Additional file 1. Table S1. Statistical comparison among manual plans and hybrid plans for moderate, hard and easy clinical goal settings. Table S2. Statistical comparison among manual plans and script plans for moderate, hard and easy clinical goal settings. Table S3. Statistical results of planmanual for added goals setting.

Additional file 1: Supplement Figure 1. Comparison of relative PUFA levels in brains with NCI and AD dementia stratified by sex. Supplement Table 1. Linear regression analyses of lipid mediator levels compared to NCI APOE 3/3. Supplement Table 2. Linear regression analyses of lipid mediator levels vs. global cognitive function. Supplement Table 3. Multivariate linear regression analyses of lipid mediator levels vs. clinical phenotype measurements. Supplement Table 4. Interaction p-value of APOE4 and lipid mediators...

Background: Formal psychosocial support programs after weight-loss surgery are limited in scope and availability. Objective: This randomized pilot study evaluated the feasibility of a postoperative behavioral intervention program. Materials and Methods: Postoperative weight-loss surgery patients (N = 50) were recruited from February 2017–July 2017 and randomized to a four-month behavioral program or usual care wait-list. Outcomes evaluated in addition to feasibility included health-related quality of life (Short Form -36), psychosocial functioning and adherence. Secondary outcomes...

To study thyroid hormone (TH) signaling in the human brain, we analyzed published microarray data sets of the temporal pole (Brodmann area 38) of 19 deceased donors. An index of TH signaling built on the expression of 19 well known TH-responsive genes in mouse brains (T3S+) varied from 0.92 to 1.1. After Factor analysis, T3S+ correlated independently with the expression of TH transporters (MCT8, LAT2), TH receptor (TR) beta and TR coregulators (CARM1, MED1, KAT2B,...

Background and Objectives: Evidence on the association of the cognitive reserve (CR) with the cognitive trajectories is limited. We aimed to examine the influence of CR indicator on domain-specific cognitive trajectories taking brain pathologies into account. Methods: Within the Rush Memory and Aging Project, 1,697 dementia-free participants (mean age: 79.6 years) were followed up to 21 years. CR indicator encompassing education, early-life, mid-life, and late-life cognitive activities, and late-life social activity was ascertained at baseline...

Abstract Background Fragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy. Design CONNECT-FX was a double-blind, randomized phase 3 trial assessing efficacy and safety of ZYN002, transdermal cannabidiol gel, for the treatment of behavioral symptoms in children and adolescents with FXS. Methods Patients were randomized to 12 weeks of ZYN002 (250 mg or 500 mg daily [weight-based]) or placebo, as add-on to standard of care. The primary...

Traffic congestion on a road segment typically begins as a small-scale spatiotemporal event that can then propagate throughout a road network and produce large-scale disruptions to a transportation system. In current techniques for the analysis of network flow, data is often aggregated to relatively large (e.g. 5 min) discrete time steps that obscure the small-scale spatiotemporal interactions that drive larger-scale dynamics. We propose a new method that handles fine-grained data to better capture those dynamics....

Supplemental material, sj-docx-3-cll-10.1177_09636897231154574 for Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 by Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu and Baoshan Wang in Cell Transplantation

Supplemental material, sj-docx-2-cll-10.1177_09636897231154574 for Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 by Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu and Baoshan Wang in Cell Transplantation

Supplemental material, sj-tif-4-cll-10.1177_09636897231154574 for Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 by Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu and Baoshan Wang in Cell Transplantation

CircRNA/miRNA/mRNA axis has been reported to play crucial regulatory roles in multiple cancers, including hepatocellular carcinoma (HCC). In addition, recent investigations revealed that aloin exerted anti-tumor functions in HCC. However, the underlying mechanism of aloin on anti-tumor functions in HCC remained elusive. Therefore, this study aimed to investigate whether circRNA/miRNA/mRNA axis medicated the anti-tumor effect of aloin in HCC. Cell viability, invasion, apoptosis and autophagy were accessed by cell counting kit-8 (CCK-8), transwell invasion assay,...

Objective: To assess whether neurodegenerative pathologies are differentially related to trajectories of change in different cognitive abilities. Methods: At annual intervals for up to 21 years, 915 older participants in a longitudinal clinical-pathologic cohort study completed a battery of 15 tests from which previously established composite measures of episodic memory, semantic memory, working memory, and perceptual speed were derived. At death, they underwent a neuropathologic examination to quantify Alzheimer’s disease (AD) pathology, Lewy bodies, transactive...

Background:Failure rates after arthroscopic shoulder stabilization are highly variable in the current orthopaedic literature. Predictive factors for risk of failure have been studied to improve patient selection, refine surgical techniques, and define the role of bony procedures. However, significant heterogeneity in the analysis and controlling of risk factors makes evidence-based management decisions challenging.Purpose:The goals of this systematic review were (1) to critically assess the consistency of reported risk factors for recurrent instability after arthroscopic Bankart...

Additional file 1: Supplement Figure 1. Comparison of relative PUFA levels in brains with NCI and AD dementia stratified by sex. Supplement Table 1. Linear regression analyses of lipid mediator levels compared to NCI APOE 3/3. Supplement Table 2. Linear regression analyses of lipid mediator levels vs. global cognitive function. Supplement Table 3. Multivariate linear regression analyses of lipid mediator levels vs. clinical phenotype measurements. Supplement Table 4. Interaction p-value of APOE4 and lipid mediators...

Supplementary data files

Abstract Background A wealth of evidence has illustrated that reductions in negative posttrauma cognitions (NPCs) predict improvement in posttraumatic stress disorder (PTSD) symptoms during treatment. Yet, the specific temporal arrangement of changes in these constructs is less well understood. This study examined the temporal association between NPC changes and PTSD symptom changes in two distinct intensive PTSD treatment samples. Methods Data from 502 veterans who completed a 3-week CPT-based intensive PTSD treatment program was used...

Additional file 1: Table S1. Models Predicting PCL-5 without items 9 and 10. Figure S1. Time trends for PTCI subscales and PCL-5 in 3-week program. Figure S2. Time trends for PTCI subscales and PCL-5 in 2-week program.

Pangolins have gained increasing global attention owing to their public health significance as potential zoonotic hosts since the identification of SARS-CoV-2-related viruses in them. Moreover, these animals could carry other respiratory viruses. In this study, we investigated the virome composition of 16 pangolins that died in 2018 with symptoms of pneumonia using metagenomic approaches. A total of eight whole virus sequences belonging to the Paramyxoviridae or Pneumoviridae families were identified, including one human parainfluenza virus...

Supplemental material, sj-tif-4-cll-10.1177_09636897231154574 for Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 by Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu and Baoshan Wang in Cell Transplantation

Supplemental material, sj-docx-3-cll-10.1177_09636897231154574 for Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6 by Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu and Baoshan Wang in Cell Transplantation

ABSTRACT Purpose: While there is strong evidence supporting the importance of telemedicine in stroke, its role in other areas of neurology is not as clear. The goal of this review is to provide an overview of evidence-based data regarding the role of teleneurology in the care of patients with neurologic disorders other than stroke. Recent findings: Studies across multiple specialties report noninferiority of evaluations by telemedicine compared with traditional, in-person evaluations in terms of patient...

We developed an application (https://rush-covid19.herokuapp.com/) to aid US hospitals in planning their response to the ongoing COVID-19 pandemic. Our application forecasts hospital visits, admits, discharges, and needs for hospital beds, ventilators, and personal protective equipment by coupling COVID-19 predictions to models of time lags, patient carry-over, and length-of-stay. Users can choose from seven COVID-19 models, customize a large set of parameters, examine trends in testing and hospitalization, and download forecast data. The data and scripts...

Objective: To report a 2017 survey of all US medical school neurology clerkship directors (CDs) and to compare the results to similar surveys conducted in 2005 and 2012. Methods: An American Academy of Neurology (AAN) Consortium of Neurology Clerkship Directors (CNCD) workgroup developed the survey that was sent to all neurology CDs listed in the AAN CNCD database. Comparisons were made to similar 2005 and 2012 surveys. Results: The response rate was 92 of 146...

Objective: To examine if indices of Parkinson’s disease (PD) pathology and other brain pathologies are associated with the progression of parkinsonism in older adults. Methods: We used data from decedents who had undergone annual clinical testing prior to death and structured brain autopsy. Parkinsonism was based on assessment with a modified United Parkinson’s Disease Rating Scale and a clinical diagnosis of PD was based on medical history. We employed a series of mixed-effects models controlling...

CircRNA/miRNA/mRNA axis has been reported to play crucial regulatory roles in multiple cancers, including hepatocellular carcinoma (HCC). In addition, recent investigations revealed that aloin exerted anti-tumor functions in HCC. However, the underlying mechanism of aloin on anti-tumor functions in HCC remained elusive. Therefore, this study aimed to investigate whether circRNA/miRNA/mRNA axis medicated the anti-tumor effect of aloin in HCC. Cell viability, invasion, apoptosis and autophagy were accessed by cell counting kit-8 (CCK-8), transwell invasion assay,...