vaccination-to-IgG time

Additional file 1 of Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen & Hou-Feng Zheng
Additional file 1: Fig. S1. Restricted cubic spline analysis to show the relationship between birth weight and Lumbar spine bone parameters. Fig. S2. Restricted cubic spline analysis to show the relationship between birth weight and Lateral spine bone parameters. Fig. S3. Restricted cubic spline analysis to show the relationship between birth weight and heel BMD. Table S1. Characteristics of the single nucleotide polymorphisms associated with the birth weight. Table S2. Detailed information on the GWAS...

Additional file 1 of Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen & Hou-Feng Zheng
Additional file 1: Fig. S1. Restricted cubic spline analysis to show the relationship between birth weight and Lumbar spine bone parameters. Fig. S2. Restricted cubic spline analysis to show the relationship between birth weight and Lateral spine bone parameters. Fig. S3. Restricted cubic spline analysis to show the relationship between birth weight and heel BMD. Table S1. Characteristics of the single nucleotide polymorphisms associated with the birth weight. Table S2. Detailed information on the GWAS...

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?

Kunihiro Asanuma, Tomoki Nakamura, Takayuki Okamoto, Tomohito Hagi, Kouji Kita, Koichi Nakamura, Yumi Matsuyama, Keisuke Yoshida, Yumiko Asanuma & Akihiro Sudo
Abstract Background Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on their surface. Tumor cells express these proteins, adjust their microenvironment and induce tumor exacerbation. We hypothesized that the expression of plasma markers for coagulation and fibrinolysis in patients with soft tissue sarcomas (STSs) was dependent on the level of tumor malignancy. To elucidate which markers are predictive...

Additional file 2 of Continuous estimation of coseismic and early postseismic slip phenomena via the GNSS carrier phase to fault slip approach: a case study of the 2011 Tohoku-Oki sequence

Yusuke Tanaka, Yusaku Ohta & Shin’ichi Miyazaki
Additional file 2. It show a full animation describing the spatio-temporal evolution of the early afterslip estimated by PTS. It uses the same expression as the snapshots in the main text, but showing temporal evolution in every 30 s.

Has long-distance flight ability been maintained by pigeons in highly insular habitats?

Daichi Tsujimoto, Haruko Ando, Hajime Suzuki, Kazuo Horikoshi, Nobuyoshi Nakajima, Yoshihisa Suyama, Ayumi Matsuo, Chieko Fujii & Yuji Isagi
Aim: A reduction in dispersal ability has been thought to be a general trend for island land birds because of their physical isolation to a limited area, scarcity of predators, and ability to forage without flight in island habitats. However, recent studies have indicated that long-distance dispersal among island habitats may be maintained in island pigeon populations, which may be related to unstable food resource availability on a single island. Here, we investigated whether pigeons...

Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Abstract Background Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in other malignant neoplasms. We aimed to determine the function of NOTCH1 expression and the effects of GSI on adult T-cell leukemia/lymphoma (ATL) caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Methods We analyzed the expression of...

Additional file 2 of Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Additional file 2.

Additional file 2 of Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno & Kenji Ishitsuka
Additional file 2.

Nonlinear time series analysis of the interaction between the citrus whitefly and the whitefly-specialist ladybird

Suzuki Noriyuki, Kazutaka Kawatsu & Shuji Kaneko
A comprehensive understanding of the top-down effects of natural enemies on agricultural pests is essential for achieving effective biological control in integrated pest management. However, it is typically difficult to identify causal effects between the interacting species from time series data, which have often been monitored for pest forecasting purposes in agricultural ecosystems, as it is likely to involve nonlinear (state-dependent) population dynamics. In this study, we applied a recently developed framework of nonlinear time...

Additional file 1 of Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura … & Kei Takase
Additional file 1: Supplementary Figure 1. Participating clinical research institutions.

Additional file 1 of Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura … & Kei Takase
Additional file 1: Supplementary Figure 1. Participating clinical research institutions.

Additional file 2 of Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial

Teruo Noguchi, Hideki Ota, Naoya Matsumoto, Yoshiaki Morita, Akira Oshita, Eiji Kawasaki, Tomohiro Kawasaki, Kensuke Moriwaki, Shingo Kato, Kazuki Fukui, Tomoya Hoshi, Hiroaki Watabe, Tomoaki Kanaya, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Kensuke Takagi, Shuichi Yoneda, Kenichiro Sawada, Takamasa Iwai, Hideo Matama, Satoshi Honda, Masashi Fujino, Hiroyuki Miura, Kunihiro Nishimura … & Kei Takase
Additional file 2: Supplementary Table 1. Standardized protocol for non-contrast T1-weighted imaging to assess coronary plaques: recommended protocol for CMR coronary plaque imaging.

Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors

Lin Zhang, Yiming Chen, Fahui Li, Lihui Zhang, Jinhong Feng & Lei Zhang
Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In the discovery of novel HDAC inhibitors with anticancer potency, the 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled as a cap group into the structure of HDAC inhibitors. The SAR revealed that presence of small groups (such as methoxy substitution) is beneficial for the HDAC inhibitory activity. In the enzyme inhibitory selectivity test, compound L20 exhibited class I selectivity with IC50 values of...

Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors

Lin Zhang, Yiming Chen, Fahui Li, Lihui Zhang, Jinhong Feng & Lei Zhang
Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In the discovery of novel HDAC inhibitors with anticancer potency, the 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled as a cap group into the structure of HDAC inhibitors. The SAR revealed that presence of small groups (such as methoxy substitution) is beneficial for the HDAC inhibitory activity. In the enzyme inhibitory selectivity test, compound L20 exhibited class I selectivity with IC50 values of...

Additional file 3 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin

Tian Du, Lu Pan, Chengyou Zheng, Keming Chen, Yuanzhong Yang, Jiewei Chen, Xue Chao, Mei Li, Jiabin Lu, Rongzhen Luo, Jinhui Zhang, Yu Wu, Jiehua He, Dongping Jiang & Peng Sun
Additional file 3. Table S2. Expression change of 17 genes in paired breast cancers and their metastases

Additional file 3 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin

Tian Du, Lu Pan, Chengyou Zheng, Keming Chen, Yuanzhong Yang, Jiewei Chen, Xue Chao, Mei Li, Jiabin Lu, Rongzhen Luo, Jinhui Zhang, Yu Wu, Jiehua He, Dongping Jiang & Peng Sun
Additional file 3. Table S2. Expression change of 17 genes in paired breast cancers and their metastases

Registration Year

  • 2022
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    22
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    19
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    12
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    12
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    8
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    15
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    10
  • 2014
    3
  • 2013
    4

Resource Types

  • Dataset
    214
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    64
  • Collection
    58
  • Image
    22
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    10
  • Other
    3

Affiliations

  • Tohoku University
    371
  • National Institute for Basic Biology
    72
  • University of Tokyo
    53
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    36
  • Kyoto University
    33
  • University of Melbourne
    32
  • Capital Medical University
    31
  • Hokkaido University
    30
  • Sun Yat-sen University
    29
  • Southern Medical University
    24