Additional file 13: Table S8. The list of differentially methylated haplotype blocks (dMHBs) and functional enrichment for hyper dMHBs.

Abstract Background Balance stabilization exercises are often prescribed to facilitate compensation in individuals with vestibular schwannoma (VS). However, both the assessment and prescription of these exercises are reliant on clinical observations and expert opinion rather than on quantitative evidence. The aim of this study was to quantify head motion kinematics in individuals with vestibular loss while they performed commonly prescribed balance stability exercises. Methods Using inertial measurement units, head movements of individuals with vestibular schwannoma...

We identified relapsing fever (RF) Borrelia in 1.45% (145/10426) of the ticks and 1.40% (40/2850) of the wild mammals in a field investigation in China. Three RF Borrelia species, including human-pathogenic Borrelia miyamotoi, Borrelia persica and unclassified Babesia sp. were determined. Main species determined from ticks was B. miyamotoi (44.14%), followed by the unclassified Borrelia sp. (42.76%), and Borrelia theileri (13.10%). In wild mammals, main species found was B. persica (57.50%), followed by the unclassified...

Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.

Additional file 5. One-Year Monthly Average Weighed Per Capita Serving (#) Per Food Group, Stratified by Diet-Related Cardiometabolic Multi-Morbid Households. Supplemental analysis the on average calories per serving for each food and drink category grouping.

Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

Abstract Purpose To inform recommendations by the Canadian Task Force on Preventive Health Care on potentially inappropriate prescribing and over-the-counter (OTC) medication use among adults aged 65 years and older in primary care settings. This protocol outlines the planned scope and methods for a systematic review of the benefits and harms and acceptability of interventions to reduce potentially inappropriate prescriptions and OTC medication use. Methods De novo systematic reviews will be conducted to synthesize the...

Additional file 1: Standards for Reporting Qualitative Research (SRQR)a.

Additional file 7. Stakeholder review and feedback.

Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. Methods Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific...

Additional file 14: Table S9. The list of differentially expressed (DE) genes and their functional enrichment.

Additional file 3: Fig. S3. Annotation of DMCs. (A-C) The annotation of DMCs in the context of CpG (A), CHG (B) and CHH (C). (D) The distribution of DMC CpG islands (CGIs) and related regions. (E-F) The number of DMCs grouped by the differences in methylation levels in gene features (E) and regions in CGI context (F).

Additional file 4: Fig. S4. DNA methylation landscape. (A) The number of DMCs grouped by the differences in methylation levels per chromosome. (B-D) Manhattan plots showing the global distribution of DMCs in the context of CpG (B), CHG (C) and CHH (D). (E) DNA methylation landscape of chromosome 2.

Additional file 5: Fig. S5. Association between DNA methylation and gene expression levels. (A-B) Scatter plots showing correlation between gene expression level and promoter methylation level (A) and first exon (B). (C) Box plot showing promoter methylation level of genes grouped by expression levels. (D-F) Scatterplots and fitting curves of DNA methylation and relative gene expression of gene body methylation (D), exon methylation (E) and intron methylation (F). (G-I) MetGDE genes selected based on the...

Additional file 7: Table S2. Read mapping statistics of whole-genome bisulfite sequencing data and RNA sequencing data of six cows.

The impacts of the invasion of Ukraine on agricultural exports and fertilizers, the food price hikes, the inflationary pressures, the unsustainable debt levels for many countries, and the possible global economic recession are severely impacting African economies and communities. In addition, the climate is changing, and Africa needs to adapt. It must adapt to rising temperatures, more extreme storms, and floods, rising sea levels, more intense heatwaves, and longer and more severe droughts. Yet though...

Additional file 4.

Additional file 1.

Additional file 8.

Additional file 3: Table S2. Microbial changes before, during, and after S. aureus clinical mastitis in Group I and Group II

Additional file 5: Table S4. Microbial network analysis in milk samples (n = 583)

Supplemental material, sj-pdf-1-smm-10.1177_09622802221139233 for Standard error estimation in meta-analysis of studies reporting medians by Sean McGrath, Stephan Katzenschlager, Alexandra J Zimmer, Alexander Seitel, Russell Steele and Andrea Benedetti in Statistical Methods in Medical Research

Additional file 1: Fig. S1. Holstein cows with S. aureus clinical mastitis. This diagram illustrates 10 dairy cows diagnosed with S. aureus clinical mastitis from five dairy herds in Quebec, Canada. All mastitis occurred via natural infections. Milk samples (n = 599) were collected from all four quarters bi-weekly. Identifiers of each cow name are ‘H’ for the herd and ‘C’ for the assigned cow number. The red and the blue square boxes represent clinical...

Additional file 2: Table S1. Metadata of all milk samples (n = 583) collected from the cows diagnosed with S. aureus clinical mastitis

Additional file 2: Fig. S2. Quality assessment of qualitative studies.