One-year sustained efficacy of erenumab in episodic migraine: Results of the STRIVE study - supplementary dataPeter Goadsby
Objective: To assess efficacy and tolerability of 1-year erenumab treatment in patients with episodic migraine. Methods: Patients were randomized (n=955; 1:1:1) during the 24-week double-blind treatment phase (DBTP) to monthly subcutaneous placebo, erenumab 70 or 140mg. At Week 24, 845 patients were re-randomized (1:1) to erenumab 70 or 140mg during the 28-week dose-blinded active-treatment phase (ATP). Monthly migraine days (MMD), achieving ≥50%, ≥75% and 100% reduction in MMD, and safety/tolerability were assessed. Results: Mean MMD...
In-depth comparative toxicogenomics of glyphosate and Roundup herbicides: Histopathology, transcriptome and epigenome signatures, and DNA damageRobin Mesnage, Mariam Ibragim, Daniele Mandrioli, Laura Falcioni, Eva Tibaldi, Inger Brandsma, Fiorella Belpoggi, Emma Bourne, Emanuel Savage, Charles A Mein & Michael Antoniou
Whether or not glyphosate activates cellular mechanisms involved in carcinogenesis remains controversial. We tested whether glyphosate and three glyphosate-based commercial herbicide formulations activate mechanisms known to be key characteristics of carcinogens. The mammalian stem cell-based genotoxicity ToxTracker assay showed that the representative EU formulation Roundup MON 52276 and the UK formulation Roundup MON 76473, but not glyphosate and the US Roundup formulation MON 76207, activated oxidative stress and unfolded protein responses. High-throughput molecular profiling of...
Plant-soil feedbacks (PSF) and functional traits are two active but not well theoretically integrated areas of research. However, PSF and traits are both affected by life history evolution, so the two should theoretically be related. We provide a conceptual framework to link plant functional traits to two types of PSF metrics, and hypothesize that individual PSF (plant performance in conspecific versus heterospecific soil) should be related to the fast-slow trait spectrum, while pairwise PSF (the...
Fragmentation in trader preferences among multiple markets: Market coexistence versus single market dominanceAleksandra Alorić, Robin Nicole & Peter Sollich
Technological advancement has lead to an increase in number and type of trading venues and diversification of goods traded. These changes have re-emphasized the importance of understanding the effects of market competition: does proliferation of trading venues and increased competition lead to dominance of a single market or coexistence of multiple markets? In this paper, we address these questions in a stylized model of Zero Intelligence traders who make repeated decisions at which of three...
Carcharhinus amblyrhynchos and Carcharhinus albimarginatus underwater acoustic telemetry data - Chagos Archipelago 2014-2018Michael Williamson
A wide array of technologies are available for gaining insight into the movement of wild aquatic animals. Although acoustic telemetry may lack the fine-scale resolution of some satellite tracking technologies, the substantially longer battery life can yield important long-term data on behaviour and movement for low per-unit cost. Typically, however, receiver arrays are designed to maximise spatial coverage at the cost of positional accuracy leading to potentially longer detection gaps as individuals move out of...
Objective: To characterize the spectrum of clinical features in a cohort of X-linked myotubular myopathy (XL-MTM) carriers, including prevalence, genetic features, clinical symptoms and signs, as well as associated disease burden. Methods: We performed a cross-sectional online questionnaire study among XL-MTM carriers. Participants were recruited from patient associations, medical centers and registries in the United Kingdom, Germany and the Netherlands. We used a custom-made questionnaire, the Checklist Individual Strength (CIS), the Frenchay Activities Index (FAI),...
Objectives: Sleep disturbance is often associated with migraine. However, there is a paucity of research investigating objective and subjective measures of sleep in migraine patients. This meta-analysis aims to determine whether there are differences in subjective sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI), and objective sleep physiology measured using polysomnography between adult and pediatric patients, and healthy controls. Methods: This review was pre-registered on PROSPERO (CRD42020209325). A systematic search of five databases...
High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of multiparametric “big data” usually requires specialist computational knowledge. Here we describe ImmunoCluster (https://github.com/kordastilab/ImmunoCluster) an R package for immune profiling cellular heterogeneity in high dimensional liquid and imaging mass cytometry, and flow cytometry data, designed to facilitate computational analysis by...
King's College London43
University College London4
Centre national de la recherche scientifique3
The Francis Crick Institute3
Institute of Genetics and Molecular and Cellular Biology1
Sun Yat-sen University1
London School of Economics and Political Science1
Utah State University1
Guy's and St Thomas' NHS Foundation Trust1