668 Works

Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model

Ting Li, Xuejiao Gao, Zhixiang Yan, Tai-Seng Wai, Wei Yang, Junru Chen & Ru Yan
Abstract Background Chinese medicines (CMs) have emerged as an alternative therapy for ulcerative colitis through reinforcing the vital qi and/or eliminating the pathogenic factors according to the traditional Chinese medicinal theory. Presystemic interactions of CMs with gut microbiota and the associated metabolic network shift are believed to be essential to achieve their holistic health benefits in traditional oral application. Methods This study first employed 16S rDNA-based microbial profiling and mass spectrometry-based urinary metabolomics to simultaneously...

Supplemental Material - Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China

Ruimei Feng, Yiquan Dai, Shanshan Du, Wenbin Liang, Hongyu Chen, Cheng Chen, Tianmin He, Tao Tao, Zhijian Hu, Pingfan Guo & Weimin Ye
Supplemental Material for Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China by Ruimei Feng, PhD, Yiquan Dai, MM, Shanshan Du, PhD, Wenbin Liang, PhD, Hongyu Chen, MM, Cheng Chen, MM, Tianmin He, MM, Tao Tao, PhD, Zhijian Hu, PhD, Pingfan Guo, MD, and Weimin Ye, PhD, MD in Angiology

Additional file 1 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 1: Figure S1. Forest plot for failure to achieve clinical remission at 4 weeks subgroup by previous TNF-α exposure in ADA and control groups.

Additional file 3 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 3: Figure S3. Forest plot for failure to achieve clinical response (70-point response) at 4 weeks subgroup by previous TNF-α exposure in ADA and control groups.

Additional file 7 of Adalimumab for induction of remission in patients with Crohn's disease: a systematic review and meta-analysis

Juntao Yin, Yang Li, Yangyang Chen, Chaoyang Wang & Xiaoyong Song
Additional file 7: Figure S7. Results of the Cochrane Risk of Bias assessment tool 2 for randomized controlled trials

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Abstract Background Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present study, we aim to investigate the effect of IUI on lung development, and to identify the key molecule involved in this process and its epigenetic regulatory mechanism. Results Serpine1 was upregulated in the lung tissue of neonatal mice with IUI. Intranasal delivery of Serpine1 siRNA markedly reversed IUI-induced...

Additional file 2 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 2: Figure S2. Genes expression levels in lung tissues of neonatal mice (A) The mRNA expression of differentially expressed genes analysed using RT-qPCR in lung tissues of neonatal mice. B, C Nr4a1 expression analysed using western blot in lung tissues of neonatal mice. D Serpine1 expression in lung tissues of neonatal mice detected using RT-qPCR on P1, P7, and P21. E, F Serpine1 expression analysed using RT-qPCR and western blot in siRNA-treated neonatal...

The effects of different parity and delivery mode on wheezing disorders in the children—a retrospective cohort study in Fujian, China

Haiyan Gao, Chong Miao, Haibo Li, Meng Bai, Huijie Zhang, Zhengqin Wu, Wei Li, Wenjuan Liu, Libo Xu, Guanghua Liu & Yibing Zhu
The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions. To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity. A total of 21716 patients were included in this retrospective observational study. Multivariable logistic regression was used to analyze the relationship between childbirth delivery method and wheezing in children under 18 years of...

Supplemental Material - Construction of a Carcinoembryonic Antigen Surface-Enhanced Raman Spectroscopy (SERS) Aptamer Sensor Based on the Silver Nanorod Array Chip

Rui Li, Lijun Li, Yan Zhang, Xin Lin, Heyuanxi Guo, Chubing Lin & Jun Feng
Supplemental Material for Construction of a Carcinoembryonic Antigen Surface-Enhanced Raman Spectroscopy (SERS) Aptamer Sensor Based on the Silver Nanorod Array Chip by Rui Li, Lijun Li, Yan Zhang, Xin Lin, Heyuanxi Guo, Chubing Lin, and Jun Feng in Applied Spectroscopy

Construction of a Carcinoembryonic Antigen Surface-Enhanced Raman Spectroscopy (SERS) Aptamer Sensor Based on the Silver Nanorod Array Chip

Rui Li, Lijun Li, Yan Zhang, Xin Lin, Heyuanxi Guo, Chubing Lin & Jun Feng
Carcinoembryonic antigen (CEA) is a cancer-related tumor marker, which is commonly used for preventive screening, auxiliary diagnosis, and recurrence monitoring. Therefore, it is of great significance to develop a new CEA detection method. In this paper, we developed an SERS aptasensor for CEA based on silver nanorod array chip, thiol aptamer, and 4-mercaptophenylboronic acid (4-MPBA). The silver nanorod array chip modified by CEA thiol aptamer (aptamer-SH) was used as SERS capture substrates. Ag@4-MPBA was used...

Additional file 1 of Convergence of two serotypes within the epidemic ST11 KPC-producing Klebsiella pneumoniae creates the “Perfect Storm” in a teaching hospital

Chao Liu, Ping Yang, Jiajia Zheng, Juan Yi, Ming Lu & Ning Shen
Additional file 1: Figure S1. Collection date of these ST11-Kp strains. Figure S2. Specimen type of these ST11-Kp strains. Table S1. Antimicrobial resistance profile of these ST11-Kp strains.

Additional file 1 of Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Additional file 1: Demographic, breast cancer epidemiological and screening factors of the female populations in China.

Additional file 3 of Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Additional file 3: Age-specific incidence, mortality and survival rates of breast cancer.

Additional file 4 of Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Additional file 4: Age-specific number of females and standardized life expectancy

Lensless imaging through thin scattering layers under broadband illumination

Wei Li, Bingjian Wang, Tengfei Wu, Feihu Xu & Xiaopeng Shao
Lensless scattering imaging is a prospective approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured speckle patterns, providing a solution in situations where the use of imaging optics is not possible. However, current lensless scattering imaging methods are typically limited by the need for a light source with a narrowband spectrum. Here, we propose two general approaches that enable single-shot lensless scattering imaging under broadband illumination...

sj-docx-1-tct-10.1177_15330338221132035 - Supplemental material for Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study

Yuting Liu, Min Sun, Ying Xiong, Xinyue Gu, Kai Zhang & Li Liu
Supplemental material, sj-docx-1-tct-10.1177_15330338221132035 for Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study by Yuting Liu, Min Sun, Ying Xiong, Xinyue Gu, Kai Zhang and Li Liu in Technology in Cancer Research & Treatment

Additional file 2 of GATA-type transcriptional factor SpGAT1 interacts with SpMIG1 and promotes lipid accumulation in the oleaginous yeast $$Saitozyma \ podzolica$$ S a i t o z y m a p o d z o l i c a zwy-2-3

Yulu Ran, Hui Xu, Qingzhuoma Yang, Yi Xu, Huahao Yang, Dairong Qiao & Yi Cao
Additional file 2: Fig. S1. Single cell lipid yield and fatty acid profile of S.podzolica zwy-2-3 cultivated in rapamycin treatment and different C/N ratio mediums. a Single cell lipid yield stained by Nile red. b Fatty acid profiles analyzed by GC-MS. Fig. S2. Results of SpGAT1 mutant identification. a Results of amplifying hygromycin gene, homologous arm, and part of SpGAT1 gene (lane 1: marker 5000 bp, lane 2: amplifying hygromycin gene and LB homologous arm...

Additional file 1 of Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li & Lei Du
Additional file 1. Supplementary tables and figures

Additional file 1 of Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li & Lei Du
Additional file 1. Supplementary tables and figures

Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs

Tao Jiang, Ziqi Ling, Zhimin Zhou, Xiaoyun Chen, Liqing Chen, Sha Liu, Yingchun Sun, Jiawen Yang, Bin Yang, Jianzhen Huang & Lusheng Huang
Abstract Background A comprehensive landscape of chromatin states for multiple mammalian tissues is essential for elucidating the molecular mechanism underlying regulatory variants on complex traits. However, the genome-wide chromatin accessibility has been only reported in limited tissue types in pigs. Results Here we report a genome-wide landscape of chromatin accessibility of 20 tissues in two female pigs at ages of 6 months using ATAC-seq, and identified 557,273 merged peaks, which greatly expanded the pig regulatory...

Supplemental Material, original_data - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, original_data for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Supplemental Material, CONSORT_b - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, CONSORT_b for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Supplemental Material, CONSORT_b - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, CONSORT_b for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Aim:Some obstructive sleep apnea (OSA) patients may have mandibular retrognathia (ANB > 4.7° and SNB < 76.2°). Currently, there are no studies that have compared the effectiveness of continuous positive airway pressure (CPAP) versus mandibular advancement device (MAD) in severe OSA patients with mandibular retrognathia. We explored the efficacy of CPAP versus MAD for the treatment of severe OSA patients with mandibular retrognathia.Methods:A total of 105 patients were enrolled. Outcomes were assessed by using polysomnography,...

Additional file 2 of Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathway

Zhaoyi Liang, Lu Liu, Ruixia Gao, Chengchuan Che & Ge Yang
Additional file 2.

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