504 Works

Additional file 1 of Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton & Helen B. Stolp
Additional file 1: Figure S1. Effect of montelukast on CysLTR1 and CysLT in the brain. Figure S2. IL-1β induces vascular inflammation, but not BBB breakdown. Figure S3. No improvement of white matter damage is evident following montelukast treatment in this model. Figure S4. No hippocampal damage evident in this model. Figure S5. Inflammation and/or montelukast treatment does not induce motor deficits.

Additional file 1 of Summarising data and factors associated with COVID-19 related conspiracy theories in the first year of the pandemic: a systematic review and narrative synthesis

Konstantinos Tsamakis, Dimitrios Tsiptsios, Brendon Stubbs, Ruimin Ma, Eugenia Romano, Christoph Mueller, Ayesha Ahmad, Andreas S. Triantafyllis, George Tsitsas & Elena Dragioti
Additional file 1. Supplementary Checklist 1; Supplementary Table 1: Quality assessment for quantitative studies based on the AHRQ (Agency for Healthcare Research and Quality) checklist ; Supplementary Table 2: Quality assessment for qualitative studies based on the CASP (Qualitative Research Checklist, adapted from Horntvedt et al. [15]); Supplementary Box 1: Search strategies ; Supplementary Box 2: Excluded studies with reasons; Supplementary Table 3: Factors and correlations with conspiracy theories and beliefs per study

Additional file 1 of Developing an implementation fidelity checklist for a vocational rehabilitation intervention

Katie Powers, Sara Clarke, Julie Phillips, Jain A. Holmes, Rachel Cripps, Kristelle Craven, Amanda Farrin, Roshan das Nair & Kathryn A. Radford
Additional file 1. ESSVR Fidelity Checklist. Digitised version of the ESSVR fidelity checklist developed in this study. ESSVR Fidelity Checklist Completion Guidance Notes. Guidance notes developed in this study to aid in checklist completion.

Additional file 1 of Developing an implementation fidelity checklist for a vocational rehabilitation intervention

Katie Powers, Sara Clarke, Julie Phillips, Jain A. Holmes, Rachel Cripps, Kristelle Craven, Amanda Farrin, Roshan das Nair & Kathryn A. Radford
Additional file 1. ESSVR Fidelity Checklist. Digitised version of the ESSVR fidelity checklist developed in this study. ESSVR Fidelity Checklist Completion Guidance Notes. Guidance notes developed in this study to aid in checklist completion.

Developing an implementation fidelity checklist for a vocational rehabilitation intervention

Katie Powers, Sara Clarke, Julie Phillips, Jain A. Holmes, Rachel Cripps, Kristelle Craven, Amanda Farrin, Roshan das Nair & Kathryn A. Radford
Abstract Background Despite growing numbers of studies reporting the efficacy of complex interventions and their implementation, many studies fail to report information on implementation fidelity or describe how fidelity measures used within the study were developed. This study aimed to develop a fidelity checklist for measuring the implementation fidelity of an early, stroke-specialist vocational rehabilitation intervention (ESSVR) in the RETAKE trial. Methods To develop the fidelity measure, previous checklists were reviewed to inform the assessment...

Developing an implementation fidelity checklist for a vocational rehabilitation intervention

Katie Powers, Sara Clarke, Julie Phillips, Jain A. Holmes, Rachel Cripps, Kristelle Craven, Amanda Farrin, Roshan das Nair & Kathryn A. Radford
Abstract Background Despite growing numbers of studies reporting the efficacy of complex interventions and their implementation, many studies fail to report information on implementation fidelity or describe how fidelity measures used within the study were developed. This study aimed to develop a fidelity checklist for measuring the implementation fidelity of an early, stroke-specialist vocational rehabilitation intervention (ESSVR) in the RETAKE trial. Methods To develop the fidelity measure, previous checklists were reviewed to inform the assessment...

Data and R Code supporting the journal article \"Estimation of temperature-dependent growth profiles for the assessment of time of hatching in forensic entomology\"

Davide Pigoli, John Aston, Frédéric Ferraty, Anjali Mazumder, Cameron Richards & Martin Hall
R Code and Data to replicate the analysis and the simulation studies in the paper "Estimation of temperature-dependent growth profiles for the assessment of time of hatching in forensic entomology" by D. Pigoli, J.A.D. Aston, F. Ferraty, A. Mazumder, C. Richards and M.H. Hall.
The code has been tested with R version 4.1.3 (2022-03-10).
The R folder contains the following: - growth_function.R : R functions used in the analysis and simulations. - plots.R...

Data and R Code supporting the journal article \"Estimation of temperature-dependent growth profiles for the assessment of time of hatching in forensic entomology\"

Davide Pigoli, John Aston, Frédéric Ferraty, Anjali Mazumder, Cameron Richards & Martin Hall
R Code and Data to replicate the analysis and the simulation studies in the paper "Estimation of temperature-dependent growth profiles for the assessment of time of hatching in forensic entomology" by D. Pigoli, J.A.D. Aston, F. Ferraty, A. Mazumder, C. Richards and M.H. Hall.
The code has been tested with R version 4.1.3 (2022-03-10).
The R folder contains the following: - growth_function.R : R functions used in the analysis and simulations. - plots.R...

Facial expression recognition is linked to clinical and neurofunctional differences in autism

Hannah Meyer-Lindenberg, Carolin Moessnang, Bethany Oakley, Jumana Ahmad, Luke Mason, Emily J. H. Jones, Hannah L. Hayward, Jennifer Cooke, Daisy Crawley, Rosemary Holt, Julian Tillmann, Tony Charman, Simon Baron-Cohen, Tobias Banaschewski, Christian Beckmann, Heike Tost, Andreas Meyer-Lindenberg, Jan K. Buitelaar, Declan G. Murphy, Michael J. Brammer & Eva Loth
Abstract Background Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. Methods Between 255 and 488 participants aged 6–30...

The opioid use disorder core outcomes set (OUD–COS) for treatment research: findings from a Delphi consensus study

Niranjan S Karnik, John Marsden, Connor McCluskey, Randy A Boley, Katharine A Bradley, Cynthia I Campbell, Megan E Curtis, David Fiellin, Udi Ghitza, Kathryn Hefner, Yih‐Ing Hser, R Kathryn McHugh, Sterling M McPherson, Larissa J Mooney, Landhing M Moran, Sean M Murphy, Robert P Schwartz, Dikla Shmueli‐Blumberg, Matisyahu Shulman, Kari A Stephens, Katherine E Watkins, Roger D Weiss & Li‐Tzy Wu
BACKGROUND AND AIM: There is no gold-standard and considerable heterogeneity in outcome measures used to evaluate treatments for opioid use disorder (OUD) along the opioid treatment cascade. The aim of this study was to develop the US National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network (CTN) opioid use disorder core outcomes set (OUD-COS). DESIGN: Four-round, e-Delphi expert panel consensus study and plenary research group discussion and targeted consultation. SETTING: United...

sj-docx-1-tva-10.1177_15248380221129596 – Supplemental material for The Association Between Child Abuse and Aggressive Behavior: A Three-Level Meta-Analysis

Guangming Ran, Qiongzhi Zhang, Qi Zhang, Jun Li & Jing Chen
Supplemental material, sj-docx-1-tva-10.1177_15248380221129596 for The Association Between Child Abuse and Aggressive Behavior: A Three-Level Meta-Analysis by Guangming Ran, Qiongzhi Zhang, Qi Zhang, Jun Li and Jing Chen in Trauma, Violence, & Abuse

Additional file 1 of Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial

Khalid Ali, Ekow A. Mensah, Eugene Ace McDermott, Frances A. Kirkham, Jennifer Stevenson, Victoria Hamer, Nikesh Parekh, Rebekah Schiff, Tischa Van Der Cammen, Stephen Nyangoma, Sally Fowler-Davis, Graham Davies, Heather Gage & Chakravarthi Rajkumar
Additional file 1: Appendix 1. Formula for calculating patient risk of experiencing MRH within 8 weeks post hospital discharge. Appendix 2. Visual analogue of risk prediction tool. Appendix 3. Study participants flow chart.

Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial

Khalid Ali, Ekow A. Mensah, Eugene Ace McDermott, Frances A. Kirkham, Jennifer Stevenson, Victoria Hamer, Nikesh Parekh, Rebekah Schiff, Tischa Van Der Cammen, Stephen Nyangoma, Sally Fowler-Davis, Graham Davies, Heather Gage & Chakravarthi Rajkumar
Abstract Background Medication-related harm (MRH) is an escalating global challenge especially among older adults. The period following hospital discharge carries high-risk for MRH due to medication discrepancies, limited patient/carer education and support, and poor communication between hospital and community professionals. Discharge Medical Service (DMS), a newly introduced NHS scheme, aims to reduce post-discharge MRH through an electronic communication between hospital and community pharmacists. Our study team has previously developed a risk-prediction tool (RPT) for MRH...

Comparative evaluation of different versions of exposure-free mosquito electrocuting traps and barrier screen trap for monitoring outdoor densities and biting time phenotypes by malaria and filariasis vectors in Tanzania

Victoria Githu, Maneno E. Baravuga, Asiya Mbarawa, Hajirani M. Msuya, Yeromin P. Mlacha, Prosper P. Chaki, Samson Kiware, Nosrat Mirzai, Heather M. Ferguson & Nicodem J. Govella
Abstract Background Estimating human exposure to mosquito vectors is crucial for the prediction of malaria transmission and intervention impact. The human landing catch method is frequently used to directly measure estimate exposure rates; however, there has been an increasing shift from this method to exposure-free alternatives, such as the mosquito electrocuting traps (MET) and other approaches. While these latter methods can provide robust and representative values of human exposure and mosquito density, they often still...

Additional file 1 of Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou & Likun Chen
Additional file 1: Fig. S1 The comparison of NGS results in paired baseline CSF, plasma, and tumor tissue samples.

Additional file 1 of Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou & Likun Chen
Additional file 1: Fig. S1 The comparison of NGS results in paired baseline CSF, plasma, and tumor tissue samples.

Additional file 8 of Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou & Likun Chen
Additional file 8: Fig. S8 The proportion of clonal and subclonal mutations in CSF and plasma samples at baseline and after 8 weeks of treatment.

Additional file 3 of Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou & Likun Chen
Additional file 3: Fig. S3 Consistency of genomic alterations between paired CSF and plasma samples.

An evaluation of the implementation of interventions to reduce postoperative infections and optimise antibiotic use across the surgical pathway in India: a mixed-methods exploratory study protocol

Shalini Ahuja, Sanjeev Singh, Esmita Charani, Surya Surendran, Vrinda Nampoothiri, Fabia Edathadathil, Anu George, Andrew Leather, Carolyn Tarrant, Alison Holmes, Nick Sevdalis & Gabriel Birgand
Abstract Introduction Postoperative infections represent a significant burden of disease, demanding antibiotic prescriptions, and are contributing to antimicrobial resistance. The burden of infection as a surgical complication is greater in low- and middle-income countries (LMICs). We report the protocol of a pilot study for the co-design, implementation and evaluation of two infection prevention and control (IPC) and antimicrobial stewardship (AMS) interventions across the surgical pathway in a teaching hospital in India. Methods and analysis The...

Additional file 2 of A genome-wide association study of mammographic texture variation

Yuxi Liu, Hongjie Chen, John Heine, Sara Lindstrom, Constance Turman, Erica T. Warner, Stacey J. Winham, Celine M. Vachon, Rulla M. Tamimi, Peter Kraft & Xia Jiang
Additional file 2: Table S1. Number of GWAS subjects by study and platform. Table S4. GWAS results of significant V loci for all V assessments and models. Table S5. Lookup results of 72 MD phenotype SNPs in GWAS of V. Table S6. Lookup results of 195 breast cancer SNPs in GWAS of V. Table S7. Genetic correlation results of all V assessments and models. Table S8. SNP-set test results of all V assessments and models.

Additional file 1 of A genome-wide association study of mammographic texture variation

Yuxi Liu, Hongjie Chen, John Heine, Sara Lindstrom, Constance Turman, Erica T. Warner, Stacey J. Winham, Celine M. Vachon, Rulla M. Tamimi, Peter Kraft & Xia Jiang
Additional file 1: Fig. S1. Correlations between the four V assessments. Fig. S2. Quantile-quantile plots of the GWAS meta-analysis results. Fig. S3. Manhattan plots of the GWAS meta-analysis results. Fig. S4. Quantile-quantile plots of the P value of heterogeneity. Table S2. Sources of summary statistics of breast cancer risk and breast cancer risk factors for calculating genetic correlation. Table S3. Sources of summary statistics of breast cancer risk and breast cancer risk factors for the...

Knockdown of miR-1275 protects against cardiomyocytes injury through promoting neuromedin U type 1 receptor

Zhu Zeng, Haixin Ma, Jing Chen, Nina Huang, Yudan Zhang, Yufei Su & Huifang Zhang
The present study aimed to assess the role of miR-1275 in cardiac ischemia reperfusion injury. H9 human embryonic stem cell (hESC)-derived cardiomyocytes stimulated by oxygen-glucose deprivation/reoxygenation (OGD/R) were used to simulate myocardial injury in vitro. miR-1275 expression levels in cells were measured by RT-qPCR. The release of lactate dehydrogenase (LDH) and creatine kinase (CK) was examined through LDH and CK ELISA kits. Cell apoptosis was detected through flow cytometry. A Fura-2 Calcium Flux Assay Kit...

Additional file 1 of Feasibility and acceptability of e-learning to upskill diabetes educators in supporting people experiencing diabetes distress: a pilot randomised controlled trial

Jennifer A. Halliday, Sienna Russell-Green, Virginia Hagger, Eric O, Ann Morris, Jackie Sturt, Jane Speight & Christel Hendrieckx
Additional file 1: Supplement 1. Summary of content in ‘Diabetes Distress’ chapter of ‘Diabetes and Emotional Health’.

Additional file 1 of Feasibility and acceptability of e-learning to upskill diabetes educators in supporting people experiencing diabetes distress: a pilot randomised controlled trial

Jennifer A. Halliday, Sienna Russell-Green, Virginia Hagger, Eric O, Ann Morris, Jackie Sturt, Jane Speight & Christel Hendrieckx
Additional file 1: Supplement 1. Summary of content in ‘Diabetes Distress’ chapter of ‘Diabetes and Emotional Health’.

Additional file 6 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 6: Mount Sinai investigators.

Registration Year

  • 2022
    390
  • 2021
    54
  • 2020
    27
  • 2019
    12
  • 2018
    7
  • 2017
    2
  • 2016
    4
  • 2015
    3
  • 2014
    3
  • 2012
    1

Resource Types

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    203
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    87
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    6
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Affiliations

  • King's College London
    504
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    106
  • Sichuan University
    102
  • Fudan University
    99
  • Huazhong University of Science and Technology
    96
  • Shandong University
    96
  • North West Agriculture and Forestry University
    92
  • Anhui Agricultural University
    92
  • Wuhan University
    88
  • Nanjing University of Chinese Medicine
    88