27 Works

Uncertainties in internal dose assessment: Lifetime dose assessment for three example workers occupationally exposed to uranium - Analysing the intercomparison results

Estelle Davesne, Richard Bull, Jeri Anderson, Derek Bingham, Alan Birchall, Carlo Maria Castellani, Cécile Challeton-de Vathaire, M. L. Fernandez, Martina Froning, A. Giomi, Anne Laure Lebacq, Jakub Ośko, Inés Gomez Parada, Anna Pántya, A. G. Rojas, Ana Rojo, Masa Takahashi, Kotaro Tani & Eric Blanchardon
Abstract: Recently, several epidemiological studies were interested in identifying potential health effects of incorporated radionuclides. To achieve this work, exposure of individuals was quantified in order to be compared with health status. In order to quantify the exposure of workers, the measurement of retained or excreted activity also called bioassay, must be interpreted in terms of dose. The data available for dose reconstruction are mostly bioassay analyses (mostly urine) carried out to verify the absence...

Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Additional file 1 of Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Additional file 1: Fig. S1. Relative counting efficiency of the GC as function of sample volume for the quantification of 225Ac using the 213Bi and 221Fr EW. Design and results of an additional experiment to study the effect of sample volume on the relative GC detector efficiency.

Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Abstract Background Quantification of actinium-225 through gamma counter measurements, when there is no secular equilibrium between actinium-225 and its gamma emitting daughters bismuth-213 and/or francium-221, can provide valuable information regarding the possible relocation of recoiled daughters such that related radiotoxicity effects can be evaluated. This study proposes a multiple time-point protocol using the bismuth-213 photopeak with measurements before secular equilibrium between actinium-225 and bismuth-213, and a single time-point protocol using both the francium-221 and bismuth-213...

A database of radionuclide biological half-life values for wildlife

N.A. Beresford, K. Beaugelin-Seiller, C. Wells, S. Vives-Lynch, J. Vives I Batlle, M.D. Wood, K. Tagami, A. Real, J. Burgos, S. Fesenko, M. Cujic, A. Kryshev, N. Pachal, B.S. Su, C.L. Barnett, S. Uchida, T. Hinton, J. Mihalík, K. Stark, C. Willrodt & J.S. Chaplow
Data comprise biological and ecological half-life values for marine, freshwater, terrestrial and riparian organisms. The database includes 1908 biological half-life values for 52 elements across a range of wildlife groups (marine, freshwater, terrestrial and riparian). The compilation of values from a range of sources was conducted by an international working group under the auspices of an International Atomic Energy Agency programme.

EURADOS Intercomparison IC2017n for Neutron Dosemeters

Sabine Mayer, Marie-Anne Chevallier, Elena Fantuzzi, Michael Hajek, Marlies Luszik-Bhadra, Rick Tanner, David J. Thomas & Filip Vanhavere
Abstract: EURADOS has carried out a number of different intercomparison exercises for personal dosemeters in the past that qualify as proficiency tests for different dosimetry systems and radiation types including one previous neutron personal dosemeter intercomparison (IC2012n). Neutron intercomparisons are especially complicated to design because of the limited availability of reference fields and the costs associated with the exposures. IC2017n was the second EURADOS organized intercomparison exercise for neutron personal dosemeters. It was an important...

Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Abstract Background Quantification of actinium-225 through gamma counter measurements, when there is no secular equilibrium between actinium-225 and its gamma emitting daughters bismuth-213 and/or francium-221, can provide valuable information regarding the possible relocation of recoiled daughters such that related radiotoxicity effects can be evaluated. This study proposes a multiple time-point protocol using the bismuth-213 photopeak with measurements before secular equilibrium between actinium-225 and bismuth-213, and a single time-point protocol using both the francium-221 and bismuth-213...

Additional file 1 of Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Additional file 1: Fig. S1. Relative counting efficiency of the GC as function of sample volume for the quantification of 225Ac using the 213Bi and 221Fr EW. Design and results of an additional experiment to study the effect of sample volume on the relative GC detector efficiency.

Additional file 1 of Occupational radiation exposure assessment during the management of [68Ga]Ga-DOTA-TOC

Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández & Antonio López Medina
Additional file 1: The available supplementary materials show additional details about the nuclear medicine facilities and materials used for the administration of 68Ga-DOTATOC.

ORAMED: Optimization of Radiation Protection of Medical Staff

F. Vanhavere, E. Carinou, G. Gualdrini, I. Clairand, M. Sans Merce, M. Ginjaume, D. Nikodemova, J. Jankowski, J.-M. Bordy, A. Rimpler, S. Wach, P. Martin, L. Struelens, S. Krim, C. Koukorava, P. Ferrari, F. Mariotti, E. Fantuzzi, L. Donadille, C. Itié, N. Ruiz, A. Carnicer, M. Fulop, J. Domienik & M. Brodecki
Abstract: The medical staff performing interventional cardiology and radiology (IC/IR) procedures stand close to the patient and thus close to the primary radiation beam. Although they wear a lead apron and thyroid collar, their hands, legs and eyes are not protected. Therefore, these parts could receive significantly high doses. Moreover, thedose ranges for the same kind of procedures vary a lot, as many factors affect extremity and eye lens doses. Additionally, there is evidence that...

EURADOS Intercomparison 2012 for Neutron Dosemeters

Elena Fantuzzi, Marie-Anne Chevallier, Rodolfo Cruz-Suarez, Marlies Luszik-Bhadra, Sabine Mayer, David J. Thomas, Rick Tanner & Filip Vanhavere
Abstract: EURADOS, within the work performed by Working Group 2 -Harmonization of Individual Monitoring in Europe, has started a self-sustained programme of regular intercomparisons and has successfully executed three intercomparisons for whole body photon dosemeters (IC2008, IC2010, IC2012) and one intercomparison for extremity dosemeters for photon and beta fields (IC2009). In 2012, the EURADOS intercomparison IC2012n was launched for personal neutron dosemeters routinely used to measure personal dose equivalent, Hp(10), in individual monitoring. No systems...

IDEAS Guidelines (Version 2) for the Estimation of Committed Doses from Incorporation Monitoring Data

C.M. Castellani, J.W. Marsh, C. Hurtgen, E. Blanchardon, P. Berard, A. Giussani & M.A. Lopez
ABstract: Doses from intakes of radionuclides cannot be measured but must be assessed from monitoringdata, such as whole body, urine or faecaldata. Such assessments require applicationofbiokinetic and dosimetric models, and the assessor may well have to make assumptions about factors such as the pattern of intake and properties of the material. Intercomparison exercises (Doerfel 2000) have shown a wide range in doses that can be obtained from the same data set as a result of...

Evaluation of the Impact of the New ICRU Operational Quantities and Recommendations for their Practical Application

P. Gilvin, M. Caresana, J.-F. Bottollier-Depois, V. Chumak, I. Clairand, J. Eakins, P. Ferrari, O. Hupe, P. Olko, A. Röttger, R.J. Tanner, F. Vanhavere, E. Bakhanova, V. Bandalo, D. Ekendahl, H. Hödlmoser, D. Matthiä, G. Reitz, M. Latocha, P. Beck, D. Thomas & R. Behrens
Abstract: The International Commissions on Radiation Units and Measurements (ICRU) and on Radiological Protection (ICRP) have published a joint report, as ICRU Report 95, recommending new operational quantities for use in radiological protection. The new quantities have been devised to address known problems with the existing ones, including the need to cover a wider range of radiation types and energies, for example arising from the increasing use of proton therapy in clinical procedures. Also related...

Additional file 1 of Occupational radiation exposure assessment during the management of [68Ga]Ga-DOTA-TOC

Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández & Antonio López Medina
Additional file 1: The available supplementary materials show additional details about the nuclear medicine facilities and materials used for the administration of 68Ga-DOTATOC.

Visions for Radiation Dosimetry over the Next Two Decades – Strategic Research Agenda of the European Radiation Dosimetry Group

Werner Rühm, Elena Fantuzzi, Roger Harrison, Helmut Schuhmacher, Filip Vanhavere, Joao Alves, Jean-Francois Bottolier-Depois, Paola Fattibene, Željka Knežević, María Antonia Lopez, Sabine Mayer, Saveta Miljanić, Stefan Neumaier, Pawel Olko, Hannes Stadtmann, Rick Tanner & Clemens Woda
Abstract: The European Radiation Dosimetry Group (EURADOS) comprises a self-sustainable network of more than 60 European institutions such as reference and research laboratories, dosimetry services and companies, as well as more than 300 scientists active in the field of radiation dosimetry. The aim of the network is to promote research and development and European cooperation in the field of dosimetry of ionizing radiation and its implementation in routine practice, in order to contribute to compatibility...

Occupational radiation exposure assessment during the management of [68Ga]Ga-DOTA-TOC

Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández & Antonio López Medina
Abstract Background Since it was first approved in Europe in 2016, the gallium-68 (68Ga) radiopharmaceutical [68Ga]Ga-DOTA-TOC has been widely used for imaging of somatostatin receptor (SSTR) positive tumours using positron emission tomography–computed tomography (PET/CT). Significant patient benefits have been reported, so its use is rapidly increasing. However, few studies have been published regarding occupational doses to nuclear medicine personnel handling this radiopharmaceutical, despite its manual usage at low distances from the skin and the beta-emission...

Occupational radiation exposure assessment during the management of [68Ga]Ga-DOTA-TOC

Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández & Antonio López Medina
Abstract Background Since it was first approved in Europe in 2016, the gallium-68 (68Ga) radiopharmaceutical [68Ga]Ga-DOTA-TOC has been widely used for imaging of somatostatin receptor (SSTR) positive tumours using positron emission tomography–computed tomography (PET/CT). Significant patient benefits have been reported, so its use is rapidly increasing. However, few studies have been published regarding occupational doses to nuclear medicine personnel handling this radiopharmaceutical, despite its manual usage at low distances from the skin and the beta-emission...

Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Development of an Adverse Outcome Pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Data from: Measuring the biodiversity of microbial communities by flow cytometry

Ruben Props, Pieter Monsieurs, Mohamed Mysara, Lieven Clement & Nico Boon
1. Measuring the microbial diversity in natural and engineered environments is important for ecosystem characterization, ecosystem monitoring and hypothesis testing. Although the conventional assessment through single marker gene surveys has resulted in major advances, the complete procedure remains slow (i.e., weeks to months), labour-intensive and susceptible to multiple sources of laboratory and data processing bias. Growing interest, in highly resolved, temporal surveys of microbial diversity, necessitates rapid, inexpensive and robust analytical platforms that require limited...

Patient maximum skin dose in interventional procedures in radiology and cardiology: summary of WG 12 activities

Olivera Ciraj Bjelac, Jérémie Dabin, Jad Farah, Hannu Järvinen, Francoise Malchair, Teemu Siiskonen & Željka Knežević
Abstract: Fluoroscopically guided interventional procedures in radiology (IR) and cardiology (IC) are techniques that have had wide diffusion in the last decades. Scarcely invasive, they reduce most of the risks to patients and the expenses of operating theatres. Nevertheless, prolonged exposures due, for instance, to complicated interventional procedures or inappropriate equipment may result in high doses to both patients and staff members, in particular, with potentially high radiation doses to the skinof a patient. Working...

Visions for Radiation Dosimetry over the Next Two Decades -Strategic Research Agenda of the European Radiation Dosimetry Group: Version 2020

Jean-François Bottolier-Depois, Isabelle Clairand, Elena Fantuzzi, Paola Fattibene, Roger Harrison, Oliver Hupe, Pawel Olko, Veronika Olšovcová, Werner Rühm, Marco Silari, Rick Tanner & Filip Vanhavere
Introduction: The European Radiation Dosimetry Group (EURADOS) comprises a self-sustainable network of more than 70 European institutions and about 600 scientists active in the field of radiation dosimetry. It was founded in 1981, and was registered in Germany as an “e.V.” (registered society) in 2008. The aim of the network is to promote research and development and European cooperation in the field of dosimetry of ionising radiation. For this, EURADOS has established Working Groups (WGs)...

EURADOS Stakeholder Workshop on June 30th, 2016

Rühm Werner, Željka Knežević, Elena Fantuzzi, Roger Harrison, Helmut Schuhmacher, Filip Vanhavere, Joao Alves, Jean-Francois Bottolier-Depois, Paola Fattibene, Phil Gilvin, María Antonia Lopez, Sabine Mayer, Saveta Miljanić, Pawel Olko, Hannes Stadtmann, Rick Tanner, Arturo Vargas & Clemens Woda
Introduction: On June 30th, 2016, the “First EURADOS Stakeholder Workshop” was held at the Helmholtz Center Munich (HMGU) in Neuherberg, Germany. The workshop was jointly organized by the HMGU and the EURADOS Office in conjunction with the 57thEURADOS Council meeting, which took place on June 29thand July 1st, also at the HMGU. In the frame of the “European Joint Programme for the Integration of Radiation Protection Research”, the CONCERT project funded by the European Commission...

EURADOS Intercomparison on Compartmental Model for 18F-FDG Developed by Hays and Segall

Wei Bo Li, David Broggio, Augusto Giussani, Tomáš Vrba, Kerstin Hürkamp, Alexandra Kamp, Dietmar Noßke, Lara Struelens & Peter Covens
Abstract: This report was originated from the analysis of the results of a joint EURADOS-EANM project about the assessment of the external radiation dose rate to comforters and caregivers exposed to patients undergoing nuclear medical diagnostics and therapy. The compartmental model for 18F-FDG developed by Hays and Segall in 1999 was applied by EURADOS members for predicting the time activity curves (TAC) in the source organs and tissues, and the urinary excretion. Inconsistencies have been...

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

Omid Azimzadeh, Simone Moertl, Raghda Ramadan, Bjorn Baselet, Evagelia C. Laiakis, Soji Sebastian, Danielle Beaton, Jaana M. Hartikainen, Jan Christian Kaiser, Afshin Beheshti, Sisko Salomaa, Vinita Chauhan & Nobuyuki Hamada
Epidemiological studies have indicated that exposure of the heart to doses of ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with a latency period of decades. The damaging effects of radiation to myocardial and endothelial structures and functions have been confirmed radiobiologically at high dose, but much less is known at low dose. Integration of radiation biology and epidemiology data is a recommended approach to improve the radiation...

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Affiliations

  • Belgian Nuclear Research Centre
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  • Federal Office for Radiation Protection
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