309 Works

Data from: Transgender transitioning and change of self-reported sexual orientation

Matthias K. Auer, Johannes Fuss, Nina Hoehne, Günter K. Stalla, Caroline Sievers & Nina Höhne
Objective: Sexual orientation is usually considered to be determined in early life and stable in the course of adulthood. In contrast, some transgender individuals report a change in sexual orientation. A common reason for this phenomenon is not known. Methods: We included 115 transsexual persons (70 male-to-female “MtF” and 45 female-to-male “FtM”) patients from our endocrine outpatient clinic, who completed a questionnaire, retrospectively evaluating the history of their gender transition phase. The questionnaire focused on...

Data from: Biofilm morphotypes and population structure among Staphylococcus epidermidis from commensal and clinical samples

Llinos Harris, Susan Murray, Ben Pascoe, James Bray, Guillaume Meric, Leonardos Magerios, Thomas S. Wilkinson, Rose E. Jeeves, Holger Rohde, Stefan Schwarz, Herminia De Lencastre, Maria Miragaia, Joana Rolo, Rory Bowden, Keith A. Jolley, Martin C. J. Maiden, Dietrich Mack, Samuel Sheppard, Llinos G. Harris, Rose Jeeves & Samuel K. Sheppard
Bacterial species comprise related genotypes that can display divergent phenotypes with important clinical implications. Staphylococcus epidermidis is a common cause of nosocomial infections and, critical to its pathogenesis, is its ability to adhere and form biofilms on surfaces, thereby moderating the effect of the host’s immune response and antibiotics. Commensal S. epidermidis populations are thought to differ from those associated with disease in factors involved in adhesion and biofilm accumulation. We quantified the differences in...

Data from: Pupil diameter tracks lapses of attention

Ruud L. Van Den Brink, Peter R. Murphy & Sander Nieuwenhuis
Our ability to sustain attention for prolonged periods of time is limited. Studies on the relationship between lapses of attention and psychophysiological markers of attentional state, such as pupil diameter, have yielded contradicting results. Here, we investigated the relationship between tonic fluctuations in pupil diameter and performance on a demanding sustained attention task. We found robust linear relationships between baseline pupil diameter and several measures of task performance, suggesting that attentional lapses tended to occur...

Data from: Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system

Christian Buchel, Stephan Miedl & Christian Sprenger
It has been hypothesized that the pleasure of a reward in humans is mediated by an opioidergic system involving the hypothalamus, nucleus accumbens and the amygdala. Importantly, enjoying the pleasure of a reward is distinct from incentive salience induced by cues predicting the reward. We investigated this issue using a within subject, pharmacological challenge design with the opioid receptor antagonist naloxone and fMRI. Our data show that blocking opioid receptors reduced pleasure associated with viewing...

Response to fumaric acid esters for plaque type psoriasis in real-world practice is largely independent of patient characteristics at baseline – a multivariable regression analysis from the German Psoriasis Registry PsoBest

Kristian Reich, Ulrich Mrowietz, Christina Sorbe, Ralph von Kiedrowski, Sebastian Diemert, Lisa Schaeffer, Natalia Kirsten, Nesrine Ben-Anaya & Matthias Augustin
Fumaric acid esters (FAEs) are a well-established treatment option for long-term therapy of moderate to severe plaque psoriasis. This study examines effectiveness of FAEs for the treatment of plaque psoriasis in real-world practice at 12 months and if patient characteristics affect the odds of clinical response. A descriptive, multivariable logistic regression analysis was conducted in a cohort drawn from the German registry PsoBest. Baseline patient characteristics were assessed as potential treatment effect modifiers. 444 patients...

Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters

Stefanie Brassen
Central insulin is involved in the regulation of hedonic feeding. Insulin resistance in overweight has recently been shown to reduce the inhibitory function of insulin in the human brain, but how this affects future weight management is unclear. Also unknown is the role of central insulin sensitivity on eating behavior of older people, who are highly vulnerable to hyperinsulinemia and in whom neural target systems of insulin action undergo age-related changes. Here, fifty overweight, pre-diabetic...

Additional file 2 of EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Additional file 2: Supplementary Figure 2. Distribution of EVI1 continuous expression in breast cancer: A: Histogram of EVI1 continuous expression in the entire cohort (N=993); B: Boxplots of EVI1 continuous expression within breast cancer subtypes. Note, 882/993 patients with available BC subtype information were included in this analysis. Horizontal bold lines present EVI1 median values of 116.65 in HR+/HER2-, 98.67 in HR+/HER2+, 114.77in HR-/HER2+, and 115.64 in TNBC; boxes present the interquartile range between first...

EVI1 expression in early-stage breast cancer patients treated with neoadjuvant chemotherapy

Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl & Stefan Gröschel
Abstract Background Overexpression of the EVI1 (ecotropic viral integration site 1) oncogene has recently been implicated as a prognostic factor in breast cancer (BC), particularly in triple-negative BC (TNBC). In this study we aimed to investigate frequency and clinical relevance of EVI1 expression in newly diagnosed BC treated with neoadjuvant chemotherapy. Methods EVI1 expression was determined by immunohistochemistry using H-score as a cumulative measurement of protein expression in pretherapeutic biopsies of BC patients treated with...

Additional file 2 of Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema

Yan Xue, Xueting Wang, Baolan Wan, Dongzhi Wang, Meiqi Li, Kang Cheng, Qianqian Luo, Dan Wang, Yapeng Lu & Li Zhu
Additional file 1. Supplementary Figure 1. CAV-1 regulated the expression of occludin under hypoxic conditions. (A) bEnd.3 cells were exposed to 1% O2 for 24 h. HIF-1α protein levels were detected by Western blot. (B and C) After transfection with siCAV1 for 48 h, bEnd.3 cells were exposed to 1% O2 for 24 h; Occludin protein levels were detected by Western blot (B) and quantified (C) (*p<0.05 and **p<0.01).

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma

Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang & Yi Ding
Abstract Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a promising antitumor effect. However, the dysregulation of the redox system often causes radioresistance and impairs the efficacy of RT. Increasing evidence indicates that nuclear protein 1 (NUPR1) plays a critical role in redox reactions. In this study, we aim to explore the role of NUPR1 in...

Statistical Learning for Individualized Asset Allocation

Yi Ding, Yingying Li & Rui Song
We establish a high-dimensional statistical learning framework for individualized asset allocation. Our proposed methodology addresses continuous-action decision-making with a large number of characteristics. We develop a discretization approach to model the effect of continuous actions and allow the discretization frequency to be large and diverge with the number of observations. We estimate the value function of continuous-action using penalized regression with our proposed generalized penalties that are imposed on linear transformations of the model coefficients....

Additional file 2 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 2: Table S1. Clinical characteristics of the fetal cases. Table S2. Fetuses with diagnostic or VUS results obtained additional new phenotypes during prenatal and/or postnatal period. Table S3. Fetuses with positive diagnostic results detected by ES. Table S4. Diagnostic rates in different malformation subgroups. Table S5. Diagnostic rates in relation to NT measurement range. Table S6. Number of variants analyzed in step 1 and 2- case by case. Table S7. Number of variants...

Additional file 2 of Between allopatry and secondary contact: differentiation and hybridization among three sympatric Gentiana species in the Qinghai-Tibet Plateau

Pengcheng Fu, Adrien Favre, Rui Wang, Yizhuo Huang & Shanshan Sun
Supplementary Material 2

Digitally-supported patient-centered asynchronous outpatient follow-up in rheumatoid arthritis - an explorative qualitative study

Ramona Stenzel, Katharina Hadaschik, Susann May, Manuel Grahammer, Hannah Labinsky, Martin Welcker, Johannes Hornig, Gerlinde Bendzuck, Corinna Elling-Audersch, Ulrike Erstling, Patricia Steffens Korbanka, Nicolas Vuillerme, Martin Heinze, Gerhard Krönke, Georg Schett, Ann-Christin Pecher, Martin Krusche, Johanna Mucke, Johannes Knitza & Felix Muehlensiepen
Abstract Objective A steadily increasing demand and decreasing number of rheumatologists push current rheumatology care to its limits. Long travel times and poor accessibility of rheumatologists present particular challenges for patients. Need-adapted, digitally supported, patient-centered and flexible models of care could contribute to maintaining high-quality patient care. This qualitative study was embedded in a randomized controlled trial (TELERA) investigating a new model of care consisting of the use of a medical app for ePRO (electronic...

Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim & Alexandra Schubert-Unkmeir
Abstract Background Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the human-specific nature of N. meningitidis, previous research investigating this complex host–pathogen interaction has mostly been done in vitro using immortalized brain endothelial cells (BECs) alone, which often do not retain relevant barrier properties in culture. Here, we developed physiologically relevant mBCSFB models using BECs...

Additional file 2 of Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection

Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim & Alexandra Schubert-Unkmeir
Additional file 2: Figure S1. Laminin expression in the iBEC-LMC co-culture model. Figure S2. Characterization of the hCMEC/D3-LMC co-culture model. Figure S3. Barrier properties of LMC monolayers and prolonged iBEC-LMC co-culture. Figure S4. N. meningitidis interaction with the hCMEC/D3-LMC direct co-culture model. Figure S5. Effects of N. meningitidis infection on cell-junction expression in hCMEC/D3 from mono- and co-culture models. Figure S6. Effects of SNAI1 knockdown on N. meningitidis induced downregulation of cell-junction expression in hCMEC/D3....

Sanfilippo syndrome: consensus guidelines for clinical care

Nicole Muschol, Roberto Giugliani, Simon A. Jones, Joseph Muenzer, Nicholas J. C. Smith, Chester B. Whitley, Megan Donnell, Elise Drake, Kristina Elvidge, Lisa Melton & Cara O’Neill
Abstract Sanfilippo syndrome is a group of rare, complex, and progressive neurodegenerative lysosomal storage disorders that is characterized by childhood dementia. The clinical management of patients with progressive neurological decline and multisystem involvement requires a multidisciplinary team with experience in the management of neurodegenerative disorders. Best practice guidelines for the clinical management of patients with these types of rare disorders are critical to ensure prompt diagnosis and initiation of appropriate care. However, there are no...

Additional file 1 of Sanfilippo syndrome: consensus guidelines for clinical care

Nicole Muschol, Roberto Giugliani, Simon A. Jones, Joseph Muenzer, Nicholas J. C. Smith, Chester B. Whitley, Megan Donnell, Elise Drake, Kristina Elvidge, Lisa Melton & Cara O’Neill
Additional file 1. Supplemental methods and results.

Additional file 1 of Trends in mortality from alcohol, opioid, and combined alcohol and opioid poisonings by sex, educational attainment, and race and ethnicity for the United States 2000–2019

Charlotte Buckley, Yu Ye, William C. Kerr, Nina Mulia, Klajdi Puka, Jürgen Rehm & Charlotte Probst
Additional file 1: Fig. S1. Total number of deaths aged 18 or older in US 2000-19 from alcohol poisoning only, opioid poisoning only and alcohol and opioid poisoning using three different versions of alcohol poisoning definition. Fig. S2. Age-standardized mortality rates for alcohol poisoning, opioid poisoning and combined alcohol and opioid poisoning for men and women by race and ethnicity categories from 2000 to 2019. Table S1. ICD-10 Codes used to define alcohol and opioid...

Efficient cell navigation methods and applications of an aperture 4 hexagonal discrete global grid system

Jianbin Zhou, Jin Ben, Xinhai Huang, Rui Wang, Xiaoyu Liang, Junjie Ding & Qishuang Liang
Hexagonal discrete global grid systems are multi-resolution frameworks for earth data and have attracted much attention in research towards the next generation of geographic information system. Each resolution of the framework divides the earth into a hexagonal grid of cells and cell codes are used instead of Cartesian coordinates to organize and query data. Aperture (the ratio of cells between resolutions) 4 systems have structural advantages compared with aperture 3 and 7, but haven’t been...

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Dan Bai, Kai Liu, Rui Wang, Wei-Han Zhang, Xin-Zu Chen & Jian-Kun Hu
China is a multi-ethnic country, and the prevalence of Helicobacter pylori (H pylori) infection may be diverse among ethnics. This meta-analysis was conducted to compare the prevalence of H pylori infection between Tibetans and Han ethnics. Ten studies that reported the prevalence of H pylori infection between Tibetans and Hans in China were eligible. The pooled prevalence of H pylori infection was 62.2% versus 55.3% among Tibetans and Hans, respectively. Tibetans had a higher risk...

sj-docx-3-aph-10.1177_10105395221134651 – Supplemental material for Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Dan Bai, Kai Liu, Rui Wang, Wei-Han Zhang, Xin-Zu Chen & Jian-Kun Hu
Supplemental material, sj-docx-3-aph-10.1177_10105395221134651 for Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES) by Dan Bai, Kai Liu, Rui Wang, Wei-Han Zhang, Xin-Zu Chen and Jian-Kun Hu in Asia Pacific Journal of Public Health

sj-docx-7-hpq-10.1177_13591053221129705 – Supplemental material for Psychometric and cross-cultural generalizability outcomes of the Chinese version of the Kids-Palatable Eating Motives Scale (K-PEMS-C)

Dan Wang, Mary M Boggiano, Ke Huang, Yuzheng Hu & Junfen Fu
Supplemental material, sj-docx-7-hpq-10.1177_13591053221129705 for Psychometric and cross-cultural generalizability outcomes of the Chinese version of the Kids-Palatable Eating Motives Scale (K-PEMS-C) by Dan Wang, Mary M Boggiano, Ke Huang, Yuzheng Hu and Junfen Fu in Journal of Health Psychology

sj-docx-7-hpq-10.1177_13591053221129705 – Supplemental material for Psychometric and cross-cultural generalizability outcomes of the Chinese version of the Kids-Palatable Eating Motives Scale (K-PEMS-C)

Dan Wang, Mary M Boggiano, Ke Huang, Yuzheng Hu & Junfen Fu
Supplemental material, sj-docx-7-hpq-10.1177_13591053221129705 for Psychometric and cross-cultural generalizability outcomes of the Chinese version of the Kids-Palatable Eating Motives Scale (K-PEMS-C) by Dan Wang, Mary M Boggiano, Ke Huang, Yuzheng Hu and Junfen Fu in Journal of Health Psychology

Additional file 6 of Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative

Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, Clara Lajonchere, Daniel H. Geschwind & Bogdan Pasaniuc
Additional file 6: Table S10. Summary of GWAS analyses in ATLAS.

Registration Year

  • 2022
    285
  • 2021
    4
  • 2020
    2
  • 2019
    3
  • 2018
    6
  • 2017
    1
  • 2016
    3
  • 2015
    2
  • 2014
    2
  • 2013
    1

Resource Types

  • Text
    112
  • Dataset
    87
  • Collection
    71
  • Image
    32
  • Audiovisual
    6
  • Other
    1

Affiliations

  • University Medical Center Hamburg-Eppendorf
    309
  • Chongqing Medical University
    104
  • Nantong University
    100
  • University of Chinese Academy of Sciences
    99
  • Zhejiang University
    98
  • Peking University
    97
  • Shanghai Jiao Tong University
    85
  • Shandong Agricultural University
    83
  • First Affiliated Hospital of Zhengzhou University
    77
  • Huazhong Agricultural University
    75