Postural tachycardia syndrome (POTS) is a form of autonomic dysregulation. There is increasing evidence that the etiology may be immune-mediated in a subgroup of patients. Patients with POTS often experience an exacerbation of their symptoms associated with infections and often fear the same symptom aggravation after vaccination. With this data we conducted a study to describe the tolerability of mRNA vaccines against COVID-19 and the consequences of a COVID-19 infection on POTS symptoms in our...

The aim of the study was to examine the predictive value of coronary computed tomographic angiography (CCTA) and coronary artery calcium score (CACS) on 1-year all-cause mortality in type 2 diabetes (T2D) patients with peripheral artery disease (PAD) undergoing partial foot amputations (PFA).MethodsThis is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 ± 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1...

Additional file 1: Table S1. Common observed PPTFs by medication. Table S2. Reason for erenumab dose discontinuation/interruption before month 6.

Objectives:We identified factors associated with healthcare costs and health-related quality of life (HRQoL) of multimorbid older adults with polypharmacy.Methods:Using data from the OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid older people) trial, we described the magnitude and composition of healthcare costs, and time trends of HRQoL, during 1-year after an acute-care hospitalization. We performed a cluster analysis to identify groups with different cost and HRQoL trends. Using multilevel models, we also...

All optical imaging systems suffer from one fundamental constraint on image resolution—the diffraction limit. Prior efforts for breaking the diffraction limit rely on near-field placements, long scanning times, fluorescence labeling, active illuminations, or specially-designed superlenses. We present a technique that combines the mathematical concept of super-oscillations (SO) and computational deconvolution techniques to achieve a passive single-shot deep sub-diffraction imaging method free of these restrictions. Furthermore, our method requires no training data and is scene-independent. We...

Supplemental Material for Pretreatment Serum Lactate Dehydrogenase and Metastases Numbers as Potential Determinants of Anti-PD-1 Therapy Outcome in Nasopharyngeal Carcinoma by Wael Abdullah Sultan Ali, Xinxin Huang, Yuehan Wu, Yuxiang Ma, Hui Pan, Jun Liao, Zhang Yang, Shaodong Hong, Yunpeng Yang, Yan Huang, Yuanyuan Zhao, Wenfeng Fang, Hongyun Zhao, and Li Zhang in Cancer Control.

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Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Abstract Background Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic dependence of cancer development, but how the signal transduction integrates methionine status to achieve the physiological demand of cancer cells remains unknown. Methods Low or high levels of dietary methionine was fed to mouse models with patient-derived xenograft or diethyl-nitrosamine induced liver cancer. RNA sequence and metabolomics were...

Abstract Background The relationship between remnant cholesterol (RC) and atherosclerotic cardiovascular risk has been given increasing attention in recent years. However, its association with verbal learning and memory performance has not been reported. Methods Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Participants aged ≥60 years with available fasting lipid data were included. Verbal learning and memory performance were evaluated using the Consortium to Establish a Registry for Alzheimer’s...

BackgroundVarious reduction techniques exist to treat traumatic shoulder dislocation, but best management remains unclear.AimsTo investigate the reduction rate of traumatic anteroinferior shoulder dislocations using two sedation-free techniques and success rates of subgroups.MethodsA single-center study was performed analysing shoulder dislocations in a two-year period. Adult patients with anteroinferior shoulder dislocation were included. Two sedation-free reduction techniques were used: the Davos self-reduction technique and the Arlt-chair technique. Two attempts were performed before sedation. All patients gave informed...

Additional file 3. Calibration plots for the logistic regression models MABE = MABESS (left side) and MMBRP (right side) based on the derivation cohort. The Brier score and scaled Brier score of MABE, MABESS was 0.14 and 17.01%, respectively. In contrast, MMBRP had a Brier score and scaled Brier score of 0.14 and 15.41%, respectively.

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known common long COVID symptoms at least 60 days after acute COVID-19. Methods The prognostic model was built based on data from a multicentre prospective Swiss cohort study. Included were adult patients diagnosed with COVID-19 between February and December 2020 and treated as outpatients,...

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known common long COVID symptoms at least 60 days after acute COVID-19. Methods The prognostic model was built based on data from a multicentre prospective Swiss cohort study. Included were adult patients diagnosed with COVID-19 between February and December 2020 and treated as outpatients,...

Osteoarthritis (OA) occurs mostly in the knees, hips, finger interphalangeal joints, and spinal facet joints, and is characterized by cartilage degeneration. The existing bulk RNA sequencing (bulk RNA-seq) and single-cell sequencing (scRNA-seq) data for chondrocytes in the osteoarthritic knee joint provide the expression profiles of entire cell populations and individual cells, respectively. Here, we aimed to analyze these two types of sequencing data in order to obtain a more comprehensive understanding of OA. We compared...

Supplemental material, sj-docx-1-hej-10.1177_00178969221133238 for Paediatric manikins and school nurses as Basic Life Support coordinators: A useful strategy for schools? by Martín Otero-Agra, Luz Rey-Fernández, David Pacheco-Rodríguez, Felipe Fernández-Méndez, Roberto Barcala-Furelos and Robert Greif in Health Education Journal

Objective:To evaluate cardiopulmonary resuscitation (CPR) skills performance and retention in schoolchildren aged 8 to 12 years following instruction by their teachers and with the guidance of a school nurse using paediatric manikins.Design:Descriptive simulation trial.Method:A school nurse provided support to six schoolteachers as they taught a modified 40-minute CPR course. Pupils were shown an out-of-hospital cardiac-arrest recognition video followed by a CPR simulation using paediatric manikins. 117 schoolchildren aged 8 to 12 years received the training....

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Additional file 1: Fig. S1. Visualization of alignment of M. bealei RC601 and six outgroups. Mahonia bealei RC601 was used as a reference sequence. Blue represents coding regions, pink represents non-coding regions and gray arrows points at genes. Fig. S2. Comparison of the LSC, IR and SSC boundary regions of plastomes of M. bealei RC601 and six outgroups. Fig. S3. Structural variation between plastomes of ten species of Mahonia revealed by Mauve. Fig. S4. Phylogenetic...

Additional file 1: Table S1. Weighted multivariable ordinal logistic regression analysis between RC levels (log-transformed) and age-stratified quartiles of the CERAD delayed score. Table S2. Weighted multivariable ordinal logistic regression analysis between the TC/RC ratio (log-transformed) and age-stratified quartiles of the CERAD delayed score.

Abstract Background The relationship between remnant cholesterol (RC) and atherosclerotic cardiovascular risk has been given increasing attention in recent years. However, its association with verbal learning and memory performance has not been reported. Methods Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Participants aged ≥60 years with available fasting lipid data were included. Verbal learning and memory performance were evaluated using the Consortium to Establish a Registry for Alzheimer’s...

Additional file 1: Table S1. Common observed PPTFs by medication. Table S2. Reason for erenumab dose discontinuation/interruption before month 6.

Abstract Background The fully human monoclonal antibody erenumab, which targets the calcitonin gene-related peptide (CGRP) receptor, was licensed in Switzerland in July 2018 for the prophylactic treatment of migraine. To complement findings from the pivotal program, this observational study was designed to collect and evaluate clinical data on the impact of erenumab on several endpoints, such as quality of life, migraine-related impairment and treatment satisfaction in a real-world setting. Methods An interim analysis was conducted...

Die alveoläre Echinokokkose (AE) ist eine zoonotische Infektionskrankheit, die durch das invasiv wachsende Larvenstadium des Fuchsbandwurms Echinococcus multilocularis (Echinococcus alveolaris) zu zystischen Veränderungen in parenchymatösen Organen, meist der Leber, führt. Kanine AE ist die Folge einer Aufnahme infektiöser Eier aus dem Kot von Endwirten, vor allem Kaniden. In diesen Fällen sind Hunde nicht, wie biologisch vorgesehen, die Endwirte für den Parasiten, sondern Fehlzwischenwirte. Dieser Fall beschreibt einen dreijährigen, kastrierten Mischlingsrüden, der mit einer großen abdominalen...

Lung cancer has been recognized as the most common malignant neoplasm of the respiratory system with extremely high morbidity, among which non-small cell lung cancer (NSCLC) accounts for the majority. Many published literatures have revealed the roles of GSG2 in the progression of ovarian cancer, bladder cancer and breast cancer. However, there were no reports on the relationship between GSG2 and NSCLC. Herein, GSG2 was identified as a potential tumor promoter in NSCLC development, whose...