3 Works

Implementing social network analysis to understand the socio-ecology of wildlife co-occurrence and joint interactions with humans in anthropogenic environments

Krishna Balasubramaniam, Stefano Kaburu, Pascal Marty, Brianne Beisner, Eliza Bliss-Moreau, Malgorzata Arlet, Nadine Ruppert, Ahmad Ismail, Sahrul Anuar Mohd Sah, Lalith Mohan, Sandeep Rattan, Ullasa Kodandaramaiah & Brenda McCowan
1. Human population expansion into wildlife habitats has increased interest in the behavioral ecology of human-wildlife interactions. To date, however, the socio-ecological factors that determine whether, when or where wild animals take risks by interacting with humans and anthropogenic factors still remains unclear. 2. We adopt a comparative approach to address this gap, using social network analysis (SNA). SNA, increasingly implemented to determine human impact on wildlife ecology, can be a powerful tool to understand...

Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies

Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri & Emira Noumi
The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches. Interestingly, molecular docking studies suggest that Emetine showed significant binding affinity toward Nsp15 (-10.8 kcal/mol) followed by Nsp12 (-9.5 kcal/mol), RNA-dependent RNA polymerase, RdRp (-9.5 kcal/mol), Nsp16 (-9.4 kcal/mol), Nsp10 (-9.2 kcal/mol), Papain-like protein (-9.0 kcal/mol), Nsp13 (-9.0 kcal/mol), Nsp14 (-8.9 kcal/mol) and Spike Protein Receptor Domain (-8.8 kcal/mol) and chymotrypsin-like protease,...

Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies

Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri & Emira Noumi
The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches. Interestingly, molecular docking studies suggest that Emetine showed significant binding affinity toward Nsp15 (-10.8 kcal/mol) followed by Nsp12 (-9.5 kcal/mol), RNA-dependent RNA polymerase, RdRp (-9.5 kcal/mol), Nsp16 (-9.4 kcal/mol), Nsp10 (-9.2 kcal/mol), Papain-like protein (-9.0 kcal/mol), Nsp13 (-9.0 kcal/mol), Nsp14 (-8.9 kcal/mol) and Spike Protein Receptor Domain (-8.8 kcal/mol) and chymotrypsin-like protease,...

Registration Year

  • 2021
    3

Resource Types

  • Text
    2
  • Dataset
    1

Affiliations

  • University of Wolverhampton
    3
  • King Saud University
    2
  • Manouba University
    2
  • Indian Institute of Science Education and Research, Thiruvananthapuram
    1
  • Universiti Putra Malaysia
    1
  • Universiti Sains Malaysia
    1
  • Emory University
    1
  • Adam Mickiewicz University in Poznań
    1
  • University of California, Davis
    1