Additional file 2: Supplementary Table 1. Baseline features of the extension BODI cohort recruited for the analysis of the association between damage accrual and Heath related quality of life (n=147).

Additional file 2: Supplementary Figs. S1 to S21. Supplementary Fig. S1. Expression in ten melanoma cell lines of genes and gene families targeted by epigenetic drugs. Supplementary Fig. S2. Differentiation profile of melanoma cell lines. Supplementary Fig. S3. Susceptibility of ten melanoma cell lines to the anti-proliferative effects of epigenetic drugs. Supplementary Fig. S4. Methylation status of LINE-1, MAGE-A1 and NY-ESO-1 in 9 melanoma cell lines treated with guadecitabine. Supplementary Fig. S5. Volcano plot of...

Additional file 5: Supplementary Table S3. Antibodies used in quantitative western blot analysis.

Additional file 7: Supplementary Table S5. Immune-related gene modulation by epigenetic drugs and by combinatorial treatments.

Slides presented by the speakers at the International Conference "Digital Publishing for the Humanities - Nw Technologies and Ideas" - Rome, Bibliotheca Hertziana - Max Planck Institute for Art History 18-19 October 2022

Additional file 2: Table S1. A detailed list of differentially expressed pEV-microRNAs obtained from high-throughput PCR profiles in metastatic melanoma patients.

Abstract Background Melanoma is the deadliest form of skin cancer and metastatic disease is associated with a significant survival rate drop. There is an urgent need for consistent tumor biomarkers to scale precision medicine and reduce cancer mortality. Here, we aimed to identify a melanoma-specific circulating microRNA signature and assess its value as a diagnostic tool. Methods The study consisted of a discovery phase and two validation phases. Circulating plasma extracellular vesicles (pEV) associated microRNA...

Additional file 1. Supplementary Methods.

Additional file 1. Supplementary Methods.

Additional file 6: Supplementary Table S4. Modulation of immune-related genes belonging to 21 functional classes by epigenetic drugs. Sheets # to #21.

Additional file 7: Supplementary Table S5. Immune-related gene modulation by epigenetic drugs and by combinatorial treatments.

Additional file 8: Supplementary Table S6. Upstream Regulator analysis on differentially expressed genes in drug-treated vs untreated cell lines VRG100 and CST30.

Abstract In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorly understood. In this study, we performed an integrated analysis of 23 public transcriptomic datasets encompassing both lesional and uninvolved skin samples from psoriasis patients. We defined comprehensive gene co-expression network models of psoriatic lesions and uninvolved skin....

Abstract In recent years, a growing interest in the characterization of the molecular basis of psoriasis has been observed. However, despite the availability of a large amount of molecular data, many pathogenic mechanisms of psoriasis are still poorly understood. In this study, we performed an integrated analysis of 23 public transcriptomic datasets encompassing both lesional and uninvolved skin samples from psoriasis patients. We defined comprehensive gene co-expression network models of psoriatic lesions and uninvolved skin....

Additional file 1: Supplementary Figure 1. Flow chart representing the patients’ recruiting process from the BODI validation cohort.

Additional file 1: Supplementary Figure 1. Flow chart representing the patients’ recruiting process from the BODI validation cohort.

Additional file 1: Figure S1. Snapshot of informative pEV-microRNAs of discovery cohort. Figure S2. Principal Component Analysis (PCA) of discovery cohort. Figure S3. Up-regulated pEV-microRNA dotplot of Gene Ontology (GO) enrichment analysis. Figure S4. Down-regulated pEV-microRNA dotplot of Gene Ontology (GO) enrichment analysis. Figure S5. Schematic representation of bioinformatics workflow for pEV-microRNA signature identification in metastatic melanoma cohorts. Figure S6. Heatmap of cell-type enrichment analysis.

Abstract Background Melanoma is the deadliest form of skin cancer and metastatic disease is associated with a significant survival rate drop. There is an urgent need for consistent tumor biomarkers to scale precision medicine and reduce cancer mortality. Here, we aimed to identify a melanoma-specific circulating microRNA signature and assess its value as a diagnostic tool. Methods The study consisted of a discovery phase and two validation phases. Circulating plasma extracellular vesicles (pEV) associated microRNA...

The chamois Rupicapra spp. is the most abundant mountain ungulate of Europe and the Near East, where it occurs as two species, the Northern chamois R. rupicapra and the Southern chamois R. pyrenaica. Here, we provide a state-of-the-art overview of research trends and the most challenging issues in chamois research and conservation, focusing on taxonomy and systematics, genetics, life history, ecology and behavior, physiology and disease, management, and conservation. Research on Rupicapra has a longstanding...

Additional file 1. Additional material including supplemetary figures and tables.

Additional file 5: Supplementary Table S3. Antibodies used in quantitative western blot analysis.

Additional file 9 Supplementary Table S7. Prognostic significance of genes in the guadecitabine and JQ1 immune-related signatures in the Cancer Genome Atlas (TCGA) melanoma dataset.

Additional file 1. Additional material including supplemetary figures and tables.