Background: People with rheumatoid arthritis (RA) have an increased risk of falls. The foot is a common site of pathology in RA and foot problems are reported in up to 90 % of patients with established disease. The aim of this study was to determine whether foot and ankle characteristics are associated with falls in people with RA. Methods: Adults with RA were recruited from rheumatology outpatient clinics in Auckland, New Zealand. Participants reported whether...

Abstract: The purpose of this paper is to explore the status of entrepreneurship education programs (EEPs) in Indonesia, expanding similar papers on related Australian EEPs in 2019 and Malaysian EEPs in 2021. The aim is to review neoteric global best practice entrepreneurship education (EE), aligning context and specific inference of EEPs in Indonesian Higher Education Institutions (HEIs) within dynamic entrepreneurial ecosystems. We provide a descriptive and emergent inquiry approach consisting of a review of prominent...

The nexus between paid work and study is important. Developing opportunities to facilitate this link is a key part of good course design especially in postgraduate programs. Strong communities of practice can also assist with improving links between research and practice. The online study environment affords some challenges to achieving these goals. The current study proposes that offering formalised interaction points- synchronous or asynchronous- during online study, is critical to facilitating the link between work...

Exosomes are small extracellular vesicles releasedby cells and play important roles in intercellular communication and pathogen transfer. Exosomes have been implicated in several neurodegenerative diseases, including prion disease and Alzheimer disease. Prion disease arises upon misfolding of the normal cellular prion protein, PrPC, into the disease-associated isoform, PrPSc. The disease has a unique transmissible etiology, and exosomes represent a novel and efficient method for prion transmission. The precise mechanism by which prions are transmitted from...

Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, La Trobe University, Victoria.

Further examination of the molecular regulators of long-term calorie restriction (CR), reported to have an anxiolytic effect, may highlight novel therapeutic targets for anxiety disorders. Here, adult male Hooded Wistar rats were exposed to a 25% CR whilst anxiety-like behaviour was assessed at 6-, 12-, and 18-months of age via the elevated plus maze, open field, and acoustic startle tests. Next-generation sequencing was then used to measure transcriptome-wide gene expression in the hypothalamus, amygdala, pituitary,...

Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Biochemistry and Genetics, School of Agriculture, Biomedicine & Environment, La Trobe University, Victoria, Australia.

Early View online article available at: https://onlinelibrary.wiley.com/doi/full/10.1111/rec.13751 Interest in carving cavities directly into trees to provide habitat for hollow-dependent wildlife is rapidly growing among researchers, conservation practitioners, community groups, and land managers. Monitoring programs have shown that some of the designs and approaches used to create these structures encourage uptake by fauna. However, evidence for occupancy of “bat specific” fissure cavities is lacking even though they are already being enthusiastically installed and advocated for by...

Submitted in total fulfilment of the requirements for a Master of Science degree to the School of Agriculture, Biomedicine & Environment, La Trobe University, Victoria.

The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression. The process is catalyzed by a family of enzymes, known as deadenylases. As the dysregulation of gene expression is a hallmark of cancer, understanding the role of deadenylases has gained additional interest. Herein, the genetic association network shows that CNOT6...

Phagocytes migrate into tissues to combat infection and maintain tissue homeostasis. As dysregulated phagocyte migration and function can lead to inflammation or susceptibility to infection, identifying molecules that control these processes is critical. Here, we show that the tetraspanin CD82 restrains the migration of neutrophils and macrophages into tissues. Cd82−/− phagocytes exhibited excessive migration during in vivo models of peritoneal inflammation, superfusion of CXCL1, retinopathy of prematurity, and infection with the protozoan parasite L. mexicana....

This study examines the response of women to disruptions caused by COVID-19 in small-scale fisheries (SSF) in the Gulf of Guinea (GOG). It interrogates the concept of resilience and its potential for mitigating women’s vulnerability in times of adversity. We define resilience as the ability to thrive amidst shocks, stresses, and unforeseen disruptions. Drawing on a focus group discussion, in-depth interviews with key informants from Cote d’Ivoire, Ghana and Nigeria, and a literature review, we...

Heat tolerance is the ability of an animal to maintain production and reproduction levels under hot and humid conditions and is now a trait of economic relevance in dairy systems worldwide because of an escalating warming climate. The Australian dairy population is one of the excellent study models for enhancing our understanding of the biology of heat tolerance because they are predominantly kept outdoors on pastures where they experience direct effects of weather elements (e.g.,...

This thesis is submitted in total fulfilment of the requirements for the degree of Master of Science to the La Trobe Institute for Molecular Science, Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.

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This thesis has been submitted in total fulfilment of the requirements for the Doctor of Philosophy to the School of Psychology and Public Health, La Trobe University, Victoria, Australia.

Characterization of tumor microenvironment features, such as its microstructures, biomolecular metabolism and functional dynamics, may provide essential pathologic information about the tumor, tumor margin, and adjacent normal tissue for early and intraoperative diagnosis. However, it can be particularly challenging to obtain faithful and comprehensive pathological information simultaneously from unperturbed tissues due to the complexity of the microenvironment in organisms. Super-multiplex nonlinear optical imaging system emerged and matured as an attractive tool for acquisition and elucidation...

Objective: Behaviour change interventions targeting changes in physical activity (PA) can benefit by examining the underlying mechanisms that promote change. This study explored the use of the Capability, Opportunity, Motivation and Behaviour (COM-B) model and the Theoretical Domains Framework (TDF) to code and contextualise the experiences of participants who completed a PA coaching intervention underpinned by motivational interviewing and cognitive-behavioural therapy. Design: Semistructured interviews were conducted with a purposive sample of participants. Setting Interviews were...

Author kit for La Trobe academics aiming to publish open educational resources with the La Trobe eBureau.
Includes:* expression of interest form* author proposal template* author copyright agreement* overview of eBureau publishing process

In plant cells, mitochondria are ideally positioned to sense and balance changes in energy metabolism in response to changing environmental conditions. Retrograde signaling from mitochondria to the nucleus is crucial for adjusting the required transcriptional responses. We show that ANAC017, the master regulator of mitochondrial stress, directly recruits a signaling cascade involving the plant hormones ethylene and auxin as well as the MAP KINASE KINASE (MKK) 9-MAP KINASE (MPK) 3/6 pathway in Arabidopsis thaliana. Chromatin...

Context: Gravelly pavement herbfields are a rare, geographically restricted community found in high mountain areas of south-eastern Australia. Gravelly pavement plant communities occur where there is continuous waterflow, with vegetation comprising sparse, semi-aquatic species on a rock or gravel substratum. Aims: This study aimed to further the understanding of the community on the Bogong High Plains, Victoria, by asking questions relating to their location, structure and floristic composition. In particular, we ask what determines the...

We cover diverse methodologies, computational approaches, and case studies illustrating the ongoing efforts to develop viable drug candidates for treatment of COVID-19.

Bayesian methods, such as BayesR, for predicting the genetic value or risk of individuals from their genotypes, such as Single Nucleotide Polymorphisms (SNP), are often implemented using a Markov Chain Monte Carlo (MCMC) process. However, the generation of Markov chains is computationally slow. We introduce a form of blocked Gibbs sampling for estimating SNP effects from Markov chains that greatly reduces computational time by sampling each SNP effect iteratively n-times from conditional block posteriors. Subsequent...

Submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy to La Trobe Business School, La Trobe University, Victoria.