Additional file 7: Table S7. The results of univariate Cox regression analysis in the MSKCC cohort.

Supplemental Material for MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway by Wei Zhang, Qiu Zhang, Qianbo Cui and Yu Xu in Human and Experimental Toxicology

Supplemental Material for MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway by Wei Zhang, Qiu Zhang, Qianbo Cui and Yu Xu in Human and Experimental Toxicology

Background:Vigabatrin (VGB) is currently the most widely prescribed first-line medication for individuals with infantile spasms (IS) and especially for those with tuberous sclerosis complex (TSC), with demonstrated efficacy. Meanwhile, its adverse events, such as vigabatrin-associated brain abnormalities on magnetic resonance imaging (MRI; VABAM), have also been widely reported.Objectives:The objectives of this study were to observe the occurrences of VABAM in patients with IS caused by TSC (IST) and further explore the associated risk factors.Methods:Children with...

Supplementary Material 4: Table S2: The risk of bias for cohort studies by the Newcastle-Ottawa scale (NOS)

Supplementary Material 4: Table S2: The risk of bias for cohort studies by the Newcastle-Ottawa scale (NOS)

Additional file 1.

Additional file 1.

Supplementary Material 1

Additional file 1: Figure S1. Surgical procedurefor augmented corticotomy in a subject with severe skeletal Angle Class IIImalocclusion: A) local anesthesia; B) full-Thickness flaps were elevatedon the labial aspect, and areas of fenestration and dehiscene were detected; C) vertical alveolar decortication wasperformed in the interradicular space; D)bone derivative material was placed; E)bioabsorbable collagen membrane was placed to completely cover the graft site; F) flaps were coronally repositionedand sutured in place.

Additional file 1: Figure S1. Surgical procedurefor augmented corticotomy in a subject with severe skeletal Angle Class IIImalocclusion: A) local anesthesia; B) full-Thickness flaps were elevatedon the labial aspect, and areas of fenestration and dehiscene were detected; C) vertical alveolar decortication wasperformed in the interradicular space; D)bone derivative material was placed; E)bioabsorbable collagen membrane was placed to completely cover the graft site; F) flaps were coronally repositionedand sutured in place.

Abstract Objectives To quantitatively assess periodontal soft tissue changes, including gingival thickness and keratinized gingiva width after periodontally accelerated osteogenic orthodontics (PAOO) surgery by digital measurements. Methods This study enrolled 15 maxillaries with 89 anterior teeth and 16 mandibles with 94 anterior teeth from Chinese adult patients with skeletal Angle Class III malocclusion for whom PAOO surgery was proposed during orthodontic treatment. Intraoral scanning and cone beam computed tomography (CBCT) examinations were performed before PAOO...

Additional file 1: Table S1. Trichoderma strains used in this study. Fig. S1 Detection of antagonistic characteristics and functions of different Trichoderma strains.

Additional file 3. Collection Proof of Strain GDFS1009.

Additional file 1: Figure S1. Differential expression of genes encoding proteins that regulate MT organization in normal vs. OA and NOA human testes based on analyses of scRNA-Seq datasets. (A) scRNA-Seq datasets from normal vs. OA and NOA human testes were analyzed used Seurat package in R toolkit using Rstudio to obtain Dot plot to identify differentially expressed genes encoding genes pertinent to MT organization. It is noted that some of these proteins overlap with...

Additional file 1: Figure S1. Differential expression of genes encoding proteins that regulate MT organization in normal vs. OA and NOA human testes based on analyses of scRNA-Seq datasets. (A) scRNA-Seq datasets from normal vs. OA and NOA human testes were analyzed used Seurat package in R toolkit using Rstudio to obtain Dot plot to identify differentially expressed genes encoding genes pertinent to MT organization. It is noted that some of these proteins overlap with...

Abstract The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is known to some extent, but its role in the etiology of azoospermia in humans remains unexplored. Here, we examined if MT cytoskeleton was defective in NOA (non-obstructive azoospermia) testes versus normal human testes based on histopathological, immunofluorescence (IF), and scRNA-Seq transcriptome profiling. Testis biopsy samples from n = 6 normal men versus n = 3 Sertoli cell only (SCO) and...

Abstract The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is known to some extent, but its role in the etiology of azoospermia in humans remains unexplored. Here, we examined if MT cytoskeleton was defective in NOA (non-obstructive azoospermia) testes versus normal human testes based on histopathological, immunofluorescence (IF), and scRNA-Seq transcriptome profiling. Testis biopsy samples from n = 6 normal men versus n = 3 Sertoli cell only (SCO) and...

Additional file 1: Table S1. Summary of CBL gene characteristics in Medicago and C. arietinum.

Additional file 2: Table S2. Summary of CIPK gene characteristics in Medicago and C. arietinum.

Additional file 6: Table S4. CIPK protein sequences used to build phylogenetic tree.

Additional file 8: Figure S3. Synteny analysis of CBL and CIPK genes among four allelic chromosomes in M. sativa spp. sativa. CBL genes are in red, and CIPK genes are in gray. Red lines represent the collinearity of duplicated CBL genes, and gray lines indicate the collinearity of duplicated CIPK genes. Four sets of chromosomes in chromosome circles are represented by four different colors, light green for the first set of chromosomes (MsaX.1), light blue...

Additional file 2: Table1

Trapa L. (Lythraceae J. ST.-HIL) is a genus of annual free-floating plant, widely distributed in the Northern Hemisphere. The Qaidam Basin is regarded as an ideal region to understand the Cenozoic palaeoclimatic and palaeobiological evolution of the northern Tibetan Plateau. A few records of Trapa have been previously mentioned from the Cenozoic deposits of the Qaidam Basin, northern Tibetan Plateau. Here, we describe some fossil fruits of Trapa from the late Miocene Shangyoushashan Formation of...

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