Traditional geographic information system models for map representation use superposition of layers to model physical reality, neglecting the integrity of the environment and limiting the ability to express interactions between features in complex phenomenon. This results in limitations regarding dynamic simulation and geographic causality reasoning. In this paper, we extend the framework of the geographic scene by formalizing the relationship between geographic processes and events to construct a dynamic data model: the process-event-centred dynamic data...

Introduction/Aims. Primary lateral sclerosis (PLS) is exceedingly rare and has been an enigmatic disease. Recent progress has drastically changed this perception, with early biomarkers being investigated and potential medications for PLS emerging at the preclinical stage. The aim of this paper is to describe a study of PLS natural history and discuss the limitations and proposed solutions to the study of a rare and slowly progressive disease. Methods. The PLS Natural History Study is a...

Abstract Background Adolescence and young adulthood is a high-risk period for the development of eating disorders. In recent years, there has been an increase in use of technology-based interventions (TBIs) for the treatment of eating disorders. The objective of this study was to determine the types of technology used for eating disorder treatment in youth and their effectiveness. Methods A scoping review was conducted according to PRISMA-ScR guidelines. Four databases were searched. Eligible articles included:...

Additional file 1. Additional Tables and Figure.

Additional file 3: Table S2. Microbial changes before, during, and after S. aureus clinical mastitis in Group I and Group II

Additional file 4: Table S3. Etiological agents isolated from clinical mastitic milk samples

Additional file 5: Table S4. Microbial network analysis in milk samples (n = 583)

Ecological quality assessment is fundamental to revealing changes in ecological environments before the development of effective ecological conservation policies. The complex ecological environment can be assessed more reliably when multiple remote sensing indices are integrated, such as in the use of the prevalent Remote Sensing-based Ecological Index (RSEI). However, for effective ecological quality assessment, the requirement of acquisition time consistency for images has become an outstanding issue for broadening the application of the RSEI. In...

The goal of precision medicine is to tailor treatment strategies on an individual patient level. Although several estimation techniques have been developed for determining optimal treatment rules, the majority of methods focus on the case of a dichotomous treatment, an example being the dynamic weighted ordinary least squares regression approach of Wallace and Moodie. We propose an extension to the aforementioned framework to allow for a continuous treatment with the ultimate goal of estimating optimal...

In this study, a superconducting high gradient magnetic separation (S-HGMS) technology was used to separate and extract quartz from sea sand. Under optimal conditions (i.e., a magnetic flow ratio of 0.085 T·s/m, slurry flow velocity of 400 ml/min, and pulp concentration of 40 g/L), the SiO2 grade increased from 79.45% of the raw material to 91.35% of quartz concentrate, and the removal rate of Al and Fe reached 91.97% and 82.10%, respectively. Weakly magnetic particles...

Medicare implemented Bundled Payments for Care Improvement (BPCI) Model 3 in 2013, in which participating skilled nursing facilities (SNFs) were accountable for episode costs. We performed comparative interrupted time series analyses to evaluate associations between SNF BPCI participation and nurse staffing levels, using Medicare claims, resident assessments, and facility-level and market-level files of 2010–2017. For persistent-participating SNFs, BPCI was associated with improved certified nursing assistant (CNA) staffing levels (differential change = .03 hours, p =...

Medicare implemented Bundled Payments for Care Improvement (BPCI) Model 3 in 2013, in which participating skilled nursing facilities (SNFs) were accountable for episode costs. We performed comparative interrupted time series analyses to evaluate associations between SNF BPCI participation and nurse staffing levels, using Medicare claims, resident assessments, and facility-level and market-level files of 2010–2017. For persistent-participating SNFs, BPCI was associated with improved certified nursing assistant (CNA) staffing levels (differential change = .03 hours, p =...

Additional file 3: Fig. S3. The time dependent ROC curves for other three prognostic models. A Time dependent ROC curves for immune-related gene signature in the TCGA GBM cohort. B Time dependent ROC curves for pyroptosis-related gene signature in the TCGA GBM cohort. C Time dependent ROC curves for autophagy-related gene signature in the TCGA GBM cohort.

Additional file 4: Fig. S4. Validation of independence of our risk score as a prognostic factor. A The forest plot showed the univariate cox analysis using risk score, age, radiotherapy, TMZ chemotherapy, and gender as variates in the GSE16011 GBM cohort. B The forest plot showed the multivariate cox analysis using risk score, age, radiotherapy, and TMZ chemotherapy as variates in the GSE16011 GBM cohort. C Stratified OS analysis in GSE16011 GBM patients with different...

Additional file 6: Table S1. The mitochondria-related genes extracted from the uniprot database.

Abstract Background Glioblastoma (GBM) is the most common primary malignant brain tumor that leads to lethality. Several studies have demonstrated that mitochondria play an important role in GBM and that mitochondria-related genes (MRGs) are potential therapeutic targets. However, the role of MRGs in GBM remains unclear. Methods Differential expression and univariate Cox regression analyses were combined to screen for prognostic differentially-expressed (DE)-MRGs in GBM. Based on LASSO Cox analysis, 12 DE-MRGs were selected to construct...

Additional file 7: Table S2. The primer sequences used in the study.

Additional file 8: Table S3. The 201 DE-MRGs between neoplatstic and non-neoplastic cells.

In this work, the influence of sand impingements on cathodic protection (CP) of marine carbon steel in natural sea water was studied in comparison with the CP performances in static and flowing sea water without sand particles. Results show that the propagation of local active anodic dissolution at the steel inclusions could be totally inhibited by providing sufficient cathodic current in the sea water free of sand particles. However, the local ‘CP shielding’, potential fluctuation...

Additional file 10: Table S5. The list of DMRs and annotation.

Additional file 11: Table S6. The list of genes harboring DMCs or overlapping with DMRs.

Additional file 13: Table S8. The list of differentially methylated haplotype blocks (dMHBs) and functional enrichment for hyper dMHBs.

Additional file 17: Table S12. The cluster of functional annotations enriched by differential methylated and expressed genes (MetGDE genes).

Additional file 2: Fig. S2. Methylation status of differentially methylated sites. (A-B) Volcano plots showing DMCs in the context of CHG (A) and CHH (B). (C) Bar plots showing distribution of differences in methylation levels of DMCs.

Additional file 7: Table S2. Read mapping statistics of whole-genome bisulfite sequencing data and RNA sequencing data of six cows.