The coevolutionary relationship between fungus-growing ants (Formicidae: Attini: Attina) and their symbionts has been well-studied in the Panamanian rainforests. To further understand the ecological context of these evolutionary relationships, we have examined the population genetic structure of the fungus-growing ant species Mycetomoellerius mikromelanos Cardenas, Schultz, & Adams 2021, in the Panama Canal Zone. We specifically investigated the presence of population structure, the significance of geographic features (i.e., creeks) limiting gene flow, and relatedness between ant...

Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection...

Additional file 1. Full study protocol

Abstract Background Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and meta-analyses, functional and oncological outcomes after both treatment modalities are similar. Historically, radiotherapy (RT) has been performed by irradiation of the whole larynx. However, only the involved vocal cord is being treated with recently introduced hypofractionated concepts that result in 8 to 10-fold smaller target volumes. Retrospective data argues for...

Additional file 1: Figure S1. Expression of microglial genes in MGLs. Violin and box plots of the normalized expression counts of key microglial genes, including IBA1/AIF1, ITGAM (CD11b), ITGAX (CD11c), P2RY12, TMEM119, and CX3CR1 in male and female induced pluripotent stem cell-derived microglial-like cells (MGLs). Figure S2. Sex labelling and identification of a population of post-menopausal female and age-matched male monocytes. A Histogram showing expression counts of the Y-chromosomal gene, RPS4Y1, in a collection of...

Additional file 2: Table S1. Sexually differentially expressed genes in the microglial nuclei. Table S2. Genes comprising each of the IR-AD gene sets. Table S3. Sexually differentially expressed genes between the F- and M-MCs. Table S4. GSVA of IR-AD gene sets between Flo- and Fhi-MDMs results. Table S5. Sexually differentially expressed genes between the Flo- and M-MDMs. Table S6. Sexually differentially expressed reactome pathways between the Flo- and M-MDMs. Table S7. Differentially expressed reactome pathways...

Additional file 1: Appendix 1. Developing a working analytical framework for the review.

Additional file 2 Appendix 2. List of eligible settings and their eligibility periods.

Additional file 3: Appendix 3. Sample search strategy.

Additional file 4: Appendix 4. Summary table of included studies.

Additional file 1. Supplemental tables and supplemental figure.

Additional file 3. PARDI-AR-Q instructions for administrators.

Formative assessment and survey data