4,130 Works

Intraspecific variation of Phragmites australis: Clinal adaption of functional traits and phenotypic plasticity vary with latitude of origin

Linjing Ren, Xiao Guo, Shuna Liu, Ting Yu, Weihua Guo, Renqing Wang, Siyuan Ye, Carla Lambertini, Hans Brix & Franziska Eller
1. Widespread plant species generally have high intraspecific variation in functional traits, which is reflected in their great variety of phenotypes. This variety can result from both genetic differences due to local adaptation and phenotypic plasticity. With high intraspecific variation and nearly global distribution, the common reed Phragmites australis is a suitable model species for studying the underlying mechanisms of intraspecific trait variation. 2. In this study, 71 genotypes of P. australis from seven phylogeographic...

NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that the expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection....

Additional file 1 of 5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo

Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li & Beixian Zhou
Additional file 1. Original images for western blot.

Recurrent disability progression endpoints in multiple sclerosis clinical trials

Alexandra Bühler, Marcel Wolbers, Fabian Model, Qing Wang, Shibeshih Belachew, Marianna Manfrini, Johannes Lorscheider, Ludwig Kappos & Jan Beyersmann
Background:The current standard endpoint to assess disability accumulation in multiple sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which excludes subsequent progression events. Including recurrent progression events may permit a more comprehensive assessment of treatment effects on disability progression.Objective:To propose a definition of recurrent disability progression events and to compare time-to-first and recurrent event analysis.Methods:Recurrent disability progression events were defined by expanding the recommended first event definition. Marginal recurrent event...

Recurrent disability progression endpoints in multiple sclerosis clinical trials

Alexandra Bühler, Marcel Wolbers, Fabian Model, Qing Wang, Shibeshih Belachew, Marianna Manfrini, Johannes Lorscheider, Ludwig Kappos & Jan Beyersmann
Background:The current standard endpoint to assess disability accumulation in multiple sclerosis (MS) clinical trials is the time to the first confirmed disability progression, which excludes subsequent progression events. Including recurrent progression events may permit a more comprehensive assessment of treatment effects on disability progression.Objective:To propose a definition of recurrent disability progression events and to compare time-to-first and recurrent event analysis.Methods:Recurrent disability progression events were defined by expanding the recommended first event definition. Marginal recurrent event...

Additional file 1 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 1: Table S1. Bacterial strains used in this study.

Additional file 5 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 5: Figure S2. Intracellular NADH content of MER-oE strains under different medium conditions. Data represent mean ± S.D. (error bars) from three independent experiments.

Additional file 2 of Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma

Yuan Qin, Dai Zhang, Huan Zhang, Lan Hou, Zhe Wang, Liu Yang, Mingkun Zhang, Ge Zhao, Qing Yao, Rui Ling & Juliang Zhang
Additional file 2: Table S2. Akaike information criterion for the prognostic signature.

A nomogram to predict nosocomial infection in patients on venoarterial extracorporeal membrane oxygenation after cardiac surgery

Xiyuan Li, Liangshan Wang, Chenglong Li, Xiaomeng Wang, Xing Hao, Zhongtao Du, Haixiu Xie, Feng Yang, Hong Wang & Xiaotong Hou
IntroductionAfter cardiac surgery, patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have a higher risk of nosocomial infection in the intensive care unit (ICU). We aimed to establish an intuitive nomogram to predict the probability of nosocomial infection in patients on VA-ECMO after cardiac surgery.MethodsWe included patients on VA-ECMO after cardiac surgery between January 2011 and December 2020 at a single center. We developed a nomogram based on independent predictors identified using univariate and multivariate logistic...

sj-docx-1-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-docx-1-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

sj-xlsx-2-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-xlsx-2-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

sj-xlsx-3-tct-10.1177_15330338221124658 - Supplemental material for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Supplemental material, sj-xlsx-3-tct-10.1177_15330338221124658 for In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells by Mike Y. Chen, Jing Li, Nianli Zhang and Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia, Yujun Wang in Technology in Cancer Research & Treatment

Learning Coefficient Heterogeneity over Networks: A Distributed Spanning-Tree-Based Fused-Lasso Regression

Xin Zhang, Jia Liu & Zhengyuan Zhu
Identifying the latent cluster structure based on model heterogeneity is a fundamental but challenging task arises in many machine learning applications. In this paper, we study the clustered coefficient regression problem in the distributed network systems, where the data are locally collected and held by nodes. Our work aims to improve the regression estimation efficiency by aggregating the neighbors’ information while also identifying the cluster membership for nodes. To achieve efficient estimation and clustering, we...

NLRC5 Restricts Dengue Virus Infection by Promoting the Autophagic Degradation of Viral NS3 through E3 Ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection. Mechanistic...

sj-pptx-1-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-1-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

sj-pptx-2-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-2-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Background:Transient tumor marker elevations caused by chemotherapy were defined as ‘Flare’ and have been demonstrated in some solid tumors. In clinical practice, we observed that some patients were accompanied by elevated tumor markers during treatment, but subsequent imaging proved that the treatment they received was effective.Objectives:We aimed to study the Flare and the prognosis in advanced gastric cancer.Design:This is an observational retrospective study. A total of 167 patients were enrolled in this study. Carcinoembryonic antigen...

Patient perception of doctor communication skills and patient trust in rural primary health care: the mediating role of health service quality

Linni Gu, Bo Tian, Yujia Xin, Shengfa Zhang, Jing Li & Zhijun Sun
Abstract Background This study aimed to explore the relationship between communication skills, health service quality, and patient trust in primary health services. Method This study was conducted in village clinics in rural China. A simple random sampling method was used to select volunteer village clinics and patients. In total, 574 participants from 25 village clinics were selected with the help of local health officers and village doctors. The response rate was 90%. Statistical analyses (hierarchical...

Additional file 1 of Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li & Lele Cui
Additional file 1: Figure S1. Vessel densities of the whole measured area, parafovea, and four quadrants (temporal, superior, nasal, and inferior) in the (a, c) SCP and (b, d) DCP measured with optical coherence tomography angiography stratified by age in males and females. Table S1. Baseline characteristics of male participants in the study. Table S2. Baseline characteristics of female participants in the study. Table S3. Vessel densities of the whole measured area, parafovea, and four...

Additional file 2 of Novel lipometabolism biomarker for chemotherapy and immunotherapy response in breast cancer

Lei Zhang, Risheng She, Jianlin Zhu, Jin Lu, Yuan Gao, Wenhua Song, Songwang Cai & Lu Wang
Additional file 2.

Additional file 2 of Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Additional file 2: List of differentially expressed gene in RNA-seq.

Additional file 2 of Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Additional file 2: List of differentially expressed gene in RNA-seq.

Additional file 1 of Cooking or heating with solid fuels increased the all-cause mortality risk among mid-aged and elderly People in China

Yuxiang Yang, Yang Liu, Luolan Peng, Shuai Zhang, Changzheng Yuan, Wenyuan Li, Zuyun Liu & Yanan Ma
Supplementary Material 1

Additional file 1 of Cooking or heating with solid fuels increased the all-cause mortality risk among mid-aged and elderly People in China

Yuxiang Yang, Yang Liu, Luolan Peng, Shuai Zhang, Changzheng Yuan, Wenyuan Li, Zuyun Liu & Yanan Ma
Supplementary Material 1

Cooking or heating with solid fuels increased the all-cause mortality risk among mid-aged and elderly People in China

Yuxiang Yang, Yang Liu, Luolan Peng, Shuai Zhang, Changzheng Yuan, Wenyuan Li, Zuyun Liu & Yanan Ma
Abstract Background Our study aimed to explore the associations between solid fuels burning for either heating or cooking and all-cause mortality based on 2859 participants from the China Health and Retirement Longitudinal Study during 2011–2018. Methods Logistic regression models were performed to estimate the risk for all-cause mortality between different types of fuels in the current longitudinal study. Furthermore, the combined impacts of applying solid fuels for both cooking and heating and the effect among...

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