173 Works

Data from: Multilevel and quasi-Monte Carlo methods for uncertainty quantification in particle travel times through random heterogeneous porous media

David Crevillen-Garcia & Henry Power
In this study, we apply four Monte Carlo simulation methods, namely, Monte Carlo, quasi-Monte Carlo, multilevel Monte Carlo and multilevel quasi-Monte Carlo to the problem of uncertainty quantification in the estimation of the average travel time during the transport of particles through random heterogeneous porous media. We apply the four methodologies to a model problem where the only input parameter, the hydraulic conductivity, is modelled as a log-Gaussian random field by using direct Karhunen–Loéve decompositions....

Data from: Nuclear magnetic resonance measurements of velocity distributions in an ultrasonically vibrated granular bed

Jonathan M. Huntley, Tahir Tarvaz, Mick D. Mantle, Andy J. Sederman, Lynn F. Gladden, Nadeem A. Sheikh & Ricky D. Wildman
We report the results of nuclear magnetic resonance imaging experiments on granular beds of mustard grains fluidized by vertical vibration at ultrasonic frequencies. The variation of both granular temperature and packing fraction with height was measured within the three-dimensional cell for a range of vibration frequencies, amplitudes and numbers of grains. Small increases in vibration frequency were found—contrary to the predictions of classical ‘hard-sphere’ expressions for the energy flux through a vibrating boundary—to result in...

Data from: Exploitation of interspecific diversity for monocot crop improvement

Julie King, Ian Armstead, John Harper, Luke Ramsay, John Snape, Robbie Waugh, Caron James, Ann Thomas, Dagmara Gasior, Rhys Kelly, Luned Roberts, Perry Gustafson, Ian King & L Ramsey
In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and largely untapped reservoir of genetic variation for a wide range of agronomically important traits that can be exploited by breeders for crop improvement. In this paper, in what we believe to be the largest introgression programme undertaken in...

Data from: Insecticide resistance mediated by an exon skipping event

Madeleine Berger, Alin Mirel Puinean, Emma Randall, Christoph T. Zimmer, Wellington M. Silva, Pablo Bielza, Linda M. Field, David Hughes, Ian Mellor, Keywan Hassani-Pak, Herbert A. A. Siqueira, Martin S. Williamson & Chris Bass
Many genes increase coding capacity by alternate exon usage. The gene encoding the insect nicotinic acetylcholine receptor (nAChR) α6 subunit, target of the bio-insecticide spinosad, is one example of this and expands protein diversity via alternative splicing of mutually exclusive exons. Here, we show that spinosad resistance in the tomato leaf miner, Tuta absoluta is associated with aberrant regulation of splicing of Taα6 resulting in a novel form of insecticide resistance mediated by exon skipping....

Data from: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P. Mongan, Richard D. Emes & Vincent J. Lynch
A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the evolution of large body sizes, the...

Data from: Formin is associated with left-right asymmetry in the pond snail and the frog

Angus Davison, Gary S. McDowell, Jennifer M. Holden, Harriet F. Johnson, Georgios D. Koutsovoulos, M. Maureen Liu, Paco Hulpiau, Frans Van Roy, Christopher M. Wade, Ruby Banerjee, Fengtang Yang, Satoshi Chiba, John W. Davey, Daniel J. Jackson, Michael Levin & Mark L. Blaxter
While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria. Here, we report that a disabling mutation...

Data from: Non-coaxiality of sand under bi-directional shear loading

Yao Li & Yunming Yang
This study aims to investigate the effect of consolidation shear stress magnitude on the shear behaviour and noncoaxiality of soils. In previous drained bi-directional simple shear test on Leighton Buzzard sand, it is showed that the level of non-coaxiality, which is indicated by the angle difference between the principal axes of stresses and the corresponding principal axes of strain rate tensors, is increased by increasing angle difference between the direction of consolidation shear stress and...

Data from: Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

Colin Selman, Jane S. McLaren, Andrew R. Collins, Garry G. Duthie & John R. Speakman
While oxidative damage due to reactive oxygen species (ROS) often increases with advancing age and is associated with many age-related diseases, its causative role in ageing is controversial. In particular, studies that have attempted to modulate ROS-induced damage, either upwards or downward, using antioxidant or genetic approaches, generally do not show a predictable effect on lifespan. Here we investigated whether dietary supplementation with either vitamin E (α-tocopherol) or vitamin C (ascorbic acid) affected oxidative damage...

Data from: An immunological marker of tolerance to infection in wild rodents

Joseph A. Jackson, Amy J. Hall, Ida M. Friberg, Catriona Ralli, Anne Lowe, Malgorzata Zawadzka, Andrew K. Turner, Alexander Stewart, Richard J. Birtles, Steve Paterson, Janette E. Bradley, Mike Begon & Ann Lowe
Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, with especially little known about how tolerance is manifested in natural populations. We monitored a natural population of field voles using longitudinal and cross-sectional sampling modes and taking measurements on body condition, infection, immune gene expression, and survival. Using...

Fatal and non-fatal events within 14 days after early, intensive mobilization post stroke

Julie Bernhardt, Karen Borschmann, Janice Collier, Amanda Thrift, Peter Langhorne, Sandy Middleton, Richard Lindley, Helen Dewey, Philip Bath, Catherine Said, Leonid Churilov, Fiona Ellery, Christopher Bladin, Christopher Reid, Judith Frayne, Velandai Srikanth, Stephen Read & Geoffrey Donnan
Objective: We examined fatal and non-fatal Serious Adverse Events (SAEs) at 14 days within AVERT. Method: A prospective, parallel group, assessor blinded, randomized international clinical trial comparing very early intensive mobilization training (VEM) with usual care (UC); with follow up to 3 months. Included: Patients with ischaemic and haemorrhagic stroke within 24 hours of onset and physiological parameters within set limits. Treatment with thrombolytics allowed. Excluded: Patients with severe premorbid disability and/or comorbidities. Interventions continued...

Validation of an eDNA-based method for the detection of wildlife pathogens in water

Natalie Sieber, Hanna Hartikainen & Christoph Vorburger
Monitoring the occurrence and density of parasites and pathogens can identify high infection-risk areas and facilitates disease control and eradication measures. Environmental DNA (eDNA) techniques are increasingly used for pathogen detection due to their relative ease of application. Since many factors affect the reliability and efficacy of eDNA-based detection, rigorous validation and assessment of method limitations is a crucial first step. We evaluated an eDNA detection method using in-situ filtration of large volume water samples,...

Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Berend J. Van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G.J. Tertoolen & Christine L. Mummery
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity but the sensitivity of measurement tools may also be limiting. Measuring action potential, calcium flux or contraction individually misses critical information that is captured when interrogating the complete excitation-contraction coupling cascade simultaneously....

Effects of neuromuscular electrical stimulation (NMES) in acutely hospitalised adult patients -protocol for a systematic review of randomised controlled trials (RCTs)

Helal Alqurashi, Katie Robinson, John Gladman, Adam Gordon, Tahir Masud & Mathew Piasecki

Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol

John Gladman, Saleh Aloraibi, Paul Greenhaff, Mathew Piasecki, Beth Phillips, Philip Atherton, T. Masud, O. Sahota, Pip Logan, Vicky Booth, Katie Robinson, E. Lunt, D. Godfrey, A. Caswell, M. Kerr, Benjamin Ollivere & Adam Gordon

Industry 4.0 in Robotics

Irene Fassi, Claudia Pagano & Serena Ruggeri

Research data supporting \"Tetralin and decalin h-donor effect on catalytic upgrading of heavy oil inductively heated with steel balls\"

Abarasi Hart, Mohamed Adam, John Robinson, Sean Rigby & Joseph Wood
Dataset includes Thermogravimetric simulated distillation analysis, thermogravimetric coking data and nitrogen adsorption data of the catalyst.

SNP genotypes for healthy and CIM-affected GSDs

Leigh Anne Clark, Sarah Bell, Jacquelyn Evans, Katy Evans, Kate Tsai, Rooksana Noorai, Thomas Famula & Dolores Holle
German shepherd dogs (GSDs) are predisposed to an inherited motility disorder of the esophagus, termed congenital idiopathic megaesophagus (CIM), in which swallowing is ineffective and the esophagus is enlarged. Affected puppies are unable to properly pass food into their stomachs and consequently regurgitate their meals and show a failure to thrive, often leading to euthanasia. Here, we generated genome-wide SNP profiles for healthy and CIM-affected GSDs using the Illumina CanineHD BeadChip, containing 220,853 SNPs.

Heterogeneity and environmental stress resistance of wild yeast isolates

S. Hewitt, A. Warry, P.S. Dyer & S. Avery
This dataset contains analytical results for wild yeast isolates from soil samples at and near a disused metal smelting works in the north-east of the UK. The main contaminant from the smelting works was lead (Pb), but Cd was also elevated. The soil near the smelting works showed above-background levels of Pb. Yeasts of similar colony morphology on laboratory agar were isolated and proved to be mostly isolates of Saitozyma podzolica: 56 independent clonal isolates...

Corine land cover 2018 for the UK, Isle of Man, Jersey and Guernsey

B. Cole, B. De La Barreda, A. Hamer, T. Codd, M. Payne, L. Chan, G. Smith & H. Balzter
This dataset is the 2018 Corine Land Cover map, consisting of 44 classes in the hierarchical three level Corine nomenclature. Corine Land Cover (CLC) 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two maps are the UK component of Europe. This inventory...

Corine land cover 2012 (revised) for the UK, Isle of Man, Jersey and Guernsey

B. Cole, B. De La Barreda, A. Hamer, T. Codd, M. Payne, L. Chan, G. Smith & H. Balzter
This dataset is the 2012 revised Corine Land Cover (CLC) map, consisting of 44 classes in the hierarchical three level Corine nomenclature, produced during the CLC2018 production to improve the CLC2012 inventory. CLC 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two...

Review of Networking and Tangible Security Techniques for Domestic IoT Devices and Initial Ideas

Sameh Zakhary, Neelima Sunil & Dereak McAuley

Elemental concentrations in representative species of the ICRP's Reference Animals and Plants and associated soils in terrestrial Mediterranean ecosystems in Spain

J. Guillén, M. Izquierdo, S. Young, C. Wells, C.L. Barnett, N.A. Beresford, A. Baeza, A. Salas, A. Muñóz-Serrano, J.M. Corrales-Vázquez, J.G. Muñoz-Muñoz, E. Tovar & J.S. Chaplow
Data comprise stable element concentrations in terrestrial Reference Animals and Plants (RAPs) and corresponding whole-body concentration ratios determined in two different Mediterranean ecosystems: a Pinewood and a Dehesa (grassland with disperse tree cover). The International Commission on Radiological Protection (ICRP) RAPs considered in the Pinewood ecosystem were Pine Tree and Wild Grass; whereas in the Dehesa ecosystem those considered were Deer, Rat, Earthworm, Bee, Frog, Duck and Wild Grass. The data include: elemental concentrations in...

Measurement of labile metal in soils. Chemical extraction and isotopic dilution data

J. Garforth, E.H. Bailey, A.M. Tye, S.D. Young & S. Lofts
This dataset contains the concentrations of Ni, Cu, Zn, Cd and Pb, extracted from four soils, using the chemical extractants: 0.43 M HNO3, 0.43 M CH3COOH, 1 M CaCl2 and 0.05 M Na2H2EDTA (MExt mg/kg). The concentrations of isotopically exchangeable (labile) Ni, Cu, Zn, Cd and Pb (EValue mg/kg) are also given. Additionally, the concentrations of isotopically exchangeable soil metal, measured when the soils when suspended in each of the above extractants (EExt mg/kg), are...

AI3SD Video: Skills4Scientists - Poster & Careers Symposium - Poster Compilation

András Vekassy, Aspen Fenzl, Erhan Gulsen, Hewan Zewdu, Jamie Longio, Maximilian Hoffman, Rhyan Barrett, Rubaiyat Khondaker, Anna Catton, Hongyang Dong, Kevin Calvache, Kaylee Patel, King Wong, Louis Greenhalgh, Rebecca Jane Clements, Thomas Allam, Sarah Scripps, Gavin Man, Samuel Munday, Michael Blakey, Graeme M. Day, Chris-Kriton Skylaris, Simon J. Coles, Stephen Gow & William Brocklesby
This video forms part of the Skills4Scientists Series which has been organised as a joint venture between the Artificial Intelligence for Scientific Discovery Network+ (AI3SD) and the Physical Sciences Data-Science Service (PSDS). This series ran over summer 2021 and aims to educate and improve scientists skills in a range of areas including research data management, python, version control, ethics, and career development. This series is primarily aimed at final year undergraduates / early stage PhD...

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