What determines how we move in the world? Motor neuroscience often focusses either on intrinsic rhythmical properties of motor circuits or extrinsic sensorimotor feedback loops. Here we show that the interplay of both intrinsic and extrinsic dynamics is required to explain the intermittency observed in continuous tracking movements. Using spatiotemporal perturbations in humans, we demonstrate that apparently discrete submovements made 2-3 times per second reflect constructive interference between motor errors and continuous feedback corrections that...
Data from: Genetic population structure and demography of an apex predator, the tiger shark Galeocerdo cuvierAgathe Pirog, Sebastien Jaquemet, Virginie Ravigné, Geremy Cliff, Eric Clua, Bonnie J. Holmes, Nigel E. Hussey, John E.G. Nevill, Andrew J. Temple, Per Berggren, Laurent Vigliola & Hélène Magalon
Population genetics have been increasingly applied to study large sharks over the last decade. Whilst large shark species are often difficult to study with direct methods, improved knowledge is needed for both population management and conservation, especially for species vulnerable to anthropogenic and climatic impacts. The tiger shark, Galeocerdo cuvier, is an apex predator known to play important direct and indirect roles in tropical and sub-tropical marine ecosystems. While the global and Indo-West Pacific population...
The dataset contains 1km gridded estimates of hourly rainfall for Great-Britain for the period 1990-2014. The estimates are derived by applying the nearest neighbour interpolation method to a national database of hourly raingauge observations collated by Newcastle University and the Centre for Ecology & Hydrology (CEH). These interpolated hourly estimates were then used to temporally disaggregate the CEH-GEAR daily rainfall dataset. The estimated rainfall on a given hour refers to the rainfall amount accumulated in...
Community antimicrobial resistance genes and concentrations of polycyclic aromatic hydrocarbons and metals in NE England soils (2016)C.W. Knapp, D.W. Graham, M. Cooke, C. McCann, Y.-G. Zhu & J. Su
The dataset collates the relative concentration of nearly 300 antimicrobial resistance (AMR) genes, and concentrations of polycyclic aromatic hydrocarbons (PAH) and potentially toxic elements (PTE; e.g., “metals”) found in soils across northeastern England during a sampling expedition in June 2016 by researchers at Newcastle University. Top soils (15cm depths; “A” horizon) were obtained from 24 rural and urban locations around Newcastle upon Tyne, representing a spectrum of landscape conditions relative to anticipated PTE contamination. There...
Arctic Terns spend their breeding and non-breeding seasons in polar environments at opposite ends of the world. The sensitivity of polar regions to climate change makes it essential to understand the ecology of Arctic Terns but the remoteness of the Antarctic presents a considerable challenge. One solution is to use ‘biologgers’ to monitor remotely their behaviour and distribution in the Antarctic. Data from birds tagged with light-level global location sensors (geolocators) in 2015 and 2017...
Data from: Natural history of limb girdle muscular dystrophy R9 over 6 years: searching for trial endpointsAlexander P. Murphy, Jasper Morrow, Julia R. Dahlqvist, Tanya Stojkovic, Tracey A. Willis, Christopher D. J. Sinclair, Stephen Wastling, Tarek Yousry, Michael S. Hanna, Meredith K. James, Anna Mayhew, Michelle Eagle, Laurence E. Lee, Jean-Yves Hogrel, Pierre G. Carlier, John S. Thornton, John Vissing, Kieren G. Hollingsworth & Volker Straub
Objective: Limb girdle muscular dystrophy type R9 (LGMD R9) is an autosomal recessive muscle disease for which there is currently no causative treatment. The development of putative therapies requires sensitive outcome measures for clinical trials in this slowly progressing condition. This study extends functional assessments and MRI muscle fat fraction measurements in an LGMD R9 cohort across 6 years. Methods: Twenty‐three participants with LGMD R9, previously assessed over a 1‐year period, were re‐enrolled at 6...
Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groupsJessica W Lo, John D Crawford, David W Desmond, Olivier Godefroy, Hanna Jokinen, Simin Mahinrad, Hee-Joon Bae, Sebastian Köhler, Elles Douven, Julie Staals, Christopher Chen, Xin Xu, Eddie J Chong, Rufus O Akinyemi, Rajesh N Kalaria, Adesola Ogunniyi, Mélanie Barbay, Martine Roussel, Byung-Chul Lee, Velandai K Srikanth, Christopher Moran, Nagaendran Kandiah, Russell J Chander, Behnam Sabayan, J. Wouter Jukema … & Perminder S Sachdev
OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile...
Objective: To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. Methods: UX001-CL301 was a Phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety of Ace-ER in patients with GNE Myopathy. Participants who could walk ≥200 meters in a 6-minute walk test at screening were randomized 1:1, and stratified by sex, to receive Ace-ER 6g/day or placebo for...
Extended abstracts from the 16th European Symposium on Comminution and Classification, ESCC 2019 held at the University of Leeds, 2-4 September 2019. Based on the abstracts received, the symposium was structured in the following themes: fundamentals of size reduction, innovations in milling and classification, nanomilling, mechano-chemistry and solid state transformations, pharmaceuticals and foods, attrition and wear, and related modelling. The notable number of abstracts received on modelling made it possible to divide them in sub-themes:...
Data from: Population structure, connectivity and demographic history of an apex marine predator, the bull shark Carcharhinus leucasAgathe Pirog, Virginie Ravigné, Michaël Fontaine, Adrien Rieux, Aude Gilabert, Geremy Cliff, Eric Clua, Ryan Daly, Michael Heithaus, Jeremy Kiszka, Philip Matich, John Nevill, Amy Smoothey, Andrew Temple, Per Berggren, Sebastien Jaquemet & Hélène Magalon
Knowledge of population structure, connectivity and effective population size remains limited for many marine apex predators, including the bull shark Carcharhinus leucas. This large-bodied coastal shark is distributed worldwide in warm temperate and tropical waters, and uses estuaries and rivers as nurseries. As an apex predator, the bull shark likely plays a vital ecological role within marine food webs, but is at risk due to inshore habitat degradation and various fishing pressures. We investigated the...
Data from: Arms races with mitochondrial genome soft sweeps in a gynodioecious plant, Plantago lanceolataRoberta Bergero, Nick Levsen, Kirsten Wolff & Deborah Charlesworth
Biological situations involving conflict can create arms race situations with repeated fixations of different functional variants, producing selective sweeps and lowering neutral diversity in genome regions linked to the functional locus. However, they can sometimes lead to balancing selection, potentially creating long coalescent times for sites with functionally different variants, and, if recombination occurs rarely, for extended haplotypes carrying such variants. We tested between these possibilities in a gynodioecious plant, Plantago lanceolata, in which cytoplasmic...
Barnacles are conspicuous members of rocky intertidal communities and settlement of the final larval stage, the cyprid, is influenced by the presence of biofilms. While modulation of cyprid settlement by biofilms has been studied extensively, the acquisition of a specific microbiome by the settling larva has not. This study investigated settlement in the field of Semibalanus balanoides in two consecutive years when the composition of the benthic bacterial community differed. In both years, settling cyprids...
Institute of Myology2
New Bulgarian University1
Seoul National University Bundang Hospital1
University of Strathclyde1
Centre for Ecology & Hydrology1
University of Queensland1
Ultragenyx Pharmaceutical (United States)1
Centre Hospitalier Universitaire D' Amiens1