268 Works

Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Abstract Background Sexual stage surface antigens are potential targets of transmission-blocking vaccines (TBVs). The gametocyte and gamete surface antigen P230, a leading TBV candidate, is critical for red blood cell binding during exflagellation and subsequent oocyst development. Here, the genetic diversity of Pvs230 was studied in Plasmodium vivax parasite isolates from the China–Myanmar border (CMB) and central Myanmar. Methods Plasmodium vivax isolates were collected in clinics from malaria-endemic areas of the CMB (143 samples) and...

Circ_0003570 Suppresses the progression of hepatocellular carcinoma through miR-182-5p/STARD13 regulatory axis

Xu Zhang, Wenwen Chen, Dan Guo, Yarui Li, Yan Zhao, Mudan Ren, Guifang Lu, Xinlan Lu & Shuixiang He
Abstract Background Emerging evidence have revealed that circRNAs exert important biological effects in the development and progression of various diseases, including cancer. Our study aimed to elaborated the biological effects of hsa-circ_0003570 in hepatocellular carcinoma (HCC) development at the molecular level. Results The results of functional experiments showed that knockdown of circ_0003570 induced HCC cell growth, migration and invasion, whereas overexpression of circ_0003570 presented the opposite effects. In vivo experiments, xenograft tumors grown from circ-overexpressed...

Additional file 7 of CEF3 is involved in membrane trafficking and essential for secondary cell wall biosynthesis and its mutation enhanced biomass enzymatic saccharification in rice

Hongrui Jiang, Yan Ren, Junyao Guo, Huijie Yang, Xiaotong Zhu, Wenhao Li, Liangzhi Tao, Yue Zhan, Qi Wang, Yuejin Wu, Binmei Liu & Yafeng Ye
Additional file 7: Figure S7. (A) Phylogenetic tree of CEF3 in rice and Arabidopsis. (B) The amino acid sequence alignment between the AtSCD2 and OsCEF3. Different rectangles represent different functional domains.

Supplementary document for Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method - 6063130.pdf

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

Additional file 1 of Dietary supplementation of Macleaya cordata extract and Bacillus in combination improve laying performance by regulating reproductive hormones, intestinal microbiota and barrier function of laying hens

Fei Wang, Peng Zou, Shujie Xu, Qi Wang, Yuanhao Zhou, Xiang Li, Li Tang, Baikui Wang, Qian Jin, Dongyou Yu & Weifen Li
Additional file 1: Table S1. Sequences of oligonucleotide primers used for RT-qPCR. Table S2. Organs indices of laying hens fed different biological feed additives1.

Additional file 2 of CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research

Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-e Huang, Fei Hou, Christine M. Eischen & Wei Jiang
Additional file 2: Figure S1. Crosstalk effect consideration detects genes known to be associated with LUAD. Figure S2. CGC genes are in top of the RS rank list, but not top of the |log2FC| rank list. Figure S3. The proportion of risk genes, overlooked by other methods. Figure S4. Comparison of DEG proportions between pathways specifically identified by CTpathway and non-specific pathways. Figure S5. Significant pathways in data sets with a small number of DEGs,...

Additional file 4 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 4: Figure S1. Validation of ω-transaminase activity based on color reaction. 1: Control 2: Empty vector plasmid strain breaking solution 3: Breaking solution of strain expressing He-ωTA protein 4: Breaking solution of strain expressing Cv-ωTA protein 5: Purified He-ωTA protein solution 6: Purified Cv-ωTA protein solution.

Additional file 5 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 5: Figure S2. Intracellular NADH content of MER-oE strains under different medium conditions. Data represent mean ± S.D. (error bars) from three independent experiments.

Additional file 6 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 6: Figure S3. The petP and petE plasmids expression in E. coil by SDS-PAGE analysis of whole cell (WC), supernatant (S), and protein marker (M).

Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Abstract Background With the development of metabolic engineering and synthetic biology, the biosynthesis of aromatic compounds has attracted much attention. Cinnamylamine is an aromatic compound derived from l-phenylalanine, which is used in the synthesis of biologically active molecules, including drugs, and energetic materials. Cinnamylamine has been mainly synthesized by chemical methods to date, and few reports have focused on the biosynthesis of cinnamylamine. Therefore, it is desirable to establish an efficient biosynthesis method for cinnamylamine....

Additional file 3 of Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Additional file 3. Data extraction form.

Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Abstract Background As systematically developed statements regarding possible courses of action, health system guidance (HSG) can assist with making decisions about addressing problems or achieving goals in health systems. However, there are conceptual and methodological challenges in HSG implementation due to the complexity of health-system policy-making, the diversity of available evidence and vast differences in contexts. To address these gaps, we aim to develop a theoretical framework for supporting HSG implementation as part of a...

Additional file 1 of Chicken intestinal microbiota modulation of resistance to nephropathogenic infectious bronchitis virus infection through IFN-I

Hai-chang Yin, Zhen-dong Liu, Wei-wei Zhang, Qing-zhu Yang, Tian-fei Yu & Xin-jie Jiang
Additional file 1: Figure S1. The dilution curve that was generated based on an operational taxonomic unit (OTU) level indicated that the sampling work had sufficient sequences to analyze bacterial diversity.

Additional file 2 of Chicken intestinal microbiota modulation of resistance to nephropathogenic infectious bronchitis virus infection through IFN-I

Hai-chang Yin, Zhen-dong Liu, Wei-wei Zhang, Qing-zhu Yang, Tian-fei Yu & Xin-jie Jiang
Additional file 2: Figure S2. Species level community composition of intestinal microbiota of specific pathogen-free chickens.

sj-docx-1-ajs-10.1177_03635465221125936 – Supplemental material for Microfracture Augmentation With Direct In Situ Radial Shockwave Stimulation With Appropriate Energy Has Comparable Repair Performance With Tissue Engineering in the Porcine Osteochondral Defect Model

Zhidong Zhao, Ji Li, Xiaowei Bai, Yuxing Wang, Qi Wang, Ningyu Lv, Huayi Gao, Zheng Guo, Heng Zhu, Quanyi Guo & Zhongli Li
Supplemental material, sj-docx-1-ajs-10.1177_03635465221125936 for Microfracture Augmentation With Direct In Situ Radial Shockwave Stimulation With Appropriate Energy Has Comparable Repair Performance With Tissue Engineering in the Porcine Osteochondral Defect Model by Zhidong Zhao, Ji Li, Xiaowei Bai, Yuxing Wang, Qi Wang, Ningyu Lv, Huayi Gao, Zheng Guo, Heng Zhu, Quanyi Guo and Zhongli Li in The American Journal of Sports Medicine

Additional file 9 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 9: Figure S9. Genome-wide composition of blastocysts following multipolar zygotic division. Circos plots of six embryos that developed to the blastocyst stage following multipolar zygotic division in which each circle represents the interpreted genome constitution per chromosome (1 - X) of a sampled single cell. The interpreted genome spanning the largest part of the chromosome was chosen as overall interpretation per chromosome, as such, segmental chromosomal errors are not depicted. On the left...

Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Abstract Background During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental biological tenet, we demonstrate here that parental genomes can segregate to distinct blastomeres during the zygotic division resulting in haploid or uniparental diploid and polyploid cells, a phenomenon coined heterogoneic division. By mapping the genomic landscape of 82 blastomeres from 25 bovine zygotes, we show that multipolar zygotic division is a...

Additional file 10 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 10. Review history.

Additional file 10 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 10. Review history.

Additional file 8 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 8: Figure S8. Anuclear blastomeres and fragments. A) Phylogenetic tree based on reassembled mitochondrial genomes of 11 anuclear blastomeres and two anuclear fragments, showing a common ancestor for sequenced blastomeres and fragments retrieved from the same embryo. One anuclear blastomere was not included. B) Box plots and median values of the number of raw reads per 10 Mb bin (y-axis) per chromosome (chr1 - chrX) and for the mitochondrial DNA (chrM) (x-axis) as...

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups

Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin & You-Zhi Tang
A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, S.aureus ATCC 29213, S.aureus AD3, and S.aureus 144) were evaluated by the broth dilution method. Compound 13 was found to have excellent antibacterial activity against MRSA (MIC = 0.0625 μg/mL). Furthermore, compound 13 was further studied by the time-killing...

Increased diaphragm echodensity correlates with postoperative pulmonary complications in patients after major abdominal surgery: a prospective observational study

Xin Fu, Zhen Wang, Luping Wang, Guangxuan Lv, Yisong Cheng, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yongfang Zhou & Qin Wu
Abstract Background Associated with increased morbidity and mortality, postoperative pulmonary complications (PPCs) often occur after major abdominal surgery. Diaphragmatic dysfunction is suggested to play an important role in the development of PPCs and diaphragm echodensity can be used as an indicator of diaphragm function. This study aimed to determine whether diaphragm echodensity could predict the occurrence of PPCs in patients after major abdominal surgery. Methods Diaphragm ultrasound images of patients after major abdominal surgery were...

Additional file 2 of Increased diaphragm echodensity correlates with postoperative pulmonary complications in patients after major abdominal surgery: a prospective observational study

Xin Fu, Zhen Wang, Luping Wang, Guangxuan Lv, Yisong Cheng, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yongfang Zhou & Qin Wu
Supplementary Material 2

Additional file 1 of Increased diaphragm echodensity correlates with postoperative pulmonary complications in patients after major abdominal surgery: a prospective observational study

Xin Fu, Zhen Wang, Luping Wang, Guangxuan Lv, Yisong Cheng, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yongfang Zhou & Qin Wu
Supplementary Material 1

Additional file 1 of Short-term efficacy of angiotensin receptor-neprilysin inhibitor treatment in patients with ST-segment elevation myocardial infarction with reduced ejection fraction after primary percutaneous coronary intervention: a propensity score matching study

Qun Zhang, Bao Qiao, Yu Han, Shukun Sun, Bailu Wang & Shujian Wei
Additional file 1: Supplement Figure 1. The flowchart of the patient enrollment. Supplemental Table 1. The Multivariate logistic regression analysist of Primary cohort. Supplemental Table 2. The Multivariate logistic regressionanalysist of PSM cohort.

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Affiliations

  • Qiqihar University
    268
  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Nanjing Medical University
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  • Capital Medical University
    226
  • West China Hospital of Sichuan University
    214
  • Huazhong University of Science and Technology
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  • Jilin Agricultural University
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  • Xuzhou Medical College
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