71 Works

Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups

Jessica W Lo, John D Crawford, David W Desmond, Olivier Godefroy, Hanna Jokinen, Simin Mahinrad, Hee-Joon Bae, Sebastian Köhler, Elles Douven, Julie Staals, Christopher Chen, Xin Xu, Eddie J Chong, Rufus O Akinyemi, Rajesh N Kalaria, Adesola Ogunniyi, Mélanie Barbay, Martine Roussel, Byung-Chul Lee, Velandai K Srikanth, Christopher Moran, Nagaendran Kandiah, Russell J Chander, Behnam Sabayan, J. Wouter Jukema … & Perminder S Sachdev
OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile...

Data from: The plastic fly: the effect of sustained fluctuations in adult food supply on life history traits

Joost Van Den Heuvel, Jelle Zandveld, Maarten Mulder, Paul M. Brakefield, Thomas B. L. Kirkwood, Daryl P. Shanley & Bas J. Zwaan
Many adult traits in Drosophila melanogaster show phenotypic plasticity, and the effects of diet on traits such as lifespan and reproduction are well explored. Although plasticity in response to food is still present in older flies, it is unknown how sustained environmental variation affects life-history traits. Here, we explore how such life-long fluctuations of food supply affect weight and survival in groups of flies and affect weight, survival and reproduction in individual flies. In both...

Data from: Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome

Graham Lough, Ilias Kyriazakis, Andreas Lengeling, Silke Bergmann & Andrea B. Doeschl-Wilson
Resistance and tolerance are two alternative strategies hosts can adopt to survive infections. Both strategies may be genetically controlled. To date, the relative contribution of resistance and tolerance to infection outcome is poorly understood. A bioluminescent Listeria monocytogenes (Lm) infection challenge model on four genetically diverse mouse strains was used to study the genetic determination and dynamic contributions of host resistance and tolerance to listeriosis, a serious food-borne infectious disease in humans. Conventional statistical analyses...

Data from: Control of parental investment changes plastically over time with residual reproductive value

Mamoru Takata, Hayato Doi, Cathleen E. Thomas & Satoshi Koyama
Evolutionary conflict between parents and offspring over parental resource investment is a significant selective force on the traits of both parents and offspring. Empirical studies have shown that for some species, the amount of parental investment is controlled by the parents, whereas in other species, it is controlled by the offspring. The main difference between these two strategies is the residual reproductive value of the parents or opportunities for future reproduction. Therefore, this could explain...

Data from: Low fossilization potential of keratin protein revealed by experimental taphonomy

Evan T. Saitta, Chris Rogers, Richard A. Brooker, Geoffrey D. Abbott, Sumit Kumar, Shane S. O'Reilly, Paul Donohoe, Suryendu Dutta, Roger E. Summons & Jakob Vinther
Recent studies have suggested the presence of keratin in fossils dating back to the Mesozoic. However, ultrastructural studies revealing exposed melanosomes in many fossil keratinous tissues suggest that keratin should rarely, if ever, be preserved. In this study, keratin's stability through diagenesis was tested using microbial decay and maturation experiments on various keratinous structures. The residues were analysed using pyrolysis-gas chromatography-mass spectrometry and compared to unpublished feather and hair fossils and published fresh and fossil...

Data from: Probabilistic distances between trees

Maryam Garba, Tom M. W. Nye, Richard J. Boys & Maryam K Garba
Most existing measures of distance between phylogenetic trees are based on the geometry or topology of the trees. Instead, we consider distance measures which are based on the underlying probability distributions on genetic sequence data induced by trees. Monte Carlo schemes are necessary to calculate these distances approximately, and we describe efficient sampling procedures. Key features of the distances are the ability to include substitution model parameters and to handle trees with different taxon sets...

Data from: Estimation of bumblebee queen dispersal distances using sibship reconstruction method

Olivier Lepais, Ben Darvill, Stephanie O'Connor, Juliet Osborne, Roy Sanderson, John Cussans, Louis Goffe & Dave Goulson
Dispersal ability is a key determinant of the propensity of an organism to cope with habitat fragmentation and climate change. Here we quantify queen dispersal in two common bumblebee species in an arable landscape. Dispersal was measured by taking DNA samples from workers in the spring and summer, and from queens in the following spring, at 14 sites across a landscape. The queens captured in the spring must be full sisters of workers that were...

Livestock grazing impacts upon components of the breeding productivity of a common upland insectivorous passerine: results from a long-term experiment

Lisa E. Malm, James W. Pearce-Higgins, Nick A. Littlewood, Alison J. Karley, Ewa Karaszewska, Robert Jaques, Robin J. Pakeman, Steve M. Redpath & Darren M. Evans
The intensity of pastoral management in areas of High Nature Value farming is declining in some regions of Europe but increasing in others. This affects open habitats of conservation concern, such as the British uplands, where bird species that benefit from low-intensity grazing may be most sensitive to such polarisation. While experimental manipulations of livestock grazing intensities have improved our understanding of upland breeding bird responses in the short-term, none have examined the longer-term impacts...

The media world versus the real world of women and political representation

Karen Ross, Marloes Jansen & Tobias Bürger

A framework of modes of awareness for team coaching practice

Joanne James , Sharon Mavin & Sandra Corlett

Data from: The predictive adaptive response: modeling the life history evolution of the butterfly, Bicyclus anynana, in seasonal environments.

Joost Van Den Heuvel, Marjo Saastamoinen, Paul M. Brakefield, Thomas B. L. Kirkwood, Bas J. Zwaan & Daryl P. Shanley
A predictive adaptive response (PAR) is a type of developmental plasticity where the response to an environmental cue is not immediately advantageous but instead is later in life. The PAR is a way for organisms to maximize fitness in varying environments. Insects living in seasonal environments are valuable model systems for testing the existence and form of PAR. Previous manipulations of the larval and the adult environments of the butterfly Bicyclus anynana have shown that...

Data from: Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy

Diane E. Frank, Frederick J. Schnell, Cody Akana, Saleh H. El-Husayni, Cody A. Desjardins, Jennifer Morgan, Jay S. Charleston, Valentina Sardone, Joana Domingos, George Dickson, Volker Straub, Michela Guglieri, Eugenio Mercuri, Laurent Servais & Francesco Muntoni
Objective To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with Duchenne muscular dystrophy (DMD) amenable to exon 53 skipping. Methods Part 1 was a randomized, double-blind, placebo-controlled, 12-week dose titration of once-weekly golodirsen; Part 2 is an ongoing, open-label evaluation. Safety and pharmacokinetics were primary and secondary objectives of Part 1. Primary biological outcome measures of part 2 were blinded exon skipping and dystrophin protein production on muscle biopsies (baseline,...

Research criteria for the diagnosis of prodromal dementia with Lewy bodies.

Ian McKeith, Tanis J. Ferman, Alan J. Thomas, Frederic Blanc, Bradley F. Boeve, Hiroshige Fujishiro, Kejal Kantarci, Cristina Muscio, John T. O'Brien, Ronald B. Postuma, Dag Aarsland, Clive Ballard, Laura Bonanni, Paul C Donaghy, Murat Emre, James E Galvin, Douglas Galasko, Jennifer G. Goldman, Stephen N. Gomperts, Lawrence S. Honig, Manabu Ikeda, James B. Leverenz, Simon J.G. Lewis, Karen S. Marder, Mario Masellis … & Pietro Tiraboschi
The prodromal phase of dementia with Lewy bodies (DLB) includes (i) mild cognitive impairment (MCI), (ii) delirium, and (iii) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a pre-dementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment...

Data from: Varietal variation and chromosome behaviour during meiosis in Solanum tuberosum

Anushree Choudhary, Liam Wright, Olga Patricia Ponce, Jing Chen, Ankush Prashar Prashar, Eugenio Sanchez-Moran, Zewei Luo & Lindsey Compton
Naturally occurring autopolyploid species such as the autotetraploid potato Solanum tuberosum face a variety of challenges during meiosis. These include proper pairing, recombination and correct segregation of multiple homologous chromosomes, which can form complex multivalent configurations at metaphase I, and in turn alter allelic segregation ratios through double reduction. Here, we present a reference map of meiotic stages in diploid and tetraploid S. tuberosum using fluorescence in situ hybridisation (FISH) to differentiate individual meiotic chromosomes...

Data from: Using structured eradication feasibility assessment to prioritise the management of new and emerging invasive alien species in Europe

Olaf Booy, Peter A. Robertson, Niall Moore, Jess Ward, Helen E. Roy, Tim Adriaens, Richard Shaw, Johan Van Valkenburg, Gabe Wyn, Sandro Bertolino, Olivier Blight, Etienne Branquart, Giuseppe Brundu, Joe Caffrey, Dario Capizzi, Jim Casaer, Olivier De Clerck, Neil Coughlan, Eithne Davis, Jaimie Dick, Franz Essl, Guillaume Fried, Piero Genovesi, Pablo González-Moreno, Frank Hysentruyt … & Aileen C. Mill
Prioritising the management of invasive alien species (IAS) is of global importance and within Europe integral to the EU IAS regulation. To prioritise management effectively the risks posed by IAS need to be assessed, but so too does the feasibility of their management. While risk of IAS to the EU has been assessed, the feasibility of management has not. We assessed the feasibility of eradicating 60 new (not yet established) and 35 emerging (established with...

Data from: Assessment of disease progression in dysferlinopathy – a one year cohort study

Volker Straub, Ursula Moore, Marni Jacobs, Meredith K. James, Anna G. Mayhew, Roberto Fernandez-Torron, Jia Feng, Avital Cnaan, Michelle Eagle, Karen Bettinson, Laura E. Rufibach & Robert Muni Lofra
Objective: To assess the ability of functional measures to detect disease progression in dysferlinopathy over 6 months and 1 year. Methods: 193 patients with dysferlinopathy were recruited to the Jain Foundation’s International Clinical Outcome Study for Dysferlinopathy. Baseline, 6 months and 1 year assessments included: adapted North Star Assessment (a-NSAA), Motor Function Measure (MFM-20), timed function tests, 6 minute walk test (6MWT), Brooke Scale, Jebsen Test, manual muscle testing (MMT) and hand-held dynamometry (HHD). Patients...

Data from: Re-assessing causality between energy consumption and economic growth

Atanu Ghoshray, Yurena Mendoza, Mercedes Monfort & Javier Ordoñez
The energy consumption-growth nexus has been widely studied in the empirical literature, though results have been inconclusive regarding the direction, or even the existence, of causality. These inconsistent results can be explained by two important limitations of the literature. First, the use of bivariate models, which fail to detect more complex causal relations, or the ad hoc approach to selecting variables in a multivariate framework; and, second, the use of linear causal models, which are...

Data from: Climate-warming alters the structure of farmland tri-trophic ecological networks and reduces crop yield

Stephane A. P. Derocles, David H. Lunt, Sophie C. F. Berthe, Paul C. Nichols, Ellen D. Moss & Darren M. Evans
It is unclear how sustained increases in temperature and changes in precipitation, as a result of climate-change, will affect crops and their interactions with agricultural weeds, insect pests and predators, due to the difficulties in quantifying changes in such complex relationships. We simulated the combined effects of increasing temperature (by 1.4°C over a growing season) and applying additional rainwater (10% extra per week) using a replicated, randomized block experiment within a wheat crop. We examined...

Substrate utilisation profiles and moisture content data from soil sampled in an upland grassland experiment at Sourhope, Scotland [NERC Soil Biodiversity Programme]

R.I. Griffiths, A. S. Whiteley, A. G. O'Donnell, M.J. Bailey & S.M. Buckland
These data comprise substrate utilisation profiles (using the BIOLOG gram-negative method) and moisture content data from soil sampled in an upland grassland experiment at Sourhope, Scotland. BIOLOG-GN (gram-negative) substrate utilisation analyses were used to give an indication of the ability of a subset of the bacterial community to utilise various carbon sources. These data include both temporal and spatial diversity in different depths of semi-natural grassland soil cores collected at different sample dates. Samples were...

Bacterial community structure and soil process data from a sewage sludge amended upland grassland soil experiment, 2000 [NERC Soil Biodiversity Programme]

N.D. Gray, R.C. Hastings, S.K. Sheppard, P. Loughnane, D. Lloyd, A.J. McCarthy & I.M. Head
This set of data comprises temporal temperature gradient electrophoresis (TTGE) and soil process measurements, used to analyse the effects of perturbations (sludge and/or lime application) on the structure, community development and activity of bacteria that catalyse fundamental processes in upland soils. These were collected to address the following questions: Do soil improvement treatments select for particular components of bacterial populations and hence drive community development? If so, at what functional and phylogenetic level is this...

Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery: supplementary material

Nishant Sinha, Yujiang Wang, Nádia Moreira Da Silva, Anna Miserocchi, Andrew McEvoy, Jane De Tisi, Sjoerd Vos, Gavin Winston, John Duncan & Peter Taylor
Objective: We assessed pre-operative structural brain networks and clinical characteristics of patients with drug resistant temporal lobe epilepsy (TLE) to identify correlates of post-surgical seizure recurrences. Methods: We examined data from 51 TLE patients who underwent anterior temporal lobe resection (ATLR) and 29 healthy controls. For each patient, using the preoperative structural, diffusion, and post-operative structural MRI, we generated two networks: ‘pre-surgery’ network and ‘surgically-spared’ network. Standardising these networks with respect to controls, we determined...

Support for the habitat amount hypothesis from a global synthesis of species density studies

James Watling, Víctor Arroyo-Rodríguez, Marion Pfeifer, Lander Baeten, Cristina Banks-Leite, Laura Cisneros, Rebecca Fang, Caroli Hamel-Leigue, Thibault Lachat, Inara Leal, Luc Lens, Hugh Possingham, Dinarzarde Raheem, Danilo Ribeiro, Eleanor Slade, Nicolas Urbina-Cardona, Eric Wood & Lenore Fahrig
Decades of research suggest that species richness depends on spatial characteristics of habitat patches, especially their size and isolation. In contrast, the habitat amount hypothesis predicts that: 1) species richness in plots of fixed size (species density) is more strongly and positively related to the amount of habitat around the plot than to patch size or isolation; 2) habitat amount better predicts species density than patch size and isolation combined, 3) there is no effect...

Hydrological modelling and simulation data for the River Trent at Colwick under climate change

E.A. Byers, A. Leathard, G.M. O'Donnell, J.W. Hall & J.M. Amezaga
This data contains the time series flow discharge results of hydrological simulation of the River Trent at Colwick using UKCP09 Weather Generator inputs for a variety of time slices and emissions scenarios. The Weather Generator (WG) inputs were run on a hydrological model (Leathard et al., unpublished), calibrated using the observed record 1961-2002. Each simulation is derived from 100 30-year time series of weather at the WG location 4400355 for Control, Low, Medium and High...

Moth abundance and pollen transport from lit and unlit matched pairs of arable field margins in south-east England

C.J. Macgregor, D.M. Evans, R. Fox & M.J.O. Pocock
This dataset contains information about moth abundance and pollen transport at sites lit by high-pressure sodium streetlights and unlit control sites. Moths were sampled at 20 matched pairs of lit and unlit sites within 40 km of Wallingford, Oxfordshire, UK (51°35' N, 1°8' W) during 2014, as part of a study of the effects of street lighting on moths and nocturnal pollen transport. Three sampling methods were used: night-time transects, light-traps and overhead flight activity...

Mammal detection data for the SAFE project site, Sabah, Malaysian Borneo, 2015 [HMTF]

N.J. Deere, G. Guillera-Arroita, E.L. Baking, H. Bernard, M. Pfeifer, G. Reynolds, O.R. Wearn, Z.G. Davies & M.J. Struebig
This data set contains stacked detection matrices for 28 recorded mammal species across 115 sampling locations at the Stability of Altered Forest Ecosystems (SAFE) project site located in Sabah, Malaysian Borneo. Information for each camera trap sampling location, including spatial information and sampling effort is included. Data were collected in order to determine the contribution of carbon-based policies to biodiversity conservation in agricultural land-use mosaics. These data are essential to the development of the occupancy...

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