6 Works

Data from: HDAC1/2-dependent P0 expression maintains paranodal and nodal integrity independently of myelin stability through interactions with neurofascins

Valérie Brügger, Stefanie Engler, Jorge A. Pereira, Sophie Ruff, Michael Horn, Hans Welzl, Emmanuelle Münger, Adrien Vaquié, Páris N. M. Sidiropoulos, Boris Egger, Peter Yotovski, Luis Filgueira, Christian Somandin, Tessa C. Lühmann, Maurizio D’Antonio, Teppei Yamaguchi, Patrick Matthias, Ueli Suter & Claire Jacob
The pathogenesis of peripheral neuropathies in adults is linked to maintenance mechanisms that are not well understood. Here, we elucidate a novel critical maintenance mechanism for Schwann cell (SC)–axon interaction. Using mouse genetics, ablation of the transcriptional regulators histone deacetylases 1 and 2 (HDAC1/2) in adult SCs severely affected paranodal and nodal integrity and led to demyelination/remyelination. Expression levels of the HDAC1/2 target gene myelin protein zero (P0) were reduced by half, accompanied by altered...

Data from: Nested species interactions promote feasibility over stability during the assembly of a pollinator community

Serguei Saavedra, Rudolf P. Rohr, Jens M. Olesen & Jordi Bascompte
The foundational concepts behind the persistence of ecological communities have been based on two ecological properties: dynamical stability and feasibility. The former is typically regarded as the capacity of a community to return to an original equilibrium state after a perturbation in species abundances and is usually linked to the strength of interspecific interactions. The latter is the capacity to sustain positive abundances on all its constituent species and is linked to both interspecific interactions...

Data from: The response of the alpine dwarf shrub Salix herbacea to altered snowmelt timing: lessons from a multi-site transplant experiment

Janosch Sedlacek, Julia A. Wheeler, Andrés J. Cortés, Oliver Bossdorf, Guenter Hoch, Christian Lexer, Sonja Wipf, Sophie Karrenberg, Mark Van Kleunen & Christian Rixen
Climate change is altering spring snowmelt patterns in alpine and arctic ecosystems, and these changes may alter plant phenology, growth and reproduction. To predict how alpine plants respond to shifts in snowmelt timing, we need to understand trait plasticity, its effects on growth and reproduction, and the degree to which plants experience a home-site advantage. We tested how the common, long-lived dwarf shrub Salix herbacea responded to changing spring snowmelt time by reciprocally transplanting turfs...

Data from: Resprouter fraction in Cape Restionaceae assemblages varies with climate and soil type

Rafael O. Wüest, Glenn Litsios, Félix Forest, Christian Lexer, H. Peter Linder, Nicolas Salamin, Niklaus E. Zimmermann & Peter B. Pearman
While fire-induced changes in biodiversity are well documented, less is known about how fire impacts life-history variation and diversity of functional traits that represent distinct strategies for persistence in fire-driven ecosystems. One example is the dichotomy in which ‘resprouter’ species usually survive fires to produce new growth, while ‘reseeder’ species perish and re-establish from seed. Variable relative numbers of reseeder and resprouter species in local assemblages of Restionaceae (Poales) of the Cape Floristic Region (CFR),...

Data from: Genetic load, inbreeding depression and hybrid vigor covary with population size: an empirical evaluation of theoretical predictions

Jennifer N. Lohr & Christoph R. Haag
Reduced population size is thought to have strong consequences for evolutionary processes as it enhances the strength of genetic drift. In its interaction with selection, this is predicted to increase the genetic load, reduce inbreeding depression, and increase hybrid vigour, and in turn affect phenotypic evolution. Several of these predictions have been tested, but comprehensive studies controlling for confounding factors are scarce. Here we show that populations of Daphnia magna, which vary strongly in genetic...

Data from: Patterns of genetic diversity and differentiation in resistance gene clusters of two hybridizing European Populus species

Celine Caseys, Kai N. Stölting, Thelma Barbara, Santiago C. Gonzalez-Martinez & Christian Lexer
Resistance genes (R-genes) are essential for long-lived organisms such as forest trees, which are exposed to diverse herbivores and pathogens. In short-lived model species, R-genes have been shown to be involved in species isolation. Here, we studied more than 400 trees from two natural hybrid zones of the European Populus species Populus alba and Populus tremula for microsatellite markers located in three R-gene clusters, including one cluster situated in the incipient sex chromosome region. The...

Registration Year

  • 2015

Resource Types

  • Dataset


  • University of Fribourg
  • University of Zurich
  • University of Vienna
  • University of the Basque Country
  • Swiss Institute of Bioinformatics
  • Centre d'Ecologie Fonctionnelle et Evolutive
  • University of Lausanne
  • Aarhus University
  • Ikerbasque
  • University of Basel