387 Works

Intergenerational encounters: a service-learning module for postgraduate university students

Donata Puntil, Gisele Dias, Carolina Kralj & Patricia Zunszain

Homelessness, Water Insecurity, and the Human Right to Water and Sanitation

Katie Meehan, Marianne Odetola & Alison Griswold

Evaluating the introduction of the Nursing Associate role in social care

Ian Kessler, Jill Manthorpe, Jess Harris, Jo Moriarty & Nicole Steils

King's Computational Research, Engineering and Technology Environment (CREATE)

Additional file 1 of Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox & Duncan Sproul
Additional file 1: Supplementary figures Fig. S1-5 and legends.

Additional file 3 of Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox & Duncan Sproul
Additional file 3. Review history.

AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Géraldine Leduc, Tristan Doussineau, Yan Wang, Qiang Liu & Olivier Tillement
Abstract In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and reduce the damage of radiation to neighboring normal tissues, radiosensitizers have been given increasing attention in recent years. As nanoparticles based on the metal element gadolinium, AGuIX nanoparticles have been shown to increase the radiosensitivity of cancers. Although it is a rare nanomaterial that has entered...

Social inclusion & autonomous vehicles: Report of a Policy Lab, June 2022

Justyna Lisinska, Finlay Malcolm & Mark Kleinman

COVID-19 and systemic lupus erythematosus genetics: a balance between autoimmune disease risk and protection against infection

Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E. Comeau, Carl D. Langefeld, Deborah S. Cunninghame Graham, David L. Morris & Timothy J. Vyse
Files in this repository contain GWAS summary statistics for the cross-trait meta-analysis between SLE and severe COVID-19 for publication. A "read me" file is included to describe the column labels.

Circulating and urinary microRNAs profile for predicting renal recovery from severe acute kidney injury

Thanawat Phulkerd, Tanat Lertussavavivat, Umaporn Limothai, Sadudee Peerapornratana, Win Kulvichit, Nuttha Lumlertgul, Kriang Tungsanga, Somchai Eiam-Ong, Yingyos Avihingsanon & Nattachai Srisawat
Abstract Background There is little known about the contribution of microRNAs (miRNAs) in the recovery from acute kidney injury (AKI). This study aimed to discover and validate miRNA profiles for predicting renal recovery from severe AKI. Patients and methods A prospective observational study was conducted between June 2020 and January 2021. Urine and serum samples of participants with AKI stage 3 were collected from two groups: renal recovery and renal non-recovery. Transcriptomic analysis was performed...

Additional file 1 of In vitro activity of ceftaroline, ceftazidime-avibactam, and comparators against Gram-positive and -negative organisms in China: the 2018 results from the ATLAS program

Peiyao Jia, Ying Zhu, Hui Zhang, Bin Cheng, Ping Guo, Yingchun Xu & Qiwen Yang
Supplementary Material 1

In vitro activity of ceftaroline, ceftazidime-avibactam, and comparators against Gram-positive and -negative organisms in China: the 2018 results from the ATLAS program

Peiyao Jia, Ying Zhu, Hui Zhang, Bin Cheng, Ping Guo, Yingchun Xu & Qiwen Yang
Abstract Background Data on antibiotic resistance is essential to adapt treatment strategies against the rapidly changing reality of antimicrobial resistance. Objective To study the in vitro activity of ceftaroline, ceftazidime-avibactam, and comparators against Gram-positive and Gram-negative bacteria collected from China in the year 2018. Methods A total of 2301 clinical isolates were collected from 17 medical center laboratories in China, which participated in the ATLAS program in 2018. Antimicrobial susceptibilities were determined by the broth...

Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort study

Wenjuan Wang, Luke B Snell, Davide Ferrari, Anna L Goodman, Nicholas M Price, Charles D Wolfe, Vasa Curcin, Jonathan D Edgeworth & Yanzhong Wang
Abstract Introduction Randomised controlled trials have shown that steroids reduce the risk of dying in patients with severe Coronavirus disease 2019 (COVID-19), whilst many real-world studies have failed to replicate this result. We aim to investigate real-world effectiveness of steroids in severe COVID-19. Methods Clinical, demographic, and viral genome data extracted from electronic patient record (EPR) was analysed from all SARS-CoV-2 RNA positive patients admitted with severe COVID-19, defined by hypoxia at presentation, between March...

Additional file 1 of Trauma-focused therapies for post-traumatic stress in psychosis: study protocol for the RE.PROCESS randomized controlled trial

Simone R. Burger, Tineke van der Linden, Amy Hardy, Paul de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Catherine van Zelst, Jennifer D. Gottlieb, Kim T. Mueser, Agnes van Minnen, Ad de Jongh, Machteld Marcelis, Mark van der Gaag & David van den Berg
Additional file 1. Model Consent Form.

Trauma-focused therapies for post-traumatic stress in psychosis: study protocol for the RE.PROCESS randomized controlled trial

Simone R. Burger, Tineke van der Linden, Amy Hardy, Paul de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Catherine van Zelst, Jennifer D. Gottlieb, Kim T. Mueser, Agnes van Minnen, Ad de Jongh, Machteld Marcelis, Mark van der Gaag & David van den Berg
Abstract Introduction Many people with psychotic disorders experience symptoms of post-traumatic stress disorder (PTSD). In recent years, several trauma-focused therapies (TFTs), including cognitive restructuring (CR), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR) have been studied and found to be safe and effective in reducing PTSD symptoms in individuals with psychosis. However, studies were conducted in different countries, with varying inclusion criteria, therapy duration, control groups, and trial outcomes. RE.PROCESS will be the...

Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen & Paul M. Matthews
Abstract Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulating body of research indicates that microglia may play a causal role in the pathogenesis of this disease. We hypothesised that sex differences in the transcriptome of human myeloid cells may contribute to the sex difference observed in AD prevalence. To explore this, we assessed bulk and single-nuclear...

Parasitism dramatically alters the ecosystem services provided by freshwater mussels

Joshua Brian, Sam Reynolds & David Aldridge
Parasites can indirectly affect ecosystem function by altering host phenotype, but the trait-mediated impacts of parasitism at an ecosystem level remain poorly characterised. However, understanding the influence of parasites is central to understanding the ecosystem services provided by host species, especially in an era of global environmental change. We examined the effect of native (the trematode Rhipidocotyle campanula) and invasive (the bitterling fish Rhodeus amarus) parasites, and their interaction, on the clearance rates of unionid...

Trusted Internet of Things at home and in the workplace: A policy landscape review

Justyna Lisinska, Sachini Weerawardhana & Mark Kleinman

Additional file 3 of Patient and public involvement in an international rheumatology translational research project: an evaluation

Savia de Souza, Eva C. Johansson, Susanne Karlfeldt, Karim Raza & Ruth Williams
Additional file 3. GRIPP2-LF.

Patient and public involvement in an international rheumatology translational research project: an evaluation

Savia de Souza, Eva C. Johansson, Susanne Karlfeldt, Karim Raza & Ruth Williams
Abstract Background Rheuma Tolerance for Cure (RTCure) is a five-year international collaboration between academia, industry and patients/members of the public. It focuses on developing approaches to predict the onset of rheumatoid arthritis (RA) and designing clinical trials to reduce the risk of disease development through immune-tolerising and other treatments. We conducted a mid-term evaluation of patient and public involvement (PPI) within the project. Methods Two surveys on PPI were co-designed by the PPI Coordinator, Patient/Public...

Additional file 1 of Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Additional file 1: Supplement 1. SPIRIT Checklist.

Additional file 1 of Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards & Robert Frithiof
Additional file 1. Clinical endpoints in Pronmed and Biobanque Québécoise de la COVID-19 (BQC19) for outcomes of acute COVID-19 and Long COVID-19 clustered as physical or mental symptoms.

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklos Lipcsey, Dave R. Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Adriana Marton, Jens Marc Titze, Sandra Nihlén, J. Brent Richards & Robert Frithiof
Abstract Background We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity of the physiological response to dehydration known as aestivation and its relevance for long-term disease outcome in COVID-19. Methods The study includes 374 COVID-19 patients from the Pronmed cohort admitted to the ICU at Uppsala University Hospital. Dehydration data was available...

Additional file 3 of Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis

Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang & Yansong Li
Additional file 3: Fig. S3. Effects of cilostazol treatment on serum inflammatory factors. The level of serum TNF-α (a) and IL-1β (b) in each group (n = 6). The data are presented as the mean ± SEM, ***P < 0.001, ****P < 0.0001, and ns indicates no significant difference.

Additional file 3 of Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis

Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang & Yansong Li
Additional file 3: Fig. S3. Effects of cilostazol treatment on serum inflammatory factors. The level of serum TNF-α (a) and IL-1β (b) in each group (n = 6). The data are presented as the mean ± SEM, ***P < 0.001, ****P < 0.0001, and ns indicates no significant difference.

Registration Year

  • 2022
    387

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    167
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Affiliations

  • King's College London
    387
  • Zhejiang University
    100
  • Sichuan University
    96
  • Capital Medical University
    94
  • Fudan University
    92
  • Huazhong University of Science and Technology
    90
  • Shandong University
    90
  • North West Agriculture and Forestry University
    86
  • Anhui Agricultural University
    86
  • Wuhan University
    82