Classic Mendelian inheritance is the bedrock of population genetics and underpins pedigree-based management of animal populations. However, assumptions of Mendelian inheritance might not be upheld in conservation breeding programs if early viability selection occurs, even when efforts are made to equalise genetic contributions of breeders. To test this possibility, we investigated deviations from Mendelian proportions in a captive meta-population of the endangered Tasmanian devil. This marsupial population is ideal for addressing evolutionary questions in conservation...

Overdose with paracetamol modified-release (MR) formulation, a bilayer tablet containing 69% slow-release component, has been increasing since its introduction to the market. However, little evidence exists for the management of MR paracetamol overdose. We aimed to develop a population pharmacokinetic (PK) model for immediate-release (IR) and MR paracetamol and its major metabolism, and quantitatively understand the formulation difference in toxicity assessment based on the nomogram line. Data from a cross-over study design in nine healthy...

Overdose with paracetamol modified-release (MR) formulation, a bilayer tablet containing 69% slow-release component, has been increasing since its introduction to the market. However, little evidence exists for the management of MR paracetamol overdose. We aimed to develop a population pharmacokinetic (PK) model for immediate-release (IR) and MR paracetamol and its major metabolism, and quantitatively understand the formulation difference in toxicity assessment based on the nomogram line. Data from a cross-over study design in nine healthy...

Data for: Vaux F, Craw D, Fraser CI, Waters JM. (2021). Northward range extension for Durvillaea poha bull kelp: response to tectonic disturbance? Journal of Phycology. https://doi.org/10.1111/jpy.13179 Understanding the forces that shape species distributions is increasingly important in a fast-changing world. Although major disturbance events can adversely affect natural populations, they can also present new opportunities, for example by opening up habitat for colonisation by other lineages. Following extensive geographic sampling, we use genomic data...

This work analyzes the prevalence of words denoting prejudice in 27 million news and opinion articles written between 1970 and 2019 and published in 47 of the most popular news media outlets in the United States. Our results show that the frequency of words that denote specific prejudice types related to ethnicity, gender, sexual, and religious orientation has markedly increased within the 2010–2019 decade across most news media outlets. This phenomenon starts prior to, but...

Although consistent between-individual differences in behaviour (i.e. animal personality) are ubiquitous in natural populations, relatively few studies have examined how personalities influence the formation of social relationships. Yet, behavioural characteristics of both sexes might be key when it comes to pair-bond formation, and the cooperation with partners to successfully rear offspring. We here use a wild population of dunnocks (Prunella modularis) to first investigate whether individuals mate non-randomly (i.e. assortative mating) with regard to four...

Major ecological disturbance events can provide opportunities to assess multispecies responses to upheaval. In particular, catastrophic disturbances that regionally extirpate habitat-forming species can potentially influence the genetic diversity of large numbers of co-distributed taxa. However, due to the rarity of such disturbance events over ecological timeframes, the genetic dynamics of multispecies recolonization processes have remained little understood. Here we use single nucleotide polymorphism (SNP) data from multiple coastal species to track the dynamics of co-colonization...