Abstract Objectives The association between habitual glucosamine use and incident gout has not been examined in previous studies. We aimed to evaluate the association of habitual use of glucosamine with the risk of gout in general population. Methods A total of 436,594 participants (55.4% female) without prior gout at baseline who completed a questionnaire on supplementation use, which included glucosamine, in the UK Biobank were enrolled. Incident gout was recorded from self-report, death register, primary...

Objectives: Quantify the independent and combined effects of abdominal muscle quantity and lumbar bone mineral density (BMD) on injury risk and in-hospital outcomes in severely injured motor vehicle crash (MVC) occupants ages 50 and older. Methods: Skeletal muscle area measurements of MVC occupants were obtained through semi-automated segmentation of an axial computed tomography (CT) slice at the L3 vertebra. An occupant height-normalized Skeletal Muscle Index (SMI) was calculated - a defining metric of sarcopenia and...

A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells. Compounds 15–21 were showed to be more effective against the four tested cell lines than erlotinib. In particular, compound 16 was found to be the most potent counterpart as it was 5.55, 4.34, 5.04, and 7.18 times more active than erlotinib against MCF-7, HepG-2, HCT-116, and A549 cells, respectively. Compound...

Additional file 3: File S2. EchinoidDB user manual contains instructions to help users with the resources and operations available in the application.

Additional file 5: File S4. Source code (in R) for EchinoDB, EchinoidDB, and OphiuroidDB. We have also provided three R scripts one for each app.

Additional file 1: Figure S1. PCR showed the DAZL withheterozygote (arrow). Figure S2. (A) Immunofluorescence assays showed the expression of DAZLin cultured A172mut cells. (B) AP staining showing PGC-like cells inA172mut glioma cells. (C) Thecomparison of indicated genes between A172 bottom cells and A172 upper cells Scale bar=25 μm. Figure S3. Increase expression of genes related to embryonic/germ cell developmentin gliomas versus normal brain tissues. *P<0.01. Figure S4. Associationbetween the expression of genes related to...

Supplementary Material 2

Additional file 1. Post-Implementation Interview Guide – includes a draft of the semi-structured interview guide to be used following intervention implementation

Additional file 2. Recruitment Materials – includes a screenshot of the LIFT webpage and the flyer given to patients for recruitment

Additional file 3. Baseline Survey – includes the patient experience survey given to patients prior to the intervention

Additional file 4. Intake Form – includes the form used by navigators to assess patient financial needs and potential resources

Abstract Background Almost half of the patients with cancer report cancer-related financial hardship, termed “financial toxicity” (FT), which affects health-related quality of life, care retention, and, in extreme cases, mortality. This increasingly prevalent hardship warrants urgent intervention. Financial navigation (FN) targets FT by systematically identifying patients at high risk, assessing eligibility for existing resources, clarifying treatment cost expectations, and working with patients and caregivers to develop a plan to cope with cancer costs. This trial...

Abstract Background Almost half of the patients with cancer report cancer-related financial hardship, termed “financial toxicity” (FT), which affects health-related quality of life, care retention, and, in extreme cases, mortality. This increasingly prevalent hardship warrants urgent intervention. Financial navigation (FN) targets FT by systematically identifying patients at high risk, assessing eligibility for existing resources, clarifying treatment cost expectations, and working with patients and caregivers to develop a plan to cope with cancer costs. This trial...

Additional file 1: Table S1. Primers used for PCR analysis.

Multicomponent signals are found throughout the animal kingdom, but how these elaborate displays evolve and diversify is still unclear. Here, we explore the evolution of the woodpecker drum display. Two components of this territorial, sexually selected signal, drum speed and drum length, are used by territory holders to assess the threat level of an intruding drummer. We explore the coevolution of these display components both among and within species. Among species, we find evidence for...

Assessing the impacts of anthropogenic degradation and climate change on global carbon cycling is hindered by a lack of clear, flexible, and easy-to-use productivity models along with scarce trait and productivity data for parameterizing and testing those models. We provide a simple solution: a mechanistic framework (RS-CFM) that combines remotely-sensed foliar-trait and canopy-structural data with trait-based metabolic theory to efficiently map productivity at large spatial scales. We test this framework by quantifying net primary productivity...

The organoid is a 3D cell architecture formed by self-organized tissues or cells in vitro with similar cell types, histological structures, and biological functions of the native organ. Depending on the unique organ structures and cell types, producing organoids requires individualized design and is still challenging. Organoids of some tissues, including adipose tissue, remain to generate to be more faithful to their original organ in structure and function. We previously established a new model of...

Additional file 1: Figure S1. PCR showed the DAZL withheterozygote (arrow). Figure S2. (A) Immunofluorescence assays showed the expression of DAZLin cultured A172mut cells. (B) AP staining showing PGC-like cells inA172mut glioma cells. (C) Thecomparison of indicated genes between A172 bottom cells and A172 upper cells Scale bar=25 μm. Figure S3. Increase expression of genes related to embryonic/germ cell developmentin gliomas versus normal brain tissues. *P<0.01. Figure S4. Associationbetween the expression of genes related to...

Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

Additional file 2: Table S1. Narrative summary of published studies investigating the accuracy of cranial ultrasound compared to CT in ICH diagnosis. AIS—acute ischemic stroke. NR-not reported or details not obtainable from data provided.

Additional file 2: Table S1. Narrative summary of published studies investigating the accuracy of cranial ultrasound compared to CT in ICH diagnosis. AIS—acute ischemic stroke. NR-not reported or details not obtainable from data provided.

Objectives: Quantify the independent and combined effects of abdominal muscle quantity and lumbar bone mineral density (BMD) on injury risk and in-hospital outcomes in severely injured motor vehicle crash (MVC) occupants ages 50 and older. Methods: Skeletal muscle area measurements of MVC occupants were obtained through semi-automated segmentation of an axial computed tomography (CT) slice at the L3 vertebra. An occupant height-normalized Skeletal Muscle Index (SMI) was calculated - a defining metric of sarcopenia and...

Additional file 2: File S1. EchinoDB user manual contains screenshots of the outputs to assist new users with the features and functionality of the application.

Additional file 3: File S2. EchinoidDB user manual contains instructions to help users with the resources and operations available in the application.

Abstract Background Diarrhea is a major cause of morbidity and mortality in young calves, resulting in considerable economic loss for dairy farms. To determine if some gut microbes might have resistance to dysbiotic process with calf diarrhea by dictating the microbial co-occurrence patterns from birth to post-weaning, we examined the dynamic development of the gut microbiota and diarrhea status using two animal trials, with the first trial having 14 Holstein dairy calves whose fecal samples...