34 Works

Data from: Late-life and intergenerational effects of larval exposure to microbial competitors in the burying beetle Nicrophorus vespilloides

Ailsa H. C. McLean, Andres N. Arce, Per T. Smiseth & Daniel E. Rozen
Intergenerational effects can have either adaptive or nonadaptive impacts on offspring performance. Such effects are likely to be of ecological and evolutionary importance in animals with extended parental care, such as birds, mammals and some insects. Here, we studied the effects of exposure to microbial competition during early development on subsequent reproductive success in the burying beetle Nicrophorus vespilloides, an insect with elaborate parental care. We found that exposure to high levels of microbial competition...

Data from: Genotypic variation in a foundation tree (Populus tremula L.) explains community structure of associated epiphytes

Chantel Davies, Christopher J. Ellis, Glenn R. Iason & Richard A. Ennos
Community genetics hypothesizes that within a foundation species the genotype of an individual significantly influences the assemblage of dependent organisms. To assess whether these intra-specific genetic effects are ecologically important, it is required to compare their impact on dependent organisms with that attributable to environmental variation experienced over relevant spatial scales. We assessed bark epiphytes on 27 aspen (Populus tremula L.) genotypes grown in a randomized experimental array at two contrasting sites spanning the environmental...

Data from: ABC inference of multi-population divergence with admixture from unphased population genomic data

John D. Robinson, Lynsey Bunnefeld, Jack Hearn, Graham N. Stone & Michael J. Hickerson
Rapidly developing sequencing technologies and declining costs have made it possible to collect genome-scale data from population-level samples in non-model systems. Inferential tools for historical demography given these datasets are, at present, underdeveloped. In particular, approximate Bayesian computation (ABC) has yet to be widely embraced by researchers generating these data. Here, we demonstrate the promise of ABC for analysis of the large datasets that are now attainable from non-model taxa through current genomic sequencing technologies....

Data from: Role of sex and migration in adaptation to sink environments

Mato Lagator, Andrew Morgan, Paul Neve & Nick Colegrave
Understanding the effects of sex and migration on adaptation to novel environments remains a key problem in evolutionary biology. Using a single-cell alga Chlamydomonas reinhardtii, we investigated how sex and migration affected rates of evolutionary rescue in a sink environment, and subsequent changes in fitness following evolutionary rescue. We show that sex and migration affect both the rate of evolutionary rescue and subsequent adaptation. However, their combined effects change as the populations adapt to a...

Data from: Parasitism in early life: environmental conditions shape intra-brood variation in responses to infection

Hanna M. V. Granroth-Wilding, Sarah J. Burthe, Sue Lewis, Thomas E. Reed, Katherine A. Herborn, Mark A. Newell, Emi A. Takahashi, Francis Daunt & Emma J. A. Cunningham
Parasites play key ecological and evolutionary roles through the costs they impose on their host. In wild populations, the effect of parasitism is likely to vary considerably with environmental conditions, which may affect the availability of resources to hosts for defense. However, the interaction between parasitism and prevailing conditions is rarely quantified. In addition to environmental variation acting on hosts, individuals are likely to vary in their response to parasitism, and the combined effect of...

Data from: Why do frog and toad forelimbs suddenly (but asynchronously) appear every time metamorphosis is near?

Luigi Zechini, Alison Lilley, J. Roger Downie & Patrick T. Walsh
1. The internal development and the emergence of the forelimbs at metamorphosis is a defining feature of anuran amphibians (frogs and toads). However, although forelimb emergence is considered sudden, it is rarely synchronous. Any asynchrony may or may not exacerbate the increased drag that is predicted to occur with the emergence of the forelimbs at metamorphic climax. 2. Despite the impact forelimb emergence is hypothesized to have on individual survival and life-history evolution, the degree...

Data from: The early spread and epidemic ignition of HIV-1 in human populations

Nuno R. Faria, Andrew Rambaut, Marc A. Suchard, Guy Baele, Trevor Bedford, Melissa J. Ward, Andrew J. Tatem, João D. Sousa, Nimalan Arinaminpathy, Jacques Pépin, David Posada, Martine Peeters, Oliver P. Pybus & Philippe Lemey
Thirty years after the discovery of HIV-1, the early transmission, dissemination and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa was the focus of early transmission and the source of pre-1960 pandemic viruses elsewhere. Location and dating estimates were validated using the earliest HIV-1 archival sample, also from Kinshasa. The epidemic histories of HIV-1 group M...

Data from: Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes

Vaishali Katju, Lucille B. Packard, Lijing Bu, Peter David Keightley & Ulfar Bergthorsson
The rate and fitness effects of new mutations have been investigated by mutation accumulation (MA) experiments in which organisms are maintained at a constant minimal population size to facilitate the accumulation of mutations with minimal efficacy of selection. We evolved 35 MA lines of Caenorhabditis elegans in parallel for 409 generations at three population sizes (N = 1, 10, and 100), representing the first spontaneous long-term MA experiment at varying population sizes with corresponding differences...

Data from: Gradual assembly of avian body plan culminated in rapid rates of evolution across dinosaur-bird transition

Stephen L. Brusatte, Graeme T. Lloyd, Steve C. Wang & Mark A. Norell
Brusatte et al. 2014 Current Biology Dryad File1Supplementary appendices: list of phylogenetic characters, phylogenetic character-taxon matrix, list of taxon ages, list of supplementary figure captions (relevant to Dryad File 2)BrusatteetalRevisionDryadFile1.docxBrusatte et al. 2014 Current Biology Dryad File2Supplementary figuresBrusatteetalRevisionDryadFile2.pdfBrusatte et al. 2014 Current Biology Dryad File3R code (Graeme T. Lloyd)BrusatteetalRevisionDryadFile3.zip

Data from: Inferring heterogeneous evolutionary processes through time: from sequence substitution to phylogeography

Filip Bielejec, Philippe Lemey, Guy Baele, Andrew Rambaut & Marc A. Suchard
Molecular phylogenetic and phylogeographic reconstructions generally assume time-homogeneous substitution processes. Motivated by computational convenience, this assumption sacrifices biological realism and offers little opportunity to uncover the temporal dynamics in evolutionary histories. Here, we propose an evolutionary approach that explicitly relaxes the time-homogeneity assumption by allowing the specification of different infinitesimal substitution rate matrices across different time intervals, called epochs, along the evolutionary history. We focus on an epoch model implementation in a Bayesian inference framework...

Data from: Population clustering and clonal structure evidence the relict state of Ulmus minor Mill. in the Balearic Islands

Luis Gil, Pablo Fuentes-Utrilla, María Valbuena-Carabaña & Richard Ennos
Field elm (Ulmus minor) is a riparian tree that grows in rare, small populations scattered along temporary watercourses in the Balearic Islands, nowadays mostly covered with Mediterranean vegetation. Agriculture and farming on the fertile land along the periodically flooded plains have reduced the elm populations to sparse tree lines along the creek beds. The presence of field elm in this very anthropic landscape has led some authors to consider it as an introduced species in...

Data from: Reassortment patterns of avian influenza virus internal segments among different subtypes

Lu Lu, Samantha J. Lycett & Andrew J. Leigh Brown
Background: The segmented RNA genome of avian Influenza viruses (AIV) allows genetic reassortment between co-infecting viruses, providing an evolutionary pathway to generate genetic innovation. The genetic diversity (16 haemagglutinin and 9 neuraminidase subtypes) of AIV indicates an extensive reservoir of influenza viruses exists in bird populations, but how frequently subtypes reassort with each other is still unknown. Here we quantify the reassortment patterns among subtypes in the Eurasian avian viral pool by reconstructing the ancestral...

Data from: Estimating quantitative genetic parameters in wild populations: a comparison of pedigree and genomic approaches

Camillo Bérénos, Philip A. Ellis, Jill G. Pilkington & Josephine M. Pemberton
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to less biased and more precise estimates. We estimated heritability, maternal genetic effects and genetic correlations for body size traits in an unmanaged long-term study population of Soay sheep on St Kilda using three increasingly complete and accurate estimates of relatedness:...

Measurements of respiration and microbial assimilation of carbon substrates and priming of soil organic matter mineralisation in tropical lowland and montane forest soils

J. Whitaker, N. Ostle, N. McNamara, A.T. Nottingham, A.W. Stott, R.D. Bardgett, N. Salinas, A.J.Q. Ccahuana & P. Meir
This dataset includes measurements of microbial community composition by phospholipid fatty acid (PLFA) analysis, soil respiration (Carbon dioxide (CO2)), soil physico-chemical properties and 13C enrichment in CO2 samples and microbial Phospholipid Fatty Acids (PLFAs). Data were produced for an investigation of the effects of carbon (C) substrate addition on soil carbon cycling processes in ten tropical soils from the Peruvian Andes. Soils were amended with 13C labelled substrates (xylose, glycine, vanillin and hemicellulose) and incubated...

Data from: Detecting slow introgression of invasive alleles in an extensively restocked game bird

Ines Sanchez-Donoso, Jisca Huisman, Jorge Echegaray, Manel Puigcerver, José Domingo Rodríguez-Teijeiro, Frank Hailer & Carles Vilà
Interbreeding of two species in the wild implies introgression of alleles from one species into the other only when admixed individuals survive and successfully backcross with the parental species. Consequently, estimating the proportion of first generation hybrids in a population may not inform about the evolutionary impact of hybridization. Samples obtained over a long time span may offer a more accurate view of the spreading of introgressed alleles in a species’ gene pool. Common quail...

Data from: Plasticity predicts evolution in a marine alga

C. Elisa Schaum & Sinéad Collins
Under global change, populations have four possible responses: ‘migrate, acclimate, adapt or die’ (Gienapp et al. 2008 Climate change and evolution: disentangling environmental and genetic response. Mol. Ecol. 17, 167–178. (doi:10.1111/j.1365-294X.2007.03413.x)). The challenge is to predict how much migration, acclimatization or adaptation populations are capable of. We have previously shown that populations from more variable environments are more plastic (Schaum et al. 2013 Variation in plastic responses of a globally distributed picoplankton species to ocean...

Data from: Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring

Laura C. Pollitt, Derek Sim, Rahel Salathé & Andrew F. Read
Artemisinin-based drugs are the front-line weapon in the treatment of human malaria cases, but there is concern that recent reports of slow clearing infections may signal developing resistance to treatment. In the absence of molecular markers for resistance, current efforts to monitor drug efficacy are based on the rate at which parasites are cleared from infections. However, some knowledge of the standing variation in parasite susceptibility is needed to identify a meaningful increase in infection...

Data from: The evolutionary dynamics of sexually antagonistic mutations in pseudoautosomal regions of sex chromosomes

Brian Charlesworth, Crispin Y. Jordan & Deborah Charlesworth
Sex chromosomes can evolve gene contents that differ from the rest of the genome, as well as larger sex differences in gene expression compared with autosomes. This probably occurs because fully sex-linked beneficial mutations substitute at different rates from autosomal ones, especially when fitness effects are sexually antagonistic (SA). The evolutionary properties of genes located in the recombining pseudo-autosomal region (PAR) of a sex chromosome have not previously been modelled in detail. Such PAR genes...

Data from: The effect of funding sources on donepezil randomised controlled trial outcome: a meta-analysis

Lewis O. J. Killin, Tom C. Russ, John M. Starr, Sharon Abrahams & Sergio Della Sala
Objective: To investigate whether there is a difference in the treatment effect of donepezil on cognition in Alzheimer disease between industry-funded and independent randomised controlled trials. Design: Fixed effects meta-analysis of standardised effects of donepezil on cognition as measured by the Mini Mental State Examination and the Alzheimer’s Disease Assessment Scale-cognitive subscale. Data sources: Studies included in the meta-analyses reported in the National Institute for Health and Care Excellence (NICE) technical appraisal 217 updated with...

Data from: The action of stabilizing selection, mutation and drift on epistatic quantitative traits

Victoria Ávila, Andrés Pérez-Figueroa, Armando Caballero, William G. Hill, Aurora García-Dorado & Carlos López-Fanjul
For a quantitative trait under stabilizing selection, the effect of epistasis on its genetic architecture and on the changes of genetic variance caused by bottlenecking were investigated using theory and simulation. Assuming empirical estimates of the rate and effects of mutations and the intensity of selection, we assessed the impact of two-locus epistasis (synergistic/antagonistic) among linked or unlinked loci on the distribution of effects and frequencies of segregating loci in populations at the mutation-selection-drift balance....

Data from: Faster-X Effects in two Drosophila lineages

Victoria Ávila, Sophie Marion De Procé, José L. Campos, Helen Borthwick, Brian Charlesworth & Andrea J. Betancourt
Under certain circumstances, X-linked loci are expected to experience more adaptive substitutions than similar autosomal loci. To look for evidence of faster-X evolution, we analyzed the evolutionary rates of coding sequences in two sets of Drosophila species, the melanogaster and pseudoobscura clades, using whole-genome sequences. One of these, the pseudoobscura clade, contains a centric 15 fusion between the ancestral X chromosome and the autosomal arm homologous to 3L in D.melanogaster. This offers an opportunity to...

Data from: Determining the phylogenetic and phylogeographic origin of highly pathogenic avian influenza (H7N3) in Mexico

Lu Lu, Samantha J. Lycett & Andrew J. Leigh Brown
Highly pathogenic (HP) avian influenza virus (AIV) H7N3 outbreaks occurred 3 times in the Americas in the past 10 years and caused severe economic loss in the affected regions. In June/July 2012, new HP H7N3 outbreaks occurred at commercial farms in Jalisco, Mexico. Outbreaks continued to be identified in neighbouring states in Mexico till August 2013. To explore the origin of this outbreak, time resolved phylogenetic trees were generated from the eight segments of full-length...

Data from: The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus

Jannice Friedman, Alex D. Twyford, John H. Willis & Benjamin K. Blackman
Differential natural selection acting on populations in contrasting environments often results in adaptive divergence in multivariate phenotypes. Multivariate trait divergence across populations could be caused by selection on pleiotropic alleles or through many independent loci with trait-specific effects. Here, we assess patterns of association between a suite of traits contributing to life history divergence in the common monkeyflower, Mimulus guttatus, and examine the genetic architecture underlying these correlations. A common garden survey of 74 populations...

Data from: Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii

Andrew D. Morgan, Rob W. Ness, Peter David Keightley & Nick Colegrave
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rate at which new genetic variation for fitness is created by mutation, are important for the understanding of many biological processes. However, the causes of interspecific variation in mutational parameters and the extent to which they vary within species remain largely unknown. We maintained multiple strains of the unicellular eukaryote Chlamydomonas reinhardtii, for approximately 1000 generations under relaxed selection...

Data from: Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses

Mato Lagator, Nick Colegrave & Paul Neve
In rapidly changing environments, selection history may impact the dynamics of adaptation. Mutations selected in one environment may result in pleiotropic fitness trade-offs in subsequent novel environments, slowing the rates of adaptation. Epistatic interactions between mutations selected in sequential stressful environments may slow or accelerate subsequent rates of adaptation, depending on the nature of that interaction. We explored the dynamics of adaptation during sequential exposure to herbicides with different modes of action in Chlamydomonas reinhardtii....

Registration Year

  • 2014

Resource Types

  • Dataset


  • University of Edinburgh
  • University of Glasgow
  • National Institutes of Health
  • David Geffen School of Medicine at UCLA
  • University of Cambridge
  • University of Warwick
  • University of Manchester
  • French National Centre for Scientific Research
  • American Museum of Natural History
  • University of California Los Angeles