5 Works

Data from: Enhancement of apoptosis by titanium alloy internal fixations during microwave treatments for fractures: an animal study

Gang Wang, Yiming Xu, Lina Zhang, Dongmei Ye, Xianxuan Feng, Tengfei Fu & Yuehong Bai
Objective: Microwaves are used in one method of physical therapy and can increase muscle tissue temperature which is useful for improving muscle, tendon and bone injuries. In the study, we sought to determine whether titanium alloy internal fixations influence apoptosis in tissues subjected to microwave treatments at 2,450 MHz and 40 W during the healing of fractures because this issue is not yet fully understood. Methods: In this study, titanium alloy internal fixations were used...

Data from: Carpal tunnel syndrome sssessment with ultrasonography: value of inlet-to-outlet median nerve area ratio in patients versus healthy volunteers

Tengfei Fu, Manlin Cao, Fang Liu, Jiaan Zhu, Dongmei Ye, Xianxuan Feng, Yiming Xu, Gang Wang & Yuehong Bai
Objective: To evaluate the diagnostic value of the Inlet-to-outlet median nerve area ratio (IOR) in patients with clinically and electrophysiologically confirmed carpal tunnel syndrome (CTS). Methods: Forty-six wrists in 46 consecutive patients with clinical and electrodiagnostic evidence of CTS and forty-four wrists in 44 healthy volunteers were examined with ultrasonography. The cross-sectional area (CSA) of the median nerve was measured at the carpal tunnel inlet (the level of scaphoid-pisiform) and outlet (the level of the...

Data from: Glucagon-like peptide-1 receptor agonist Liraglutide has anabolic bone effects in ovariectomized rats without diabetes

Nan Lu, Hanxiao Sun, JingJia Yu, Xiaojing Wang, Dongmei Liu, Lin Zhao, Lihao Sun, Hongyan Zhao, Bei Tao & Jianmin Liu
Recently, a number of studies have demonstrated the potential beneficial role for novel anti-diabetic GLP-1 receptor agonists (GLP-1RAs) in the skeleton metabolism in diabetic rodents and patients. In this study, we evaluated the impacts of the synthetic GLP-1RA Liraglutide on bone mass and quality in osteoporotic rats induced by ovariectomy (OVX) but without diabetes, as well as its effect on the adipogenic and osteoblastogenic differentiation of bone marrow stromal cells (BMSCs). Three months after sham...

Data from: Correlation between either Cupriavidus or Porphyromonas and primary pulmonary tuberculosis found by analysing the microbiota in patients’ bronchoalveolar lavage fluid

Yuhua Zhou, Feishen Lin, Zelin Cui, Xiangrong Zhang, Chunmei Hu, Tian Shen, Chunyan Chen, Xia Zhang & Xiaokui Guo
Pulmonary tuberculosis (TB) has gained attention in recent decades because of its rising incidence trend; simultaneously, increasing numbers of studies have identified the relationship between microbiota and chronic infectious diseases. In our work, we enrolled 32 patients with primary TB characterised by unilateral TB lesion formation diagnosed by chest radiographic exam. Bronchoalveolar lavage fluid was taken from both lungs. Twenty-four healthy people were chosen as controls. Pyrosequencing was performed on the V3 hypervariable region of...

Data from: Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426

Yu Zhang, Jiao An, Guang-Yu Yang, Aixi Bai, Baisong Zheng, Zhiyong Lou, Geng Wu, Wei Ye, Hai-Feng Chen, Yan Feng & Giuseppe Manco
Enzyme promiscuity is a prerequisite for fast divergent evolution of biocatalysts. A phosphotriesterase-like lactonase (PLL) from Geobacillus kaustophilus HTA426 (GkaP) exhibits main lactonase and promiscuous phosphotriesterase activities. To understand its catalytic and evolutionary mechanisms, we investigated a “hot spot” in the active site by saturation mutagenesis as well as X-ray crystallographic analyses. We found that position 99 in the active site was involved in substrate discrimination. One mutant, Y99L, exhibited 11-fold improvement over wild-type in...

Registration Year

  • 2015

Resource Types

  • Dataset


  • Shanghai Jiao Tong University
  • Jilin University
  • Tsinghua University
  • Institute of Protein Biochemistry