620 Works

Supplementary document for Littrow 3D measurement based on 2D grating dual-channel equal-optical path interference - 6108368.pdf

yin yunfei, Lin Liu, yu bai, Jiri Jirigalantu, hongzhu Yu, heshig bayan, zhaowu liu & Wenhao Li
Part 3

Supplementary document for Littrow 3D measurement based on 2D grating dual-channel equal-optical path interference - 6095376.pdf

yin yunfei, Lin Liu, yu bai, Jiri Jirigalantu, hongzhu Yu, heshig bayan, zhaowu liu & Wenhao Li
Part 3

Additional file 2 of Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis

Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou & Xiaohu Wang
Additional file 2: Fig. S2. The pooled incidences of local control at 1, 2, 3, 4, 5 and 10 years after C-ion RT for chondrosarcoma.

Additional file 4 of Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis

Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou & Xiaohu Wang
Additional file 4:Fig. S4. The pooled incidences of overall survival at 3, 5 and 10 years after C-ion RT for chordoma.

Additional file 1 of Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Additional file 1: Table S1. DFS and OS for 29 neoadjuvant patients after surgery.

China's Gridded Manufacturing Dataset

Chenjing Fan, Xinran Huang, Lin Zhou, Zhenyu Gai, Chaoyang Zhu & Haole Zhang
The growth of the manufacturing industry is the engine of rapid economic growth in developing regions. Characterizing the geographical distribution of manufacturing firms is critically important for scientists and policymakers. However, data on the manufacturing industry used in previous studies either have a low spatial resolution (or fuzzy classification) or high-resolution information is lacking. Here, we propose a map point-of-interest classification method based on machine learning technology and build a dataset of the distribution of...

Additional file 4 of Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Additional file 4: Table S4. Derived neutrophil-to-lymphocyte ratio (dNLR) supports the negative predictive role of neutrophils.

Additional file 6 of Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Additional file 6: Table S6. Comparison of UICC VIII stages between MPR and non-MPR cases.

Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Abstract Background Although neoadjuvant anti-PD-1 immunotherapies have shown good efficacy in non-small cell lung cancer (NSCLC) patients, there is still a lack of effective predictive markers. We aimed to develop a pretreatment histologic scoring system to predict the efficacy of neoadjuvant immunotherapy. Methods One hundred forty NSCLC cases were evaluated in this study. Initially, surgical specimens from 31 squamous cell lung cancer patients treated with neoadjuvant anti-PD-1 therapy and their eligible paired pretreatment biopsies were...

Additional file 7 of Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Additional file 7: Supplemental methods. irHPC: a pretreatment scoring system.

Additional file 2 of High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai & Jorge D. Erusalimsky
Additional file 2. Table S1. Relationships between sRAGE, NEWS2 and IL-6. Table S2. Univariate analysis for potential predictors of mortality in dexamethasone-treated COVID-19 patients. Table S3. Performance of sRAGE and NEWS2 in their ability to predict mortality in dexamethasone-treated COVID-19 patients

High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai & Jorge D. Erusalimsky
Abstract Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unclear. In this study we investigated the association between sRAGE and mortality in dexamethasone-treated COVID-19 patients. We studied 89 SARS-CoV-2 positive subjects and 22 controls attending the emergency department of a University...

Source data of Deficiency or excess groundwater iodine and its health implications.xlsx

Ruoqi Ma, Mingquan Yan, Peng Han, Ting Wang, Bin Li, Shungui Zhou, Tong Zheng, Yandi Hu, Alistair G. L. Borthwick, Chunmiao Zheng & Jinren Ni
The dataset includes geographical information of groundwater sampling sites, and concentration of groundwater iodine and its species (iodide, iodate and organo-iodine).

Additional file 3 of CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Additional file 3: Supplementary Figure 3. CircLRFN5 silencing promotes GSCs viability, proliferation, neurospheres formation and stemness. a, b MTS assays showed the cell viabilities of GSC56 (a) and GSC53 (b) after circLRFN5 knockdown. c, d Representive EdU assays showed the proliferation of GSC53 and GSC56 after circLRFN5 knockdown. Scale bar = 50 μm. e Representive neurospheres formation assays showed the relative sizes of neurospheres after circLRFN5 knockdown in GSC53 and GSC56. Scale bar = 20...

Additional file 4 of CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Additional file 4: Supplementary Figure 4. PRRX2 promotes GSCs viability and proliferation via inhibiting ferroptosis. a, b Cell viability assays showed the cell viabilities of GSC51 (a) and GSC58 (b) after PRRX2 overexpression, followed by RSL3 treatment. c, d Representative images of EdU assays showed the proliferation of PRRX2 overexpressed GSC51 and GSC58, followed by RSL3 treatment. Scale bar = 50 μm. e Representative images of neurospheres formation assays showed the relative sizes of neurospheres...

Additional file 3 of CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Additional file 3: Supplementary Figure 3. CircLRFN5 silencing promotes GSCs viability, proliferation, neurospheres formation and stemness. a, b MTS assays showed the cell viabilities of GSC56 (a) and GSC53 (b) after circLRFN5 knockdown. c, d Representive EdU assays showed the proliferation of GSC53 and GSC56 after circLRFN5 knockdown. Scale bar = 50 μm. e Representive neurospheres formation assays showed the relative sizes of neurospheres after circLRFN5 knockdown in GSC53 and GSC56. Scale bar = 20...

Additional file 6 of CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Additional file 6: Supplementary Figure 6. PRRX2 transcriptionally upregulates GCH1 expression in GSCs. a-d qPCR showed the mRNA expression of STEAP3 (a, b) and GCH1 (c, d) in PRRX2 overexpressed GSC51 and GSC58 or PRRX2 knockdown GSC53 and GSC56. e, f Western blotting showed the expression of GCH1 in PRRX2 overexpressed (e) or knockdown (f) GSCs. g-j The luciferase reporter assays showed the luciferase promoter activities of GCH1 after PRRX2 overexpression in GSC51 (g) and...

Additional file 1 of Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer

Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang & Liangxing Wang
Additional file 1: Figure S1. A. H460 and PC-9 cells were treated with different concentrations of celastrol (0, 1, 2, and 4 μM) for 24 h, after 10 min of trypan blue dyeing, viable and non-viable cells were counted in hemocytometer. Green represents viable cells, red represents non-viable cells. B. Representative Figures of H520 and Beas-2B cell migration assays. (*P < 0.05, **P < 0.01, ***P < 0.001).

Additional file 2 of Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer

Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang & Liangxing Wang
Additional file 2: Figure S2. A–B and E–F. H460 and H520 cells were treated with 4 μM celastrol, and the levels of intracellular ROS were determined by flow cytometry and fluorescence microscope. C–D and G–H. H460 and H520 cells were treated with different concentrations of celastrol (0, 1, 2, and 4 μM) for 2 h. NAC was used at a dose of 5 μM, either alone or as a1h pretreatment, and the levels of intracellular...

Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in spinal cord injury

Wen-Chen Ji, Meng Li, Wan-Ting Jiang, Xing Ma & Jia Li
Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is a promising alternative treatment strategy. Here we investigated the effect and mechanism of adipose-derived stem/stromal cells (ASCs) with overexpressing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) (BDNF-NT3) in combination with silk fibroin/chitosan scaffold (SFCS) in SCI. Methods: Female Sprague-Dawley rats were used as an SCI model. SFCS,SFCS and ASCs, or ASCs overexpressing NT3, BDNF, and BDNF-NT3 were implanted into SCI rats....

Additional file 1 of Workforce Diversity and disparities in wait time and retention among opioid treatment programs

Erick G. Guerrero, Yinfei Kong, Jemima A. Frimpong, Tenie Khachikian, Suojin Wang, Thomas D’Aunno & Daniel L. Howard
Additional file 1: Appendix A. Comparative analysis of missing records for wait time and retention

Additional file 1 of Workforce Diversity and disparities in wait time and retention among opioid treatment programs

Erick G. Guerrero, Yinfei Kong, Jemima A. Frimpong, Tenie Khachikian, Suojin Wang, Thomas D’Aunno & Daniel L. Howard
Additional file 1: Appendix A. Comparative analysis of missing records for wait time and retention

Additional file 1 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Additional file 1: Table S1. Baseline characteristics on death and MACE risks. Table S2. Baseline characteristics on LVEF and LVMI. Table S3. Relationship between metabolites and death risk. Table S4. Relationship between metabolites and MACE risk. Table S5. Multivariate Cox proportional hazards model for clinical outcomes. Table S6. Spearman correlation analysis between clinical factors and those metabolites associated with death risk. Table S7. Spearman correlation analysis between clinical factors and those metabolites associated with death...

Additional file 2 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Additional file 2. Additional Methods. Fig. S1. The Kaplan–Meier curves of LVEF (A-B) and LVMI (C-D) for risks of death and MACE in the discovery cohort. Fig. S2. Correlation network of metabolic signatures for MACE risk and clinical factors. Fig. S3. Representative total ion flow diagrams between different QC samples under positive ion mode (A) and negative ion mode (B). Fig. S4. The visualization image analysis of the quality improvement procedures for typical features (Kynurenine)...

Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventricular remodeling remains limited. We aim to assess the contribution of plasma metabolites to the risk of death and major adverse cardiovascular events (MACE) as well as left ventricular remodeling. Results In a prospective study with 1606 Chinese patients with CAD, we have identified...

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