620 Works

sj-rar-3-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Supplemental material, sj-rar-3-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

sj-tif-5-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Supplemental material, sj-tif-5-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering

Results of survey for selected parasites in Alaska brown bears (Ursus arctos)

Ellen Haynes, Sarah Coker, Michael Yabsley, Kevin Niedrighaus, Andrew Ramey, Guilherme Verocai, Grant Hilderbrand, Kyle Joly, David Gustine, Buck Mangipane, William Leacock, Anthony Crupi & Christopher Cleveland
To assess the prevalence of endo- and ectoparasites in Alaska brown bears (Ursus arctos), blood and fecal samples were collected during 2013 – 2016 from five locations: Gates of the Arctic National Park and Preserve (GAAR), Katmai National Park (KATM), Lake Clark National Park and Preserve (LACL), Yakutat Forelands (YAK), and Kodiak Island (KOD). Standard fecal centrifugal-flotation was used to screen for gastrointestinal parasites, molecular techniques were used to test blood for the presence of...

Is Internalized Racism One More Piece of the Puzzle in Racial Disparities in Prosecution?

Besiki Luka Kutateladze & Lin Liu
Although diversifying the criminal justice apparatus may yield more equitable outcomes, empirical tests of how prosecutors’ race affects their decisions are limited. Informed by Internalized Racism Theory (IRT), we hypothesized that Black prosecutors would be most punitive toward Black defendants, followed by Latino/a defendants, and least toward White and Asian defendants. Employing hierarchical logistic modelling, we analyzed data from a large prosecutorial office to examine the extent to which prosecutors’ race is associated with racial...

Additional file 1 of Changes in health care utilization and financial protection after integration of the rural and urban social health insurance schemes in Beijing, China

Zhenyu Shi, Ping He, Dawei Zhu, Feng Lu & Qingyue Meng
Additional file 1.

Additional file 1 of Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output

Juan P. Wulff, Kevin B. Temeyer, Jason P. Tidwell, Kristie G. Schlechte, Kimberly H. Lohmeyer & Patricia V. Pietrantonio
Additional file 1: Data S1. Nucleotide sequences of the Rhimi-CAP2bR (KC614697.1), two Rhimi-CAP2bR clones (clones #4 and #6) both identical to the original KC614697.1 cDNA, and a 5’-RACE PCR sequence obtained to extend the 5’-UTR region of the R. microplus periviscerokinin receptor. An alignment between the R. microplus genome (isolate Rmic-2018 chromosome 3, ASM1333972v1, NC_051167.1) and the R. microplus periviscerokinin receptor extended RACE-5’-UTR fragment (Accession number OP191701) is provided.

Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output

Juan P. Wulff, Kevin B. Temeyer, Jason P. Tidwell, Kristie G. Schlechte, Kimberly H. Lohmeyer & Patricia V. Pietrantonio
Abstract Background The cattle fever tick, Rhipicephalus (Boophilus) microplus, is a vector of pathogens causative of babesiosis and anaplasmosis, both highly lethal bovine diseases that affect cattle worldwide. In Ecdysozoa, neuropeptides and their G-protein-coupled receptors play a critical integrative role in the regulation of all physiological processes. However, the physiological activity of many neuropeptides is still unknown in ticks. Periviscerokinins (CAP2b/PVKs) are neuropeptides associated with myotropic and diuretic activities in insects. These peptides have been...

How do frontline healthcare workers learn from COVID-19 webinars during a pandemic? An online survey study

Shahraz Qamar, Aysun Tekin, Romil Singh, Salim Surani, Ramesh Adhikari, Vikas Bansal, Mayank Sharma, Marija Bogojevic, Neha Deo, Simon Zec, Diana J. Valencia Morales, Jamil Taji, Vishakha K. Kumar, Karen Boman, Syed Anjum Khan, Juan Pablo Domecq & Rahul Kashyap
The COVID-19 pandemic severely restricted in-person learning. As a result, many educational institutions switched to online platforms to continue teaching. COVID-19 webinars have been useful for rapidly disseminating information to frontline healthcare workers. While conducting COVID-19 webinars through online platforms is a popular method to train medical professionals, their effectiveness has never been investigated. Our aim was to ascertain the usefulness of COVID-19 webinars during the pandemic. We conducted an online survey of about 400...

China's Gridded Manufacturing Dataset

Chenjing Fan, Xinran Huang, Lin Zhou, Zhenyu Gai, Chaoyang Zhu & Haole Zhang
The growth of the manufacturing industry is the engine of rapid economic growth in developing regions. Characterizing the geographical distribution of manufacturing firms is critically important for scientists and policymakers. However, data on the manufacturing industry used in previous studies either have a low spatial resolution (or fuzzy classification) or high-resolution information is lacking. Here, we propose a map point-of-interest classification method based on machine learning technology and build a dataset of the distribution of...

Label-Free Measurement of Wall Shear Stress in Brain Venule and Arteriole Using Dual-Wavelength Third-Harmonic-Generation Line-Scanning Imaging

Hui Cheng, Xinlin Chen, Zhong jincheng, Jia Li, Ping Qiu & Ke Wang
Wall shear stress (WSS) is of fundamental physiological and pathological significance. Current measurement technologies suffer from poor spatial resolution, or cannot measure instantaneous values in a label-free manner. Here we demonstrate dual-wavelength third-harmonic-generation (THG) line-scanning imaging, for instantaneous wall shear rate and WSS measurement in vivo. We used soliton self-frequency shift to generate dual-wavelength femtosecond pulses. Simultaneous acquisition of dual-wavelength THG line-scanning signals extract blood flow velocities at adjacent radial positions for instantaneous wall shear...

Fig.1.tif

Hui Cheng, Xinlin Chen, Zhong jincheng, Jia Li, Ping Qiu & Ke Wang
Supplemental materials

Label-Free Measurement of Wall Shear Stress in Brain Venule and Arteriole Using Dual-Wavelength Third-Harmonic-Generation Line-Scanning Imaging

Hui Cheng, Xinlin Chen, Zhong jincheng, Jia Li, Ping Qiu & Ke Wang
Wall shear stress (WSS) is of fundamental physiological and pathological significance. Current measurement technologies suffer from poor spatial resolution, or cannot measure instantaneous values in a label-free manner. Here we demonstrate dual-wavelength third-harmonic-generation (THG) line-scanning imaging, for instantaneous wall shear rate and WSS measurement in vivo. We used soliton self-frequency shift to generate dual-wavelength femtosecond pulses. Simultaneous acquisition of dual-wavelength THG line-scanning signals extract blood flow velocities at adjacent radial positions for instantaneous wall shear...

Supplementary document for Label-Free Measurement of Wall Shear Stress in Brain Venule and Arteriole Using Dual-Wavelength Third-Harmonic-Generation Line-Scanning Imaging - 6087953.pdf

Hui Cheng, Xinlin Chen, Zhong jincheng, Jia Li, Ping Qiu & Ke Wang
Supplemental methods

Additional file 2 of Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Additional file 2: Table S2. Different pathologists’ pretreatment prediction of pathologic response after neoadjuvant anti-PD-1 treatment according to irHPC.

Design, synthesis and biological evaluation of novel diosgenin–benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells

Jinling Zhang, Wenbao Wang, Yanzhao Tian, Liwei Ma, Lin Zhou, Hao Sun, Yukun Ma, Huiling Hou, Xiaoli Wang, Jin Ye & Xiaobo Wang
To discover new lead compounds with anti-tumour activities, in the present study, natural diosgenin was hybridised with the reported benzoic acid mustard pharmacophore. The in vitro cytotoxicity of the resulting newly synthesised hybrids (8–10, 14a–14f, and 15a–15f) was then evaluated in three tumour cells (HepG2, MCF-7, and HeLa) as well as normal GES-1 cells. Among them, 14f possessed the most potential anti-proliferative activity against HepG2 cells, with an IC50 value of 2.26 µM, which was...

Additional file 5 of Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis

Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou & Xiaohu Wang
Additional file 5: Fig. S5. The pooled incidences of overall survival at 1, 2, 3, 4, 5 and 10 years after C-ion RT for chondrosarcoma.

Additional file 6 of Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis

Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou & Xiaohu Wang
Additional file 6: Fig. S6. The pooled incidences of overall survival at 2, 3 and 5 years after C-ion RT for osteosarcoma.

Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in spinal cord injury

Wen-Chen Ji, Meng Li, Wan-Ting Jiang, Xing Ma & Jia Li
Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is a promising alternative treatment strategy. Here we investigated the effect and mechanism of adipose-derived stem/stromal cells (ASCs) with overexpressing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) (BDNF-NT3) in combination with silk fibroin/chitosan scaffold (SFCS) in SCI. Methods: Female Sprague-Dawley rats were used as an SCI model. SFCS,SFCS and ASCs, or ASCs overexpressing NT3, BDNF, and BDNF-NT3 were implanted into SCI rats....

Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer

Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang & Liangxing Wang
Abstract Background Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compound, which has been found to possess potential antitumor activity. However, the underlying molecular mechanisms of celastrol activity in NSCLC remain elusive. Methods Cellular function assays were performed to study the suppressive role of celastrol in human NSCLC cells (H460,...

Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer

Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang & Liangxing Wang
Abstract Background Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compound, which has been found to possess potential antitumor activity. However, the underlying molecular mechanisms of celastrol activity in NSCLC remain elusive. Methods Cellular function assays were performed to study the suppressive role of celastrol in human NSCLC cells (H460,...

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

Qihong Yan, Ruitian Hou, Xiaohan Huang, Yanjun Zhang, Ping He, Yudi Zhang, Banghui Liu, Qian Wang, Haiyue Rao, Xianying Chen, Xinwei Zhao, Xuefeng Niu, Jincun Zhao, Xiaoli Xiong & Ling Chen
SARS-CoV-2 variants continue to emerge facing established herd immunity. L452R, previously featured in the Delta variant, quickly emerged in Omicron subvariants, including BA.4/BA.5, implying a continued selection pressure on this residue. The underlying links between spike mutations and their selective pressures remain incompletely understood. Here, by analyzing 221 structurally characterized antibodies, we found that IGHV1-69-encoded antibodies preferentially contact L452 using germline-encoded hydrophobic residues at the tip of HCDR2 loop. Whereas somatic hypermutations or VDJ rearrangements...

Serum levels of IL-12, IL-18, and IL-21 are indicators of viral load in patients chronically infected with HBV

Fangye Zhou, Haoran Xiong, Shenghang Zhen, Aimin Chen, Min Huang & Yupeng Luo
This study explored the correlation between interleukins (IL)-12, IL-18, and IL-21 and the viral load in patients with chronic hepatitis B virus (HBV). A total of 142 patients were consecutively enrolled. All were hepatitis B surface antigen (HBsAg)-positive for >6 months and did not receive drug therapy. An ELISA kit was used to test the IL-12, IL-18, IL-21, and acetylcholinesterase (AchE) levels in serum samples from chronic HBV patients and healthy control groups. The amounts...

Additional file 1 of Plant sex affects plant-microbiome assemblies of dioecious Populus cathayana trees under different soil nitrogen conditions

Qingxue Guo, Lin Liu, Jiantong Liu, Helena Korpelainen & Chunyang Li
Additional file 1: Supplementary methods. Table S1. Bacterial and fungal co-occurrence network characteristics in each niche. Table S2. The physiological traits and microbial functions of rhizosphere soil affected by sex and nitrogen treatment. Table S3. The growth characteristics of P. cathayana males and females under different N treatments. Figure S1. The composition and relative abundance of bacterial (a) and fungal (b) communities in the rhizosphere soil, roots, old leaves and young leaves of P. cathayana...

Weibo sentiment analysis validation dataset

Chenjing Fan, Zhenyu Gai, Shiqi Li, Yirui Cao, Yueying Gu, Chenxi Jin, Yiyang Zhang, Yanling Ge & Lin Zhou
Humans spend most of their time in settlements, and the built environment of settlements may affect the residents’ sentiments. Research in this field is interdisciplinary, integrating urban planning and public health. However, it has been limited by the difficulty of quantifying subjective sentiments and the small sample size. This study uses 147,613 Weibo text check-ins in Xiamen from 2017 to quantify residents' sentiments in 1,096 neighborhoods in the city. A multilevel regression model and gradient...

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Abstract Background Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via several mechanisms, including regulating iron metabolism, glutathione metabolism, lipid peroxidation and mitochondrial-related proteins, there are many novel circRNAs regulating ferroptosis need to be found, and they may become a new molecular treatment target in GBM. Methods The expression levels of circLRFN5, PRRX2...

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