3 Works

Data from: Population genetic structure and connectivity of deep-sea stony corals (Order Scleractinia) in the New Zealand region: implications for the conservation and management of Vulnerable Marine Ecosystems

Cong Zeng, Ashley A. Rowden, Malcolm R. Clark, Jonathan P.A. Gardner & Jonathan P. A. Gardner
Deep-sea stony corals, which can be fragile, long-lived, late to mature and habitat-forming, are defined as vulnerable marine ecosystem indicator taxa. Under United Nations resolutions these corals require protection from human disturbance such as fishing. To better understand the vulnerability of stony corals (Goniocorella dumosa, Madrepora oculata, Solenosmilia variabilis) to disturbance within the New Zealand region, and to guide marine protected area design, genetic structure and connectivity were determined using microsatellite loci and DNA sequencing....

Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer

Hongzhi Qiao, Zhenzhu Zhu, Dong Fang, Yuan Sun, Chen Kang, Liuqing Di, Lei Zhang & Yahan Gao
Multidrug resistance (MDR) severely hinders the efficient chemotherapeutic treatments of cancer. d-α-Tocopherol polyethylene 1000 succinate (TPGS) based drug delivery system holds the potential of re-sensitizing resistant cancer cells. In this study, a TPGS prodrug containing both TPGS and mitoxantrone (MTO) via a disulphide bond was synthesised and assembled into micelle (TSMm) with a monodispersed diameter of 46.50 ± 1.12 nm. The disulphide bonds within the micelles could be cleaved in response to a high concentration...

Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer

Hongzhi Qiao, Zhenzhu Zhu, Dong Fang, Yuan Sun, Chen Kang, Liuqing Di, Lei Zhang & Yahan Gao
Multidrug resistance (MDR) severely hinders the efficient chemotherapeutic treatments of cancer. d-α-Tocopherol polyethylene 1000 succinate (TPGS) based drug delivery system holds the potential of re-sensitizing resistant cancer cells. In this study, a TPGS prodrug containing both TPGS and mitoxantrone (MTO) via a disulphide bond was synthesised and assembled into micelle (TSMm) with a monodispersed diameter of 46.50 ± 1.12 nm. The disulphide bonds within the micelles could be cleaved in response to a high concentration...

Registration Year

  • 2017
    3

Resource Types

  • Text
    2
  • Dataset
    1

Affiliations

  • Hunan Agricultural University
    3
  • Yunnan University
    2
  • North West Agriculture and Forestry University
    2
  • New York University Langone Medical Center
    2
  • Jilin University
    2
  • Huazhong University of Science and Technology
    2
  • Shanghai University of Traditional Chinese Medicine
    2
  • Sichuan University
    2
  • University of Cambridge
    2
  • Fudan University
    2