119 Works

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion

Bing Chen, Xuewen Wang, Yanyan Zhang, Kangping Huang, Hao Liu, Dafen Xu, Shaoguang Li, Qicai Liu, Jianyong Huang, Hong Yao & Xinhua Lin
Amentoflavone, robustaflavone, 2″,3″-dihydro-3′,3‴-biapigenin, 3′,3‴-binaringenin, and delicaflavone are five major hydrophobic components in the total biflavonoids extract from Selaginella doederleinii (TBESD) that display favorable anticancer properties. The purpose of this study was to develop a new oral delivery formulation to improve the solubilities, dissolution rates, and oral bioavailabilities of the main ingredients in TBESD by the solid dispersion technique. Solid dispersions of TBESD with various hydrophilic polymers were prepared, and different technologies were applied to select...

A seven-gene signature and the C–C motif chemokine receptor family genes are the sarcoma-related immune genes

Jiarui Chen, Tuo Liang, Jiemei Cen, Jie Jiang, Shixin Pan, Shengsheng Huang, Liyi Chen, Xuhua Sun, Hao Li, Tianyou Chen, Wei Liang, Shian Liao, Chaojie Yu, Yuanlin Yao, Zhen Ye, Wuhua Chen, Hao Guo, Xinli Zhan & Chong Liu
Cells of the tumor microenvironment exert a vital influence on sarcoma prognosis. This study aimed to analyze and identify differentially expressed genes (DEGs) related to immunity and their significance as immune biomarkers for the accurate prediction of overall survival of patients with sarcoma. The Cancer Genome Atlas was adopted for obtaining sarcoma gene microarray and corresponding clinical information. ESTIMATE algorithm was used to calculate tumor immune microenvironment indices. Immune-associated DEGs were identified using the limma...

N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1

Zedong Hu, Liang Zhu, Yilin Zhang & Bing Chen
Accumulating evidence indicates that N6-methyladenosine (m6A) and long noncoding RNAs (lncRNAs) play crucial roles in cancer development. However, the biological roles of m6A and lncRNAs in lung cancer tumorigenesis are largely unknown. In this study, SVIL antisense RNA 1 (SVIL-AS1) was downregulated in lung adenocarcinoma (LUAD) tissues and was associated with a favorable prognosis in patients with LUAD. SVIL-AS1 overexpression suppressed LUAD cell proliferation and blocked cell cycle arrest. Mechanistically, METTL3 increased the m6A modification...

Additional file 3 of Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

Xiao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo, Xin-Lin Gong & Chen-Zhu Wang
Additional file 3. Figure S2. (A, B) TPM of Irs in females and males. (C, D, E, F) TPM of other olfactory related genes in females and males. Multiple t test was used with *, P < 0.05; **, P < 0.01; ***, P < 0.001 as significant differences. Error bars, mean ± SD.

Additional file 3 of Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

Xiao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo, Xin-Lin Gong & Chen-Zhu Wang
Additional file 3. Figure S2. (A, B) TPM of Irs in females and males. (C, D, E, F) TPM of other olfactory related genes in females and males. Multiple t test was used with *, P < 0.05; **, P < 0.01; ***, P < 0.001 as significant differences. Error bars, mean ± SD.

Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

Xiao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo, Xin-Lin Gong & Chen-Zhu Wang
Abstract Background Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or. Other types of olfactory receptor proteins, such as ionotropic receptors (IRs) and some gustatory receptors (GRs), are also involved in the olfactory system of insects. Orco as an obligatory subunit of ORs is highly conserved, providing an opportunity to systematically evaluate OR-dependent...

Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway

Ping Chen, Sungui Wu, Xiaoqing Dong, Min Zhou, Peipei Xu & Bing Chen
Multiple myeloma (MM) is an incurable plasma cell malignancy associated with poor survival. Novel therapeutic drugs are urgently needed to improve MM therapy and patient outcomes. This study aimed to investigate the effect of formosanin C (FC), a Chinese medicine monomer, on MM in vitro and disclose the underlying molecular mechanism. The effect of FC on the viability, proliferation, apoptosis, and autophagy of MM cell lines (NCI-H929 and ARP1) was studied through CCK-8, colony formation,...

Additional file 1 of A successful hybrid deep learning model aiming at promoter identification

Ying Wang, Qinke Peng, Xu Mou, Xinyuan Wang, Haozhou Li, Tian Han, Zhao Sun & Xiao Wang
Additional file 1. Supplementary Material for a Successful Hybrid Deep Learning Model aiming at Promoter Identification.

Cenozoic thermal-rheological evolution of the coastal cathaysia block of East Asia: geodynamic implications

Haonan Gan, Xiao Wang, Bo Wang & Guiling Wang
The thermal-rheological structure of the continental lithosphere is an important indicator of geodynamic processes. Tectonic compression and extension may change thermal-rheological structure of lithosphere. However, the thermal-rheological evolution over geological time may be difficult to determine because of overprints of subsequent geological events. Mantle xenolith temperature and pressure conditions can differentiate the lithospheric thermal structure over geological time and indicate the lithospheric rheological strength. Chronological and temperature-pressure condition data from 11 mantle xenoliths in Cenozoic...

Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis

Yunfeng Ning, Xiaoyue Zou, Jing Xu, Xiao Wang, Min Ding & Hulin Lu
To compare the risk of mortality in patients with cirrhosis with and without the associated acute kidney injury (AKI). We performed a systematic search in the PubMed, Embase, and Scopus databases for observational studies that were done on patients with cirrhosis. Eligible studies reported AKI in patients with cirrhosis and compared mortality among patients with and without AKI. We used a random-effects model, using STATA version 16.0, for deriving pooled effect sizes that were reported...

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Xiaoxia Duan, Chaoyong Zhang, Xiao Wang, Xueling Ren, Hongxia Peng, Xueqin Tang, Liangzhi Zhang, Zhenhua Chen, Yan Ye, Mengmou Zheng, Wanzhen Zhong, Xiyue Chen, Yilan Zeng, Ping Yuan & Lu Long
Three inactivated enterovirus A71 (EV-A71) vaccines have been widely vaccinated among children in the targeted age group in mainland China since mid-2016. However, comprehensive virological surveillance of hand, foot and mouth disease (HFMD) over multiple years after the use of EV-A71 vaccines has rarely been conducted. Using long-term data extracted from the Public Health and Clinical Center of Chengdu, we described the clinical, aetiological, and epidemiological characteristics of HFMD inpatients after the use of EV-A71...

NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer

Yu Dong, Tao Xu, Dongfan Li, Hua Guo, Xusheng Du, Guangshun Li, Jiakuan Chen, Bo Wang, Peng Wang, Gang Yu, Xuan Zhao & Ruiqi Xue
It is well known that non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence in the world. We aimed to clarify a possible target and identify its precise molecular biological mechanism in NSCLC. NLR family CARD domain containing 5 (NLRC5) is widely expressed in tissues and exerts a vital role in anti-tumor immunity. We determined NLRC5 expression by RT-qPCR and western blot assay. The role of NLRC5 in the development of NSCLC...

Antioxidant supplements relieve insulin resistance but do not improve lipid metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials

Ruye Wang, Chenyun Miao, Yun Chen, Ying Zhao, Liuqing Yang, Wei Cheng & Qin Zhang
Objective: The effect of antioxidant supplements on glucose metabolism and lipid profiles in polycystic ovary syndrome (PCOS) remains controversial. This systematic review and meta-analysis aimed to evaluate whether antioxidant supplements improve glucose metabolism and lipid profiles in women with PCOS to provide optimal nutritional supplement advice in clinical practice. Methods: The search was conducted across multiple medical databases from inception to January 1, 2022 and performed following the Preferred Reporting Items for Systematic Reviews and...

sj-xlsx-2-jhs-10.1177_17531934221141986 - Supplemental material for Abnormal MRI signal intensity of the triangular fibrocartilage complex in asymptomatic wrists

Zhixin Wang, Shanlin Chen, Bo Liu, Zhanhua Qian, Jin Zhu & Qianqian Wang
Supplemental material, sj-xlsx-2-jhs-10.1177_17531934221141986 for Abnormal MRI signal intensity of the triangular fibrocartilage complex in asymptomatic wrists by Zhixin Wang, Shanlin Chen, Bo Liu, Zhanhua Qian, Jin Zhu and Qianqian Wang in Journal of Hand Surgery (European Volume)

sj-xlsx-4-jhs-10.1177_17531934221141986 - Supplemental material for Abnormal MRI signal intensity of the triangular fibrocartilage complex in asymptomatic wrists

Zhixin Wang, Shanlin Chen, Bo Liu, Zhanhua Qian, Jin Zhu & Qianqian Wang
Supplemental material, sj-xlsx-4-jhs-10.1177_17531934221141986 for Abnormal MRI signal intensity of the triangular fibrocartilage complex in asymptomatic wrists by Zhixin Wang, Shanlin Chen, Bo Liu, Zhanhua Qian, Jin Zhu and Qianqian Wang in Journal of Hand Surgery (European Volume)

MOVER-R and Penalized MOVER-R Confidence Intervals for the Ratio of Two Quantities

Peng Wang, Yilei Ma, Siqi Xu, Yi-Xin Wang, Yu Zhang, Xiangyang Lou, Ming Li, Baolin Wu, Guimin Gao, Ping Yin & Nianjun Liu
Developing a confidence interval for the ratio of two quantities is an important task in statistics because of its omnipresence in real world applications. For such a problem, the MOVER-R (method of variance recovery for the ratio) technique, which is based on the recovery of variance estimates from confidence limits of the numerator and the denominator separately, was proposed as a useful and efficient approach. However, this method implicitly assumes that the confidence interval for...

Physicochemical parameters of groundwater in coastal sandy aquifer

Zhenyan Wang, Qianqian Wang, Xuejing Wang, Yifan Guo, Yan Zhang, Kai Xiao, Shengchao Yu, Xiaolang Zhang, Chunmiao Zheng & Hailong Li
In the Yangjiang profile, a total of 29 (27 groundwater samples and 2 surface water samples: seawater and aquaculture wastewater) and 32 (29 groundwater samples and 2 surface water samples: seawater and aquaculture wastewater) samples were collected on August 12, 2020 (wet season) and November 8, 2020 (dry season), respectively. The measurement procedures for the trace metals (As, Ba, Cd, Cr, Fe, Mn, Pb, and Zn) in groundwater samples were described elsewhere (Luo et al.,...

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

Qihong Yan, Ruitian Hou, Xiaohan Huang, Yanjun Zhang, Ping He, Yudi Zhang, Banghui Liu, Qian Wang, Haiyue Rao, Xianying Chen, Xinwei Zhao, Xuefeng Niu, Jincun Zhao, Xiaoli Xiong & Ling Chen
SARS-CoV-2 variants continue to emerge facing established herd immunity. L452R, previously featured in the Delta variant, quickly emerged in Omicron subvariants, including BA.4/BA.5, implying a continued selection pressure on this residue. The underlying links between spike mutations and their selective pressures remain incompletely understood. Here, by analyzing 221 structurally characterized antibodies, we found that IGHV1-69-encoded antibodies preferentially contact L452 using germline-encoded hydrophobic residues at the tip of HCDR2 loop. Whereas somatic hypermutations or VDJ rearrangements...

QTL for yield per plant under water deficit and well-watered conditions and drought susceptibility index in soybean (Glycine max (L.) Merr.)

Zhangxiong Liu, Huihui Li, Xingrong Wang, Yanjun Zhang, Zuowang Gou, Xingzhen Zhao, Honglei Ren, Zixiang Wen, Yinghui Li, Lili Yu, Huawei Gao, Dechun Wang, Xusheng Qi & Lijuan Qiu
Drought has historically represented the greatest abiotic stress to adversely affect the stability of soybean (Glycine max (L.) Merr.) yields in non-irrigated field conditions. To investigate the genetic basis underlying drought tolerance in soybean, we screened the seed yield per plant (YP) in a natural diversity panel of 149 accessions under both water deficit (drought-stressed; YP-S) and well-watered (full irrigation; YP-W) conditions in field and greenhouse trials and calculated a drought susceptibility index (DSI) based...

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion

Bing Chen, Xuewen Wang, Yanyan Zhang, Kangping Huang, Hao Liu, Dafen Xu, Shaoguang Li, Qicai Liu, Jianyong Huang, Hong Yao & Xinhua Lin
Amentoflavone, robustaflavone, 2″,3″-dihydro-3′,3‴-biapigenin, 3′,3‴-binaringenin, and delicaflavone are five major hydrophobic components in the total biflavonoids extract from Selaginella doederleinii (TBESD) that display favorable anticancer properties. The purpose of this study was to develop a new oral delivery formulation to improve the solubilities, dissolution rates, and oral bioavailabilities of the main ingredients in TBESD by the solid dispersion technique. Solid dispersions of TBESD with various hydrophilic polymers were prepared, and different technologies were applied to select...

Plant diversity data from modern sedimentary DNA of lakes in Siberia and China

Kathleen R. Stoof-Leichsenring, Sisi Liu, Weihan Jia, Kai Li, Luidmila A. Pestryakova, Steffen Mischke, Xianyong Cao, Xinqui Liu, Jian Ni, Stefan Neuhaus & Ulrike Herzschuh
Here we provide a large dataset on genetic plant diversity retrieved from surface sedimentary DNA (sedDNA) of lakes from Siberia and China spanning over a large environmental gradient. Our dataset encompasses sedDNA sequence data of 244 surface lake sediments and 3 soil samples originating from Siberia and Chinese lakes. We used a PCR-based metabarcoding approach combined with Next-Generation Sequencing to assess the modern and local plant diversity in and around the analysed lake localities. As...

Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211042575 - Strategic Framing Matters But Varies: A Structural Topic Modeling Approach to Analyzing China’s Foreign Propaganda About the 2019 Hong Kong Protests on Twitter

Maggie Mengqing Zhang, Xiao Wang & Yang Hu
Supplemental Material, sj-pdf-1-ssc-10.1177_08944393211042575 for Strategic Framing Matters But Varies: A Structural Topic Modeling Approach to Analyzing China’s Foreign Propaganda About the 2019 Hong Kong Protests on Twitter by Maggie Mengqing Zhang, Xiao Wang and Yang Hu in Social Science Computer Review

A Gypsy element contributes to the nuclear retention and transcriptional regulation of the resident lncRNA in locusts

Xia Zhang, Ya′Nan Zhu, Bing Chen & Le Kang
The majority of long noncoding RNAs (lncRNAs) contain transposable elements (TEs). PAHAL, a nuclear-retained lncRNA that is inserted by a Gypsy retrotransposon, has been shown to be a vital regulator of phenylalanine hydroxylase (PAH) gene expression that controls dopamine biosynthesis and behavioural aggregation in the migratory locust. However, the role of the Gypsy retrotransposon in the transcriptional regulation of PAHAL remains unknown. Here, we identified a Gypsy retrotransposon (named Gypsy element) as an inverted long...

A seven-gene signature and the C–C motif chemokine receptor family genes are the sarcoma-related immune genes

Jiarui Chen, Tuo Liang, Jiemei Cen, Jie Jiang, Shixin Pan, Shengsheng Huang, Liyi Chen, Xuhua Sun, Hao Li, Tianyou Chen, Wei Liang, Shian Liao, Chaojie Yu, Yuanlin Yao, Zhen Ye, Wuhua Chen, Hao Guo, Xinli Zhan & Chong Liu
Cells of the tumor microenvironment exert a vital influence on sarcoma prognosis. This study aimed to analyze and identify differentially expressed genes (DEGs) related to immunity and their significance as immune biomarkers for the accurate prediction of overall survival of patients with sarcoma. The Cancer Genome Atlas was adopted for obtaining sarcoma gene microarray and corresponding clinical information. ESTIMATE algorithm was used to calculate tumor immune microenvironment indices. Immune-associated DEGs were identified using the limma...

Tire wear particles: An emerging threat to soil health

Jing Ding, Min Lv, Dong Zhu, Eva F. Leifheit, Qing-Lin Chen, Yun-Qing Wang, Ling-Xin Chen, Matthias C. Rillig & Yong-Guan Zhu
Tire wear particles (TWP) have caused widespread contamination in the environment. However, their behavior and potential impacts in soil remain unclear since studies have so far been mainly conducted in aquatic ecosystems. It is possible that soil ecosystems are already under pressure from pollution by TWP. We here firstly synthesize knowledge about the composition, distribution, and behavior of TWP in soils. By comparing with effects of microplastics (MP) in soil, we further outline several potential...

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