Abstract Objective In this study, we aimed to investigate the predictive efficacy of magnetic resonance imaging (MRI) radiomics features at different time points of neoadjuvant therapy for rectal cancer in patients with pathological complete response (pCR). Furthermore, we aimed to develop and validate a radiomics space–time model (RSTM) using machine learning for artificial intelligence interventions in predicting pCR in patients. Methods Clinical and imaging data of 83 rectal cancer patients were retrospectively analyzed, and the...

Supplementary Material 1

Abstract Objective In this study, we aimed to investigate the predictive efficacy of magnetic resonance imaging (MRI) radiomics features at different time points of neoadjuvant therapy for rectal cancer in patients with pathological complete response (pCR). Furthermore, we aimed to develop and validate a radiomics space–time model (RSTM) using machine learning for artificial intelligence interventions in predicting pCR in patients. Methods Clinical and imaging data of 83 rectal cancer patients were retrospectively analyzed, and the...

During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not NREM, sleep. REM sleep specific optogenetic silencing of LHvgat cells induced a re-organization of these activity patterns...

Background: Infection with human immunodeficiency virus type 1 (HIV) typically results from transmission of a small and genetically uniform viral population. Following transmission, the virus population becomes more diverse because of recombination and acquired mutations through genetic drift and selection. Viral intrahost genetic diversity remains a major obstacle to the cure of HIV; however, there is a disagreement whether intrahost viral genetic diversification associates positively or negatively with disease progression and progression markers. Viral load...

Supplemental Material for Coronary artery calcium score and coronary computed tomography angiography predict one-year mortality in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation by Evgeniya Shalaeva, Arjola Bano, Ulugbek Kasimov, Bakhtiyor Janabaev, Iris Baumgartner, Markus Laimer and Hugo Saner in Diabetes and Vascular Disease Research

Additional file 1.

Supplemental material, sj-docx-1-hej-10.1177_00178969221133238 for Paediatric manikins and school nurses as Basic Life Support coordinators: A useful strategy for schools? by Martín Otero-Agra, Luz Rey-Fernández, David Pacheco-Rodríguez, Felipe Fernández-Méndez, Roberto Barcala-Furelos and Robert Greif in Health Education Journal

Additional file 2. SPIRIT checklist

Abstract Background Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiquitin–proteasome system facilitates the turnover of most intracellular proteins with E3 ligase conferring the target selection and specificity. Ubiquitin protein ligase E3 component N-recognin 7 (UBR7), among the least studied E3 ligases, recognizes its substrate through a plant homeodomain (PHD) finger. Here, we bring into focus...

Additional file 1. Histogram, smooth function and Pearson's correlation coefficients for continuous candidate predictors.

Additional file 2. Partial plots for continuous candidate predictors of the global logistic generalized additive model. The y-axis contains the REST outcome on the log-odds scale $$(ln(\frac{\hat{y}}{1-\hat{y}}))$$ ( l n ( y ^ 1 - y ^ ) ) , with the patient's predicted probability $$\hat{y}$$ y ^ of developing REST symptoms.

Objectives: Both, Human Immunodeficiency Virus (HIV) infection and malnutrition are major challenges in pregnancy and postpartum in low-resource settings and the respective cytokine levels remain poorly described. The main objectives of this study were to find immune markers that are associated with HIV infection and malnutrition in pregnant women and to determine how these would change at 14 weeks postpartum.Method: Pregnant women of at least 20 weeks gestational age were enrolled into this longitudinal observational...

Background:Early identification of patients developing symptomatic intracranial hemorrhage and symptomatic brain edema after acute ischemic stroke is essential for clinical decision-making. Astroglial protein S-100B is a marker of blood-brain barrier disruption, which plays an important role in the formation of intracranial hemorrhage and brain edema. In this study, we assessed the prognostic value of serum S-100B for the development of these complications.Methods:Serum S-100B levels were measured within 24 h from symptom onset in 1749 consecutive...

Supplemental material, sj-docx-1-sel-10.1177_17585732221145608 for Fast treatment of anterior shoulder dislocations with two sedation-free methods: The Davos self-reduction method and Arlt method by Lukas Werner Widmer, Till Dominic Lerch, Anna Genthner, Lara Pozzi, James Geiger and Hans-Curd Frei in Shoulder & Elbow

BackgroundWe aimed to investigate the determinant factors of anti-PD-1 therapy outcome in nasopharyngeal carcinoma (NPC).MethodsIn this retrospective study, we included 64 patients with recurrent/metastatic NPC. The association of patients’ characteristics, C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), and lactate dehydrogenase (LDH) with survival benefit of anti-PD-1 therapy were analyzed using Cox regression models and Kaplan-Meier analyses. Patients were divided based on the median value of CRP, NLR or LDH into different subgroups.ResultsAt a median...

Supplemental material, sj-docx-2-eso-10.1177_23969873221145391 for Serum S-100B adds incremental value for the prediction of symptomatic intracranial hemorrhage and brain edema after acute ischemic stroke by Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P Westphal, Valerie Schütz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kägi, Joan Montaner, Alejandro Bustamante, Elena Palà, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja...

Additional file 1: Table S1. Weighted multivariable ordinal logistic regression analysis between RC levels (log-transformed) and age-stratified quartiles of the CERAD delayed score. Table S2. Weighted multivariable ordinal logistic regression analysis between the TC/RC ratio (log-transformed) and age-stratified quartiles of the CERAD delayed score.

Additional file 2. Results deep learning segmented outliers.

Additional file 3: Table S2. The changes of metabolite levels upon methionine restriction in livers of HCC mouce models.

Additional file 1. Results synthetic experiments.

Extra simulations and experimental results

All optical imaging systems suffer from one fundamental constraint on image resolution—the diffraction limit. Prior efforts for breaking the diffraction limit rely on near-field placements, long scanning times, fluorescence labeling, active illuminations, or specially-designed superlenses. We present a technique that combines the mathematical concept of super-oscillations (SO) and computational deconvolution techniques to achieve a passive single-shot deep sub-diffraction imaging method free of these restrictions. Furthermore, our method requires no training data and is scene-independent. We...

Additional files from Green HEMS: how to make it happen

Supplementary Material 1 Appendix