Additional file 1: Figure S1. Funnel plots and LOO plots which detect outlier SNPs in RA and CD. Figure S2. Scatter plots showing the effect of liability to ALS on risk of autoimmune disorders. Table S1. Sensitivity analysis, heterogeneity, and pleiotropy, investigating MR assumption violation. Table S2. Sensitivity analysis, heterogeneity, and pleiotropy, investigating MR reverse assumption violation. Code used in this study includes all the code used to produce all the results in this paper.

Additional file 6: Table S5. Bacterial species/strains and their relative abundance (%) found in three milk samples from the shotgun metagenomic sequneces

Additional file 1: Fig. S1 The distributions of variant allele frequencies (VAFs) of ARID1A, ARID1B, ARID2, PBRM1, SMARCA4, and SMARCB1. The median VAFs of the above genes were 16.1%, 13.4%, 13.3%, 17.2%, 15.2%, and 16.7%, respectively. Red solid line, median; black dotted line, quartiles.

Additional file 3: Fig. S3 The signaling pathway enrichment of the variated genes in the SWI/SNF-mutant tumors by GO analysis. The GO analysis was performed on all the mutated genes in 1001 SWI/SNF-mutant samples.

Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.

Additional file 1: Table S1. Diagnostic codes for mental disorders. Table S2. Characteristics of women with and without preterm birth at first delivery. Table S3. Association between preterm birth at first delivery and maternal mental illness hospitalization. Table S4. Association between severity of preterm birth at first delivery and maternal mental illness hospitalization.

Abstract Background Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored the relationship between preterm delivery and the long-term risk of maternal hospitalization for mental illness after pregnancy. Methods We performed a longitudinal cohort study of 1,381,300 women who delivered between 1989 and 2021 in Quebec, Canada, and had no prior history of mental illness. The exposure was preterm birth, including extreme (<28 weeks), very (28-31...

Additional file 2: Table S2. Primer sequences for quantitative real-time PCR and real-time PCR analyses.

Abstract Background Endoplasmic reticulum (ER) stress and autophagy are implicated in the pathophysiology of intestinal inflammation; however, their roles in intrauterine growth retardation (IUGR)-induced colon inflammation are unclear. This study explored the protective effects of natural stilbene pterostilbene on colon inflammation using the IUGR piglets and the tumor necrosis factor alpha (TNF-α)-treated human colonic epithelial cells (Caco-2) by targeting ER stress and autophagy. Results Both the IUGR colon and the TNF-α-treated Caco-2 cells exhibited inflammatory...

Abstract Background Endoplasmic reticulum (ER) stress and autophagy are implicated in the pathophysiology of intestinal inflammation; however, their roles in intrauterine growth retardation (IUGR)-induced colon inflammation are unclear. This study explored the protective effects of natural stilbene pterostilbene on colon inflammation using the IUGR piglets and the tumor necrosis factor alpha (TNF-α)-treated human colonic epithelial cells (Caco-2) by targeting ER stress and autophagy. Results Both the IUGR colon and the TNF-α-treated Caco-2 cells exhibited inflammatory...

Abstract Background Homeothermic marine animals in Polar Regions face an energetic bottleneck in winter. The challenges of short days and cold temperatures are exacerbated for flying seabirds with small body size and limited fat stores. We use biologging approaches to examine how habitat, weather, and moon illumination influence behaviour and energetics of a marine bird species, thick-billed murres (Uria lomvia). Methods We used temperature-depth-light recorders to examine strategies murres use to survive winter in the...

Supplementary Material 1

Objective:Sex and gender are of growing scientific interest in disease onset and course. While sex differences have been shown to exist in systemic sclerosis, there is a paucity of data on gender. Our objective was to examine the association between occupation, a gender-related role and outcomes in systemic sclerosis.Methods:An occupation score ranging from 0 to 100, with lower scores representing occupations traditionally held by men and higher scores traditionally held by women, was constructed using...

Simulations with light sources, such as squares, circles, ellipses, octagons, and peaks, are presented.

Abstract Background Characteristics of patients using newer 2nd and 3rd line antidiabetic drugs in a real-world setting are poorly understood. We described the characteristics of new users of sodium-glucose co-transporter-2 inhibitors (SGLT-2i), dipeptidyl peptidase-4 inhibitors (DPP-4i), and glucagon-like peptide-1 receptor agonists (GLP-1 RA) in Canada and the United Kingdom (UK) between 2016 and 2018. Methods We conducted a multi-database cohort study using administrative health databases from 7 Canadian provinces and the UK Clinical Practice Research...

Additional file 2. Table E1. Descriptive statistics for HU distribution for pulmonary gas volume and blood volume maps. Whole population (n = 60). Comparison between the whole parenchyma and hypoinflated areas. Data were reported as mean ± standard deviation (SD) as well as percent. Wilcoxon rank-sum test was used to test statistical differences between the whole parenchyma and the hypoinflated one (α = 0.05); *: to mark statistically significant differences. Table E2. Descriptive statistics for...

Additional file 1. Fig. S1 Effect of lithium chloride 1mM for 7 days on telomere length in human-derived neural precursors cells (NPCs). Li: lithium treated; ns: not significant.

Supplemental Material for Skilled Nursing Facility Participation in Bundled Payments was Related to Small Increases in Nurse Staffing Levels by Meiling Ying, Helena Temkin-Greener, Caroline P. Thirukumaran, Karen E. Joynt Maddox, Robert G. Holloway, and Yue Li in Journal of Applied Gerontology.

Additional file 1: Fig. S1. Validation of DE-MRGs related prognostic risk model for GBM. A, E Time dependent ROC curves for 12 DE-MRGS prognostic model in the GSE147352 and GSE16011 GBM cohort. B, F The distribution of risk scores, survival time, and status of GBM patients in the GSE147352 and GSE16011 GBM cohort. C, GThe heatmap of the 12 model DE-MRGs in the GSE147352 and GSE16011 GBM cohort. D, H Kaplan–Meier curves for OS in...

Additional file 3: Fig. S3. The time dependent ROC curves for other three prognostic models. A Time dependent ROC curves for immune-related gene signature in the TCGA GBM cohort. B Time dependent ROC curves for pyroptosis-related gene signature in the TCGA GBM cohort. C Time dependent ROC curves for autophagy-related gene signature in the TCGA GBM cohort.

Additional file 4: Fig. S4. Validation of independence of our risk score as a prognostic factor. A The forest plot showed the univariate cox analysis using risk score, age, radiotherapy, TMZ chemotherapy, and gender as variates in the GSE16011 GBM cohort. B The forest plot showed the multivariate cox analysis using risk score, age, radiotherapy, and TMZ chemotherapy as variates in the GSE16011 GBM cohort. C Stratified OS analysis in GSE16011 GBM patients with different...

Abstract Background Glioblastoma (GBM) is the most common primary malignant brain tumor that leads to lethality. Several studies have demonstrated that mitochondria play an important role in GBM and that mitochondria-related genes (MRGs) are potential therapeutic targets. However, the role of MRGs in GBM remains unclear. Methods Differential expression and univariate Cox regression analyses were combined to screen for prognostic differentially-expressed (DE)-MRGs in GBM. Based on LASSO Cox analysis, 12 DE-MRGs were selected to construct...

Additional file 7: Table S2. The primer sequences used in the study.

Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC50 0.163 μM), A549/T (IC50 0.064 μM) and MCF-7/ADR (IC50 0.057 μM).

In this work, the influence of sand impingements on cathodic protection (CP) of marine carbon steel in natural sea water was studied in comparison with the CP performances in static and flowing sea water without sand particles. Results show that the propagation of local active anodic dissolution at the steel inclusions could be totally inhibited by providing sufficient cathodic current in the sea water free of sand particles. However, the local ‘CP shielding’, potential fluctuation...