5 Works

Data from: The evolution of defense mechanisms correlate with the explosive diversification of autodigesting Coprinellus mushrooms (Agaricales, Fungi)

László Nagy, Judit Házi, Balázs Szappanos, Sándor Kocsubé, Balázs Bálint, Gábor Rákhely, Csaba Vágvölgyi & Tamás Papp
Bursts of diversification are known to have contributed significantly to the extant morphological and species diversity, but evidence for many of the theoretical predictions about adaptive radiations have remained contentious. Despite their tremendous diversity, patterns of evolutionary diversification and the contribution of explosive episodes in fungi are largely unknown. Here, using the genus Coprinellus (Psathyrellaceae, Agaricales) as a model, we report the first explosive fungal radiation, and infer that the onset of the radiation follows...

Data from: The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

Qingqing Zhu, Lu Song, Guangdun Peng, Na Sun, Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong Han, Jinsong Li, Naihe Jing & Jing-Dong Jackie Han
The neural fate commitment of pluripotent stem cells requires the repression of extrinsic inhibitory signals and the activation of intrinsic positive transcription factors. However, how these two events are integrated to ensure appropriate neural conversion remains unclear. Here, we showed that Pou3f1 is essential for the neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimeric analysis showed that Pou3f1 knockdown leads...

Data from: Model choice, missing data and taxon sampling impact phylogenomic inference of deep Basidiomycota relationships

Arun N. Prasanna, Daniel Gerber, Teeratas Kijpornyongpan, M. Catherine Aime, Vinson P. Doyle & Laszlo G. Nagy
Resolving deep divergences in the tree of life is challenging even for analyses of genome-scale phylogenetic datasets. Relationships between Basidiomycota subphyla, the rusts and allies (Pucciniomycotina), smuts and allies (Ustilaginomycotina) and mushroom-forming fungi and allies (Agaricomycotina) were found particularly recalcitrant both to traditional multigene and genome-scale phylogenetics. Here, we address basal Basidiomycota relationships using concatenated and gene-tree based analyses of various phylogenomic datasets to examine the contribution of several potential sources of bias. We evaluate...

Data from: Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis

Wei Jiang, Jing-Jie Tang, Hong-Hua Miao, Yu-Xiu Qu, Jie Qin, Jie Xu, Jinbo Yang, Bo-Liang Li & Bao-Liang Song
Somatic cell genetics is a powerful approach for unraveling the regulatory mechanism of cholesterol metabolism. However, it is difficult to identify the mutant gene(s) due to cells are usually mutagenized chemically or physically. To identify important genes controlling cholesterol biosynthesis, an unbiased forward genetics approach named validation-based insertional mutagenesis (VBIM) system was used to isolate and characterize the 25-hydroxycholesterol (25-HC)-resistant and SR-12813-resisitant mutants. Here we report that five mutant cell lines were isolated. Among which,...

Data from: The evolution of defense mechanisms correlate with the explosive diversification of autodigesting Coprinellus mushrooms (Agaricales, Fungi)

László Nagy, Judit Házi, Balázs Szappanos, Sándor Kocsubé, Balázs Bálint, Gábor Rákhely, Csaba Vágvölgyi & Tamás Papp
Bursts of diversification are known to have contributed significantly to the extant morphological and species diversity, but evidence for many of the theoretical predictions about adaptive radiations have remained contentious. Despite their tremendous diversity, patterns of evolutionary diversification and the contribution of explosive episodes in fungi are largely unknown. Here, using the genus Coprinellus (Psathyrellaceae, Agaricales) as a model, we report the first explosive fungal radiation, and infer that the onset of the radiation follows...

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  • Institute of Biochemistry
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  • Shanghai Institutes for Biological Sciences
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