4 Works

Data from: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HDHQ150/Q150 mouse model of Huntington's disease

Ivan Rattray, Edward J. Smith, William R. Crum, Thomas J. Walker, Richard Gale, Gillian P. Bates, Mike Modo & Michel Modo
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington’s disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction) was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated...

Data from: Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture

Kari Britt Schroeder, Philip Asherson, Peter R. Blake, Susan K. Fenstermacher & Kimberly J. Saudino
Cumulative culture ostensibly arises from a set of sociocognitive processes which includes high-fidelity production imitation, prosociality and group identification. The latter processes are facilitated by unconscious imitation or social mimicry. The proximate mechanisms of individual variation in imitation may thus shed light on the evolutionary history of the human capacity for cumulative culture. In humans, a genetic component to variation in the propensity for imitation is likely. A functional length polymorphism in the serotonin transporter...

Data from: Neurofunctional abnormalities during sustained attention in severe childhood abuse

Lena Lim, Heledd Hart, Mitul A. Mehta, Andrew Simmons, Kah Mirza & Katya Rubia
Childhood maltreatment is associated with adverse affective and cognitive consequences including impaired emotion processing, inhibition and attention. However, the majority of functional magnetic resonance imaging (fMRI) studies in childhood maltreatment have examined emotion processing, while very few studies have tested the neurofunctional substrates of cognitive functions and none of attention. This study investigated the association between severe childhood abuse and fMRI brain activation during a parametric sustained attention task with a progressively increasing load of...

Data from: Short-term and medium-term survival of critically ill patients with solid tumours admitted to the intensive care unit: a retrospective analysis

Richard Fisher, Carole Dangoisse, Siobhan Crichton, Craig Whiteley, Luigi Camporota, Richard Beale & Marlies Ostermann
Objectives: Patients with cancer frequently require unplanned admission to the Intensive Care Unit (ICU). Our objectives were to assess hospital and 180-day mortality in patients with a non-haematological malignancy and unplanned ICU admission, and to identify which factors present on admission were the best predictors of mortality. Design: Retrospective review of all patients with a diagnosis of solid tumours following unplanned admission to the ICU between 1st August 2008 and 31st July 2012. Setting: Single...

Registration Year

  • 2016
    4

Resource Types

  • Dataset
    4

Affiliations

  • King's College London
    4
  • University of Vermont
    1
  • University of Pittsburgh
    1
  • King's College
    1
  • Guy's Hospital
    1
  • Boston University
    1