1,280 Works

Foot and ankle characteristics associated with falls in adults with established rheumatoid arthritis: a cross-sectional study

A Brenton-Rule, N Dalbeth, Hylton Menz, S Bassett & K Rome
Background: People with rheumatoid arthritis (RA) have an increased risk of falls. The foot is a common site of pathology in RA and foot problems are reported in up to 90 % of patients with established disease. The aim of this study was to determine whether foot and ankle characteristics are associated with falls in people with RA. Methods: Adults with RA were recruited from rheumatology outpatient clinics in Auckland, New Zealand. Participants reported whether...

The emergence of entrepreneurship education programs in Indonesian higher education institutions

Alex Maritz, Alice Li, Whidya Utami & Yoseva Sumani
Abstract: The purpose of this paper is to explore the status of entrepreneurship education programs (EEPs) in Indonesia, expanding similar papers on related Australian EEPs in 2019 and Malaysian EEPs in 2021. The aim is to review neoteric global best practice entrepreneurship education (EE), aligning context and specific inference of EEPs in Indonesian Higher Education Institutions (HEIs) within dynamic entrepreneurial ecosystems. We provide a descriptive and emergent inquiry approach consisting of a review of prominent...

Beyond Coursework: Developing Communities in an Online Program of Study

Jodi Oakman
The nexus between paid work and study is important. Developing opportunities to facilitate this link is a key part of good course design especially in postgraduate programs. Strong communities of practice can also assist with improving links between research and practice. The online study environment affords some challenges to achieving these goals. The current study proposes that offering formalised interaction points- synchronous or asynchronous- during online study, is critical to facilitating the link between work...

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

BB Guo, SA Bellingham & Andrew Hill
Exosomes are small extracellular vesicles releasedby cells and play important roles in intercellular communication and pathogen transfer. Exosomes have been implicated in several neurodegenerative diseases, including prion disease and Alzheimer disease. Prion disease arises upon misfolding of the normal cellular prion protein, PrPC, into the disease-associated isoform, PrPSc. The disease has a unique transmissible etiology, and exosomes represent a novel and efficient method for prion transmission. The precise mechanism by which prions are transmitted from...

Culture and Morality: A Comparison of Moral Endorsements and the Formation of Moral Intentions in Australia and Indonesia

Sutarimah Ampuni
Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, La Trobe University, Victoria.

Long-Term Calorie Restriction Alters Anxiety-like Behaviour and the Brain and Adrenal Gland Transcriptomes of the Ageing Male Rat

Antonina Govic, Helen Nasser, Elizabeth Levay, Matthew Zelko, Esmaeil Ebrahimie, Manijeh Mohammadi Dehcheshmeh, Stephen Kent, Jim Penman & Agnes Hazi
Further examination of the molecular regulators of long-term calorie restriction (CR), reported to have an anxiolytic effect, may highlight novel therapeutic targets for anxiety disorders. Here, adult male Hooded Wistar rats were exposed to a 25% CR whilst anxiety-like behaviour was assessed at 6-, 12-, and 18-months of age via the elevated plus maze, open field, and acoustic startle tests. Next-generation sequencing was then used to measure transcriptome-wide gene expression in the hypothalamus, amygdala, pituitary,...

Using Co-stimulation to Shape the T Cell Response

Terri Scanlon
Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Biochemistry and Genetics, School of Agriculture, Biomedicine & Environment, La Trobe University, Victoria, Australia.

“Set and forget” does not work when it comes to fissure roosts carved into live trees for bats

Stephen Griffiths, PE Lentini, Kristin Semmens & Kylie Robert
Early View online article available at: https://onlinelibrary.wiley.com/doi/full/10.1111/rec.13751 Interest in carving cavities directly into trees to provide habitat for hollow-dependent wildlife is rapidly growing among researchers, conservation practitioners, community groups, and land managers. Monitoring programs have shown that some of the designs and approaches used to create these structures encourage uptake by fauna. However, evidence for occupancy of “bat specific” fissure cavities is lacking even though they are already being enthusiastically installed and advocated for by...

Exploring the Use of BH3-mimetics for the Treatment of Sarcomas

Seirian Hart
Submitted in total fulfilment of the requirements for a Master of Science degree to the School of Agriculture, Biomedicine & Environment, La Trobe University, Victoria.

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas

A Kyritsis, E Papanastasi, I Kokkori, P Maragozidis, Dimitra Chatzileontiadou, P Pallaki, M Labrou, SG Zarogiannis, GP Chrousos, D Vlachakis, KI Gourgoulianis & NAA Balatsos
The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression. The process is catalyzed by a family of enzymes, known as deadenylases. As the dysregulation of gene expression is a hallmark of cancer, understanding the role of deadenylases has gained additional interest. Herein, the genetic association network shows that CNOT6...

Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation

ENS McGowan, O Wong, E Jones, J Nguyen, J Wee, MC Demaria, D Deliyanti, Chad Johnson, MJ Hickey, MJ McConville, JL Wilkinson-Berka, MD Wright & Katrina Binger
Phagocytes migrate into tissues to combat infection and maintain tissue homeostasis. As dysregulated phagocyte migration and function can lead to inflammation or susceptibility to infection, identifying molecules that control these processes is critical. Here, we show that the tetraspanin CD82 restrains the migration of neutrophils and macrophages into tissues. Cd82−/− phagocytes exhibited excessive migration during in vivo models of peritoneal inflammation, superfusion of CXCL1, retinopathy of prematurity, and infection with the protozoan parasite L. mexicana....

“Ocean Optimism” and Resilience: Learning From Women’s Responses to Disruptions Caused by COVID-19 to Small-Scale Fisheries in the Gulf of Guinea

IM Okafor-Yarwood, S van den Berg, YA Collins & Clement Sefa-Nyarko
This study examines the response of women to disruptions caused by COVID-19 in small-scale fisheries (SSF) in the Gulf of Guinea (GOG). It interrogates the concept of resilience and its potential for mitigating women’s vulnerability in times of adversity. We define resilience as the ability to thrive amidst shocks, stresses, and unforeseen disruptions. Drawing on a focus group discussion, in-depth interviews with key informants from Cote d’Ivoire, Ghana and Nigeria, and a literature review, we...

Improving Genomic Selection for Heat Tolerance in Dairy Cattle: Current Opportunities and Future Directions

Evans Kiptoo Cheruiyot, M Haile-Mariam, Benjamin Cocks & Jennie Pryce
Heat tolerance is the ability of an animal to maintain production and reproduction levels under hot and humid conditions and is now a trait of economic relevance in dairy systems worldwide because of an escalating warming climate. The Australian dairy population is one of the excellent study models for enhancing our understanding of the biology of heat tolerance because they are predominantly kept outdoors on pastures where they experience direct effects of weather elements (e.g.,...

Characterisation and Engineering of Bacterial Dsb Proteins for Therapeutic and Biotechnological Applications

Lachlan Mitchell
This thesis is submitted in total fulfilment of the requirements for the degree of Master of Science to the La Trobe Institute for Molecular Science, Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.

Exercise and COVID‐19: reasons individuals sought coaching support to assist them to increase physical activity during COVID‐19

Stephen Barrett, Kane Rodda, Stephen Begg, Paul O'Halloran & Michael Kingsley
No description supplied

Secondary pre-service teachers' voices of becoming mathematics teachers

Jacolyn Weller
No description supplied

Genomics Research and Involving People

Jack Nunn
This thesis has been submitted in total fulfilment of the requirements for the Doctor of Philosophy to the School of Psychology and Public Health, La Trobe University, Victoria, Australia.

Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy

Yanping Li, Binglin Shen, Yuan Lu, Jinhui Shi, Zewei Zhao, Huixian Li, Rui Hu, Junle Qu & Liwei Liu
Characterization of tumor microenvironment features, such as its microstructures, biomolecular metabolism and functional dynamics, may provide essential pathologic information about the tumor, tumor margin, and adjacent normal tissue for early and intraoperative diagnosis. However, it can be particularly challenging to obtain faithful and comprehensive pathological information simultaneously from unperturbed tissues due to the complexity of the microenvironment in organisms. Super-multiplex nonlinear optical imaging system emerged and matured as an attractive tool for acquisition and elucidation...

Factors influencing adults who participate in a physical activity coaching intervention: a theoretically informed qualitative study

Stephen Barrett, Stephen Begg, Paul O'Halloran, J Breckon, K Rodda, G Barrett & Michael Kingsley
Objective: Behaviour change interventions targeting changes in physical activity (PA) can benefit by examining the underlying mechanisms that promote change. This study explored the use of the Capability, Opportunity, Motivation and Behaviour (COM-B) model and the Theoretical Domains Framework (TDF) to code and contextualise the experiences of participants who completed a PA coaching intervention underpinned by motivational interviewing and cognitive-behavioural therapy. Design: Semistructured interviews were conducted with a purposive sample of participants. Setting Interviews were...

La Trobe eBureau author kit

La Trobe eBureau, Steven Chang & Sebastian Kainey
Author kit for La Trobe academics aiming to publish open educational resources with the La Trobe eBureau.
Includes:* expression of interest form* author proposal template* author copyright agreement* overview of eBureau publishing process

The retrograde signaling regulator ANAC017 recruits the MKK9-MPK3/6, ethylene, and auxin signaling pathways to balance mitochondrial dysfunction with growth

Cunman He, Lim Liew, Lingling Yin, Mathew Lewsey, James Whelan & Oliver Berkowitz
In plant cells, mitochondria are ideally positioned to sense and balance changes in energy metabolism in response to changing environmental conditions. Retrograde signaling from mitochondria to the nucleus is crucial for adjusting the required transcriptional responses. We show that ANAC017, the master regulator of mitochondrial stress, directly recruits a signaling cascade involving the plant hormones ethylene and auxin as well as the MAP KINASE KINASE (MKK) 9-MAP KINASE (MPK) 3/6 pathway in Arabidopsis thaliana. Chromatin...

Distribution, composition and environmental correlates of high-altitude gravelly pavement herbfields in north-eastern Victoria, Australia

Alexandra Blackburn-Smith & John Morgan
Context: Gravelly pavement herbfields are a rare, geographically restricted community found in high mountain areas of south-eastern Australia. Gravelly pavement plant communities occur where there is continuous waterflow, with vegetation comprising sparse, semi-aquatic species on a rock or gravel substratum. Aims: This study aimed to further the understanding of the community on the Bogong High Plains, Victoria, by asking questions relating to their location, structure and floristic composition. In particular, we ask what determines the...

A Critical Overview of Computational Approaches Employed for COVID-19 Drug Discovery

Evgeny Muratov, Rommie Amaro, Carolina H Andrade, Nathan Brown, Sean Ekins, Denis Fourches, Olexandre Isayev, Dima Kozakov, José L. Medina-Franco, Kenneth Merz, Tudor Oprea, Vladimir Poroikov, Gisbert Schneider, Matthew H. Todd, Alexandre Varnek, David Winkler, A Zakharov, A Cherkasov & Alexander Tropsha
We cover diverse methodologies, computational approaches, and case studies illustrating the ongoing efforts to develop viable drug candidates for treatment of COVID-19.

BayesR3 enables fast MCMC blocked processing for largescale multi-trait genomic prediction and QTN mapping analysis

EJ Breen, IM MacLeod, PN Ho, M Haile-Mariam, Jennie Pryce, CD Thomas, Hans Daetwyler & ME Goddard
Bayesian methods, such as BayesR, for predicting the genetic value or risk of individuals from their genotypes, such as Single Nucleotide Polymorphisms (SNP), are often implemented using a Markov Chain Monte Carlo (MCMC) process. However, the generation of Markov chains is computationally slow. We introduce a form of blocked Gibbs sampling for estimating SNP effects from Markov chains that greatly reduces computational time by sampling each SNP effect iteratively n-times from conditional block posteriors. Subsequent...

Semiotic Knowledge, Recycling Consideration, and Purchase Intention: The Interplay on Sustainable Packaging and its Role in Tackling the Waste Crisis in Australia

Trung Dung Nguyen
Submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy to La Trobe Business School, La Trobe University, Victoria.

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  • La Trobe University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Chinese Academy of Sciences
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