49 Works

What Peer-review Experiences Can Offer To Early Career Scientists And To The Scientific Community

Gwenaëlle Gremion, Mathieu Casado, Kelsey Aho, Jilda Alicia Caccavo, Nicolas Champollion, Emily Choy, Sarah L. Connors, Rahul Dey, Alfonso Fernandez, Gerlis Fugmann, Juan Höfer, Shridhar Jawak, Martine Lizotte, Sarah Maes, Kyle Mayers, Katja Mintenbeck, Jhon Fredy Mojica Moncada, Prashant H. Pandit, Elvira Poloczanska, Paul Rosenbaum, Elisa Seyboth, Sarah Shakil & Maud van Soest

Mass spectrometry data of Chalmydomonas reinhardtii central pair mutants

Khanh Huy Bui, Muneyoshi Ichikawa, Daniel Dai, Reid Rebinsky & Katya Peri
The following data includes the mass spectrometry results from 5 different strains of Chlamydomonas reinhardtii. The first strain is CC-124 or more commonly referred to as the wild type strain. The second strain is a mutant that lacks the central pair pf15. Other central pair mutants are pf16, pf6 and cpc1. All strains were cultured under identical conditions and the doublet microtubules were purified and treated twice with NaCl before mass spectrometry. Biological triplicates were...

Communities that thrive in extreme conditions captured from a freshwater lake

Etienne Low-Decarie, Gregor F. Fussmann, Alex J. Dumbrell & Graham Bell
Organisms that can grow in extreme conditions would be expected to be confined to extreme environments. However, we were able to capture highly productive communities of algae and bacteria capable of growing in acidic (pH 2), basic (pH 12) and saline (40 ppt) conditions from an ordinary freshwater lake. Microbial communities may thus include taxa that are highly productive in conditions that are far outside the range of conditions experienced in their host ecosystem. The...

Data from: Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation

Josué Haubrich, Matteo Bernabo & Karim Nader
Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we extend the understanding of the mechanisms implicated in reconsolidation-resistant memories by investigating the hypothesis that specific modulatory signals shape memory formation into a state that...

Fish mock community with 41 species from 13 orders

Jose Sergio Hleap, Joanne E. Littlefair, Dirk Steinke, Paul D. N. Hebert & Melania E. Cristescu
Tissue extracts of 41 North American fish species were obtained from the Ministère des Forêts, de la Faune et des Parcs (Québec). The selected species were chosen to represent a diversity of families within the Actinopterygii, and to include some species known to be present at the Experimental Lakes Area. Muscle or fin tissue was extracted using Qiagen Blood and Tissue kits and equimolarised to 15ng/µl. Library preparation and next-generation sequencing (NGS) was performed by...

The evolution of reproductive isolation in Daphnia

Tiffany Chin, Carla E. Cáceres & Melania E. Cristescu
Background The process by which populations evolve to become new species involves the emergence of various reproductive isolating barriers (RIB). Despite major advancements in understanding this complex process, very little is known about the order in which RIBs evolve or their relative contribution to the total restriction of gene flow during various stages of speciation. This is mainly due to the difficulties of studying reproductive isolation during the early stages of species formation. This study...

A global meta-analysis of temperature effects on marine fishes’ digestion across trophic groups

Nicole Knight, Frederic Guichard & Andrew Altieri
Aim: The temperature constraint hypothesis proposes that marine herbivorous fishes are rare at high latitudes relative to carnivorous fishes because low temperatures impair the digestion of plant material. To test this hypothesis, we compared the effects of temperature on the digestive performance and investment of marine fishes across trophic groups. Location: Global marine ecosystems. Major Taxa Studied: Marine fishes. Methods: We analyzed data from 304 species consuming a range of diets to quantify the effects...

Environmental drivers of Sphagnum growth in peatlands across the Holarctic region

Fia Bengtsson, Håkan Rydin, Jennifer Baltzer, Luca Bragazza, Zhao-Jun Bu, Simon Caporn, Ellen Dorrepaal, Kjell Ivar Flatberg, Olga Galanina, Mariusz Gałka, Anna Ganeva, Irina Goia, Nadezhda Goncharova, Michal Hajek, Akira Haraguchi, Lorna Harris, Elyn Humphreys, Martin Jiroušek, Katarzyna Kajukało, Edgar Karofeld, Natalia Koronatova, Natalia Kosykh, Anna Laine, Mariusz Lamentowicz, Elena Lapshina … & Richard J. Payne
The relative importance of global versus local environmental factors for growth and thus carbon uptake of the bryophyte genus Sphagnum – the main peat-former and ecosystem engineer in northern peatlands – remains unclear. 2) We measured length growth and net primary production (NPP) of two abundant Sphagnum species across 99 Holarctic peatlands. We tested the importance of previously proposed abiotic and biotic drivers for peatland carbon uptake (climate, N deposition, water table depth, and vascular...

Adding the third dimension to studies of parallel evolution of morphology and function: an exploration based on parapatric lake-stream stickleback

Grant Haines, Yoel Stuart, Dieta Hanson, Tania Tasneem, Daniel Bolnick, Hans Larsson & Andrew Hendry
Recent methodological advances have led to a rapid expansion of evolutionary studies employing three-dimensional landmark-based geometric morphometrics (GM). GM methods generally enable researchers to capture and compare complex shape phenotypes, and to quantify their relationship to environmental gradients. However, some recent studies have shown that the common, inexpensive, and relatively rapid two-dimensional GM methods can distort important information and produce misleading results because they cannot capture variation in the depth (Z) dimension. We use micro-CT...

Genetic and phenotypic diversity of guppy population pre- and post-flood disturbance

Léa Blondel
Rare extreme “black swan” disturbances can impact ecosystems in many ways, such as destroying habitats, depleting resources, and causing high mortality. In rivers, for instance, exceptional floods that occur infrequently (e.g., so-called “50-year floods”) can strongly impact the abundance of fishes and other aquatic organisms. Beyond such ecological effects, these floods could also impact intraspecific diversity by elevating genetic drift or dispersal and by imposing strong selection, which could then influence the population’s ability to...

Effect of the Central American Isthmus on gene flow and divergence of the American crocodile Crocodylus acutus

Jose Avila-Cervantes, Carlos Arias, Miryam Venegas-Anaya, Marta Vargas, Hans C. E. Larsson & W. Owen McMillan
The final formation of the Central American Isthmus (CAI) about 3.5 Ma altered global ocean circulation, connected North and South America terrestrial biotas and established the Caribbean Sea. The nature of this event creates a natural scenario to test vicariance, divergence, and speciation by allopatry. Studies have shown the effect of the CAI on marine and terrestrial species, but none have examined a large-bodied amphibious taxon. We used RAD sequencing on populations of the American...

Thermal stratification and fish thermal preference explain vertical eDNA distributions in lakes

Joanne Littlefair, Lee Hrenchuk, Paul Blanchfield, Michael Rennie & Melania Cristescu
Significant advances have been made towards surveying animal and plant communities using DNA isolated from environmental samples. Despite rapid progress, we lack a comprehensive understanding of the “ecology” of environmental DNA (eDNA), particularly its temporal and spatial distribution and how this is shaped by abiotic and biotic processes. Here, we tested how seasonal variation in thermal stratification and animal habitat preferences influence the distribution of eDNA in lakes. We sampled eDNA depth profiles of five...

Seasonal upwelling reduces herbivore control of tropical rocky intertidal algal communities

Andrew Sellers, Brian Leung, Andrew Altieri, Benjamin Turner, Jess Glanz & Mark Torchin
Communities are shaped by a variety of ecological and environmental processes, each acting at different spatial scales. Seminal research on rocky shores highlighted the effects of consumers as local determinants of primary productivity and community assembly. However, it is now clear that the species interactions shaping communities at local scales are themselves regulated by large-scale oceanographic processes that generate regional variation in resource availability. Upwelling events deliver nutrient-rich water to coastal ecosystems, influencing primary productivity...

Polybrominated diphenyl ethers in human follicular fluid dysregulate mural and cumulus granulosa cell gene expression

Barbara Hales
Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants incorporated into numerous consumer products, leach out into dust resulting in widespread exposure. There is evidence from in vitro and in vivo animal studies that PBDEs affect ovarian granulosa cell function and follicular development, yet human studies of their association with female infertility are inconclusive. Here, we tested the hypothesis that exposure to the PBDEs in follicular fluid is associated with dysregulation of gene expression...

Data for: Environmental conditions alter behavioural organization and rhythmicity of a large Arctic ruminant across the annual cycle

Floris Van Beest, Laissa Beumer, Marianna Chimienti, Jean-Pierre Desforges, Nicholas Huffeldt, Stine Pedersen & Niels Schmidt
The existence and persistence of rhythmicity in animal activity during phases of environmental change is of interest in ecology and chronobiology. A wide diversity of biological rhythms in response to exogenous conditions and internal stimuli have been uncovered, especially for polar vertebrates. However, empirical data supporting circadian organization of large ruminating herbivores remains inconclusive. Using year-round tracking data of the largest Arctic ruminant, the muskox (Ovibos moschatus), we modelled rhythmicity as a function of behaviour...

Code for individual-based simulations in \"Environmental fluctuations can promote evolutionary rescue in high-extinction-risk scenarios\"

James Peniston, Michael Barfield, Andrew Gonzalez & Robert Holt
Substantial environmental change can force a population onto a path towards extinction, but under some conditions, adaptation by natural selection can rescue the population and allow it to persist. This process, known as evolutionary rescue, is believed to be less likely to occur with greater magnitudes of random environmental fluctuations because environmental variation decreases expected population size, increases variance in population size, and increases evolutionary lag. However, previous studies of evolutionary rescue in fluctuating environments...

Patient burden and clinical advances associated with post-approval monotherapy cancer drug trials: a systematic review

Benjamin Gregory Carlisle, Adélaïde Doussau & Jonathan Kimmelman
Objectives: After regulatory approval, drug companies, public funding agencies and academic researchers often pursue trials aimed at extending the uses of a new drug by testing it in new non-approved indications. Patient burden and clinical impact of such research is not well understood. Design/setting: We conducted a retrospective cohort study of post-approval clinical trials launched within five years after the drug's first approval, testing anticancer drugs in monotherapy in indications that were first pursued after...

Data from: Stressed connections: cortisol levels following acute psychosocial stress disrupt affiliative mimicry in humans

Jonas P. Nitschke, Cecile S. Sunahara, Evan W. Carr, Piotr Winkielman, Jens C. Pruessner & Jennifer A. Bartz
Mimicry, and especially spontaneous facial mimicry, is a rudimentary element of social–emotional experience that is well-conserved across numerous species. Although such mimicry is thought to be a relatively automatic process, research indicates that contextual factors can influence mimicry, especially in humans. Here, we extend this work by investigating the effect of acute psychosocial stress on spontaneous facial mimicry. Participants performed a spontaneous facial mimicry task with facial electromyography (fEMG) at baseline and approximately one month...

Data from: Differential impact of severe drought on infant mortality in two sympatric neotropical primates

Fernando Campos, Urs Kalbitzer, Amanda Melin, Jeremy Hogan, Saul Cheves, Evin Murillo-Chacon, Adrián Guadamuz, Monica Myers, Colleen Schaffner, Katharine Jack, Filippo Aureli & Linda Fedigan
Extreme climate events can have important consequences for the dynamics of natural populations, and severe droughts are predicted to become more common and intense due to climate change. We analysed infant mortality in relation to drought in two primate species (white-faced capuchins, Cebus capucinus imitator, and Geoffroy's spider monkeys, Ateles geoffroyi) in a tropical dry forest in north-western Costa Rica. Our survival analyses combine several rare and valuable long-term data sets, including long-term primate life-history,...

Differential ESR1 promoter Methylation in the peripheral blood of healthy middle-aged and older women- findings from the women 40+ healthy aging study

Elena Gardini, Gary G. Chen, Serena Fiacco, Laura Mernone, Jasmine Willi, Gustavo Turecki & Ulrike Ehlert
Background Estrogen receptor alpha (ERα) contributes to maintain biological processes preserving health during aging. DNA methylation changes of ERα gene (ESR1) were established as playing a direct role in the regulation of ERα levels. In this study, we hypothesized decreased DNA methylation of ESR1 associated with postmenopause, lower estradiol levels and increased age among healthy middle-aged and older women. Methods We assessed DNA methylation of ESR1 promoter region from dried blood spots and estradiol from...

Data for: Parasitism risk and infection alter host dispersal

Celina Baines, Salma Diab & Shannon McCauley
Dispersal determines the spatial dynamics of host-parasite assemblages, particularly during invasions and disease epidemics. The risk of parasitism may create an incentive for dispersal, but infection is expected to reduce dispersal ability, which may alter the host’s dispersal response to biotic stressors including population density. We measured the dispersal of the semi-aquatic insect, Notonecta undulata, in aquatic mesocosms in which we manipulated the presence of ectoparasitic Hydrachnidia mites and of infected conspecifics. We found that...

Five-years of ocrelizumab in relapsing multiple sclerosis: OPERA studies open-label extension

Stephen L Hauser, Ludwig Kappos, Douglas L Arnold, Amit Bar-Or, Bruno Brochet, Robert T Naismith, Anthony Traboulsee, Jerry S Wolinsky, Shibeshih Belachew, Harold Koendgen, Victoria Levesque, Marianna Manfrini, Fabian Model, Stanislas Hubeaux, Lahar Mehta & Xavier Montalban
Objective To assess over 3 years of follow-up, the effects of maintaining or switching to ocrelizumab (OCR) therapy on clinical and MRI outcomes and safety measures in the open-label extension (OLE) phase of the pooled OPERA studies in relapsing multiple sclerosis. Methods After 2 years of double-blind, controlled treatment, patients continued OCR (600 mg infusions every 24 weeks) or switched from interferon (IFN) β-1a (44 μg 3 times weekly) to OCR when entering the OLE...

Frontal tau pathology underlies behavioural/dysexecutive presentations of Alzheimer’s disease

Joseph Therriault, Tharick Pascoal, Melissa Savard, Andrea Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Emilie Thomas, Tatsuhiro Terada, Soham Rej, Gassan Massarweh, Ziad Nasreddine, Paolo Vitali, Jean-Paul Soucy, Paramita Saha-Chaudhuri, Serge Gauthier & Pedro Rosa-Neto
Objective: To determine the associations between amyloid-PET, tau-PET and atrophy with the behavioural/dysexecutive presentation of Alzheimer’s disease (AD) and how these differ from amnestic AD. Background: The behavioural/dysexecutive variant of AD is a rare clinical syndrome presenting with behavioural changes, apathy and/or executive dysfunction, similar to frontotemporal dementia. Small autopsy studies provide conflicting reports of frontal pathology and recent studies challenge the notion of frontal involvement in this condition. We tested the hypothesis that patterns...

Data from: Climate change increases predation risk for a keystone species of the boreal forest

Michael Peers, Yasmine Majchrzak, Allyson Menzies, Emily Studd, Guillaume Bastille-Rousseau, Rudy Boonstra, Murray Humphries, Thomas Jung, Alice Kenney, Charles Krebs, Dennis Murray & Stan Boutin
Canada lynx (Lynx canadensis) and snowshoe hares (Lepus americanus) form a keystone predator-prey cycle that has large impacts on the North-American boreal forest vertebrate community. Snowshoe hares and lynx are both well-suited for snowy winters, but climate change associated shifts in snow conditions could lower hare survival and alter cyclic dynamics. Using detailed monitoring of snowshoe hare cause-specific mortality, behaviour, and prevailing weather, we demonstrate that hare mortality risk is strongly influenced by variation in...

Data from: The effects of food supply on reproductive hormones and timing of reproduction in an income-breeding seabird

Shannon Whelan, Scott A. Hatch, Z. Morgan Benowitz-Fredericks, Charline Parenteau, Olivier Chastel & Kyle Elliott
Current food supply is a major driver of timing of breeding in income-breeding animals, likely because increased net energy balance directly increases reproductive hormones and advances breeding. In capital breeders, increased net energy balance increases energy reserves, which eventually leads to improved reproductive readiness and earlier breeding. To test the hypothesis that phenology of income-breeding birds is independent of energy reserves, we conducted an experiment on food-supplemented (“fed”) and control female black-legged kittiwakes (Rissa tridactyla)....

Registration Year

  • 2020

Resource Types

  • Dataset
  • Text


  • McGill University
  • University of Alberta
  • University of Toronto
  • University of British Columbia
  • University of Calgary
  • Queen Mary University of London
  • University of Florida
  • Smithsonian Tropical Research Institute
  • Colorado State University
  • Uppsala University