474 Works

Additional file 1 of Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen & Paul M. Matthews
Additional file 1: Figure S1. Expression of microglial genes in MGLs. Violin and box plots of the normalized expression counts of key microglial genes, including IBA1/AIF1, ITGAM (CD11b), ITGAX (CD11c), P2RY12, TMEM119, and CX3CR1 in male and female induced pluripotent stem cell-derived microglial-like cells (MGLs). Figure S2. Sex labelling and identification of a population of post-menopausal female and age-matched male monocytes. A Histogram showing expression counts of the Y-chromosomal gene, RPS4Y1, in a collection of...

Additional file 2 of Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen & Paul M. Matthews
Additional file 2: Table S1. Sexually differentially expressed genes in the microglial nuclei. Table S2. Genes comprising each of the IR-AD gene sets. Table S3. Sexually differentially expressed genes between the F- and M-MCs. Table S4. GSVA of IR-AD gene sets between Flo- and Fhi-MDMs results. Table S5. Sexually differentially expressed genes between the Flo- and M-MDMs. Table S6. Sexually differentially expressed reactome pathways between the Flo- and M-MDMs. Table S7. Differentially expressed reactome pathways...

Additional file 1 of Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies

Roy R. Gerona, Jill L. Reiter, Igor Zakharevich, Cathy Proctor, Jun Ying, Robin Mesnage, Michael Antoniou & Paul D. Winchester
Supplementary Material 1

Out of pocket expenses in obsessive compulsive disorder

Margaret Heslin, Judith Gellatly, Rebecca Pedley, Jasmin Knopp-Hoffer, Gillian Hardy, Catherine Arundel, Penny Bee, Dean McMillan, Emily Peckham, Lina Gega, Michael Barkham, Peter Bower, Simon Gilbody, Karina Lovell & Sarah Byford
Despite anecdotal evidence that the out of pocket costs of OCD can be substantial in some cases, there is no evidence on how many people they affect, or the magnitude of these costs. This paper explores the type and quantity of out of pocket expenses reported by a large sample of adults with OCD. Data on out of pocket expenses were collected from participants taking part in the OCTET multi-centre randomised controlled trial. Participants were...

Perception of providers on use of the WHO mental health Gap Action Programme-Intervention Guide (mhGAP-IG) electronic version and smartphone-based clinical guidance in Nigerian primary care settings

Akin Ojagbemi, Stephanie Daley, Lola Kola, Tatiana Taylor Salisbury, Yvonne Feeney, Akerke Makhmud, Heidi Lempp, Graham Thornicroft & Oye Gureje
Abstract Background Taking advantage of the rapidly increasing access to digital technology in low- and middle-income countries, the World Health Organization has launched an electronic version of the mental health Gap Action Programme intervention guide (emhGAP-IG). This is suitable for use on smartphones or tablets by non-specialist primary healthcare providers (PHCWs) to deliver evidence-based intervention for priority mental, neurological and substance use disorders. We assessed the perceptions of PHCWs on the feasibility, acceptability, and benefits...

Additional file 1 of Implementing service transformation for children and adolescents with eating disorders across England: the theory, politics, and pragmatics of large-scale service reform

Ivan Eisler, Mima Simic, Peter Fonagy & Rachel Bryant-Waugh
Additional file 1: Table S1. Outline programme of National Whole Team training.

Cessation of collisional tectonism and rapid crustal uplift recorded by 430–420 Ma igneous rocks in the South Kunlun belt, northwest China

Jing Chen, Bing-Zhang Wang, Fu-Cheng Yu, Jie Han & Wu-Fu Li
The Wanbaogou granitic plutons are exposed along with coeval volcanic rocks, and provide an opportunity to investigate Silurian tectonism in the South Kunlun belt, northwest China. This study presents new whole-rock geochemical, and zircon U–Pb geochronological and Lu–Hf isotope data for Silurian intrusive rocks of the Wanbaogou area. We analysed four samples: a porphyritic monzogranite and dioritic dike from the Wanbaogou pluton and a granodiorite and monzogranite from the Wudaogou pluton. Zircon U–Pb dating yielded...

Experimental study on the seismic behavior of RC columns improved with central large-diameter butted steel rods

Hanming Zhang, Jie Luo, Jianchun Xiao, Jing Chen, Zhuoqun Liu, Yi Zhang, Zongli Luo & Hong Zhang
Abstract A reinforced concrete (RC) column improved with central large-diameter butted steel rods (CLBSR column) has been proposed to increase the limit value of the axial compression ratio. This paper presents the seismic behavior analysis of CLBSR columns subjected to low-cycle reciprocating loading. The CLBSR columns were also compared with the RC column improved with central large-diameter steel rods (CLSR column) and the RC column improved with central reinforcement bars (CRB column) under the same...

Experimental study on the seismic behavior of RC columns improved with central large-diameter butted steel rods

Hanming Zhang, Jie Luo, Jianchun Xiao, Jing Chen, Zhuoqun Liu, Yi Zhang, Zongli Luo & Hong Zhang
Abstract A reinforced concrete (RC) column improved with central large-diameter butted steel rods (CLBSR column) has been proposed to increase the limit value of the axial compression ratio. This paper presents the seismic behavior analysis of CLBSR columns subjected to low-cycle reciprocating loading. The CLBSR columns were also compared with the RC column improved with central large-diameter steel rods (CLSR column) and the RC column improved with central reinforcement bars (CRB column) under the same...

Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox & Duncan Sproul
Abstract Background DNA methylation is an epigenetic mark associated with the repression of gene promoters. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with epigenetic clocks. Altered rates of aging inferred from these clocks are observed in human disease. However, the molecular mechanisms underpinning age-associated DNA methylation changes remain unknown. Local DNA sequence can program steady-state DNA methylation levels, but how it influences age-associated...

Patient perspectives of recovery after hip fracture: a systematic review and qualitative synthesis

Natasha Beer, Aleena Riffat, Brittannia Volkmer, David Wyatt, Kate Lambe & Katie J. Sheehan
The purpose of the current review is to synthesize the evidence of patients’ perspectives of recovery after hip fracture across the care continuum. A systematic search was conducted, focusing on qualitative data from hip fracture patients. Screening, quality appraisal, and a subset of articles for extraction were completed in duplicate. Themes were generated using a thematic synthesis of data from original studies. Fourteen high-quality qualitative studies were included. Four review themes were identified: recovery as...

Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Abstract Background Systematically screening for child anxiety problems, and offering and delivering a brief, evidence-based intervention for children who are identified as likely to benefit would minimise common barriers that families experience in accessing treatment. We have developed a short parent-report child anxiety screening questionnaire, and procedures for administering screening questionnaires, sharing screening outcomes with families, and offering and delivering a brief parent-led online intervention (OSI: Online Support and Intervention for child anxiety) through schools....

Additional file 2 of Patient and public involvement in an international rheumatology translational research project: an evaluation

Savia de Souza, Eva C. Johansson, Susanne Karlfeldt, Karim Raza & Ruth Williams
Additional file 2. Patient-Public Research Partner Survey.

Targeted delivery and ROS-responsive release of Resolvin D1 by platelet chimeric liposome ameliorates myocardial ischemia–reperfusion injury

Xueyi Weng, Haipeng Tan, Zheyong Huang, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Weiyan Li, Guangrui Zhu, Zhiqing Pang, Yanan Song, Juying Qian & Junbo Ge
Abstract Resolvin D1 (RvD1) has been shown to provide effective protection against ischemia–reperfusion injury in multiple vital organs such as the heart, brain, kidney. However, the clinical translational potential of systemic administration of RvD1 in the treatment of ischemia–reperfusion injury is greatly limited due to biological instability and lack of targeting ability. Combining the natural inflammatory response and reactive oxygen species (ROS) overproduction after reperfusion injury, we developed a platelet-bionic, ROS-responsive RvD1 delivery platform. The...

Clinical correlates of early onset antipsychotic treatment resistance

Daniela Fonseca de Freitas, Deborah Agbedjro, Giouliana Kadra-Scalzo, Emma Francis, Isobel Ridler, Megan Pritchard, Hitesh Shetty, Aviv Segev, Cecilia Casetta, Sophie E. Smart, Anna Morris, Johnny Downs, Søren Rahn Christensen, Nikolaj Bak, Bruce J. Kinon, Daniel Stahl, Richard D. Hayes & James H. MacCabe
Background:There is evidence of heterogeneity within treatment-resistant schizophrenia (TRS), with some people not responding to antipsychotic treatment from illness onset and others becoming treatment-resistant after an initial response period. These groups may have different aetiologies.Aim:This study investigates sociodemographic and clinical correlates of early onset of TRS.Method:Employing a retrospective cohort design, we do a secondary analysis of data from a cohort of people with TRS attending the South London and Maudsley. Regression analyses were conducted to...

Clinical correlates of early onset antipsychotic treatment resistance

Daniela Fonseca de Freitas, Deborah Agbedjro, Giouliana Kadra-Scalzo, Emma Francis, Isobel Ridler, Megan Pritchard, Hitesh Shetty, Aviv Segev, Cecilia Casetta, Sophie E. Smart, Anna Morris, Johnny Downs, Søren Rahn Christensen, Nikolaj Bak, Bruce J. Kinon, Daniel Stahl, Richard D. Hayes & James H. MacCabe
Background:There is evidence of heterogeneity within treatment-resistant schizophrenia (TRS), with some people not responding to antipsychotic treatment from illness onset and others becoming treatment-resistant after an initial response period. These groups may have different aetiologies.Aim:This study investigates sociodemographic and clinical correlates of early onset of TRS.Method:Employing a retrospective cohort design, we do a secondary analysis of data from a cohort of people with TRS attending the South London and Maudsley. Regression analyses were conducted to...

Additional file 1 of Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards & Robert Frithiof
Additional file 1. Clinical endpoints in Pronmed and Biobanque Québécoise de la COVID-19 (BQC19) for outcomes of acute COVID-19 and Long COVID-19 clustered as physical or mental symptoms.

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards & Robert Frithiof
Abstract Background We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity of the physiological response to dehydration known as aestivation and its relevance for long-term disease outcome in COVID-19. Methods The study includes 374 COVID-19 patients from the Pronmed cohort admitted to the ICU at Uppsala University Hospital. Dehydration data was available...

AMEE Guide to ethical teaching in online medical education: AMEE Guide No. 146

Ken Masters, David Taylor, Teresa Loda & Anne Herrmann-Werner
The Covid-19 pandemic necessitated Emergency Remote Teaching (ERT): the sudden move of educational materials online. While ERT served its purpose, medical teachers are now faced with the long-term and complex demands of formal online teaching. One of these demands is ethical online teaching. Although ethical teaching is practiced in face-to-face situations, online teaching has new ethical issues that must be accommodated, and medical teachers who wish to teach online must be aware of these and...

Additional file 6 of Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis

Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang & Yansong Li
Additional file 6: Fig. S6. Single-cell sequencing analysis of adult mice intestine. a Dotplot for highest specificity gene markers of cell clusters. Dot size represents the percentage of cells expressing the denoted gene, and the color represents average normalized expression level within the denoted cluster. b The expression of GFAP in different cell clusters by analysis of the Uniform Manifold Approximation and Projection (UMAP). c Different cell subpopulation of the GSE156905 dataset derived from the...

sj-docx-1-cre-10.1177_02692155221136046 - Supplemental material for Effect of pelvic floor muscle training on urinary incontinence after radical prostatectomy: An umbrella review of meta-analysis and systematic review

Jia-ming Yang, Hua Ye, Yi Long, Qiang Zhu, Hui Huang, Hui-yong Xie, Yun Luo, Yan-biao Zhong, Jing Chen & Mao-yuan Wang
Supplemental material, sj-docx-1-cre-10.1177_02692155221136046 for Effect of pelvic floor muscle training on urinary incontinence after radical prostatectomy: An umbrella review of meta-analysis and systematic review by Jia-ming Yang, Hua Ye, Yi Long, Qiang Zhu, Hui Huang, Hui-yong Xie, Yun Luo, Yan-biao Zhong, Jing Chen and Mao-yuan Wang in Clinical Rehabilitation

Knockdown of miR-1275 protects against cardiomyocytes injury through promoting neuromedin U type 1 receptor

Zhu Zeng, Haixin Ma, Jing Chen, Nina Huang, Yudan Zhang, Yufei Su & Huifang Zhang
The present study aimed to assess the role of miR-1275 in cardiac ischemia reperfusion injury. H9 human embryonic stem cell (hESC)-derived cardiomyocytes stimulated by oxygen-glucose deprivation/reoxygenation (OGD/R) were used to simulate myocardial injury in vitro. miR-1275 expression levels in cells were measured by RT-qPCR. The release of lactate dehydrogenase (LDH) and creatine kinase (CK) was examined through LDH and CK ELISA kits. Cell apoptosis was detected through flow cytometry. A Fura-2 Calcium Flux Assay Kit...

Additional file 1 of A genome-wide association study of mammographic texture variation

Yuxi Liu, Hongjie Chen, John Heine, Sara Lindstrom, Constance Turman, Erica T. Warner, Stacey J. Winham, Celine M. Vachon, Rulla M. Tamimi, Peter Kraft & Xia Jiang
Additional file 1: Fig. S1. Correlations between the four V assessments. Fig. S2. Quantile-quantile plots of the GWAS meta-analysis results. Fig. S3. Manhattan plots of the GWAS meta-analysis results. Fig. S4. Quantile-quantile plots of the P value of heterogeneity. Table S2. Sources of summary statistics of breast cancer risk and breast cancer risk factors for calculating genetic correlation. Table S3. Sources of summary statistics of breast cancer risk and breast cancer risk factors for the...

A genome-wide association study of mammographic texture variation

Yuxi Liu, Hongjie Chen, John Heine, Sara Lindstrom, Constance Turman, Erica T. Warner, Stacey J. Winham, Celine M. Vachon, Rulla M. Tamimi, Peter Kraft & Xia Jiang
Abstract Background Breast parenchymal texture features, including grayscale variation (V), capture the patterns of texture variation on a mammogram and are associated with breast cancer risk, independent of mammographic density (MD). However, our knowledge on the genetic basis of these texture features is limited. Methods We conducted a genome-wide association study of V in 7040 European-ancestry women. V assessments were generated from digitized film mammograms. We used linear regression to test the single-nucleotide polymorphism (SNP)-phenotype...

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