The aim of this study was to identify the epidemiological characteristics of paediatric eye injury in a large metropolitan city based on age group and sex. This prospective, multicentre, observational study used data extracted from the eye injury registry for tertiary teaching hospitals in Daegu, South Korea, between August 2016 and July 2018. Children aged < 16 years were classified as infants, pre-schoolers, school children, and adolescents based on their age group. This study included...

To identify common factors associated with the loss of an eye using the NIH All of Us database. In this case-controlled study, we extracted electronic health record and socio-demographic data for 231 cases of eye loss from All of Us enrollment sites. Controls (N = 924) matched the demographic characteristics of the 2020 United States Census. Bivariate analyses and multivariable logistic regression identified variables significantly associated with increased odds of eye loss. Medical and social...

Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma. Methods: We included nine databases contributing data from January to June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients (‘diagnosed’ and ‘hospitalized’) based on COVID-19 disease codes. We followed patients from COVID-19 index...

Allyl alkynoic esters were synthesized by the reaction of allyl amines and alkynoic acids via deaminative esterification. The reaction of allyl alkynoic esters with Pd(dba)2 and Xantphos in digylme at 110 °C for 12 h afforded the desired decarboxylated allyl alkynes in good yields.

Purpose The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (≥2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. Methods The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures...

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant morbidity and mortality worldwide. Despite a successful vaccination programme, the emergence of mutated variants that can escape current levels of immunity mean infections continue. Herein, we report the development of CT-P63, a broad-spectrum neutralizing monoclonal antibody. In vitro studies demonstrated potent neutralizing activity against the most prevalent variants, including Delta and the BA.1 and BA.2 sub-lineages of Omicron. In a...

We investigate the upper-crustal seismic velocity structure in the Seoul metropolitan area, where about 20 million people live. The Chugaryeong fault zone (CFZ) is placed in this area, but the seismic hazard potential remains unclear. We conducted ambient noise tomography to illuminate the high-resolution upper-crustal structure in the Seoul metropolitan area. We analyzed continuous vertical seismic records for ~5 months from a dense seismic array with 77 broadband stations. Group velocity dispersion curves and tomographic...

Three new monoterpenoid glycosides (1–3) and one new flavanol (4) along with 15 known compounds were isolated from the twig of Hamamelis japonica Sieb. et Zucc. The chemical constituent study of the twig of H. japonica has performed for the first time in the present investigation. Their structures were determined based on extensive spectroscopic methods including 1 D and 2 D NMR and CD spectra data. All isolated compounds were tested for their antiviral activities...

Abstract Zika virus is a highly infectious virus that is part of the flavivirus group. Precise diagnosis of the Zika virus is significant issue for controlling a global pandemic after the COVID-19 era. For the first time, we describe a zika virus aptamer-based electrical biosensor for detecting Zika virus in human serum. The electrical biosensor composed of a Zika virus aptamer/MXene nanoparticle heterolayer on Au micro-gap electrode (AuMGE)/print circuit board (PCB) system. The Zika virus...

Additional file 2.

The mass dislocations caused by large coseismic slips in megathrust earthquakes are large enough to produce elastogravity waves. Despite successful identification of elastogravity-wave development during megathrust earthquakes, the nature of ground motions and hazard potentials in regional and teleseismic distances remains unknown. The dynamic ground motions from the 11 March 2011 MW9.0 Tohoku-Oki megathrust earthquake are retrieved from broadband seismic records throughout the Korean Peninsula. The dynamic ground motions of the megathrust earthquake are dominated...

Abstract Background Based on a previous study on the feasibility of TomoEQA, an exit detector-based patient-specific pre-treatment quality assurance (QA) method for helical tomotherapy, an in-depth clinical evaluation was conducted. Methods Data of one hundred patients were analyzed to evaluate the clinical usefulness of TomoEQA for patient-specific pre-treatment QA in comparison with the conventional phantom-based method. Additional investigations were also performed under unusual measurement conditions to validate the off-axis region. In addition to the clinical...

Supplemental material, sj-pdf-1-ajs-10.1177_03635465221130759 for Effect of Quality of Repair on Clinical and Structural Outcomes of Rotator Cuff Repair by Tae Won Go, Ji Eun Park, Sohee Oh, Minjoon Cho and Chris Hyunchul Jo in The American Journal of Sports Medicine

Background:Anatomic repair of a torn rotator cuff tendon on the greater tuberosity (GT) is an important surgical goal in rotator cuff repair. However, few studies have investigated whether the efforts made to maximize coverage of the GT are associated with the clinical and structural outcomes after rotator cuff repair surgery.Purpose:To investigate whether the quality of repair at the time of surgery is associated with clinical and structural outcomes after surgery and to identify factors influencing...

Background:The clinical utility of plasma tumor mutational burden (pTMB) requires further validation. Herein, the pTMB and genetic alterations were investigated as predictive biomarkers for anti-PD-1 monotherapy outcome in metastatic non-small cell lung cancer (NSCLC).Methods:The GuardantOMNI panel (Guardant Health) was used to identify pTMB and genetic alterations. Data from 99 patients with metastatic NSCLC treated with pembrolizumab or nivolumab in first-, second-, or third-line settings between June 2016 and December 2020 were collected. Associations between pTMB...

Additional file 1: Table S1. Clinical data of patients with primary CRC.

Additional file 2: Figure S1. Indicator profiles by enterotype.

Additional file 4: Figure S3. Characterization of ASVs assigned to Bacteroides sp.

Additional file 4: Figure S3. Characterization of ASVs assigned to Bacteroides sp.

Purpose: We aimed to investigate the dose calculation accuracy of Mobius3D for small-field flattening-filter-free x-rays, mainly utilized for stereotactic body radiation therapy (SBRT). The accuracy of beam modeling and multileaf collimator (MLC) modeling in Mobius3D, significantly affecting the dose calculation is investigated. Methods: The commissioning procedures of Mobius3D were performed for unflattened 6 MV and 10 MV x-ray beams of the linear accelerator, including beam model adjustment and dosimetric leaf gap (DLG) optimization. An experimental...

The precipitation hardening is widely applied to strengthen Al alloys. Here, we report an alternative way to achieve high-strength Al alloys via forming the dislocation gradient through pre-torsion. Remarkably, the gradient Al alloys exhibit a sharp increase in ultimate tensile strength up to 605 MPa yet nearly without reducing the uniform elongation, thereby outperforming their counterparts. The superior strength–ductility combination is ascribed to the excellent strengthening and strain hardening effects stemming from the substantial hetero-deformation-induced...

Additional file 10: Supplementary Figure 10. Different microbial communities by inoculation of probiotics in germ-free mice. a,b, Beta (Bray-Curtis distance) diversities of the gut microbiome between (a), before inoculation of probiotics (0th week, n = 13) and after inoculation of probiotics (8th week, n = 15) in germ-free mice and (b), types of treatment (Pre, n = 13; HFD, n = 5; B. longum, n = 5, B. bifidum, n = 5). Each below table...

Additional file 10: Supplementary Figure 10. Different microbial communities by inoculation of probiotics in germ-free mice. a,b, Beta (Bray-Curtis distance) diversities of the gut microbiome between (a), before inoculation of probiotics (0th week, n = 13) and after inoculation of probiotics (8th week, n = 15) in germ-free mice and (b), types of treatment (Pre, n = 13; HFD, n = 5; B. longum, n = 5, B. bifidum, n = 5). Each below table...

Additional file 12: Supplementary Figure 12. Summary of mechanisms of B. longum and B. bifidum for anti-obesity in HFD-induced obesity mice. Inoculation of B. longum and B. bifidum induced physiological changes of WAT, BAT, and liver to prevent HFD-induced obesity in mice.

Additional file 13: Supplementary Table 1. Clinical characteristics of human donors.