78 Works

Data from: Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse

Tia DiTommaso, Lynelle K. Jones, Denny L. Cottle, The WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E. Vancollie, Fiona M. Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, John P. Sundberg, Jacqueline K. White, Ian Smyth & Ian M. Smyth
The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To identify genes important in skin development and homeostasis, we have applied a high throughput, multi-parameter phenotype screen to the conditional targeted mutant mice generated by the Wellcome Trust Sanger Institute's Mouse Genetics Project (Sanger-MGP). A total of 562 different mouse lines were...

Data from: Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture

Kari Britt Schroeder, Philip Asherson, Peter R. Blake, Susan K. Fenstermacher & Kimberly J. Saudino
Cumulative culture ostensibly arises from a set of sociocognitive processes which includes high-fidelity production imitation, prosociality and group identification. The latter processes are facilitated by unconscious imitation or social mimicry. The proximate mechanisms of individual variation in imitation may thus shed light on the evolutionary history of the human capacity for cumulative culture. In humans, a genetic component to variation in the propensity for imitation is likely. A functional length polymorphism in the serotonin transporter...

Data from: Chemo-mechanical characterisation of carious dentine using Raman microscopy and Knoop microhardness

Mohammed Alturki, Garrit Koller, Ulrica Almhöjd & Avijit Banerjee
One of the aims in the clinical operative management of dental carious lesions is to remove selectively, the highly infected and structurally denatured dentine tissue, while retaining the deeper, repairable affected and intact, healthy tissues for long-term mechanical strength. The present study examined the correlation of chemical functional groups and the microhardness through the different depths of a carious lesion using Raman spectroscopy and Knoop microhardness testing. The null hypothesis investigated was that there was...

Subjective sleep quality and sleep architecture in patients with migraine: a meta-analysis

Emily Stanyer, Hannah Creeney, Jan Hoffmann, Alexander Nesbitt, Philip Holland & Jan Hoffmann
Objectives: Sleep disturbance is often associated with migraine. However, there is a paucity of research investigating objective and subjective measures of sleep in migraine patients. This meta-analysis aims to determine whether there are differences in subjective sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI), and objective sleep physiology measured using polysomnography between adult and pediatric patients, and healthy controls. Methods: This review was pre-registered on PROSPERO (CRD42020209325). A systematic search of five databases...

Anne Curry, Malcolm Vale, Frédéric Boutoulle, Paul Booth, Philip Morgan, Paul Spence, Francoise Lainé, Frank Byrne, Paul Caton, Nigel Coulton, Jon Denton, Nathan Dobson, Elise Dudézert, Dilys Firn, Eric Foster, John Gowling, Nicholas A. Gribit, Simon Harris, Catherine Howarth, Neil Jakeman, Adrian Jobson, Maureen Jurkowski, Faith Lawrence, Jonathan Mackman, Nelly Martin … & Chris Watson
The Gascon Rolls CKAN Dataset makes available the following resources: - The set of rolls in TEI-XML format; - An Eatsml file in XML containing the set of entity records (for persons, places, etc.) out of which the indexes and search available on the project site are generated; - The project guidelines for encoding the calendared versions of the rolls into TEI-XML.

Safeguarding, homelessness and rough sleeping: An analysis of Safeguarding Adults Reviews

Stephen Martineau, Michelle Cornes, Jill Manthorpe, Bruno Ornelas & James Fuller

Learning the Right Lessons for the Next Pandemic: How to Design Public Inquiries into the UK Government’s Handling of COVID-19

Christoph Meyer, Nikki Ikani, Mauricio Avendano Pabon & Ann Kelly

Social workers' knowledge and skills and the Care Act: Practice Advice Note

Angela Jenkinson & John Chamberlain
The need for a practice advice note on the roles of social workers in the Care Act was identified by the Chief Social Worker and was reinforced by a consultation with 140 social workers, who agreed the general content of this advice. The Advice Note identifies social workers as being fundamental to the achievability of the Care Act because they are registered as having the knowledge and skills to achieve changes to protect, safeguard, promote...

Tenancy Sustainment Team health research: morbidity and mortality amongst people with experience of rough sleeping: Findings report

Michelle Cornes, Becky Rice, Caroline Shulman & Briony Hudson
This report presents the key findings of a small-scale research project exploring the mortality and health needs of clients of Tenancy Sustainment Team (TST) services. The research was commissioned in response to concerns by the Greater London Authority (GLA) and TST service managers about premature deaths among TST clients and the need to learn more about the health needs of this group, particularly the incidence of chronic or long-term health conditions (LTCs).

Consistent unsupervised estimators for anchored PCFGs

Alexander Clark & Nathanaël Fijalkow

Culture wars in the UK: how the public understand the debate

Bobby Duffy, Kirstie Hewlett, George Murkin, Rebecca Benson, Rachel Elizabeth Hesketh, Ben Page, Gideon Skinner & Glenn Gottfried

Imaging mass cytometry data: Head and neck squamous cell carcinoma tissue section

Jessica Timms, James Opzoomer, Kevin Blighe, Thanos Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Mahvash Tavassoli, Claire Harrison, Francesca Ciccarelli, Peter Parker, James Arnold, Benedetta Apollonio, Alan Ramsay, Michaela Fontenay, Paul Barber, James Arnold & Shahram Kordasti
High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of multiparametric “big data” usually requires specialist computational knowledge. Here we describe ImmunoCluster (https://github.com/kordastilab/ImmunoCluster) an R package for immune profiling cellular heterogeneity in high dimensional liquid and imaging mass cytometry, and flow cytometry data, designed to facilitate computational analysis by...

Global ammonia emissions from seabirds

S.N. Riddick, U. Dragosits, T.D. Blackall, F. Daunt, S. Wanless & M.A. Sutton
The dataset contains three modelled estimates of global ammonia emissions from seabird colonies, at a spatial resolution of 0.1 degrees latitude/longitude. The model estimates were derived with a) detailed global seabird population data collated from a large number of sources (data sources date from 1980-2010 for different parts of the world) b) climate data (source: High-resolution Gridded Datasets, Climatic Research Unit, University of East Anglia, UK. http://www.cru.uea.ac.uk/cru/data/hrg/ last updated by Harris, I. (2007), date: 1995)...

Imaging mass cytometry data: Diffuse large B-cell lymphoma lymph node section

Jessica Timms, James Opzoomer, Kevin Blighe, Thanos Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Benedetta Apollonio, Alan Ramsay, Mahvash Tavassoli, Claire Harrison, Francesca Ciccarelli, Peter Parker, Michaela Fontenay, Paul Barber, James Arnold & Shahram Kordasti
High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of large multiparametric datasets usually requires specialist computational knowledge. Here we describe ImmunoCluster (https://github.com/kordastilab/ImmunoCluster) an R package for immune profiling cellular heterogeneity in high dimensional liquid and imaging mass cytometry, and flow cytometry data, designed to facilitate computational analysis by...

Flow cytometry data: healthy donor bone marrow taken during hip surgery

Jessica Timms, James Opzoomer, Kevin Blighe, Thanos Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Benedetta Apollonio, Alan Ramsay, Mahvash Tavassoli, Claire Harrison, Francesca Ciccarelli, Peter Parker, Michaela Fontenay, Paul Barber, James Arnold & Shahram Kordasti
High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of large multiparametric datasets usually requires specialist computational knowledge. Here we describe ImmunoCluster (https://github.com/kordastilab/ImmunoCluster) an R package for immune profiling cellular heterogeneity in high dimensional liquid and imaging mass cytometry, and flow cytometry data, designed to facilitate computational analysis by...

United Kingdom

Martin Moore & Gordon Ramsay

The four sides in the UK’s culture wars

Bobby Duffy, Kirstie Hewlett, George Murkin, Rebecca Benson, Rachel Hesketh, Ben Page, Gideon Skinner & Glenn Gottfried

Rapid review on understanding morale in the NHS workforce

Ian Kessler, Jill Manthorpe, Kritika Samsi, Nicole Steils & John Woolham

Transforming Out of Hospital Care for People who are Homeless: Support Tool for the High Impact Change Model

Michelle Cornes & Manthorpe Jill

‘A new vision!’: Exploring coachee experiences of using photography in coaching – An interpretative phenomenological analysis

Maureen Donaldson-Wright & Kate Hefferon

Data from: Fire evolution in the radioactive forests of Ukraine and Belarus: future risks for the population and the environment

Nikolaos Evangeliou, Yves Balkanski, Anne Cozic, Wei Min Hao, Florent Mouillot, Kirsten Thonicke, Ronan Paugam, Sergey Zibtsev, Timothy A. Mousseau, Rong Wang, Benjamin Poulter, Alex Petkov, Chao Yue, Patricia Cadule, Brigitte Koffi, Johannes W. Kaiser & Anders Pape Møller
This paper analyzes the current and future status of forests in Ukraine and Belarus that were contaminated after the nuclear disaster in 1986. Using several models, together with remote sensing data and observations, we studied how climate change in these forests may affect fire regimes. We investigated the possibility of 137Cs displacement over Europe by studying previous fire events, and examined three fire scenarios that depended on different emission altitudes of 137Cs, assuming that 10%...

Data from: Patterns of relapse in extrapulmonary small cell carcinoma: retrospective analysis of outcomes from two cancer centres

Spyridon Gennatas, Jillian Noble, Susannah Stanway, Ranga Gunapala, Mahfuja Chowdhury, Andrew Wotherspoon, Taqdir Benepal & Sanjay Popat
Objectives: We conducted a retrospective review of patients with extrapulmonary small cell carcinomas (EPSCCs) to explore the distribution, treatments, patterns of relapse and outcomes by primary site. Setting: We have reviewed the outcomes of one of the largest data sets of consecutive patients with EPSCC identified from two major cancer centres. Participants: Consecutive patients with a histopathological diagnosis of EPSCC from the two institutions were retrospectively identified. Primary and secondary outcome measures: Outcomes were evaluated...

Data from: Glutamate receptor delta2 serum antibodies in paediatric opsoclonus myoclonus ataxia syndrome

Georgina Berridge, David A Menassa, Teresa Moloney, Patrick J Waters, Imogen Welding, Selina Thomsen, Sameer Zuberi, Roman Fischer, A. Radu Aricescu, Michael Pike, Russell C Dale, Benedikt Kessler, Angela Vincent, Ming Lim, Sarosh R Irani & Bethan Lang
Objective: To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) usingcontemporary antigen discovery methodology. Methods: OMAS patient serum IgG immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electrophoresis and mass spectrometry. Data are available via ProteomeXchange (identifier PXD009578). This generated a list of potential neuronal surface cerebellar autoantigens. Live cell-based assays (CBA) were used to confirm membrane-surface antigens and adsorb antigen-specific IgGs. The serological results were compared to the clinical...

Data from: Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1

Koa Hosoki, Sun Ying, Christopher Corrigan, Huibin Qi, Alexander Kurosky, Kristofer Jennings, Qian Sun, Istvan Boldogh & Sanjiv Sur
We sought to identify cells and cytokines in bronchoalveolar lavage (BAL) fluids that distinguish asthma from healthy control subjects and those that distinguish controlled asthma from uncontrolled asthma. Following informed consent, 36 human subjects were recruited for this study. These included 11 healthy control subjects, 15 subjects with controlled asthma with FEV1≥80% predicted and 10 subjects with uncontrolled asthma with FEV1 <80% predicted. BAL fluid was obtained from all subjects. The numbers of different cell...

Data from: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HDHQ150/Q150 mouse model of Huntington's disease

Ivan Rattray, Edward J. Smith, William R. Crum, Thomas J. Walker, Richard Gale, Gillian P. Bates, Mike Modo & Michel Modo
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington’s disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction) was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated...

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  • King's College London
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