244 Works

Rare plant species are at a disadvantage when both herbivory and pollination interactions are considered in an alpine meadow

Xinqiang Xi, Wenlong Zhou, Zhao Li, Lei Hu, Yuran Dong, Karl Niklas & Shucun Sun
1. Rare plant species often suffer less damage than common species because of positive density-dependent herbivory, and it has been suggested that this “rare species advantage” fosters plant species coexistence. However, it is unknown whether rare species have an advantage when pollination interactions are also considered. 2. We hypothesized that a “positive density-dependent pollination success” across plant species would result in common plants experiencing higher seed set rates compared to rare species, and that positive...

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu & Xian Wang
Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1–3 against the damage of PC12...

The lipoprotein NlpD in Cronobacter sakazakii responds to acid stress and regulates macrophage resistance and virulence by maintaining membrane integrity

Xuemeng Ji, Ping Lu, Juan Xue, Ning Zhao, Yan Zhang, Lu Dong, Xuejiao Zhang, Ping Li, Yaozhong Hu, Jin Wang, Bowei Zhang, Jingmin Liu, Huan lv & Shuo Wang
Cronobacter sakazakii, an emerging opportunistic pathogen, is implicated in severe foodborne outbreak infections in premature and full-term infants. Generally, acid tolerance is vital for the pathogenesis of foodborne pathogens; however, its role in C. sakazakii virulence remains largely unknown. To screen out acid-tolerance determinants from transposon mutants, anovel counterselection method using gentamicin and acid was developed. Using the counterselection method and growth assay, we screened several acid-sensitive mutants and found that nlpD encodes an acid-resistance...

The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies

Yu Li, Xiaoxuan Su, Qing Ye, Xiaodan Guo, Bo Xu, Tianjun Guan & Anqun Chen
This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of DR was assessed using sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and...

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence,...

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities

Ying Chen, Li Li, Li-Rui Jiang, Jia-Yin Tan, Li-Na Guo, Xiao-Li Wang, Wei Dong, Wen-Bao Wang, Ji-Kai Sun & Bo Song
Two new alkaloids, phranisines A–B (1–2), along with two known compounds, N-p-Coumaroyl serotonin (3) and N-p-coumaroyl-tryptamine (4), were isolated from the roots of Phragmites australis. The structures of 1–4 were established on the basis of extensive spectroscopic. The absolute configuration of compounds 1–2 were identified through quantum-chemical electronic circular dichroism (ECD) calculation compared with their experimental CD. All the isolated compounds were tested for their cytotoxic activities against HeLa and MCF-7 human cancer cell lines,...

Cement Catalyzed Valorization of Rice Straw into Upgraded Bio-Oil and Fuel Gases Using Pyrolysis Reactions

Ikram Uddin, Guijin Wang, Deyang Gao, Ning Li, Zahid Hussain & Baolin Hou
Rice straw is one of the major agricultural residues that is generated enormously in Asian countries. Thus, it is critical to develop an efficient process of converting this residue into valuable compounds in replacing fossil-based products. Herein, we developed an economically viable cement catalyst to pyrolyze the rice straw into bio-oil and fuel gas in a batch-type reactor. Under the optimized conditions, the maximum bio-oil yield of 41.07 wt.%, and gas yield of 30.53 wt.%...

The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer

Song Wan, Xuan Liu, Wei Hua, Ming Xi, Yulin Zhou & Yueping Wan
Telomerase reverse transcriptase (TERT) promoter mutations have been recognized as a common genetic event in bladder cancer (BC). Many studies have found the high TERT promoter mutations’ prevalence in BC recurrence patients which may make the TERT promoter mutations become a potential prognosis prediction of BC. We performed a systematic search in Embase, PubMed, and Web of Science in January 2021. The aspects of evaluation, methods, validation, and results were used to evaluate the included...

The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer

Song Wan, Xuan Liu, Wei Hua, Ming Xi, Yulin Zhou & Yueping Wan
Telomerase reverse transcriptase (TERT) promoter mutations have been recognized as a common genetic event in bladder cancer (BC). Many studies have found the high TERT promoter mutations’ prevalence in BC recurrence patients which may make the TERT promoter mutations become a potential prognosis prediction of BC. We performed a systematic search in Embase, PubMed, and Web of Science in January 2021. The aspects of evaluation, methods, validation, and results were used to evaluate the included...

SP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis

Yaxuan Zhang, Yin Zhang, Sen Wang, Qingquan Li, Boqiang Cao, Baosheng Huang, Tianlu Wang, Ruijuan Guo & Ning Liu
Glioma is a common life-threatening tumor with high malignancy and high invasiveness. LncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) was confirmed to be implicated in numerous tumors, while its biological function and mechanism have not been thoroughly understood in glioma. The gene expression was measured by RT-qPCR. Cell proliferation, cell cycle, and cell apoptosis of glioma cells were validated by CCK-8, colony formation, flow cytometry and TUNEL assays. The effect of ZFPM2-AS1 on tumor growth was...

Improved kth power expectile regression with nonignorable dropouts

Dongyu Li & Lei Wang
The kth (1<k≤ 2) power expectile regression (ER) can balance robustness and effectiveness between the ordinary quantile regression and ER simultaneously. Motivated by a longitudinal ACTG 193A data with nonignorable dropouts, we propose a two-stage estimation procedure and statistical inference methods based on the kth power ER and empirical likelihood to accommodate both the within-subject correlations and nonignorable dropouts. Firstly, we construct the bias-corrected generalized estimating equations by combining the kth power ER and inverse...

Improved kth power expectile regression with nonignorable dropouts

Dongyu Li & Lei Wang
The kth (1<k≤ 2) power expectile regression (ER) can balance robustness and effectiveness between the ordinary quantile regression and ER simultaneously. Motivated by a longitudinal ACTG 193A data with nonignorable dropouts, we propose a two-stage estimation procedure and statistical inference methods based on the kth power ER and empirical likelihood to accommodate both the within-subject correlations and nonignorable dropouts. Firstly, we construct the bias-corrected generalized estimating equations by combining the kth power ER and inverse...

Clinical outcomes, quality of life, and costs evaluation of peritoneal dialysis management models in Shanghai Songjiang District: a multi-center and prospective cohort study

Xiaoyan Ma, Min Tao, Yan Hu, Lunxian Tang, Jiasun Lu, Yingfeng Shi, Hui Chen, Si Chen, Yi Wang, Binbin Cui, Lin Du, Weiwei Liang, Guansen Huang, Xun Zhou, Andong Qiu, Shougang Zhuang, Xiujuan Zang & Na Liu
Background: The new Family-Community-Hospital (FCH) three-level comprehensive management aimed to improve the efficiency and scale of peritoneal dialysis (PD) to meet the increased population of end-stage renal disease (ESRD). Our study focused on the clinical outcomes, quality of life, and costs evaluation of this model in a multi-center and prospective cohort study. Methods: A total of 190 ESRD patients who commenced PD at Shanghai Songjiang District were enrolled. According to different PD management models, patients...

Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer

Rong Liao, Qi-Zhi Ma, Cong-Ya Zhou, Jun-Jun Li, Ning-Na Weng, Yang Yang & Qing Zhu
Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network analysis based on CRC expression data from the Gene Expression Omnibus database. Next, three hub genes (ADAM8, IL-1A, VAV3) related to infiltrating immune cells were identified...

Comparative molecular dynamics simulations identify a salt-sensitive loop responsible for the halotolerant activity of GH5 cellulases

Yuxuan Song, Xiuyun Wu, Yue Zhao, Xukai Jiang & Lushan Wang
Halotolerant glycoside hydrolases (GH) have broad application potentials in biorefinery industries. Elucidating the structure-activity relationship underlying the halotolerant catalysis is essential to design superior biocatalysts. Here, we performed molecular dynamics simulations to investigate the structural dynamics of two GH5 cellulases, namely the halotolerant Cel5R and non-halotolerant TfCel5A. Through characterizing the physical properties at different salt concentrations, the results revealed that the overall structures of Cel5R and TfCel5A were marginally affected by the increase in salt...

The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer

Lingyu Hu, Haokai Xu, Xiaoguang Wang, Bin Wu, Fei Chen, Wei Chen, Yong Gao & Zhengxiang Zhong
Pancreatic cancer (PAAD) is a common malignancy with a poor survival rate. The identification of novel biomarkers could improve clinical outcomes for patients with PAAD. Here we evaluated the expression and clinical significance of PPP1CB in PAAD. PPP1CB expression was higher in PAAD tissue than in matched paracancerous tissue (P < 0.05). We predicted a network of regulatory targets and protein interaction partners of PPP1CB, and identified a PPI network consisting of 39 node genes....

Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer

Xiaowei Huang, Chan Chen, Yajing Xu, Lanxiao Shen, Yi Chen & Huafang Su
EMT-related gene expression reportedly exhibits correlation with the anti-tumor immunity of T cells. In the present study, we explored the factors that might affect the efficacy of immunotherapy in colon cancer with treatment. In this regard, RNA-seq and clinical data of 469 colon cancer samples derived from the Cancer Genome Atlas (TCGA) database were used to calculate infiltrating T-cell abundance (ITA), to illustrate a pathway enrichment analysis, and to construct Cox proportional hazards (CPH) regression...

Novel modified nano-silica/polymer composite in water-based drilling fluids to plug shale pores

Fei Liu, Zheng Zheng, Xiuying Wang, Xiaqing Li, Zhaoxiang Zhang, Xuewu Wang, Xiaodong Dai, Yanping Xin, Qingxue Liu, Hailei Yao, Shunyao Jiang, Chao Liu & Xingyan Li
The rapid growth of global energy demand necessitates high-performance water-based drilling fluids (WDFs) with excellent-plugging performance in the deep excavation of shale gas formation. Herein, we report an organic-inorganic nanocomposite (NS-D) as a plugging agent in WDFs to plug the nanoporous of shale and abate the hydration expansion of shale by integrating the advantages of inorganic and polymer nano plugging agents. The results of Fourier Transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (H-NMR)...

Risk of Ophthalmic Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis

Yan-Li Hou, Di-Ya Wang, Jie-Xuan Hu, Ru-Yue Tian, Wei Wang, Qiang Su, Hongyang Li & Yan-Ling Wang
Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Methods: Eligible studies were selected from phase II/III randomized controlled trials investigating ICIs. The data were analyzed by R software and Stata. Odds ratio of treatment-related AE (trAEs) and nonspecific ophthalmic trAEs (NS-trAEs) were lower for PD-1/PD-L1...

Inhibition of CDK9 activity compromises global splicing in prostate cancer cells

Qiang Hu, Ninu Poulose, Samuel Girmay, Alma Helevä, Dimitrios Doultsinos, Aishwarya Gondane, Rebecca E Steele, Xiaozhuo Liu, Massimo Loda, Song Liu, Dean G. Tang, Ian G Mills & Harri M Itkonen
Cyclin-dependent kinase 9 (CDK9) phosphorylates RNA polymerase II to promote productive transcription elongation. Here we show that short-term CDK9 inhibition affects the splicing of thousands of mRNAs. CDK9 inhibition impairs global splicing and there is no evidence for a coordinated response between the alternative splicing and the overall transcriptome. Alternative splicing is a feature of aggressive prostate cancer (CRPC) and enables the generation of the anti-androgen resistant version of the ligand-independent androgen receptor, AR-v7. We...

Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents

Chao Wang, Yujing Zhang, Zeyu Wang, Yuelin Li, Qi Guan, Dongming Xing & Weige Zhang
Chemical drug design based on the biochemical characteristics of cancer cells has become an important strategy for discovering new anti-tumour drugs to improve tumour targeting effects and reduce off-target toxicities. Colchicine is one of the most prominent and historically microtubule-targeting drugs, but its clinical applications are hindered by notorious adverse effects. In this study, we presented a novel tumour-specific conjugate 9 that consists of deacetylcolchicine (Deac), biotin, and a cleavable disulphide linker. 9 was found...

Ensemble and calibration multiply robust estimation for quantile treatment effect

Xiaohong He & Lei Wang
Quantile treatment effects can be important causal estimands in the evaluation of biomedical treatments or interventions for health outcomes such as birthweight and medical cost. However, the existing estimators require either a propensity score model or a conditional density vector model is correctly specified, which is difficult to verify in practice. In this paper, we allow multiple models for propensity score and conditional density vector, then construct a class of calibration estimators based on multiple...

Physical properties of deep eutectic solvents based on p-toluene sulfonic acid and employment as catalyst

Shan Jiang, Zuoxiang Zeng, Weilan Xue, Zhijie Mao & Ying Wang
This work studied the physical properties of three deep eutectic solvents (DESs) and their catalytic activity in the esterification of palmitic acid and ethanol. Three types of deep eutectic solvents (DESs) were successfully prepared using p-toluene sulfonic acid monohydrate (PTSA) as hydrogen bond donor (HBD) with dodecyl trimethyl ammonium chloride (DTAC), tetradecyl trimethyl ammonium chloride (TTAC) and octadecyl trimethyl ammonium chloride (OTAC) as hydrogen bond acceptor (HBA). The freezing points of DESs were measured in...

Cenozoic rifting and inversion of Beibuwan Basin and its linkage with the strike-slip movement along the Ailao Shan-Red River Shear Zone

Yanjun Cheng, Zhiping Wu, Jie Zhang, Yuqing Liu, Zhengkai Wang & Yining Dai
The Cenozoic Beibuwan Basin is located along the eastern margin of the Ailao Shan Red River Shear Zone (ASRRSZ). The rifting and inversion processes of this basin provide important clues to the mechanism by which extrusion tectonics drive continental rifting and inversion development. However, the rifting and inversion of this basin remain ambiguous. Here, we employ seismic data, information about the time and displacement of faulting, syn-rift fault and isopach maps to analyse the Cenozoic...

Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data

Hang Huang, Haokai Xu, Ping Li, Xueting Ye, Wei Chen & Xixi Huang
The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis of public datasets from The Cancer Genome Atlas database (TCGA). The results showed that the expression levels of ZFC3H1 were notably lower than the corresponding non-cancerous tissues in prostate adenocarcinoma (PRAD), and patients in the high ZFC3H1-expression group showed poor survival. We hypothesized that the low expression of ZFC3H1 in tumor tissue might have be...

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  • Nanjing University
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