10 Works

Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Berend J. Van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G.J. Tertoolen & Christine L. Mummery
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity but the sensitivity of measurement tools may also be limiting. Measuring action potential, calcium flux or contraction individually misses critical information that is captured when interrogating the complete excitation-contraction coupling cascade simultaneously....

Heterogeneity and environmental stress resistance of wild yeast isolates

S. Hewitt, A. Warry, P.S. Dyer & S.V. Avery
This dataset contains analytical results for wild yeast isolates from soil samples at and near a disused metal smelting works in the north-east of the UK. The main contaminant from the smelting works was lead (Pb), but Cd was also elevated. The soil near the smelting works showed above-background levels of Pb. Yeasts of similar colony morphology on laboratory agar were isolated and proved to be mostly isolates of Saitozyma podzolica: 56 independent clonal isolates...

Inductive heating assisted‑catalytic dehydrogenation of tetralin as a hydrogen source for downhole catalytic upgrading of heavy oil

Hart Abarasi, Mohamed Adam, John Robinson, Sean Rigby & Joseph Wood
Dataset for publication with induction heating data, conversion and selectivity for the dehydrogenation of tetralin in a catalytic bed reactor

Data from: Effect of lianas on forest-level tree carbon accumulation does not differ between seasons: results from a liana removal experiment in Panama

Geertje M.F. Van Der Heijden, Jennifer S. Powers & Stefan A. Schnitzer
1. Lianas are prevalent in Neotropical forests, where liana-tree competition can be intense, resulting in reduced tree growth and survival. The ability of lianas to grow relative to trees during the dry season suggests that liana-tree competition is also strongest in the dry season. If correct, the predicted intensification of the drying trend over large areas of the tropics in the future may therefore intensify liana-tree competition, resulting in a reduced carbon sink function of...

Data from: Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird

Kang-Wook Kim, Benjamin C. Jackson, Hanyuan Zhang, David P. L. Toews, Scott A. Taylor, Emma I. Greig, Irby J. Lovette, Mengning M. Liu, Angus Davison, Simon C. Griffith, Kai Zeng & Terry Burke
Colour polymorphisms play a key role in sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully understood. Here, we use genomic and transcriptomic tools to identify the precise genetic architecture and evolutionary history of a sex-linked colour polymorphism in the Gouldian finch Erythrura gouldiae that is also accompanied by remarkable differences in behaviour and physiology. We find that differences in colour are associated with an ~72-kbp region of the...

Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep

Jasmeet Kaler, Jurgen Mitsch, Jorge Vazquez Diosdado, Nicola Bollard, Tania Dottorini & Keith Ellis
Lameness in sheep is the biggest cause of concern regarding poor health and welfare among sheep producing countries. Best practice for lameness relies on rapid treatment, yet there are no objective measures of lameness detection. Use of accelerometers and gyroscopes have been widely used in human activity studies and their use is becoming increasingly common in livestock. In this study, we used 23 datasets (10 non-lame and 13 lame sheep) from an accelerometer and gyroscope-based...

Technetium-99 (99Tc) transformations in aerobic soils following experimental addition of the radioactive anion 99TcO4-

M. Izquierdo, E. Bailey, N. Crout, H. Sanders, S. Young & G. Shaw
The data comprise measurements of the ‘soluble’, ‘adsorbed’ and ‘organically bound’ 99Tc concentrations in a diverse set of soils following experimental addition of 99TcO4- and incubation in the laboratory under controlled temperature conditions for 897 days. The long term behaviour of 99Tc in aerobic soils was studied by conducting a laboratory-based experiment in which a set of 20 topsoils from central England with contrasting properties (e.g. pH, organic matter content, land use) were contaminated with...

Data from: Epigenome-wide association study of lung function level and its change

Medea Imboden, Matthias Wielscher, Faisal I Rezwan, Andre F S Amaral, Emmanuel Schaffner, Ayoung Jeong, Anna Beckmeyer-Borowko, Sarah E Harris, John M Starr, Ian J Deary, Claudia Flexeder, Melanie Waldenberger, Annette Peters, Holger Schulz, Su Chen, Shadia KHan Sunny, Wilfried J J Karmaus, Yu Jiang, Gertraud Erhart, Florian Kronenberg, Ryan Arathimos, Gemma C Sharp, Alexander John Henderson, Yu Fu, Paivi Piirila … & Nicole M Probst-Hensch
Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P<5x10-7) were tested...

Data from: Predictable genome-wide sorting of standing genetic variation during parallel adaptation to basic versus acidic environments in stickleback fish

Quiterie Haenel, Marius Roesti, Dario Moser, Andrew D. C. MacColl & Daniel Berner
Genomic studies of parallel (or convergent) evolution often compare multiple populations diverged into two ecologically different habitats to search for loci repeatedly involved in adaptation. Because the shared ancestor of these populations is generally unavailable, the source of the alleles at adaptation loci, and the direction in which their frequencies were shifted during evolution, remain elusive. To shed light on these issues, we here use multiple populations of stickleback fish adapted to two different types...

Data from: Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus

Christopher H. Taylor, Stuart Young, Jonathan Fenn, Angela L. Lamb, Ann E. Lowe, Benoit Poulin, Andrew D. C. MacColl & Jannette E. Bradley
1.The ability, propensity and need to mount an immune response vary both among individuals and within a single individual over time. 2.A wide array of parameters have been found to influence immune state in carefully controlled experiments, but we understand much less about which of these parameters are important in determining immune state in wild populations. 3.Diet can influence immune responses, for example when nutrient availability is limited. We therefore predict that natural dietary variation...

Registration Year

  • 2019

Resource Types

  • Dataset


  • University of Nottingham
  • Helmholtz Zentrum München
  • Public Health England
  • University of Memphis
  • University of Edinburgh
  • University of Southampton
  • Macquarie University
  • University Medical Center Hamburg-Eppendorf
  • University of Basel
  • Institute for Molecular Medicine Finland