3 Works

Data from: A Curated Cancer Clinical Outcomes Data Base (C3OD) for accelerating patient recruitment in cancer clinical trials

Dinesh Pal Mudaranthakam, Jeffery Thompson, Jinxiang Hu, Dong Pei, Shanthan Reddy Chintala, Michele Park, Brooke Fridley, Byron Gajewski, Devin Koestler, Matthew Mayo, Jeffrey Thompson, Devin C Koestler, Matthew S Mayo & Brooke L Fridley
Data used to determine patient eligibility for cancer clinical trials often come from disparate sources that are typically maintained by different groups within an institution, use differing technologies, and are stored in different formats. Collecting data and resolving inconsistencies across sources increase the time it takes to screen eligible patients, potentially delaying study completion. To address these challenges, the Biostatistics and Informatics Shared Resource at The University of Kansas Cancer Center developed the Cancer Curated...

Data from: Comparative dynamics of microglialand glioma cell motility at the infiltrative margin of brain tumours

Joseph Juliano, Orlando Gil, Andrea Hawkins-Daarud, Sonal Noticewala, Russell C. Rockne, Jill Gallaher, Susan C. Massey, Peter A. Sims, Alexander R. A. Anderson, Kristin R. Swanson & Peter Canoll
Microglia are a major cellular component of gliomas, and abundant in the centre of the tumour and at the infiltrative margins. While glioma is a notoriously infiltrative disease, the dynamics of microglia and glioma migratory patterns have not been well characterized. To investigate the migratory behaviour of microglia and glioma cells at the infiltrative edge, we performed two-colour time-lapse fluorescence microscopy of brain slices generated from a platelet-derived growth factor-B (PDGFB)-driven rat model of glioma,...

Data from: A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Heather E. Stefanski, Leslie Jonart, Emily Goren, James J. Mulé & Bruce R. Blazar
Chemotherapy or chemoradiotherapy conditioning regimens required for bone marrow transplantation (BMT) cause significant morbidity and mortality as a result of insufficient immune surveillance mechanisms leading to increased risks of infection and tumor recurrence. Such conditioning causes host stromal cell injury, impairing restoration of the central (thymus) and peripheral (spleen and lymph node) T cell compartments and slow immune reconstitution. The chemokine, CCL21, produced by host stromal cells, recruits T- and B-cells that provide lymphotoxin mediated...

Registration Year

  • 2018
    3

Resource Types

  • Dataset
    3

Affiliations

  • Moffitt Cancer Center
    3
  • University of Kansas Cancer Center
    1
  • Columbia University
    1
  • City Of Hope National Medical Center
    1
  • University of California, San Diego
    1
  • University of Minnesota
    1
  • University of Kansas Medical Center
    1
  • University of Southern California
    1
  • Mayo Clinic
    1