10 Works

Data from: Should the WHO growth charts be used in France?

Pauline Scherdel, Jérémie Botton, Marie-Françoise Rolland-Cachera, Juliane Léger, Fabienne Pelé, Pierre Yves Ancel, Chantal Simon, Katia Castetbon, Benoit Salanave, Hélène Thibault, Sandrine Lioret, Sandrine Péneau, Gaelle Gusto, Marie-Aline Charles & Barbara Heude
Background: Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. Objective: To evaluate and compare the growth of French children who were born between 1981 and 2007, with the WHO growth charts and the French reference curves currently used. Design: Anthropometric measurements from French children, who participated in 12...

Data from: Molecular determinants of agonist selectivity in glutamate-gated chloride channels which likely explain the agonist selectivity of the vertebrate glycine and GABAA-ρ receptors

Thomas Blarre, Hugues-Olivier Bertrand, Francine C. Acher & JacSue Kehoe
Orthologous Cys-loop glutamate-gated chloride channels (GluClR’s) have been cloned and described electrophysiologically and pharmacologically in arthropods and nematodes (both members of the invertebrate ecdysozoan superphylum). Recently, GluClR’s from Aplysia californica (a mollusc from the lophotrochozoan superphylum) have been cloned and similarly studied. In spite of sharing a common function, the ecdysozoan and lophotrochozoan receptors have been shown by phylogenetic analyses to have evolved independently. The recent crystallization of the GluClR from C. elegans revealed the...

Data from: Mutation dynamics and fitness effects followed in single cells

Lydia Robert, Jean Ollion, Jerome Robert, Xiaohu Song, Ivan Matic & Marina Elez
Mutations have been investigated for more than a century but remain difficult to observe directly in single cells, which limits the characterization of their dynamics and fitness effects. By combining microfluidics, time-lapse imaging, and a fluorescent tag of the mismatch repair system in Escherichia coli, we visualized the emergence of mutations in single cells, revealing Poissonian dynamics. Concomitantly, we tracked the growth and life span of single cells, accumulating ~20,000 mutations genome-wide over hundreds of...

Data from: Developmental venous anomaly in diffuse glioma adult patients: a clinically relevant coexistence?

Alexandre Roux, Myriam Edjlali, Sayuri Porelli, Arnault Tauziede, Marc Zanello, Edouard Dezamis, Gilles Zha-Bi, Marc Sanson, Stéphanie Puget, Laurent Capelle, Pascale Varlet, Catherine Oppenheim & Johan Pallud
Objective: To determine the prevalence of developmental venous anomaly in diffuse glioma adult patients. Methods: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in two centers: Sainte-Anne Hospital (experimental and control sets), and Pitié-Salpêtrière Hospital (external validation set). We included 219 diffuse glioma patients (experimental set), 252 brain metastasis patients (control set), and 200 diffuse glioma patients (validation set). The inclusion criteria were: age ≥18 years at...

Data from: Risks of 23 specific malformations associated with prenatal exposure to ten antiepileptic drugs

Pierre-Olivier Blotière, Fanny Raguideau, Alain Weill, Elisabeth Elefant, Isabelle Perthus, Véronique Goulet, Florence Rouget, Mahmoud Zureik, Joël Coste & Rosemary Dray-Spira
Objective: To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AED) during the first two months of pregnancy and the risk of 23 major congenital malformations (MCMs). Methods: This nationwide cohort study, based on the French healthcare databases, included all pregnancies&[ge]20 weeks and ending between January 2011 and March 2015. Women were considered to be exposed when an AED had been dispensed between one month before and two months after the...

Data from: Posttraumatic stress reactions in parents of children esophageal atresia.

Morgane Le Gouëz, Luis Alvarez, Véronique Rousseau, Philippe Hubert, Véronique Abadie, Alexandre Lapillonne & Elsa Kermorvant-Duchemin
Objective – The aim of this study was to investigate psychological stress in parents of children with esophageal atresia and to explore factors associated with the development of Posttraumatic Stress disorder (PTSD). Design - Self-report questionnaires were administered to parents of children with EA. Domains included: (1) sociodemographic data, current personal difficulties, assessment scales for the quality of life and for the global health status of the child (2) French-validated versions of the Perinatal Posttraumatic...

Data from: PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

Arman Javadi, Ravi K. Deevi, Emma Evergren, Elodie Blondel-Tepaz, George S. Baillie, Mark G.H. Scott, Frederick Charles Campbell & Mark GH Scott
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that PTEN controls Cdc42-dependent morphogenic processes through a β-Arrestin1-ARHGAP21 complex. Here we show that PTEN knockdown (KD) impairs β-Arrestin1 membrane localization, β-Arrestin1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenesis....

Data from: Two stochastic processes shape diverse senescence patterns in a single-cell organism

Ulrich K. Steiner, Adam Lenart, Ming Ni, Peipei Chen, Xiaohu Song, François Taddei, James W. Vaupel & Ariel B. Lindner
Despite advances in aging research, a multitude of aging models, and empirical evidence for diverse senescence patterns, understanding of the biological processes that shape senescence is lacking. We show that senescence of an isogenic Escherichia coli bacterial population results from two stochastic processes. The first process is a random deterioration process within the cell, such as generated by random accumulation of damage. This primary process leads to an exponential increase in mortality early in life...

Data from: Ultrasonic cavitation induces necrosis and impairs growth in three-dimensional models of pancreatic ductal adenocarcinoma

Einas Abou Ali, Benoit Bordacaha, Jean-Louis Mestas, Frederic Batteux, Cyril Lafon, Marine Camus & Frederic Prat
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a rapidly increasing cause of mortality whose dismal prognosis is mainly due to overwhelming chemoresistance. New therapeutic approaches include physical agents such as ultrasonic cavitation, but clinical applications require further insights in the mechanisms of cytotoxicity. Three dimensional in vitro culture models such as spheroids exploit realistic spatial, biochemical and cellular heterogeneity that may bridge some of the experimental gap between conventional in vitro and in vivo experiments. Purpose:...

Data from: Force encoding in muscle spindles during stretch of passive muscle

Kyle P. Blum, Boris Lamotte D’Incamps, Daniel Zytnicki & Lena H. Ting
Muscle spindle proprioceptive receptors play a primary role in encoding the effects of external mechanical perturbations to the body. During externally-imposed stretches of passive, i.e. electrically-quiescent, muscles, the instantaneous firing rates (IFRs) of muscle spindles are associated with characteristics of stretch such as length and velocity. However, even in passive muscle, there are history-dependent transients of muscle spindle firing that are not uniquely related to muscle length and velocity, nor reproduced by current muscle spindle...

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