Supplemental material, sj-pdf-1-ras-10.1177_00208523211012752 for Exploring e-maturity in Italian local governments: empirical results from a three-step latent class analysis by Luca Tangi, Mara Soncin, Tommaso Agasisti and Giuliano Noci in International Review of Administrative Sciences

Supplemental material, sj-pdf-1-ras-10.1177_00208523211012752 for Exploring e-maturity in Italian local governments: empirical results from a three-step latent class analysis by Luca Tangi, Mara Soncin, Tommaso Agasisti and Giuliano Noci in International Review of Administrative Sciences

This article undertakes a quantitative and holistic approach to frame a model of e-maturity in local governments, defined as the extent to which technologies permeate public service delivery. Moreover, the study adds evidence on the performance associated with different levels of e-maturity. In so doing, we collect survey data from 814 Italian local governments and integrate it with secondary sources. We propose a new angle for assessing e-maturity at the local government level, where the...

Green and blue water currently used in the Spanish NEL [m3/y]

Green and blue water currently used in the Italian NEL [mm] for durum wheat (1), olives (22) and sunflowers (23).

In-stent restenosis in superficial femoral arteries (SFAs) is a complex, multi-factorial and multi-scale vascular adaptation process whose thorough understanding is still lacking. Multi-scale computational agent-based modelling has recently emerged as a promising approach to decipher mechanobiological mechanisms driving the arterial response to the endovascular intervention. However, the long-term arterial response has never been investigated with this approach, although being of fundamental relevance. In this context, this study investigates the 1-year post-operative arterial wall remodelling in...

This work explores how the narrative on immigration changes when society is threatened by “real” risks, i.e., during the COVID-19 health crisis. We compared the frequency and engagement of over 348,684 posts published on Facebook between December 2019 and November 2020 by Italian politicians and news media. We identified two waves of “tangible crisis” assuming that in these two periods the risk stemming from COVID-19 was strongly perceived by the Italian population, contrasting our observations...

Additional file 4: Table S3. Bacteria used for genome analysis.

Additional file 7: Table S7. Summary of the number of samples assigned to secondary classes with peculiar molecular features as MSI status, BRAF/KRAS mutation and EMT, WNT and paneth scoring. For dichotomous variables, hypergeometric p-value has been computed to assign statistical significance at the ratio Observed over the Expected. For continuous variable, Student's T-test was performed. NC, not assigned to reference class, i.e. not assigned to that class.

Additional file 7: Table S7. Summary of the number of samples assigned to secondary classes with peculiar molecular features as MSI status, BRAF/KRAS mutation and EMT, WNT and paneth scoring. For dichotomous variables, hypergeometric p-value has been computed to assign statistical significance at the ratio Observed over the Expected. For continuous variable, Student's T-test was performed. NC, not assigned to reference class, i.e. not assigned to that class.

Additional file 17: Table S16. Multi-label assignments of the algorithm-adapted LSVM on PDX samples, compared with multi-label assignments from the multiCRIS version of the NTP approach.

This paper investigates the economic impact of the three tiers risk framework implemented in Italy against the COVID-19 pandemic during the Autumn of 2020. Exploiting a large-scale dataset encompassing daily credit card transactions mediated by a large Italian bank, we estimate a set of panel event study models to disentangle the impact of restrictions with low, medium and high stringency levels in terms of consumption reduction. We show that space-time differentiated policies tend to produce...

Supplemental Material for Do We Learn From Errors? The Economic Impact of Differentiated Policy Restrictions in Italy by Francesco Scotti, Andrea Flori, Giovanni Bonaccorsi, and Fabio Pammolli in International Regional Science Review.

Additional file 2: Figure S3. ESI–MS experiment for guanine produced by 34mel. Figure S4. ESI–MS and MS/MS experiments for commercial guanine. Figure S5. 1H-NMR characterization of 34mel crystals. Figure S6. UV–vis spectra for commercial and 34mel guanine in acid solution. Additional data 1. Elemental analysis of crystals purified from 34mel.

IntroductionLimb ischemia is a severe complication of peripheral veno-arterial extracorporeal life support (V-A ECLS). Several techniques have been developed to prevent this, but it remains a major and frequent adverse event (incidence: 10–30%). In 2019, a new cannula with bidirectional flow (retrograde towards the heart and antegrade towards the distal limb) has been introduced. A single-centre experience with this cannula in patients undergoing peripheral V-A ECLS is herewith reported.MethodsThis prospective observational study included adults (≥18...

Green and blue water currently used in the NEL in Tunisia [m3/y]

Green and blue water currently used in the NEL in Egypt [m3/y]

Green and blue water currently used in the Italian NEL [mm] for durum wheat (1), olives (22) and sunflowers (23).

Additional file 8: Figure S1. Distribution of genes detected in scRNA-seq data of patient derived organoidswith a coverage of 1 to 5 reads for transcripts. Figure S2. Distribution of Pearson correlation values obtained by analysing unmatchedand matchedCRC PDO bulk / PDO pseudo-bulk pairs. Figure S3. CRIS classification of CRC single sample data from GSE132465, pseudo-bulk, and at scRNA-seq resolution. B) represents the distribution of CRIS distances evaluated on each single cell, grey points. Black points...

Abstract Background Transcriptional classification has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent discrete, mutually exclusive entities or molecular/phenotypic states with potential overlap. Therefore, we focused on the CRC Intrinsic Subtype (CRIS) classifier and evaluated whether assigning multiple CRIS subtypes to the same sample provides additional clinically and biologically relevant information. Methods A multi-label version of the CRIS...

Additional file 14: Table S13. Single-label performance evaluations of the considered algorithms on testing data, comparing their results with the ones of the original NTP approach.

Additional file 13: Table S12a. NTP-based multiCRIS classification on the single-cell RNA-seq profiles from CRC patient. NTP analysis has been performed on scRNA-seq CRC patient data identifying cell with Single-label class CRIS, Multi-labels classes CRIS, and Not classification. For classassignmentby NTP, FDR < 0.2 was considered significant. Table S12b. NTP-based multiCRIS classification on the single-cell RNA-seq profiles from CRC patient. Summary table of NTP results on total single-cells datasets and at sample levels with percentages...

Additional file 12: Table S11. NTP-based multiCRIS classification on pseudo-bulk CRC patients. NTP analysis has been performed on CRC patients data identifying sample with Single-label CRIS classification, Multi-labels CRIS classification, and Not classification. For classassignmentby NTP, FDR < 0.2 was considered significant.

Additional file 15: Table S14. Multi-label performance evaluations of the considered algorithm-adapted strategies on testing data, comparing their results with multi-label assignments obtained from the multiCRIS version of the NTP approach.

Additional file 2: Table S2. Assignment of 620 TCGA samples using the Nearest Template PredictionmultiCRIS classifier. In the results, we identified samples with single label class CRIS, multi-label classes CRIS, and not classified. For classassignmentby NTP, FDR < 0.2 was considered significant.