7 Works

Data from: Glutamate receptor delta2 serum antibodies in paediatric opsoclonus myoclonus ataxia syndrome

Georgina Berridge, David A Menassa, Teresa Moloney, Patrick J Waters, Imogen Welding, Selina Thomsen, Sameer Zuberi, Roman Fischer, A. Radu Aricescu, Michael Pike, Russell C Dale, Benedikt Kessler, Angela Vincent, Ming Lim, Sarosh R Irani & Bethan Lang
Objective: To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) usingcontemporary antigen discovery methodology. Methods: OMAS patient serum IgG immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electrophoresis and mass spectrometry. Data are available via ProteomeXchange (identifier PXD009578). This generated a list of potential neuronal surface cerebellar autoantigens. Live cell-based assays (CBA) were used to confirm membrane-surface antigens and adsorb antigen-specific IgGs. The serological results were compared to the clinical...

Data from: Brain myo-inositol as a potential marker of amyloid-related pathology: a longitudinal study.

Olga Voevodskaya, Konstantinos Poulakis, Pia Sundgren, Danielle Van Westen, Sebastian Palmqvist, Lars Olof Wahlund, Erik Stomrud, Oskar Hansson & Eric Westman
Objective: To investigate the association between longitudinal changes in proton magnetic spectroscopy (MRS) metabolites and amyloid pathology in non-demented individuals; to explore the relationship between MRS and cognitive decline. Methods: In this longitudinal multiple time point study (a subset of the Swedish BioFINDER) we included cognitively healthy participants, individuals with subjective cognitive decline and mild cognitive impairment (MCI). MRS was acquired serially in 294 participants (670 individual spectra) from the posterior cingulate/precuneus. Using mixed-effects models,...

Substrate utilisation profiles for saprotrophic fungi and moisture content data from soil sampled in an upland grassland experiment at Sourhope, Scotland, 2001 [NERC Soil Biodiversity Programme]

L.J. Deacon, E.J. Pryce-Miller, J.C. Frankland, B.W. Bainbridge, P.D. Moore, C.H. Robinson & N. Parekh
This set of data comprises substrate utilisation profiles for saprotrophic fungi (using the commercially available BIOLOG plate method) and moisture content data from soils sampled from experimental plots at Sourhope, Scotland. The data were collected in order to determine how the high species richness of decomposer (saprotrophic) fungi and their relative frequencies of occurrence influence the decomposition of organic matter. Data were collected during a project funded under the NERC Soil Biodiversity Programme, established in...

Data from: Clinical spectrum of STX1B-related epileptic disorders

Stefan Wolking, Patrick May, Davide Mei, Rikke S. Møller, Simona Balestrini, Katherine L. Helbig, Cecilia Desmettre Altuzarra, Nicolas Chatron, Charu Kaiwar, Katharina Stoehr, Peter Widdess-Walsh, Bryce A. Mendelsohn, Adam Numis, Maria R. Cilio, Wim Van Paesschen, Lene L. Svendsen, Stephanie Oates, Elaine Hughes, Sushma Goyal, Kathleen Brown, Margarita Sifuentes Saenz, Thomas Dorn, Hiltrud Muhle, Alistair T. Pagnamenta, Dimitris V. Vavoulis … & Julian Schubert
Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to STX1B, encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants. Methods: We used next generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. To estimate the pathogenicity of the variants, we used established and newly developed in silico prediction tools. Results: We...

Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials

Trevor Thompson, Fiona Whiter, Katy Gallop, Nicola Veronese, Marco Solmi, Paul Newton & Brendon Stubbs
OBJECTIVES: We conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of N-methyl-D-aspartate receptor (NMDAR) antagonists. METHODS: Six major databases were systematically searched (to 03/2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis. RESULTS: Searches identified 70 eligible trials (N=1069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease...

Data from: Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa Chand, Darren Byrne, Venkatesh N. Murthy & Matthew Grubb
Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally-generated neurons often match those of their embryonically-produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation:...

Data from: Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: a cluster-randomised controlled trial

Clive Ballard, Anne Corbett, Martin Orrell, Gareth Williams, Esme Moniz-Cook, Renee Romeo, Bob Woods, Lucy Garrod, Ingelin Testad, Barbara Woodward-Carlton, Jennifer Wenborn, Martin Knapp & Jane Fossey
Background: Agitation is a common, challenging symptom affecting large numbers of people with dementia and impacting on quality of life (QoL). There is an urgent need for evidence-based, cost-effective psychosocial interventions to improve these outcomes, particularly in the absence of safe, effective pharmacological therapies. This study aimed evaluate the efficacy of a person-centered care and psychosocial intervention (WHELD) on QoL, agitation and antipsychotic use in people with dementia living in nursing homes, and to determine...

Registration Year

  • 2018
    7

Resource Types

  • Dataset
    7

Affiliations

  • King's College London
    7
  • University College London
    2
  • University of Padua
    1
  • Massachusetts General Hospital
    1
  • Bangor University
    1
  • John Radcliffe Hospital
    1
  • University of Antwerp
    1
  • London School of Economics and Political Science
    1
  • University of Greenwich
    1
  • Hvidovre Hospital
    1