12 Works

Transforming Out of Hospital Care for People who are Homeless: Support Tool for the High Impact Change Model

Michelle Cornes & Manthorpe Jill

Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi C. Lam, Felix D. Weiss, Zoe Powis, Pim Suwannarat, Christopher J. Lelliot, Sally J. Dawson, Jacqueline K. White & Karen P. Steel
Adult-onset hearing loss is very common but we know little about the underlying molecular pathogenesis, impeding development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly-generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response. We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested,...

Data from: Quantifying niche availability, niche overlap and competition for recruitment sites in plant populations without explicit knowledge of niche axes.

Elizabeth M. Wandrag, Jane A. Catford & Richard P. Duncan
1. Niche availability, niche overlap and competitive ability are key determinants of the distribution and abundance of species. However, quantifying each of these components is difficult because it is not always possible to identify or measure relevant environmental gradients (niche axes) along which species might partition or compete for niche space. 2. We describe a method that uses seed addition experiments to quantify the number of ‘safe-sites’ (microsites suitable for a species to recruit from...

Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in mycosis fungoides and Sezary syndrome

Christine Jones, Andrea Degasperi, Vieri Grandi, Tracey Mitchell & Serena Nik-Zainal
T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of mutational catalogues derived from whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mutational signatures and recurrent gene mutations associated with specific causal peaks within these signatures. Signature 1, indicative of age-related deamination, was prevalent across all T-cell lymphoma subtypes, reflecting the derivation of these malignancies from memory T-cell subsets. The majority of...

What students think about freedom of expression

Jonathan Grant, Kirstie Hewlett, Tamar Nir & Bobby Duffy

Social workers' knowledge and skills and the Care Act: Practice Advice Note

Angela Jenkinson & John Chamberlain
The need for a practice advice note on the roles of social workers in the Care Act was identified by the Chief Social Worker and was reinforced by a consultation with 140 social workers, who agreed the general content of this advice. The Advice Note identifies social workers as being fundamental to the achievability of the Care Act because they are registered as having the knowledge and skills to achieve changes to protect, safeguard, promote...

Anne Curry, Malcolm Vale, Frédéric Boutoulle, Paul Booth, Philip Morgan, Paul Spence, Francoise Lainé, Frank Byrne, Paul Caton, Nigel Coulton, Jon Denton, Nathan Dobson, Elise Dudézert, Dilys Firn, Eric Foster, John Gowling, Nicholas A. Gribit, Simon Harris, Catherine Howarth, Neil Jakeman, Adrian Jobson, Maureen Jurkowski, Faith Lawrence, Jonathan Mackman, Nelly Martin … & Chris Watson
The Gascon Rolls CKAN Dataset makes available the following resources: - The set of rolls in TEI-XML format; - An Eatsml file in XML containing the set of entity records (for persons, places, etc.) out of which the indexes and search available on the project site are generated; - The project guidelines for encoding the calendared versions of the rolls into TEI-XML.

Safeguarding, homelessness and rough sleeping: An analysis of Safeguarding Adults Reviews

Stephen Martineau, Michelle Cornes, Jill Manthorpe, Bruno Ornelas & James Fuller

Data from: Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

Wei Cheng, Edmund T. Rolls, Trevor W. Robbins, Weikang Gong, Zhaowen Liu, Wujun Lv, Jingnan Du, Hongkai Wen, Liang Ma, Erin Burke Quinlan, Hugh Garavan, Eric Artiges, Dimitri Papadopoulos Orfanos, Michael N. Smolka, Gunter Schumann, Keith Kendrick & Jianfeng Feng
In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the precuneus. Participants who drank a high amount had overall increases in resting state functional connectivity, and specific increases in reward-related systems including the medial orbitofrontal cortex and the cingulate cortex. Increased impulsivity was...

David Carpenter, Louise Wilkinson, David Crook, Harold Short, Paul Dryburgh, Beth Hartland, Polly Hanchett, Jonathan Mackman, Ben Wild, Simon Harris, Sean Cunningham, Jess Nelson, Adrian Jobson, Aidan Lawes, Paul Spence, Zaneta Au, Paul Caton, Arianna Ciula, Eleonora Litta Modignani Picozzi, Tamara Lopez, Paul Vetch, José Miguel Vieira, Raffaele Viglianti, John Bradley, Gerhard Brey … & Simon Tanner
The Project A fine in the reign of King of England Henry III (1216–1272) was an agreement to pay the king a sum of money for a specified concession. The rolls on which the fines were recorded provide the earliest systematic evidence of what people and institutions across society wanted from the king and he was prepared to give. They open a large window onto the politics, government, economy and society of England in the...

Roles, responsibilities, and relationships: hearing the voices of Personal Assistants and Directly Employed Care Workers

John Woolham, Caroline Norrie, Kritika Samsi & Jill Manthorpe

Data from: Ecosystem services provided by bromeliad plants: a systematic review

Geraldine Ladino, Fabiola Ospina-Bautista, Jaime Estévez Varón, Lucie Jerabkova & Pavel Kratina
The unprecedented loss of biological diversity has negative impacts on ecosystems and the associated benefits which they provide to humans. Bromeliads have high diversity throughout the Neotropics, but they have been negatively affected by habitat loss and fragmentation, climate change, herbivorous species invasions, and they are also being commercialized for ornamental use. These plants provide direct benefits to the human society and they also form micro ecosystems in which accumulated water and nutrients support the...

Registration Year

  • 2019
    12

Resource Types

  • Dataset
    5
  • Text
    5

Affiliations

  • King's College London
    12
  • University of Cambridge
    2
  • Keele University
    1
  • Shanghai University
    1
  • Fudan University
    1
  • University of Vermont
    1
  • National Institute for Health Research
    1
  • University of Warwick
    1
  • University of Southampton
    1
  • Queen Mary University of London
    1