1,490 Works

miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury

Yunguang Wang, Fangfang Feng, Wenfang He, Lifang Sun, Qiang He & Juan Jin
Mitochondrial injury-triggered podocyte apoptosis is a major risk factor for diabetic nephropathy (DN). However, the detailed relationship between mitochondrial homeostasis and podocyte apoptosis remains unclear. The present study aimed to explore the role and functional mechanism of germacrone in DN in type I diabetes (type I DN). A mouse model of type I DN was established by injecting streptozocin, and a podocyte injury model was constructed using high glucose (HG) induction. Histopathology was detected by...

Analysis of the genetic diversity of grain legume germplasm resources in China and the development of universal SSR primers

Runnan Zhou, Siqi Yang, Bo Zhang, Zhaoming Qi, Dawei Xin, Anyu Su, Sinan Li, Peng Cheng, Yunqi Bai, Zhengong Yin, Binshuo Zhang, Yujing Zhao, Ying Zhao, Qingshan Chen & Xiaoxia Wu
The research objects of this paper are Vigna angularis, Vigna radiata and Phaseolus vulgaris, which are important grain legume resources in China. However, the genetic structure between the three species is not clear. Therefore, this study developed a set of universal gSSR (simple sequence repeat) primers based on the whole-genome sequences of adzuki beans, mung beans and common beans and analysed the genetic diversity of the test resources based on universal gSSR loci. A total...

Analysis of the genetic diversity of grain legume germplasm resources in China and the development of universal SSR primers

Runnan Zhou, Siqi Yang, Bo Zhang, Zhaoming Qi, Dawei Xin, Anyu Su, Sinan Li, Peng Cheng, Yunqi Bai, Zhengong Yin, Binshuo Zhang, Yujing Zhao, Ying Zhao, Qingshan Chen & Xiaoxia Wu
The research objects of this paper are Vigna angularis, Vigna radiata and Phaseolus vulgaris, which are important grain legume resources in China. However, the genetic structure between the three species is not clear. Therefore, this study developed a set of universal gSSR (simple sequence repeat) primers based on the whole-genome sequences of adzuki beans, mung beans and common beans and analysed the genetic diversity of the test resources based on universal gSSR loci. A total...

Circular RNA–microRNA–mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma

Qiang Zhang, Yungang Sun, Chao Wang & Feng Shao
Circular RNAs (circRNAs) are involved in multiple physiological processes. However, whether circRNAs function as the indicators of lung adenocarcinoma (LUAD) remains unclear. Three LUAD-related microarray datasets were downloaded from the Gene Expression Omnibus database, and overlapping differentially expressed circRNAs (DECs) in LUAD were identified. circ_0007618 and circ_0029426 were revealed to be significantly dysregulated in LUAD and verified in LUAD tissues and serum obtained in this study. Subsequently, the overall survival curve and receiver operating characteristics...

Data from: Historical mitochondrial genome introgression confounds species delimitation—evidence from phylogenetic inference in the Odorrana grahami species complex

Dongyi Wu, Zhiyong Yuan, Yang Wen, Wei Xu, Wei Gao, A. Dahn Hollis, Xiaolong Liu, Jieqiong Jin, Chuanxin Yu, Jing Che & Heng Xiao
Species delimitation is essential to informing conservation policy and understanding ecological and evolutionary processes. Most of our recent gains in knowledge on animal diversity rely on morphological characteristics and mitochondrial (mt) DNA variation. Concordant results based on both have led to an unprecedented acceleration in the identification of new species and enriched the field of taxonomy. However, discordances are also found commonly between morphological and mtDNA evidence. This confounds species delimitation, especially when gene flow...

Expression status and prognostic value of autophagy-related lncRNAs in prostate cancer

Guo Chen, Xiaoping Qin, Yu Wang, Biyun Gao, Muan Ling, Wenjun Yin, Yutong Li & Bin Pan
LncRNAs involve in the autophagy to regulate prostate cancer (PCA) initiation and progression. Therefore, it urges to explore more significant AR-lncRNAs in PCa. mRNA data and clinical information of PCa were achieved from TCGA database, and ARGs were obtained from the HADb. AR-lncRNAs were identified by correlation analysis of DE ARGs and lncRNAs. Univariate Cox regression, LASSO regression, and multivariate Cox regression were used to identify the prognostic AR-lncRNA signature and constructed a risk model....

Crop heterogeneity is positively associated with beneficial insect diversity in subtropical farmlands

Eben Goodale, Tharaka S. Priyadarshana, Myung-Bok Lee, John S. Ascher & Lu Qiu
Increasing crop configurational heterogeneity – smaller crop fields with more field margins – has been repeatedly found to support farmland biodiversity. But research on compositional crop heterogeneity – the number and evenness of crop types – has usually shown only weak effects. However, much of this research has been conducted in large-scale temperate agroecosystems. We examined smallholder subtropical agroecosystems in southern China to assess the effects of crop heterogeneity on beneficial insect biodiversity. In addition...

Extraintestinal pathogenic Escherichia coli utilizes the surface-expressed elongation factor Tu to bind and acquire iron from holo-transferrin

Yu Sun, Xuhang Wang, Jin Li, Feng Xue, Fang Tang & Jianjun Dai
Extraintestinal pathogenic Escherichia coli (ExPEC) is a common anthropozoonotic pathogen that causes systemic infections. To establish infection, ExPEC must utilize essential nutrients including iron from the host. Transferrin is an important iron source for multiple bacteria. However, the mechanism by which ExPEC utilizes transferrin remains unclear. In this study, we found that iron-saturated holo-transferrin rather than iron-free apo-transferrin promoted the vitality of ExPEC in heat-inactivated human serum. The multifunctional protein Elongation factor Tu (EFTu) worked...

Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Yu Xie, Miaojuan Ye, Ying Zhang, Xiangjun Chen, Xiaoyong Wu, Yuyao Feng, Zhi Hong, Yigang Wang, Wei Liu & Cong Yi
Atg11 is an adaptor protein required for the induction of selective autophagy via receptor binding. However, our understanding of the molecular mechanisms by which it regulates selective autophagy remains incomplete. Here, we show that Atg11 is phosphorylated by Atg1. Rapamycin treatment or starvation conditions induced slower electrophoretic mobility of Atg11 in an Atg1 kinase activity-dependent manner. Through in vitro kinase assays combined with mutagenesis, we determined that Atg1 phosphorylates S949, S1057, and S1064 residues in...

Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Yu Xie, Miaojuan Ye, Ying Zhang, Xiangjun Chen, Xiaoyong Wu, Yuyao Feng, Zhi Hong, Yigang Wang, Wei Liu & Cong Yi
Atg11 is an adaptor protein required for the induction of selective autophagy via receptor binding. However, our understanding of the molecular mechanisms by which it regulates selective autophagy remains incomplete. Here, we show that Atg11 is phosphorylated by Atg1. Rapamycin treatment or starvation conditions induced slower electrophoretic mobility of Atg11 in an Atg1 kinase activity-dependent manner. Through in vitro kinase assays combined with mutagenesis, we determined that Atg1 phosphorylates S949, S1057, and S1064 residues in...

Кража безналичных и электронных денег: об актуальных проблемах правоприменения

Андрей Андреевич Байбарин & Дина Николаевна Садчикова
Предметом исследования выступают проблемы законодательной регламентации и практической реализации нормы об уголовной ответственности за кражу с банковского счета, а равно в отношении электронных денежных средств. Целью исследования является анализ особенностей законодательной регламентации и современных правоприменительных проблем, возникающих при привлечении к уголовной ответственности за кражу с банковского счета, а равно в отношении электронных денежных средств. Задачи исследования: проанализировать специфику законодательного регулирования уголовной ответственности за кражу с банковского счета, а равно в отношении электронных денежных средств, определить...

Effects of Chloride, Sulfate and Magnesium Ions on the Biomineralization of Calcium Carbonate Induced by Lysinibacillus xylanilyticus DB1-12

Huaxiao Yan, Meiyu Huang, Tiantian Wang, Yudong Xu, Long Meng, Lanmei Zhao, Zuozhen Han, Jihan Wang, Maurice E. Tucker & Hui Zhao
Microbially-induced calcium carbonate precipitation (MICP) has been studied extensively. However, the effect of different sources of magnesium ions on calcium carbonate biomineralization has rarely been examined. In this study, Lysinibacillus xylanilyticus DB1-12 bacteria isolated from petroleum samples were used to biomineralize calcium ions under the action of different sources of magnesium (magnesium chloride and magnesium sulfate). The results show that calcium ion precipitation ratios were much higher in MgSO4 group experiments than in the MgCl2...

Data from: The hydrochorous dispersal of plant propagules in a giant river reservoir: implications for restoration of riparian vegetation

Xiaolei Su, Shan Wu, Lovisa Lind, Fu Cai & Bo Zeng
The riparian vegetation of many rivers around the world is impacted by flow regulation for hydropower. Water levels behind dams are being raised to generate electric energy, forming river reservoirs. River regulation has a large impact on the riparian vegetation which influences both the adjacent aquatic and terrestrial ecosystems. Therefore, restoration of degraded riparian vegetation in river reservoirs has been of increasing research interest. Propagules dispersed from connected tributaries via water (hydrochory) are considered a...

Additional file 1 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 1: Supplementary Figure 1. Funnel plot in themeta-analysis on the association of waist circumference between prematureovarian insufficiency and control group. Supplementary Figure 2. Funnel plot in the meta-analysis on the association of systolic blood pressure betweenpremature ovarian insufficiency and control group. Supplementary Figure 3. Funnel plot in the meta-analysis on the association of diastolic blood pressurebetween premature ovarian insufficiency and control group. Supplementary Figure 4. Funnel plot in the meta-analysis on the association...

Additional file 2 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 2: Supplementary table 1. PRISMA 2022 checklist.

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cells overcome lipid peroxidation to sustain their metastatic colonization in the liver. Methods Orthotopic colorectal liver metastasis (CRLM) and CRC liver colonization mouse models were constructed to determine the roles of lipid peroxidation and AADAC in CRC liver colonization. The levels of...

Additional file 6 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 6: Figure S2. (A, F, K) Comparison of the relationship between the clinical characteristics of patients between high- and low-risk groups in the training, testing, and entire sets, respectively. (B–E) The scatter diagram showed the relationship between gender (B), clinical stage (C), T stage (D), N stage (E) and the risk score in the training set. (G–J) The scatter diagram showed the relationship between gender (G), clinical stage (E), T stage (F), N...

Additional file 2 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 2: Table S2. Median survival times for the high- and low- risk groups ESCC patients of survival curves stratified by these clinical characteristics in the training, testing, and entire sets.

Additional file 4 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 4: Table S3. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.

Additional file 1 of Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Additional file 1. Supplementary Tables and Figures.

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Abstract Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In the present study, we screened for the expression of oxidative stress-responsive miRNAs in the development of DCM. Furthermore, we aimed to explore the mechanism and therapeutic potential of miR-92a-2-5p in preventing diabetes-induced myocardial damage. Methods...

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Abstract Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In the present study, we screened for the expression of oxidative stress-responsive miRNAs in the development of DCM. Furthermore, we aimed to explore the mechanism and therapeutic potential of miR-92a-2-5p in preventing diabetes-induced myocardial damage. Methods...

EFFECT OF THE PROBLEM-BASED LEARNING METHOD ON STUDENT ELECTROENCEPHALOGRAMS AND MICROCIRCULATORY BLOOD PERFUSION IN THE TEACHING OF SPORTS PHYSIOLOGY

Xiaoli Liu, Huan Zhu, Shufeng Zhou, Yong Peng, Mei Yang, Fen Chen & Xiaoming Li
ABSTRACT Introduction Applying the problem-based learning (PBL) method to the teaching of sports physiology. Objective This study explored the mechanism of the PBL method to improve the interest and learning effectiveness of students. Methods Twenty male students at the Physical Education College of Hubei Minzu University were randomly divided into a PBL group (10) and a traditional teaching method group (TTM). During the test, the subjects in the TTM group sat quietly listening to the...

CTPS1 suppresses proliferation and migration in colorectal cancer cells

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei, Tianwei Wang, Jia Wang & Youcheng Zhang
Colorectal cancer (CRC) is now the third most prevalent tumor and one of the deadliest cancers worldwide, with an increasing prevalence every year. Therefore, we urgently need to understand the mechanisms regulating the progression of colorectal cancer and find potential diagnostic biomarkers. In this study, we performed an analysis using the TCGA and GEO databases to find a molecular biomarker for the diagnosis of CRC, namely CTPS1. The results of this analysis revealed that CTPS1...

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Géraldine Leduc, Tristan Doussineau, Yan Wang, Qiang Liu & Olivier Tillement
Abstract In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and reduce the damage of radiation to neighboring normal tissues, radiosensitizers have been given increasing attention in recent years. As nanoparticles based on the metal element gadolinium, AGuIX nanoparticles have been shown to increase the radiosensitivity of cancers. Although it is a rare nanomaterial that has entered...

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