4 Works

Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection

Erich Smith-Peter, David Lalonde Séguin, Émilie St-Pierre, Ognjen Sekulovic, Simon Jeanneau, Cédrick Tremblay-Tétreault, Anne-Marie Lamontagne, Pierre-Étienne Jacques, Daniel A. Lafontaine & Louis-Charles Fortier
Clostridioides difficile is the main cause of nosocomial antibiotic-associated diarrhoea. There is a need for new antimicrobials to tackle this pathogen. Guanine riboswitches have been proposed as promising new antimicrobial targets, but experimental evidence of their importance in C. difficile is missing. The genome of C. difficile encodes four distinct guanine riboswitches, each controlling a single gene involved in purine metabolism and transport. One of them controls the expression of guaA, encoding a guanosine monophosphate...

Rethinking early intervention rehabilitation services for children with motor difficulties: engaging stakeholders in the conceptualization of telerehabilitation primary care

Karen Hurtubise, Gabrielle Pratte, Caroline Hamel, Irma Clapperton & Chantal Camden
Rehabilitation services for children with mild motor difficulties are limited. Telehealth could be a novel avenue through which to provide these services. With the input of various stakeholder groups, this study aimed to develop a logic model for a new primary care telerehabilitation intervention and to identify influencing implementation factors. A participatory research design was used. A logic model, developed in consultation with five healthcare managers, was discussed with four stakeholder groups. Focus groups were...

Rethinking early intervention rehabilitation services for children with motor difficulties: engaging stakeholders in the conceptualization of telerehabilitation primary care

Karen Hurtubise, Gabrielle Pratte, Caroline Hamel, Irma Clapperton & Chantal Camden
Rehabilitation services for children with mild motor difficulties are limited. Telehealth could be a novel avenue through which to provide these services. With the input of various stakeholder groups, this study aimed to develop a logic model for a new primary care telerehabilitation intervention and to identify influencing implementation factors. A participatory research design was used. A logic model, developed in consultation with five healthcare managers, was discussed with four stakeholder groups. Focus groups were...

Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection

Erich Smith-Peter, David Lalonde Séguin, Émilie St-Pierre, Ognjen Sekulovic, Simon Jeanneau, Cédrick Tremblay-Tétreault, Anne-Marie Lamontagne, Pierre-Étienne Jacques, Daniel A. Lafontaine & Louis-Charles Fortier
Clostridioides difficile is the main cause of nosocomial antibiotic-associated diarrhoea. There is a need for new antimicrobials to tackle this pathogen. Guanine riboswitches have been proposed as promising new antimicrobial targets, but experimental evidence of their importance in C. difficile is missing. The genome of C. difficile encodes four distinct guanine riboswitches, each controlling a single gene involved in purine metabolism and transport. One of them controls the expression of guaA, encoding a guanosine monophosphate...

Registration Year

  • 2021
    4

Resource Types

  • Dataset
    2
  • Text
    2

Affiliations

  • Université de Sherbrooke
    4
  • Centre Hospitalier Universitaire de Sherbrooke
    4